检索结果-南通市图书馆

Science China(life Sciences) 2022年第10期65卷 2114-2117页

作者： Zhenjie li Hongwei cheng Jingsong Mao gang liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China Department of Radiology Xiang'an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

Interventional embolization is one of the most common treatment strategies in the clinical cancer treatment,especially in liver cancer(Sieghart et al.,2015).However,unstable dispersion and rapid drug release are the bottlenecks in clinical practice.The superstable homogeneous iodinated formulation technology(SHIFT)in interventional embolization treatment has achieved homogeneous dispersion of drugs in lipiodol embolic agent,showing promising clinical translation prospects(Chen et al.,2020 a;He et al.,2022 a.

关键词： unstable drugs treatment

Mass balance of the Antarctic Ice Sheet from 2013 to 2018 estimated using the input-output method with updated remote sensing products

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2023年第7期66卷 1478-1492页

作者： Yuan cheng gang HAI Xiangbin CUI Da LV gang QIAO Rongxing li Institute for the Conservation of Cultural Heritage School of Cultural Heritage and Information ManagementShanghai UniversityShanghai 200444China Center for Spatial Information Science and Sustainable Development Tongji UniversityShanghai 200092China College of Surveying and Geo-Informatics Tongji UniversityShanghai 200092China Polar Research Institute of China Shanghai 200136China

The Antarctic Ice Sheet(AIS)has been losing ice mass and contributing to the rise in the global sea-level(GSL)for the last 4 decades,as quantified by using satellite observations.We developed a framework for implementing the state-of-the-art input-output(IO)method that has the advantage of explicit estimation of the mass balance of individual glaciers,basins and the continent.We estimated the mass balance of the AIS from 2013 to 2018 using improved observations and updated datasets recently made available,including annual ice flow velocity maps from the Inter-mission Time Series of Land Ice Velocity and Elevation(ITS_liVE)dataset,the Bed Machine and the Princess Elizabeth Land(PEL)Earth System Science Data(ESSD)datasets,and the surface mass balance from the RACMO 2.3 system.For example,using the improved ice thickness data,the proposed method for ice discharge estimation enables a 10%reduction of uncertainty in ice discharge.During the period of 2013–2018,an ice discharge acceleration of 6.9±6.5 Gt yr^(–2)in West Antarctica(WA)was detected,which contributed significantly to the estimated mass loss of~1069 Gt(–178.2±108.9 Gt yr^(–1))in the AIS.On the other hand,Queen Maud Land,East Antarctica(EA),showed clearly a mass gain rate of 56.0±10.0 Gt yr^(–1)due to the regional increase in surface mass balance.Our results extended the estimation period by 3 years in comparison to the published study using the same annual velocity maps from the ITS_liVE dataset.Furthermore,our results,along with those from other studies using the IO method,reassures the acceleration of recent mass loss in WA and Wilkes Land in EA,which are caused by glacier thinning and ice shelf basal melting.Compared with the long-term mass balance record since 1979,our results suggest that the mass loss in AIS accelerated in the last decade.The developed framework can be modified for mass balance estimation of the AIS or for other ice sheets by using velocity maps from other satellite data or from different periods.

关键词： Antarctic Ice Sheet Mass balance Input-output method BedMachine ITS_liVE

Correlations of Ni Contents, Formation of Reversed Austenite and Toughness for Ni-Containing Cryogenic Steels

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2017年第3期30卷 238-249页

作者： Meng Wang Zhen-Yu liu Cheng-Gang Li State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110819 China

It has been widely demonstrated that addition of Ni in low-carbon steels can effectively improve the cryogenic toughness, but the mechanism behind it has yet to be clarified. In the present work, the evolutions of microstructure and mechanical properties after quenching and tempering for Ni-containing cryogenic steels with different Ni contents （3.5-9 wt%） were investigated. The results showed that after quenching and tempering, the Ni-containing cryogenic steels were composed of tempered martensite and reversed austenite. The volume fraction of reversed austenite has increased from 0 up to 6.3% when the Ni content increases from 3.5% to 9%. The Charpy impact tests indicated that the low- temperature toughness was markedly improved with the increase in Ni content, which can be correlated with the increase in reversed austenite amount. The main contribution of reversed austenite to the toughness lies in：（1） the elimination of cementite precipitates improved the plastic deformation capacity of matrix, and （2） the crack propagation is hindered through plastic deformation.

关键词： Ni-containing cryogenic steel Microstructure Reversed austenite Impact toughness Crackpropagation

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第5期16卷 7248-7259页

作者： Xianyun Wang Shiqi Hu Dashuai Zhu Junlang li Ke cheng gang liu Department of Cardiology The First Hospital of Hebei Medical UniversityShijiazhuang 050000China Scientific Research Data Center The First Hospital of Hebei Medical UniversityShijiazhuang 050000China Hebei Key Laboratory of Cardiac Injury Repair Mechanism Study Shijiazhuang 050000China Hebei International Joint Research Center for Structural Heart Disease Shijiazhuang 050000China Department of Molecular Biomedical Science North Carolina State UniversityRaleigh 27607North CarolinaUSA Department of Biomedical Engineering University of North CarolinaChapel Hill and North Carolina State UniversityRaleigh 27607North CarolinaUSA

Extracellular vesicles(EVs)generated from mesenchymal stem cells(MSCs)play an essential role in modulating cell–cell communication and tissue regeneration.The clinical translation of EVs is constrained by the poor yield of EVs.Extrusion has recently become an effective technique for producing a large scale of nanovesicles(NVs).In this study,we systematically compared MSC NVs(from extrusion)and EVs(from natural secretion).Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs.Additionally,microRNAs in NVs are related to cardiac repair,fibrosis repression,angiogenesis.Lastly,intravenous delivery of MSC NVs improved heart repair and cardiac function in a mouse model of myocardial infarction.

关键词： nanovesicles(NVs) exosomes,cardiac repair mesenchymal stem cells(MSCs) extracellular vesicles(EVs) myocardial infarction(MI)

Recent advances in synthesis strategies and solar-to-hydrogen evolution of 1T phase MS_(2)(M=W,Mo)co-catalysts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第6期101卷 242-263页

作者： Shuo li Jinyan Xiong Xueteng Zhu Weijie li Rong Chen gang cheng School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyDonghu New&High Technology Development ZoneWuhan 430205China College of Chemistry and Chemical Engineering Hubei Key Laboratory of Biomass Fibers and Ecodyeing&FinishingWuhan Textile UniversityWuhan 430200China School of Materials Science and Hydrogen Energy Foshan UniversityFoshan 528000China Institute for Superconducting and Electronic Materials Innovation CampusSquires WayUniversity of WollongongNorth WollongongNSW 2500Australia Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450002China

Photocatalytic water splitting is a promising strategy to produce hydrogen as a sustainable and clean energy carrier,based on abundant solar energy and semiconductor photocatalysts,and it has received extensive research and discussion over the past several decades.It is challenging,however,to achieve an efficient solar-to-hydrogen evolution process with a single particulate photocatalyst due to the weak solar spectrum harvest and the rapid recombination of photogenerated electron-hole pairs during the photocatalysis reaction.Combining semiconductors to create different co-catalysts presents a viable solution to the above issues.Recently,semiconductor photocatalysts modified by different transition metal sulfidebased co-catalysts with designed functions,especially in light absorption enhancement and chargecarrier-separation efficiency promotion,have attracted much attention.As continued breakthroughs have been made in the preparation,modification,and solar-to-hydrogen evolution application of the 1T phase MS_(2)(M=W,Mo)co-catalyst-based photocatalysis system in recent years,we believe that a comprehensive review of this kind of co-catalyst would further promote its research and development to address the energy and environmental challenges that we are currently facing.Herein,recent studies and progress are summarized on the fabrication of 1T phase MS_(2)(M=W,Mo)-based co-catalyst materials,as well as their roles and functional mechanisms for photocatalytic H;evolution.Finally,concluding perspectives on the opportunities in and challenges for the further exploration of the 1T-MS_(2)(M=W,Mo)-based solar-tohydrogen evolution system are presented.

关键词： Solar-to-hydrogen evolution Co-catalysts 1T-MS_(2)(M=W Mo) Water splitting Synthesis strategies Photocatalysis

Forecast of natural gas supply and demand in China under the background of “Dual Carbon Targets”

在线全文

学校读者我要写书评

暂无评论

Petroleum Exploration and Development 2023年第2期50卷 492-504页

作者： JIA Ailin cheng gang CHEN Weiyan li Yilong PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China

As a kind of clean energy which creates little carbon dioxide, natural gas will play a key role in the process of achieving “Peak Carbon Dioxide Emission” and “Carbon Neutrality”. The Long-range Energy Alternatives Planning System(LEAP) model was improved by using new parameters including comprehensive energy efficiency and terminal effective energy consumption. The Back Propagation(BP) Neural Network–LEAP model was proposed to predict key data such as total primary energy consumption, energy mix, carbon emissions from energy consumption, and natural gas consumption in China. Moreover, natural gas production in China was forecasted by the production composition method. Finally, based on the forecast results of natural gas supply and demand, suggestions were put forward on the development of China’s natural gas industry under the background of “Dual Carbon Targets”. The research results indicate that under the background of carbon peak and carbon neutrality, China’s primary energy consumption will peak(59.4×10^(8)tce) around 2035, carbon emissions from energy consumption will peak(103.4×10^(8)t) by 2025, and natural gas consumption will peak(6100×10^(8)m^(3)) around 2040, of which the largest increase will be contributed by the power sector and industrial sector. China’s peak natural gas production is about(2800–3400)×10^(8)m^(3), including(2100–2300)×10^(8)m^(3)conventional gas(including tight gas),(600–1050)×10^(8)m^(3)shale gas, and(150–220)×10^(8)m^(3)coalbed methane. Under the background of carbon peak and carbon neutrality, the natural gas consumption and production of China will further increase, showing a great potential of the natural gas industry.

关键词： carbon peak and carbon neutrality energy mix carbon emissions natural gas consumption natural gas produc-tion new energy system terminal consumption scale production,supply,storage and marketing

Perineural invasion of hilar cholangiocarcinoma in Chinese population: One center’s experience

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2020年第4期12卷 457-466页

作者： Cheng-Gang Li Zhi-Peng Zhou Xiang-Long Tan Zhi-Ming Zhao Second Department of Hepatobiliary Surgery Chinese PLA General HospitalBeijing 100853China

BACKGROUND Hilar cholangiocarcinoma(HCCA)often produces perineural invasion(PNI)extending to extra-biliary sites,while significant confusion in the incidence of PNI in HCCA has occurred in the literature,and the mechanism of that procedure remains unclear.AIM To summarize the incidence of PNI in HCCA and to provide the distribution of nerve plexuses around hepatic portal to clinical surgeons.METHODS Reported series with PNI in HCCA since 1996 were reviewed.A clinicopathological study was conducted on sections from 75 patients with HCCA to summarize the incidence and modes of PNI.Immunohistochemical stains for CD34 and D2-40 in the cancer tissue were performed to clarify the association of PNI with microvessel and lymph duct.Sections of the hepatoduodenal ligament from autopsy cases were scanned and handled by computer to display the distribution of nerve plexuses around the hepatic portal.RESULTS The overall incidence of PNI in this study was 92%(69 of 75 patients),while the rate of PNI in HCCA in the literature ranging from 38%to 100%.The incidence of PNI did not show any remarkable differences among various differentiated groups and Bismuth-Corlette classification groups.Logistic regression analysis identified the depth of tumor invasion was the only factor that correlated significantly with PNI(Pligament and Glisson’s sheath were classified,and they all surrounded the great vessels very closely.CONCLUSION The incidence of PNI of HCCA in Chinese population is around 92%and correlated significantly with a depth of tumor invasion.It also should be considered when stratifying HCCA patients for further treatment.

关键词： Hilar cholangiocarcinoma Perineural invasion Pathology Nerve plexus Incidence Treatment

Beyond Antibiotics:Photo/Sonodynamic Approaches for Bacterial Theranostics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第10期12卷 313-335页

作者： Xin Pang Dengfeng li Jing Zhu Jingliang cheng gang liu Henan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging Department of Magnetic Resonance ImagingThe First Affiliated Hospital of Zhengzhou University450052 ZhengzhouPeople’s Republic of China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen University361102 XiamenPeople’s Republic of China Amoy Hopeful Biotechnology Co. Ltd361027 XiamenPeople’s Republic of China

Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics,but antimicrobial photodynamic therapy(aPDT)provides an excellent alternative.This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species(ROS),which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern.When replacing light with low-frequency ultrasonic wave to activate sensitizer,a novel ultrasounddriven treatment emerges as antimicrobial sonodynamic therapy(aSDT).Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections,especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers,and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization.In this review,we systemically outline the mechanisms,targets,and current progress of aPDT/SDT for bacterial theranostic application.Furthermore,potential limitations and future perspectives are also highlighted.

关键词： Photodynamic therapy Sonodynamic therapy Theranostics Multidrug resistant Reactive oxygen species

Accurate structural descriptor enabled screening for nitrogen and oxygen vacancy codoped TiO_(2) with a large bandgap narrowing

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第27期122卷 84-90页

作者： Kangyu Zhang lichang Yin gang liu Hui-Ming cheng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Department of Physics and Electronic Information Huaibei Normal UniversityHuaibei 235000China

Nitrogen(N)doping has been widely adopted to improve the light absorption of TiO_(2).However,the newly introduced N-2p states are largely localized thus barely overlap with O-2p states in the valence band of TiO_(2),resulting in a shoulder-like absorption edge.To realize an apparent overlap between N-2p and O-2p states,charge compensation between N^(3-)and O^(2-)via electron transfer from oxygen vacancies(VO)to N dopants is one possible strategy.To verify this,in numerous doping configurations of N/VO-codoped anatase TiO_(2),we identified two types of VOposition independent N-dopant spatial orderings by efficient screening enabled with a newly designed structural descriptor.Compared with others,these two types of the N-dopant spatial orderings are highly beneficial for charge compensation to produce an apparent overlap between N-2p and O-2p states,therefore achieving a large bandgap narrowing.Furthermore,the two types of the N-dopant spatial orderings can also be generalized to N/VO-codoped rutile TiO_(2)for bandgap narrowing.

关键词： Structural descriptor TiO_(2) Bandgap narrowing Doping Machine learning Density functional theory

Long-term efficacy and safety of Huangqi(Radix Astragali Mongolici)-based Traditional Chinese Medicine in diabetic peripheral neuropathy:a Meta-analysis of randomized controlled trials

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第2期44卷 229-242页

作者： PING Jing HAO Hongzheng WU Zhenqi ZOU Meijuan li Zuojing cheng gang School of life Sciences and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110000China Department of Endocrinology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000China Department of Research Administration Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110000China

OBJECTIVE:To assess the long-term effectiveness of Huangqi(Radix Astragali Mongolici,HQ)-based Traditional Chinese Medicine(TCM)in the treatment of diabetic peripheral neuropathy(DPN).METHODS:Nine databases were searched to retrieve available randomized controlled trials that compared HQbased TCM and Western Medicines in the treatment of DPN.The methodological quality of the included studies was assessed using the Cochrane bias risk tool,and RevMan 5.4 was used for data analysis.The effect estimates of interest were risk ratio(RR),mean difference(MD)or standardized mean difference(SMD)with 95%confidence interval(CI).RESULTS:The results from 48 available studies assessing 3759 patients demonstrated that cases administered HQ-based TCM[RR=1.30,95%CI(1.21,1.40),Plinical Scoring System scores[MD=-1.50,95%CI(-1.83,-1.17),Plipids,oxidative stress and adverse drug reactions,there were no significant differences between the HQ-based TCM groups and the Western Medicine control group.CONCLUSION:The current Meta-analysis revealed that HQ-based TCM yields higher efficacy and safety than Western Medicine alone for the treatment of DPN,although further well-designed RCTs are required to validate these findings.

关键词： Huangqi(Radix Astragali Mongolici) medicine Chinese traditional diabetic peripheral neuropathy Meta-analysis