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Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant

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World Journal of Pediatrics 2024年第9期20卷 966-975页

作者： Yue Tao cheng-juan luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang Rd.Shanghai200127China Department of Hematology and Oncology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang Rd.Shanghai200127China Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Medical Affairs BioMérieux(Shanghai)CompanyLimitedShanghaiChina Clinical Research Institute School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Diarrhea is a common complication of hematopoietic stem cell transplantation(HSCT)and is associated with substantial morbidity,but its etiology is often *** of diarrhea in this population include infectious causes,chemotherapy-or medication-induced mucosal injury and graft-versus-host disease(GVHD).Distinguishing these potential causes of diarrhea is challenging since diarrheal symptoms are often multifactorial,and the etiologies often overlap in transplant *** objectives of this study were to evaluate whether the FilmArray gastrointestinal(GI)panel would increase diagnostic yield and the degree to which pre-transplantation colonization predicts post-transplantation *** From November 2019 to February 2021,a total of 158 patients undergoing HSCT were prospectively included in the *** specimens were obtained from all HSCT recipients prior to conditioning therapy,28±7 days after transplantation and at any new episode of *** stool samples were tested by the FilmArray GI panel and other clinical microbiological *** The primary cause of post-transplantation diarrhea was infection(57/84,67.86%),followed by medication(38/84,45.24%)and GVHD(21/84,25.00%).Ninety-five of 158 patients were colonized with at least one gastrointestinal pathogen before conditioning therapy,and the incidence of infectious diarrhea was significantly higher in colonized patients(47/95,49.47%)than in non-colonized patients(10/63,15.87%)(P<0.001).Fourteen of 19(73.68%)patients who were initially colonized with norovirus pre-transplantation developed a post-transplantation norovirus ***-four of 62(38.71%)patients colonized with Clostridium difficile developed a diarrheal *** addition,FilmArray GI panel testing improved the diagnostic yield by almost twofold in our study(55/92,59.78%vs.30/92,32.61%).Conclusions Our data show that more than half of pediatric patients who were admitted for HSCT were colonized

关键词： Children Diarrhea Hematopoietic stem cell transplantation Multiplexed polymerase chain reaction

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Interventions to improve chronic cyclosporine A nephrotoxicity through inhibiting renal cell apoptosis： a systematic review

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Chinese Medical Journal 2013年第19期126卷 3767-3774页

作者： XIAO Zheng LI cheng-wen SHAN juan luo Lei FENG Li LU Jun LI Sheng-fu LONG Dan LI You-ping Key Laboratory of Transplant Engineering and Immunology of Ministry Health of China West China Hospital Sichuan University ChengduSichuan 610041 China

Objective To reveal interventions for chronic cyclosporine A nephrotoxicity （CCN） and provide new targets for further studies,we analyzed all relevant studies about interventions in renal cell *** sources We collected all relevant studies about interventions for cyclosporine A （CsA）-induced renal cell apoptosis in Medline （1966 to July 2010）,Embase （1980 to July 2010） and ISI （1986 to July 2010）,evaluated their quality,extracted data following PICOS principles and synthesized the *** selection We included all relevant studies about interventions in CsA-induced renal cell apoptosis no limitation of research design and language） and excluded the duplicated articles,meeting abstracts and reviews without specific *** There were three kinds of intervention,include anti-oxidant （sulfated polysaccharides,tea polyphenols,apigenin,curcumin,spirulina,etc）,biologics （recombinant human erythropoietin （rhEPO）,a murine pan-specific transforming growth factor （TGF）-beta-neutralizing monoclonal antibody1D11,cartilage oligomeric matrix protein （COMP）-angiopoietin-1 and hepatocyte growth factor （HGF） gene）,and other drugs （spironolactone,rosiglitazone,pirfenidone and colchicine）.These interventions significantly improved the CCN,renal cell apoptosis and renal dysfunction through intervening in four apoptotic pathways in animals or protected renal cells from apoptosis induced by CsA and increased cell survival through respectively four pathways in *** There are three group interventions for *** anti-oxidant drugs can significantly improve CCN,renal cell apoptosis and renal *** drugs can improve CCN through intervening in Fas/Fas ligand or mitochondrial pathway with sufficient *** Ⅱ,nitric oxide （NO） and endoplasmic reticulum （ER） pathways will be new targets for CCN.

关键词： cyclosporine A interventions renal cells apoptosis chronic cyclosporine A nephrotoxicity

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者： Jing Chen cheng juan luo Chi Kong LI Yasuhiro Okamoto Godfrey Chi-fung CHAN Suradej Hongeng TAN Poh Lin TAN Ah Moy Kleebsabai Sanpakit Chun Fu LI Shanghai Jiao Tong University School of Medicine Shanghai Children’s Medical Centre Prince of Wales Hospital Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System KK Women’s and Children’s Hospital Faculty of Medicine Siriraj hospital Mahidol University Nanfang Hospital Southern Medical University Mount Elizabeth Hospital Singapore Anselm LEE and for Viva-Asia Blood and Marrow Transplantation (VABMT) Group

From August 2000 to November 2011, 127 children under the age of 18 years with acquired severe aplastic anemia (SAA) received hematopoietic stem cell transplantation (HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium, including 53 with matched sibling donor (MSD) and 74 with alternative donor (AD). Among these 74 AD, 22 were matched unrelated donor (MUD), 32 were mismatched unrelated donor (MMUD) and 20 were mismatched related donor (MMRD). Although the MSD group developed less grade

关键词： HLA High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

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新建高职院校构建教学质量保障体系的思考

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通化师范学院学报 2011年第7期32卷 111-112,F0003页

作者：程慧娟罗维斯福建对外经济贸易职业技术学院福建福州350016

教学质量是高职院校生存和发展的生命线,新建高职院校通过构建内部教学质量保障体系,提高办学水平,增强学校的竞争力,从而达到学校以质量求生存、以特色求发展的目的,保证教学质量和人才培养质量的不断提高。

关键词：高职院校教学质量保障体系

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang luo Jia-cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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无关供体造血干细胞移植治疗46例儿童难治性白血病疗效分析

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中华儿科杂志 2010年第3期48卷 170-174页

作者：陈静罗成娟江华罗长缨薛惠良汤静燕潘慈董璐周敏叶启东王耀平顾龙君上海交通大学医学院附属上海儿童医学中心血液/肿瘤科 200127

目的评估无关供体造血干细胞移植（UDT）治疗儿童难治性白血病的疗效。方法回顾性分析连续在我院接受UDT的46例白血病患儿的临床资料。急性淋巴细胞性白血病（ALL）患儿接受全身放疗为主的预处理、急性髓细胞性白血病（AML）和慢性粒细... 详细信息

目的评估无关供体造血干细胞移植（UDT）治疗儿童难治性白血病的疗效。方法回顾性分析连续在我院接受UDT的46例白血病患儿的临床资料。急性淋巴细胞性白血病（ALL）患儿接受全身放疗为主的预处理、急性髓细胞性白血病（AML）和慢性粒细胞性白血病（CML）患儿采用白消安清髓。结果中位年龄8．0（2—17）岁，3年总存活率（0s）63．0％，23．9％患儿死于移植相关并发症，13．0％患儿死于白血病复发。移植过程中33．3％出现Ⅲ～Ⅳ度急性移植物抗宿主病（aGVHD），55．6％发生慢性移植物抗宿主病（GVHD）（13．9％为慢性广泛性GVHD）。大于10岁、小于10岁患儿的0S差异有统计学意义（45．0％掷．76．9％，P=0．015）；ALL患儿3年0s明显差于CML和AML（38，4％、66．7％vs．80．0％，P=0．034）；高危白血病疗效明显差于低危患儿（45．8％VS．81．8％，P=0．012）；人类白细胞抗原（HLA）高分辨6／6全相合、1／6不合较2／6位点不合患儿的OS显著增高（75．0％，75．0％vs.16．7％，P=0．007）；移植中出现Ⅲ～Ⅳ度与0～Ⅱ度aGVHD患儿相比0s差异无统计学意义（66．0％vs．66．7％，P=0．494）。结论UDT治疗我国儿童难治性白血病疗效令人满意。小于10岁、HLA相合度高是UDT的有利因素，髓系、低危白血病疗效优于其他白血病。

关键词：白血病造血干细胞移植儿童无关供体

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VARIABLE SELECTION FOR RECURRENT EVENT DATA WITH INFORMATIVE CENSORING

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Journal of Systems Science & Complexity 2012年第5期25卷 987-997页

作者： Ximing cheng Li luo School of Applied Science Beijing Information Science and Technology University Academy of Mathematics and Systems Science Chinese Academy of Sciences Information System Management Dept.SINOPEC

Recurrent events data with a terminal event （e.g., death） often arise in clinical and ob- servational studies. Variable selection is an important issue in all regression analysis. In this paper, the authors first propose the estimation methods to select the significant variables, and then prove the asymptotic behavior of the proposed estimator. Furthermore, the authors discuss the computing algorithm to assess the proposed estimator via the linear function approximation and generalized cross validation method for determination of the tuning parameters. Finally, the finite sample estimation for the asymptotical covariance matrix is also proposed.

关键词： Backward exclusion estimating equation forward inclusion informative censoring oracleproperties recurrent event data sparsity.

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Phase and particle of Y-doped Ni(OH)_2 prepared from different nickel sources and Na_2CO_3 amount

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Rare Metals 2014年第2期33卷 219-224页

作者： Qing-Sheng Xu Yan-juan Zhu Liang-Guo Huang Jie luo Zhong-Ju Zhang cheng-cheng Miao Hu Ye School of Physics and Optoelectronic Engineering Guangdong University of Technology School of Mechanical and Electronic Engineering Guangdong Institute of Science and Technology

Multiple nano-sized a-Ni（OH）2was synthesized by ultrasonic-assisted precipitation under different conditions. The crystal structure and particle size distribution of the sample were characterized with X-ray diffraction（XRD）, infrared spectroscopy, and laser particle size analyzer（PSA）. The results show that the samples are anisotropic polycrystalline of a and b Ni（OH）2, and the ratio of a and b changes with the difference of nickel source, resulting in the largest ratio of a-Ni（OH）2using nickel nitrate as reactant. Larger amount of Na2CO3is conducive to the formation of a-Ni（OH）2; while the resultant phases are all b with the same conditions but no doping. The results of PSD indicate that the samples are about 100–120 nm in size, and the sample with nickel sulfate as nickel source has the minimum particle size. The three ions of nickel source appear in the absorption peaks in the Fourier transform infrared spectrum showing that the ions change the crystal structure of Ni（OH）2. EDS testing shows that Y and anion distribute in the lattice of aNi（OH）2uniformly.

关键词： Multiphase nano-Ni(OH)2 Y-doping Nickel source

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Controlled Synthesis of NaV_6O_(15) Nanorods with High Reversible Capacity and Excellent Cycling Stability

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Journal of Materials Science & Technology 2017年第3期33卷 271-275页

作者： Taotao Ding juan Xu cheng Chen Zhongwei luo Jiangnan Dai Yu Tian Changqing Chen Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology School of Physics and Information Engineering Jianghan University

In this work, we demonstrate an effective method to improve capacitive performance of NaV6O（15） intrinsically by annealing. NaV6O（15） nanorods（NRs） prepared by a simple annealing treatment exhibit significantly improved electrochemical performance compared with the untreated NaV6O（15） electrode, and yield a high specific capacitance（402.8 F/g at 300 mA/g）. Furthermore, the annealing treated nanorods show excellent rate capability and cycling stability（ca. 80% capacitance retention after 1000 cycles at a scan rate of100 mV/s）. Our results have confirmed that the annealing treatment has great influence on the capacitive performance of NaV6O（15）, which may be attributed to the intrinsic three dimensional（3D） tunneled structures of NaV6O（15）, and NR morphology. These findings may further broaden the application of NaV6O（15）-based materials for high performance supercapacitors（SCs）, aqueous rechargeable lithium batteries and Li-ion capacitors.

关键词： NaV6O(15) Nanobelt Nanorod Supercapacitor

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