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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： cheng-Yan hu Yan-Ling WANG Zhen-Xing FAN Xi-Peng SUN Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

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Experimental investigation on indoor daylight environment of building with Cadmium Telluride photovoltaic window

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Energy and Built Environment 2024年第3期5卷 404-413页

作者： Yilin hu Qingwen Xue Haobo Wang Peng Zou Jinming Yang Shikeng Chen Yuanda cheng State Key Laboratory of Green Building in Western China Xian University of Architecture&TechnologyXianChina College of Civil Engineering Taiyuan University of TechnologyTaiyuanChina

Photovoltaic(PV)windows have received more and more attention in recent years since their active energy-saving *** the surface covered with solar cell modules,the indoor daylight environment of PV windows is obviously different with clear glass ***,despite many scholars have studied the indoor daylight environment of PV windows,there few investigations study it from the perspective of human subjective visual *** this paper,the indoor daylight environment and human visual comfort of building with Cadmium Telluride Photovoltaic(CdTe-PV)window were ***,the parameters of indoor daylight environment and subjective questionnaires in rooms with CdTe-PV window and clear glass window were analyzed *** the basis of this,combined with indoor working surface illuminance and results of subjective questionnaires,the daylight illuminance threshold of human visual comfort was investigated by the method of Mean Bias Degree(MBD).Finally,an evaluation model for indoor daylight environment of buildings with CdTe-PV window was developed by Fuzzy Comprehensive Evaluation *** results showed that the working surface illuminance of CdTe-PV window was lower than that of clear glass room,the CCT of different windows room had a minor gap and the CdTe-PV window room was closer to the recommended range that was *** for CRI,both the CdTe-PV window room and the clear glass room could meet the visual comfort requirements of office ***,it was found that the requirement of human visual comfort was met when indoor working surface illuminance varies between 500-2200lx in the room with CdTe-PV *** last,according to the comprehensive evaluation model proposed in this paper,it was found that the indoor daylight environment of buildings with CdTe-PV window was excellent in the present experiment.

关键词： Cadmium Telluride photovoltaic(CdTe-PV)window daylight environment human visual comfort Fuzzy comprehensive evaluation method

Acoustic radiation force on a cylindrical composite particle with an elastic thin shell and an internal eccentric liquid column in a plane ultrasonic wave field

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Chinese Physics B 2024年第9期33卷 423-431页

作者： Rui-Qi Pan Zhi-Wei Du cheng-hui Wang Jing hu Run-Yang Mo Institute of Shaanxi Key Laboratory of Ultrasonics Shaanxi Normal UniversityXi’an 710119China

A model with three-layer structure is introduced to explore the acoustic radiation force(ARF)on composite particles with an elastic thin *** acoustic scattering of cylinder and the thin-shell theorem,the ARF expression was derived,and the longitudinal and transverse components of the force and axial torque for an eccentric liquid-filled composite particle was *** was found that many factors,such as medium properties,acoustic parameters,eccentricity,and radius ratio of the inner liquid column,affect the acoustic scattering field of the particle,which in turn changes the forces and *** acoustic response varies with the particle structures,so the resonance peaks of the force function and torque shift with the eccentricity and radii ratio of *** acoustic response of the particle is enhanced and exhibits higher force values due to the presence of the elastic thin shell and the coupling effect with the eccentricity of the internal liquid *** decrease of the inner liquid density may suppress the high-order resonance peaks,and internal fluid column has less effects on the change in force on composite particle at ka>3,while limited differences exist at ka<*** axial torque on particles due to geometric asymmetry is closely related to ka and the *** distribution of positive and negative force and torque along the axis ka exhibits that composite particle can be manipulated or separated by *** theoretical analysis can provide support for the acoustic manipulation,sorting,and targeting of inhomogeneous particles.

关键词： acoustic radiation force acoustic scattering of cylinders elastic shell composite particles

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A Versatile BenzimidazoleSubstituted Spirolactam Mechanophore:When Excited State Intramolecular Proton Transfer Couples with Rhodamine

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CCS Chemistry 2024年第7期6卷 1798-1809页

作者： huan hu Xin cheng Zhimin Ma Qingyuan Yang Rint PSijbesma Zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 College of Engineering Peking UniversityBeijing 100871 Department of Chemical Engineering and Chemistry Institute for Complex Molecular SystemsEindhoven University of Technology5600 MBEindhoven

Exploration of multicolor mechanochromic bulk polymers based on a single mechanophore is a big challenge to ***,we report a versatile benzimidazole-substituted spirolactam mechanophore where excited state intramolecular proton transfer(ESIPT)coupled with *** mechanophore was facilely synthesized and then covalently linked to polyurethane(PU)*** PU film containing the mechanophore(1@PU)showed cooperative photochromism upon irradiation involving simultaneous enhancement of normalized enol and rhodol emissions based on a cooperative ESIPT process and the ring-opening reaction of ***,the film exhibited dual-mode multicolor mechanochromism upon stretching and *** normalized intensity of enol emission increased and the fluorescence turned from light green to cyan after stretching,then red coloration appeared from colorless after *** experiments and density functional theory calculations confirmed that the stretch-induced increase of enol emission was attributed to torsion of the dihedral angle between xanthene and benzimidazole in the mechanophore via force-induced disaggregation and direct force action on the isolated *** of the dihedral angle and the ring-opening reaction of spirolactam in a single mechanophore occurred sequentially during compression,resulting in an observed red *** study might provide a glimpse into the design of novel multicolor mechanochromic mechanophores.

关键词： mechanophore rhodamine excited state intramolecular proton transfer cooperative photochromism dual-mode mechanochromism

Mucinous neoplasm of the appendix:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 944-954页

作者： Hao-cheng Chang Jung-cheng Kang Ta-Wei Pu Ruei-Yu Su Chao-Yang Chen Je-Ming hu Department of Surgery Tri-Service General HospitalTaipei 114TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTaiwanChina Adventist HospitalTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105TaiwanChina Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325TaiwanChina

BACKGROUND Appendiceal mucinous neoplasms(AMNs),although not classified as rare,are relatively uncommon tumors most often discovered incidentally during colorectal *** identification of AMNs is difficult due to non-specific sym-ptoms,overlapping tumor markers with other conditions,and the potential for *** underscores the urgent need for precision in diagnosis to pre-vent severe *** SUMMARY This case report describes the unexpected discovery and treatment of a low-grade AMN(LAMN)in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma(AC).Preoperatively,non-specific gastroin-testinal symptoms and elevated tumor markers masked the presence of *** tumor,presumed to be an AMN peritoneal cyst intraoperatively,was con-firmed as LAMN through histopathological *** neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile:Positive for Ho-meobox protein CDX-2,Cytokeratin 20,special AT-rich sequence-binding protein 2,and Mucin 2 but negative for cytokeratin 7 and Paired box gene *** profile aids in distinguishing appendiceal and ovarian mucinous *** recovery was uncomplicated,and the patient initiated adjuvant chemotherapy for the colon *** This case highlights the diagnostic complexity of AMNs,emphasizing the need for vigilant identification to avert potential complications,such as pseudomyxoma peritonei.

关键词： Adenocarcinoma Appendiceal neoplasms Low-grade appendiceal mucinous neoplasm Peritoneal neoplasms Pseudomyxoma peritonei Case report

Non-Hermitian polarization quantized by time-reversal symmetry

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Jing cheng Jinbing hu Zhigao hu Lin Chen Minghui Lu Songlin Zhuang Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai) Engineering Research Center of Nanophotonics & Advanced Instrument (Ministry of Education)Department of Physics and Electronic Science East of China Normal University College of Optical-Electrical Information and Computer Engineering University of Shanghai for Science and Technology Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and Technology National Laboratory of Solid State Microstructures Science and Engineering Nanjing University

It is well known that in one-dimensional(1D) crystalline insulators, the electric polarization is a manifestation of Berry phase,which can not be quantized by time-reversal symmetry(TRS) as in Hermitian physics TRS does not induce any topological phase in one dimension. In this paper we report that even though associated with complex eigenenergies a 1D non-Hermitian insulator obeying only TRS is capable of presenting quantized bulk polarization. The underlying physical reason is unveiled: TRS guarantees the complex energies to come in pair(E, E*), and the corresponding decaying and amplifying wave functions also come in pair and have the same variation rate, hence, giving rise to a stable wannier center. The electron transport is performed by means of charge pumping process, which verifies the physical mechanism above. At last, we discuss the possible experimental implementation of the proposed model by means of twisted-π gauge flux.

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Gambogenic acid induces apoptosis via upregulation of Noxa in oral squamous cell carcinoma

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Chinese Journal of Natural Medicines 2024年第7期22卷 632-642页

作者： cheng Xinran FENG Mengyuan ZHANG Anjie GUO Jian GONG Yunlai hu Xiaohui HAN Quanbin LI Shengbao YU Xianjun Department of Gastroenterology Taihe HospitalHubei University of MedicineShiyan 442000China Laboratory of Inflammation and Molecular Pharmacology School of Basic Medical Sciences&Biomedical Research InstituteHubei Key Laboratory of Wudang Local Chinese Medicine ResearchSchool of PharmacyHubei University of MedicineShiyan 442000China Inflammation-Cancer Transformation and Wudang Chinese Medicine Research Hubei Talent Introduction and Innovation Demonstration BaseHubei University of MedicineShiyan 442000China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China

Gambogenic acid(GNA),a bioactive compound derived from the resin of Garcinia hanburyi,has demonstrated significant antitumor ***,its mechanisms of action in oral squamous cell carcinoma(OSCC)remain largely *** study aimed to elucidate the apoptotic effects of GNA on OSCC cell lines CAL-27 and *** results indicated that GNA induced apoptosis by upregulating the pro-apoptotic protein *** investigations revealed that GNA treatment led to the generation of reactive oxygen species(ROS),which activated endoplasmic reticulum(ER)stress,culminating in cell *** of ROS production and ER stress pathways significantly mitigated GNA-induced Noxa upregulation and subsequent ***,in vivo studies using a murine xenograft model demonstrated that GNA administration effectively inhibited the growth of CAL-27 ***,these findings underscore GNA’s potential as a therapeutic agent for the treatment of OSCC.

关键词： Oral squamous cell carcinoma Gambogenic acid Apoptosis Noxa ROS/ER stress

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Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han Bao Can hu Yan-Qiang Zhang Peng-cheng Yu Yi Wang Zhi-Yuan Xu huan-Ying Fu Xiang-Dong cheng Department of Interventional Radiology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Colonic Surgery Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina Department of Breast Surgery Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the *** patients are already in the advanced stage when they are diagnosed,which also leads to poor overall *** effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local *** To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV *** A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December *** to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression ***,the use of PD-1 did not increase postoperative complications or the adverse effects of *** A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.

关键词： Neoadjuvant therapy Immunotherapy Gastric cancer Borrmann type Tumor regression grade

Casual associations between blood metabolites and colon cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-Yue hu Yi-Quan cheng Zhi-Long Shi Fu-Peng Ren Gang-Feng Xiao Department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robustness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies Casual

Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano Research 2024年第7期17卷 6111-6118页

作者： Tao hu Qiang Wu cheng Wang Jialu Chen Fu Su Zibo Chen Yizhou Wang Jianyu Chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting