检索结果-南通市图书馆

BIOMARKERS INDICATING SEDIMENTARY PALEOENVIRONMENTS

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 1989年第2期32卷 242-256页

作者：范璞 R.P.PHILP 孟仟祥程学惠李景贵于沁科李振西陈宁 Lanzhou Institute of Geology Academia Sinica The University of Oklahoma USA

Samples involved in this paper are 35 pieces of crude oils and 43 pieces of source rocks, from which a series of biomarkers, capable of indicating paleoecology and paleoenvironment. This will provide a scientific basi... 详细信息

关键词： paleoenvironment biomarker sediment drimane secohopane bicyclic sesquiterpane benzohopane.

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi hui Ren Woon Genevieve Saw li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Modification strategies on nickel-based electrocatalysts for energyefficient anodic reactions

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 50-75页

作者： Jingwen Yu Yunliang liu Naiyun liu Yaxi li Yuanyuan cheng Peng Cao Yixian liu Xinya Yuan Xinyue Zhang Haitao li Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Electrocatalytic chemical oxidation(ECO)is an energy-efficient anodic reaction alternative to the oxygen evolution reaction(OER).ECO lowers the reaction potential and yields higher-value fine chemicals at the *** catalyst material plays a crucial role in influencing and determining ECO *** catalyst performance encompasses aspects such as activity,stability,selectivity and *** electrocatalysts have garnered significant attention for their exceptional performance and widespread use in ECO *** modifying nickel-based electrocatalysts,the formation of NiOOH active centers can be *** such as adjusting size and morphology,doping,introducing defects and constructing heterojunctions are advantageous for enhancing *** the rapid advancements in related research fields,it is imperative to comprehend the mechanisms of nickel-based electrocatalysts in ECO and develop innovative *** article provides an overview of the modification strategies of nickel-based electrocatalysts,as well as their applications and mechanisms in ECO.

关键词： anodic reactions electrocatalytic chemical oxidation nickel-based electrocatalysts NiOOH modification strategies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

蓝芩口服液定性定量方法的研究

中南药学 2011年第9期9卷 680-683页

作者：程力惠周晔广东药学院广州510627

目的研究蓝芩口服液的定性定量方法。方法利用薄层色谱法对蓝芩口服液中的板蓝根、栀子、黄柏、胖大海进行研究;用高效液相色谱法测定蓝芩口服液中黄芩苷的含量。结果在硅胶板上样品与对照品相应的位置上,显相同的颜色斑点,阴性样品无干... 详细信息

目的研究蓝芩口服液的定性定量方法。方法利用薄层色谱法对蓝芩口服液中的板蓝根、栀子、黄柏、胖大海进行研究;用高效液相色谱法测定蓝芩口服液中黄芩苷的含量。结果在硅胶板上样品与对照品相应的位置上,显相同的颜色斑点,阴性样品无干扰;HPLC法测定黄芩苷在0.21-5.13μg与峰面积线性关系良好,r=0.999 8,平均回收率97.4%,RSD为1.9%（n=6）,蓝芩口服液中黄芩苷的含量为18.439-20.456 mg.支-1。结论所建立的方法可用于蓝芩口服液质量控制的补充。

关键词：蓝芩口服液质量标准黄芩苷薄层色谱法高效液相色谱法

负压封闭引流联合皮质激素雾化吸入预防肝切除患者术后肺部感染的效果观察

在线全文

学校读者我要写书评

暂无评论

中华医院感染学杂志 2018年第9期28卷 1380-1383页

作者：李晓明姚立鹏程丽慧姚本来邢福元三亚市人民医院肝胆外科海南三亚572000

目的研究负压封闭引流联合内皮质激素雾化吸入预防肝切除术后肺部感染的应用效果。方法选取2014年1月-2017年1月在医院接受肝切除术治疗的240例患者作为研究对象,根据随机数表法分为两组,每组各120例;对照组患者在肝切除术后1d给予雾化... 详细信息

目的研究负压封闭引流联合内皮质激素雾化吸入预防肝切除术后肺部感染的应用效果。方法选取2014年1月-2017年1月在医院接受肝切除术治疗的240例患者作为研究对象,根据随机数表法分为两组,每组各120例;对照组患者在肝切除术后1d给予雾化吸入布地奈德、氨溴索,治疗7d;研究组患者在对照组治疗基础上开展负压封闭引流方式进行治疗,7d/疗程,比较两组患者治疗前后动脉血气指标、疼痛程度变化及肺部感染发生率。结果治疗后两组患者血氧分压(PaO_2)、氧合指数(OI)、血氧饱和度(SaO_2)水平均高于治疗前,肺泡-动脉血氧梯度(A-aDO_2)水平均低于治疗前(P<0.05),且研究组指标变化幅度优于对照组(P<0.05);两组患者疼痛评分均低于治疗前(P<0.05),且研究组疼痛评分下降幅度优于对照组(P<0.05);治疗后研究组患者肺部感染率5.8%低于对照组的15.0%,差异有统计学意义(χ2=5.403,P=0.046)。结论针对肝切除手术患者而言,采用负压封闭引流联合内皮质激素雾化吸入治疗能有效减轻疼痛,减少肺部感染发生率,改善肺部通气情况,临床应用效果显著,值得推广应用。

关键词：负压封闭引流内皮质激素肝切除术肺部感染

在线全文

学校读者我要写书评

暂无评论

网络教育语境下外语自主学习能力的构建

常熟理工学院学报 2007年第12期21卷 87-91页

作者：程黎辉吴雪云常熟理工学院外语系江苏常熟215500 南京审计学院外语系南京210029

网络教育语境下外语自主学习是一种新的学习方式。网络自主学习的自主性、独立性、开放性、电子性特点要求学习者具有基于网络进行自主学习的能力素质。通过网络自主学习模式的创设与网络自主学习的指导,有效构建学习者的外语自主学习... 详细信息

网络教育语境下外语自主学习是一种新的学习方式。网络自主学习的自主性、独立性、开放性、电子性特点要求学习者具有基于网络进行自主学习的能力素质。通过网络自主学习模式的创设与网络自主学习的指导,有效构建学习者的外语自主学习能力。

关键词：网络教育外语自主学习能力构建

在线全文

学校读者我要写书评

暂无评论

大黄中大黄酸提取工艺研究

亚热带植物科学 2014年第1期43卷 15-18页

作者：程力惠李晓蒙广东药学院广东广州510627

以大黄酸含量为参考指标,通过单因素实验分别考察硫酸浓度(A)、液料比(B)、提取加热时间(C)、提取加热温度(D)对大黄中大黄酸提取量的影响,并根据单因素试验结果设计正交试验。结果表明,影响大黄中大黄酸提取工艺的主次因素为:加热温度D... 详细信息

以大黄酸含量为参考指标,通过单因素实验分别考察硫酸浓度(A)、液料比(B)、提取加热时间(C)、提取加热温度(D)对大黄中大黄酸提取量的影响,并根据单因素试验结果设计正交试验。结果表明,影响大黄中大黄酸提取工艺的主次因素为:加热温度D>加热时间C>硫酸浓度A>液料比B,大黄中大黄酸的最佳提取工艺为:15%硫酸、5∶1液料比、55℃加热回流2.5 h。此法操作性强,优选出最佳提取工艺条件,为开发大黄中泻下有效部位提供了理论依据。

关键词：大黄酸提取工艺单因素试验正交试验

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan liu Wei Wu Xuejuan li chengyan Wang Ke Chai Fanru Yuan huijuan Zheng Yuxing Yao Chenlu li Zu-cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles