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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai lin Chen Ming-Hui Zeng xue-Mei Tao Jia-Xin Han Yue-Kui Wang Lian-Xin xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Number-phase quantization of a mesoscopic RLC circuit

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Chinese Physics B 2012年第2期21卷 114-116页

作者： xu cheng-lin Department of Mathematics Yunnan Normal UniversityKunming 650092China

With the help of the time-dependent Lagrangian for a damped harmonic oscillator, the quantization of mesoscopic RLC circuit in the context of a number-phase quantization scheme is realized and the corresponding Hamiltonian operator is obtained. Then the evolution of the charge number and phase difference across the capacity are obtained. It is shown that the number-phase analysis is useful to tackle the quantization of some mesoscopic circuits and dynamical equations of the corresponding operators.

关键词： mesoscopic RLC circuit number-phase quantization Lagrangian function

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song lin xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Chemical transdifferentiation： closer to regenerative medicine

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Frontiers of Medicine 2016年第2期10卷 152-165页

作者： Aining xu lin cheng State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Cell transdifferentiation, which directly switches one type of differentiated cells into another cell type, is more advantageous than cell reprogramming to generate pluripotent cells and differentiate them into functional cells. This process is crucial in regenerative medicine. However, the cell-converting strategies, which mainly depend on the virus-mediated expression of exogenous genes, have clinical safety concerns. Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversion. In this review, we briefly retrospect the nature of cell transdifferentiation and summarize the current developments in the research of small molecules in promoting cell conversion. Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which is closer to the clinical translation in cell therapy. Despite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely unknown. More importantly, identifying drugs that induce resident cell conversion in vivo to repair damaged tissue remains to be the end-goal in current regenerative medicine.

关键词： cell therapy cell transdifferentiation chemical compounds small molecules tissue regeneration

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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A non-myopic scheduling method of radar sensors for maneuvering target tracking and radiation control

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Defence Technology（防务技术） 2020年第1期16卷 242-250页

作者： Gan-lin Shan Gong-guo xu cheng-lin Qiao Department of Electronic and Optical Engineering Army Engineering UniversityShijiazhuang 050003China

In decades,the battlefield environment is becoming more and more complex with plenty of electronic ***,in order to improve the survivability of radar sensors and satisfy the requirement of maneuvering target tracking with a low probability of intercept,a non-myopic scheduling is proposed to minimize the radiation cost with tracking accuracy *** first,the scheduling problem is formulated as a partially observable Markov decision process(POMDP).Then the tracking accuracy and radiation cost over the future finite time horizon are predicted by the posterior carmer-rao lower bound(PCRLB) and the hidden Markov model filter,***,the proposed scheduling is implemented efficiently by utilizing the branch and bound(B&B) pruning *** results show that the performance of maneuvering target tracking was improved by the improved interacting multiple model(IMM),and the scheduler time and maximum memory consumption were significant reduced by the present B&B pruning algorithm without losing the optimal solution.

关键词： Non-myopic scheduling Radiation control PCRLB POMDP Branch and bound

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Unified Classification and Rejection:A One-versus-all Framework

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Machine Intelligence Research 2024年第5期21卷 870-887页

作者： Zhen cheng xu-Yao Zhang cheng-lin Liu State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China

Classifying patterns of known classes and rejecting ambiguous and novel(also called as out-of-distribution(OOD))inputs are involved in open world pattern *** neural network models usually excel in closed-set classification while perform poorly in rejecting OOD *** tackle this problem,numerous methods have been designed to perform open set recognition(OSR)or OOD rejection/detection *** methods mostly take post-training score transformation or hybrid models to ensure low scores on OOD inputs while separating known *** this paper,we attempt to build a unified framework for building open set classifiers for both classification and OOD *** formulate the open set recognition of K-known-class as a(K+1)-class classification problem with model trained on known-class samples *** decomposing the K-class problem into K one-versus-all(OVA)binary classification tasks and binding some parameters,we show that combining the scores of OVA classifiers can give(K+1)-class posterior probabilities,which enables classification and OOD rejection in a unified *** maintain the closed-set classification accuracy of the OVA trained classifier,we propose a hybrid training strategy combining OVA loss and multi-class cross-entropy *** implement the OVA framework and hybrid training strategy on the recently proposed convolutional prototype network and prototype classifier on vision transformer(ViT)*** on popular OSR and OOD detection datasets demonstrate that the proposed framework,using a single multi-class classifier,yields competitive performance in closed-set classification,OOD detection,and misclassification *** code is available at https://***/zhen-cheng121/CPN_OVA_unified.

关键词： Open set recognition out-of-distribution detection misclassification detection convolutional prototype network oneversus-all Dempster-Shafer theory of evidence

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基于STM32的全自动病理染色控制系统的设计与实现

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工程设计学报 2022年第4期29卷 510-518页

作者：谭鑫平甘浪林成旭李雪梅李倩闫旺陈刚廖广兰刘智勇华中科技大学机械科学与工程学院湖北武汉430074 武汉康录生物技术股份有限公司湖北武汉430000

FISH(fluorescence in situ hybridization,荧光原位杂交)染色是应用于病理分析的重要技术。传统的手工染色方式由于操作繁琐及实验条件限制难以控制杂交质量,而国内现有的染色系统存在自动化程度低等缺点。为了解决上述问题,基于STM32... 详细信息

FISH(fluorescence in situ hybridization,荧光原位杂交)染色是应用于病理分析的重要技术。传统的手工染色方式由于操作繁琐及实验条件限制难以控制杂交质量,而国内现有的染色系统存在自动化程度低等缺点。为了解决上述问题,基于STM32嵌入式系统和GUI(graphical user interface,图形用户界面)开发了一套全自动病理染色控制系统。以STM32F103ZET6作为下位机处理器,利用QT软件和C++语言设计GUI界面,实现了对多样本FISH染色过程的全自动化控制。所研发的控制系统能够满足全自动病理染色系统的控制要求,滴加试剂的位置精度达到0.05 mm,试剂体积精度达到0.6μL,设备故障响应时间小于0.5 s,多次实验设备运行故障率小于3%,加样时试剂类型选择准确率达到100%,图像可判读率达到90%以上。该控制系统具有高效率、高鲁棒性的优点,结合全自动病理染色硬件系统进行染色实验,取得了均匀、良好的染色效果,因此具有良好的应用价值。

关键词：全自动病理染色系统控制系统 STM32F103ZET6 GUI(图形用户界面) FISH(荧光原位杂交)染色技术

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Design and Optimization of VLC Enabled Data Center Network

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Tsinghua Science and Technology 2020年第1期25卷 81-92页

作者： Yudong Qin Deke Guo xu lin Geyao cheng Science and Technology on Information Systems Engineering Laboratory National University of Defense TechnologyChangsha 410073China School of Computer Science and Technology Xidian UniversityXi’an 710000China

Visible-Light Communication(VLC) has the potential to provide dense and fast connectivity at low cost. In this paper we propose SFNet, a novel VLC-enabled hybrid data center network that extends the design of wireless Data Center Networks(DCNs) into three further dimensions:(1) fully wireless at the inter-rack level;(2) no need for a centralized control mechanism on wireless links;and(3) no need for any infrastructure-level alterations to data centers. Previous proposals typically cannot realize these three rationales simultaneously. To achieve this vision,the proposed SFNet augments fat-tree by organizing all racks into a wireless small-world network via VLC links. The use of VLC links eliminates hierarchical switches and cables in the wireless network, and thus reduces hardware investment and maintenance costs. To fully exploit the benefits of the topology of SFNet, we further propose its topology design and optimization method, routing scheme, and online flow scheduling algorithm. Comprehensive experiments indicate that SFNet exhibits good topological properties and network performance.

关键词： Data Center Network(DCN) Visible Light Communication(VLC) topology design

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