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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients

World Journal of Gastrointestinal Oncology 2024年第3期16卷 945-967页

作者： Jia-Li Hu Mei-Jin Huang Halike Halina Kun Qiao Zhi-Yuan Wang Jia-Jie Lu cheng-liang yin Feng Gao Department of Gastroenterology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Digestive Disease Urumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Oncology 920th Hospital of PLA Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination *** is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of *** also affects the prognosis of GC *** reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour ***,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still *** To investigate inflammatory-related biomarkers in predicting the prognosis of GC *** constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO *** patients from the GSE26253 cohort were used for *** and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was *** calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the *** decision curve analysis results were plotted to quantify and assess the clinical value of the *** set enrichment analysis was performed to explore the potential regulatory pathways *** relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and ***,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy *** A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was *** prognostic analysis revealed that the risk score was a separate prognostic factor in GC *** to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group ha

关键词： Gastric cancer Inflammation Immune infiltration Prognosis signature Subt

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Surgical treatment of left-sided renal carcinoma with grade II inferior vena cava tumour thrombus: a report and review of the literature

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Biomedical Engineering Communications 2024年第1期3卷 31-37页

作者： Yan-Chen Wang Xiao-Yan Guo Yao-Fei Sun Li-Hui Guan Yuan Gao Zhe Meng cheng-liang yin Tong-Bin Gao Department of Urology Weifang People's HospitalWeifang 261000China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

The surgical removal of renal cancer,along with the thrombectomy of the inferior vena cava tumour thrombus,represents a remarkable milestone in urological *** procedure is not only technically demanding but also requires a high level of surgical *** renal cancer combined with a vena cava tumour thrombus poses significant challenges,especially when dealing with combined grade Ⅱ-Ⅳ inferior vena cava tumour *** complexity of these cases is further exacerbated by the delicate anatomical structures involved and the need to preserve critical vessels while effectively removing the *** Upper Urethral Tumour Treatment Centre of Weifang People's Hospital successfully treated a challenging case of left renal tumour combined with grade II inferior vena cava tumour *** surgical team,led by experienced urological surgeons,meticulously planned and executed the procedure,ensuring minimal trauma to the patient and complete removal of the *** achievement not only demonstrates the hospital's commitment to providing state-of-the-art surgical care but also highlights the importance of continued research and training in urological *** successful outcome of this case is a testament to the expertise and dedication of the medical team and offers hope to patients facing similar complex surgical challenges.

关键词： renal carcinoma vena cava tumour thrombus renal artery embolism transoesophageal echocardiography three-dimensional reconstruction techniques

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Hotspots and frontiers of the relationship between gastric cancer and depression:A bibliometric study

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World Journal of Gastroenterology 2023年第46期29卷 6076-6088页

作者： Jia-Yu Liu Ji-Qi Zheng cheng-liang yin Wen-Pei Tang Jian-Ning Zhang Department of Neurosurgery The First Medical CentreChinese PLA General HospitalBeijing 100853China School of Health Humanities Peking UniversityBeijing 100191China Medical Big Data Research Center Medical Innovation Research Division of Chinese PLA General HospitalBeijing 100853China National Engineering Research Center for Medical Big Data Application Technology Chinese PLA General HospitalBeijing 100853China

BACKGROUND A significant relationship between gastric cancer(GC)and depression has been found in the last 20 ***,there is no comprehensive information that helps researchers find popular and potential research directions on GC and *** To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between GC and *** We used the Web of Science Core Collection to search and collate the literature on GC and depression from 2000 to 2022 on 31 May,***,visualization analysis was performed using VOSviewer software(version 1.6.19)and the Bibliometrix package in R *** We retrieved 153 pertinent publications from 2000 to *** annual publication count showed an overall upward *** had the most prominent publications and significant contributions to this field(n=64,41.83%).Before 2020,most studies focused on“the effect of GC on the development and progression of depression in patients.”The latest research trends indicate that“the effect of depression on the occurrence and development of GC and its mechanism”will receive more attention in the *** The study of“the effect of depression on the occurrence and development of GC and its mechanism”has emerged as a novel research theme over the past two years,which may become a research hotspot in this *** study provides new insights into the hotpots and frontiers of the relationship between GC and depression,potentially guiding researchers toward hot research topics in the future.

关键词： Gastric cancer Depression Bibliometric analysis Visualization Web of Science

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Configuration design,energy management and experimental validation of a novel series-parallel hybrid electric transit bus

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1269-1276页

作者： Wei-wei XIONG Yong ZHANG cheng-liang yin Institute of Automotive Engineering Shanghai Jiao Tong University Shanghai 200240 China

This paper aims to present the configuration design approach and the energy management strategy (EMS) of a series-parallel hybrid electric transit bus (SPHEB) jointly developed by Shanghai Automotive Industry Co. Ltd. (SAIC) and Shanghai Jiao Tong University (SJTU), China. A major feature of this SPHEB is that a novel manual transmission is designed to switch the powertrain configuration between series and parallel types. To reduce the fuel consumption as well as sustain the battery state of charge, an EMS including seven energy flow modes is designed and applied to this SPHEB. Governed by this EMS, the engine is maintained to operate in high efficiency regions. The experimental test carried on the transit bus city driving cycle is described and analyzed. The experimental results demonstrate the technical feasibility and fuel economy of this approach.

关键词：混合动力电动客车配置设计实验测试并联型能源管理能量管理策略环境管理体系验证

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Nutrient transport following water transfer through the world's largest water diversion channel

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Journal of Environmental Sciences 2024年第1期135卷 703-714页

作者： Yuanhui cheng Hong Zhang Wei yin State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085 China Changjiang Water Resources Protection Institute Wuhan 430051China University of Chinese Academy of Sciences Beijing 100049China

Nutrient levels in the artificial channel constructed for the Middle Route Project are significant indicators of water quality safety and aquatic ecological integrity for this large,interbasin ***,the distribution and transport of nutrients along the channel were poorly *** on a time-series dataset as well as mass balance and material flow analysis methods,the water and nutrient transport fluxes in the Middle Route of the South-to-North Water Diversion Project were identified in this *** results indicate that the nutrient concentrations varied considerably with time,but there was no significant difference among the 30 stations of the main *** temperature difference was the major factor in the large fluctuations of water quality indicators over *** nutrient loadings varied with the water volume outputs from the main channel to the waterreceiving *** deposition was an important source of nutrients in the main channel,accounting for 9.13%,20.6%,and 0.635%of the nitrogen,phosphorus,and sulfur input from the Danjiangkou Reservoir,*** 2021,a net accumulation of 988 tons of N,29 tons of P,and 2,540 tons of S,respectively,were present in the main *** increase of these external and internal nutrient loadings would cause water quality fluctuation and deterioration in some local sections of the main *** study quantified the spatial and temporal patterns of nutrient transport in the Middle Route and revealed the ecological effects on the aquatic environment,assisting authorities on the project to develop effective water conservation strategies.

关键词： Nutrient transport Spatiotemporal patterns The Middle Route The South-to-North Diversion Project Hydro-ecological effects Water-receiving cities

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Drivability improvements for a single-motor parallel hybrid electric vehicle using robust controls

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第4期15卷 291-301页

作者： Hu ZHANG Cun-lei WANG Yong ZHANG Jun-yi liang cheng-liang yin National Engineering Laboratory for Automotive Electronic Control Technology Shanghai Jiao Tong University Shanghai 200240 China

研究目的:改善一种单电机并联式混合动力电动汽车的驾驶性能。创新要点:1.建立面向控制器设计的系统模型,并且考虑系统参数的不确定性和CAN通讯延迟;2.设计基于mu综合的鲁棒控制器,减小了模式切换时车辆的冲击度,改善车辆的驾驶性能。... 详细信息

研究目的:改善一种单电机并联式混合动力电动汽车的驾驶性能。创新要点:1.建立面向控制器设计的系统模型,并且考虑系统参数的不确定性和CAN通讯延迟;2.设计基于mu综合的鲁棒控制器,减小了模式切换时车辆的冲击度,改善车辆的驾驶性能。研究方法:1.将发动机端和电机端的控制解耦,并对其进行单独的控制设计(图5、8);2.发动机端控制主要用于发动机调速,电机端控制主要用于补偿离合器转矩对传动系造成的干扰;3.控制器设计时采用前馈控制和鲁棒控制结合的方法。重要结论:通过采用鲁棒控制,使得一种单电机并联式混合动力电动汽车的驾驶性得到了改善。同时,在参数的不确定性和CAN通讯延迟的干扰下,整个系统依旧稳定运行且性能良好。

关键词：并联式混合动力电动汽车驾驶性能单电机动力传动系统鲁棒控制器发动机起动控件驱动模式

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Energy management strategy for a parallel hybrid electric vehicle equipped with a battery/ultra-capacitor hybrid energy storage system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第8期14卷 535-553页

作者： Jun-yi liang Jian-long ZHANG Xi ZHANG Shi-fei YUAN cheng-liang yin National Engineering Laboratory for Automotive Electronic Control Technology Shanghai Jiao Tong University

To solve the low power density issue of hybrid electric vehicular batteries, a combination of batteries and ultracapacitors (UCs) could be a solution. The high power density feature of UCs can improve the performance of battery/UC hybrid energy storage systems (HESSs). This paper presents a parallel hybrid electric vehicle (HEV) equipped with an internal combus- tion engine and an HESS. An advanced energy management strategy (EMS), mainly based on fuzzy logic, is proposed to improve the fuel economy of the HEV and the endurance of the HESS. The EMS is capable of determining the ideal distribution of output power among the internal combustion engine, battery, and UC according to the propelling power or regenerative braking power of the vehicle. To validate the effectiveness of the EMS, numerical simulation and experimental validations are carried out. The results indicate that EMS can effectively control the power sources to work within their respective efficient areas. The battery load can be mitigated and prolonged battery life can be expected. The electrical energy consumption in the HESS is reduced by 3.91% compared with that in the battery only system. Fuel consumption of the HEV is reduced by 24.3% compared with that of the same class conventional vehicles under Economic Commission of Europe driving cycle.

关键词： Energy management Fuel economy Parallel hybrid electric vehicle Hybrid energy storage system (HESS) Fuzzy logic

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The role of autophagy in the treatment of osteoporosis by Chinese medicines(natural)

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Traditional Medicine Research 2023年第10期8卷 30-46页

作者： Yu Zhou Xin Li Yang Chen Liqi Ng Swastina Nath Varma Chao-Zong Liu Qing Gong cheng-liang yin Foot and Ankle Surgery Chongqing Orthopedic Hospital of Traditional Chinese MedicineChongqing 400012China Institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalLondon HA74LPUK Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130117China Department of Endocrinology Chongqing Hospital of Traditional Chinese MedicineChongqing 400011China Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchun 130117China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and *** recent years,Chinese medicine(natural)has had a unique advantage in the treatment of osteoporosis and has shown good *** is an inherent cellular survival mechanism for the removal and recycling of damaged proteins and organelles and plays an important role in maintaining the stability of the intracellular environment and organ ***,this article aims to provide a comprehensive review of these Chinese medicines(natural)for the treatment of osteoporosis through *** have been intensively studied and reported to have effects such as promoting osteogenesis and anti-bone *** Chinese medicines include plants such as Cistanche deserticola,Epimedium,Curculigo orchioides Gaertn,Achyranthes bidentata Blume,Leonurus japonicus Houtt,Ginseng,Chuanxiong Rhizome,Eucommia ulmoides,Morindae Officinalis Radix,Curcuma longa,Polygoni Cuspidati Rhizoma et Radix,Anemarrhena asphodeloides Bunge,Salvia miltiorrhiza Bge and Pueraria Lobata,thus providing evidence for the use of alternative herbal therapies for the effective treatment of osteoporosis.

关键词： osteoporosis traditional Chinese medicine autophagy herb review

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Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 617-627页

作者： Xueqing yin Xinzhong RUAN Yongmeng ZHU Yongfang yin Rui HUANG Chao liang The First Affiliated Hospital of Ningbo University Ningbo 315000China Ningbo Medical Center Lihuili Hospital Ningbo 315000China

Objectiveperitoneal free cancer cells can negatively impact disease progression and patient outcomes in gastric cancer. This study aimed to investigate the feasibility of using golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging (GRASP DCE-MRI) to predict the presence of peritoneal free cancer cells in gastric cancer *** enrolled patients were consecutively divided into analysis and validation groups. Preoperative magnetic resonance imaging (MRI) scans and perfusion were performed in patients with gastric cancer undergoing surgery, and peritoneal lavage specimens were collected for examination. Based on the peritoneal lavage cytology (PLC) results, patients were divided into negative and positive lavage fluid groups. The data collected included clinical and MR information. A nomogram prediction model was constructed to predict the positive rate of peritoneal lavage fluid, and the validity of the model was verified based on data from the verification *** was no statistical difference between the proportion of PLC-positive cases predicted by GRASP DCE-MR and the actual PLC test. MR tumor stage, tumor thickness, and perfusion parameter Tofts-Ketty model volume transfer constant (Ktrans) were independent predictors of positive peritoneal lavage fluid. The nomogram model featured a concordance index (C-index) of 0.785 and 0.742 for the modeling and validation groups, *** DCE-MR could effectively predict peritoneal free cancer cells in gastric cancer patients. The nomogram model constructed using these predictors may help clinicians to better predict the risk of peritoneal free cancer cells being present in gastric cancer patients.

关键词： Gastric cancer Magnetic resonance Golden-angle radial sampling Nomogram model Peritoneal free cancer cells

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Amino acids in piglet diarrhea: Effects, mechanisms and insights

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Animal Nutrition 2024年第1期16卷 267-274页

作者： Xihong Zhou Jing liang Xia Xiong Yulong yin Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture The Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Piglet diarrhea is among one of the most serious health problems faced by the pig industry, resulting in significant economic losses. Diarrheal disease in piglets has a multifactorial etiology that is affected by physiology, environment, and management strategy. Diarrhea is the most apparent symptom of intestinal dysfunction. As a key class of essential nutrients in the piglet diet, amino acids confer a variety of beneficial effects on piglets in addition to being used as a substrate for protein synthesis, including maintaining appropriate intestinal integrity, permeability and epithelial renewal, and alleviating morphological damage and inflammatory and oxidative stress. Thus, provision of appropriate levels of amino acids could alleviate piglet diarrhea. Most amino acid effects are mediated by metabolites, gut microbes, and related signaling pathways. In this review, we summarize the current understanding of dietary amino acid effects on gut health and diarrhea incidence in piglets, and reveal the mechanisms involved. We also provide ideas for using amino acid blends and emphasize the importance of amino acid balance in the diet to prevent diarrhea in piglets.

关键词： Piglet Amino acid Diarrhea Gut microbe Immune

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