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Potential Role and Clinical Value of PPP2CA in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 661-671页

作者： cheng-lei yang Xue Qiu Jin-Yan Lin Xiao-Yu Chen Yu-Mei Zhang Xiao-Yin Hu Jian-Hong Zhong Shen Tang Xi-Yi Li Bang-De Xiang Zhi-Ming Zhang Department of Hepatobiliary Surgery Guangxi Medical University Cancer HospitalNanningGuangxiChina The First Clinical Medical School Guangxi Medical UniversityNanningGuangxiChina Department of Pathology Guangxi Medical University Cancer HospitalNanningGuangxiChina Department of Medical Oncology Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina School of Basic Medical Sciences Guangxi Medical UniversityNanningGuangxiChina School of Public Health Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Protein phosphatase 2A(PP2A)is associated with many *** study aimed to clarify whether PPP2CA,which encodes the alpha isoform of the catalytic subunit of PP2A,plays a role in hepatocellular carcinoma(HCC)and to identify the potential underlying molecular ***:Based on bioinformatics,public databases and our in-house RNA-Seq database,we analyzed the clinical value and molecular mechanism of PPP2CA in ***:Data were analyzed from 2,545 patients with HCC and 1,993 controls without HCC indexed in The Cancer Genome Atlas database,the Gene Expression Omnibus database and our in-house RNA-Seq ***2CA expression was significantly higher in HCC tissue than in non-cancerous tissues(standardized mean difference:0.69,95%confidence interval[CI]:0.50–0.89).PPP2CA expression was able to differentiate HCC from non-HCC,with an area under the summary receiver operator characteristic curve of 0.79(95%CI:0.75–0.83).Immunohistochemistry of tissue sections confirmed that PPP2CA protein was up-regulated in HCC *** PPP2CA expression in HCC patients was associated with shorter overall,progression-free and disease-free *** molecular pathways through which PPP2CA may be involved in HCC were determined using miRWalk 2.0 as well as analysis of Gene Ontology categories,Kyoto Encyclopedia of Genes and Genomes pathways,and protein-protein interaction ***:PPP2CA is up-regulated in HCC and higher expression correlates with worse ***2CA shows potential as a diagnostic marker for *** studies should examine whether PPP2CA contributes to HCC through the candidate microRNAs,pathways and hub genes identified in this study.

关键词： Hepatocellular carcinoma PPP2CA Molecular mechanism Diagnostic marker

Superconductivity at 36 K in gadolinium-arsenide oxides GdO_(1-x)F_xFeAs

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Science China(Physics,Mechanics & Astronomy) 2008年第6期51卷 719-722页

作者： cheng Peng, FANG lei, yang Huan, ZHU XiYu, MU Gang, LUO HuiQian, WANG ZhaoSheng & WEN HaiHu National Laboratory for Superconductivity, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China 1. National Laboratory for Superconductivity Institute of Physics Chinese Academy of Sciences Beijing 100190 China 2. Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

In this paper we report the fabrication and superconducting properties of GdO1-xFxFeAs. It was found that when x is equal to 0.17, GdO0.83F0.17FeAs is a su-perconductor with the onset transition temperature Tcon ≈ 36.6 K. Resistivity anomaly near 130 K was observed for all samples up to x = 0.17, and such a phenomenon is similar to that of LaO1-xFxFeAs. Hall coefficient indicates that GdO1-xFxFeAs is conducted by electron-like charge carriers.

关键词： iron-based superconductor high-temperature superconductor

Clinical prognostic value and potential molecular pathway of Cell division cycle associated 5(CDCA5) in hepatocellular carcinoma(HCC)

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Clinical prognostic value and potential molecular pathway of...

Synthesis and Crystal Structure of Lu11Sn10

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： cheng-lei yang Guo-Qun Liu Kun-Ying Huang Ao Jia Bang-De Xiang Department of Hepatobiliary Surgery Guangxi Medical University Cancer Hospital 广西医科大学第一临床医学院广西医科大学基础医学院

Objective:The purpose of this study is to investigate the prognostic value and possible molecular pathway of CDCA5 in hepatocellular carcinoma(HCC) and its relationship with the immune microenvironment of ***:Based on bioinformatics,public databases and our in-house RNA sequencing(RNA-seq)data,we explored the CDCA5 mRNA expression ***,the protein expression level of CDCA5 in HCC was also investigated using immunohistochemical analysis based on our RNA-seq *** combination with TIMER immune database and TISCH single cell database,immune infiltration level and single cell localization of CDCA5 in HCC were ***,the potential molecular pathways that CDCA5 involved in HCC were explored according to TCGA ***:Firstly,1649 HCC samples and 1044 non-cancerous tissues were included from GEO,TCGA and our in-house RNA-seq *** results of comprehensive meta-analysis suggested that CDCA5 m RNA expression level in HCC was significantly higher than non-HCC tissues(SMD=1.61).Besides,CDCA5 was proved that it had strong diagnostic ability for distinguishing HCC from non-tumor tissues(AUC=0.94).Furthermore,immunohistochemical analysis indicated that CDCA5 protein expression was up-regulated in HCC as ***,no significant statistical difference was found the enrichment of CDCA5+T cells between primary and early recurrent *** pathological parameters analysis showed that up-regulated CDCA5 was associated with adverse clinical characteristics and worse survival and prognosis of HCC ***,16457 single cells from 18 HCC tumor tissues were used for cell classification and marker gene identification by Seurat.28 subpopulations and 10 cell types were identified,in which cells expressing CDCA5 were defined as CDCA5+T cells that highly expressed proliferation genes MKI67,CD4,CD8A,GZMH and immune exhaustion cell marker genes(TIGIT,CTLA4,PDCD1 and HAVCR2).CDCA5+T cells were related to cell division,mitot

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Synthesis and Crystal Structure of Lu11Sn10

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

中国化学会第六届全国结构化学学术会议

作者： Xiao-Wu lei,cheng-yang Yue Department of Chemistry and Chemical Engineering,Jining University,Qufu,Shandong, 273155,People''s Republic of China

＜正＞The binary rare earth-tin system show a rich class of compounds with various types of structures and unusual physical *** these phases,tin can form a variety of phases based on tin rings, ladders,chains and olig...

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering

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Science China Chemistry 2025年第01期 317-328页

作者： Qingmin yang Jian Zhao Yujia Zhang Xingyu Zhou Hao Ren Bowen Hu Zhongli lei Lixin Chen Peng yang School of Material and Chemical Engineering Bengbu University Anhui Provincial Engineering Laboratory of Silicon-Based Materials School of Chemistry and Chemical Engineering Northwestern Polytechnical University Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical EngineeringShaanxi Normal University Xi'an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical Engineering Shaanxi Normal University International Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical EngineeringShaanxi Normal University

The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular economy. Herein, we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal ions. Our method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical reagents. Amyloid-mediated molecular engineering manipulates the phase transition of bovine serum albumin(BSA)on particulate waste surfaces, resulting in a remarkable ～3.1 times improvement in the adsorption capacity of fly ash, a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA(PTB). The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins, activated carbon(AC), covalent organic frameworks(COFs), and metal-organic frameworks(MOFs). We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste leachates. Consequently, this strategy could increase the value of waste materials nearly 27 times. In addition, this method is generally extendable to other conventional industrial adsorbents such as resin, clay, and Al2O3, and enhances their adsorption capabilities at least twofold. Overall, this work provides a simple and green approach for improving the adsorption performance of solid particles, and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.

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双位移随机脉冲位置调制技术在DC-DC变换器中的应用

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兵工自动化 2017年第1期36卷 46-49页

作者：朱磊程帅杨小龙杨蕾中国人民解放军63981部队武汉430311

为了解决常规的脉冲宽度调制(pulse width modulation,PWM)技术由于开关的高速动作导致严重的电磁干扰问题,对双位移随机脉冲调制(dual randomized pulse position modulation,DRPPM)技术在DC-DC变换器中进行应用。该方法保持采样周期不... 详细信息

为了解决常规的脉冲宽度调制(pulse width modulation,PWM)技术由于开关的高速动作导致严重的电磁干扰问题,对双位移随机脉冲调制(dual randomized pulse position modulation,DRPPM)技术在DC-DC变换器中进行应用。该方法保持采样周期不变,在传统随机位移调制的基础上,增加1个独立的位移变量,由于2个随机变量同时作用,使得随机效果更加明显,通过Matlab仿真验证该方法的可行性和正确性,并在TMS320F28335的DSP上进行实验验证。仿真和实验结果表明:该方法可以有效减小DC-DC变换器在开关频率处的谐波峰值,使得输出电压谐波成分更加均匀地分布在较宽的频带范围内,从而减小系统的电磁干扰。

关键词：双位移随机脉冲位置电磁干扰谐波电力电子

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu yang lei Xiao Zhiyong Kan Jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms