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Investigating intratumour heterogeneity by single-cell sequencing

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Asian Journal of Andrology 2013年第6期15卷 729-734,I0005页

作者： Shan-cheng ren Min Qu Ying-Hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China

Intratumour heterogeneity is a longstanding field of focus for both researchers and clinicians. It refers to the diversity amongst cells within the same tumour. Two major hypotheses have attempted to explain the existence of intratumour heterogeneity：（i） the clonal evolution （CE） theory and （ii） the cancer stem cell （CSC） model. CE theory emphasizes the evolutionary biological characteristics of the tumour, underscoring the initiation and progression of the disease. In contrast, the CSC model focuses on stem cell differentiation into distinct functions in order to stabilize the tumour microenvironment. Here we consider single-cell sequencing （SCS） as a newly developed technique for application to the investigation of intratumour heterogeneity and assess its relevance within research and clinical environments. Early detection of rare tumour cells, monitoring of circulating tumour cells （CTCs） and control of the occurrence of drug resistance are imoortant goals in early diagnosis, prognosis prediction and individualized medicine.

关键词： clinical applications intratumour heterogeneity single-cell sequencing

Molecular mechanisms of exercise contributing to tissue regeneration

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4368-4391页

作者： Jibao Chen ren Zhou Ye Feng Lin cheng Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiChina Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Physical activity has been known as an essential element to promote human health for ***,exercise intervention is encouraged to battle against sedentary *** rapid advances in molecular biotechnology have demonstrated that both endurance and resistance exercise training,two traditional types of exercise,trigger a series of physiological responses,unraveling the mechanisms of exercise regulating on the human ***,exercise has been expected as a candidate approach of alleviating a wide range of diseases,such as metabolic diseases,neurodegenerative disorders,tumors,and cardiovascular *** particular,the capacity of exercise to promote tissue regeneration has attracted the attention of many researchers in recent *** most adult human organs have a weak regenerative capacity,it is currently a key challenge in regenerative medicine to improve the efficiency of tissue *** research progresses,exercise-induced tissue regeneration seems to provide a novel approach for fighting against injury or senescence,establishing strong theoretical basis for more and more“exercise mimetics.”These drugs are acting as the pharmaceutical alternatives of those individuals who cannot experience the benefits of ***,we comprehensively provide a description of the benefits of exercise on tissue regeneration in diverse organs,mainly focusing on musculoskeletal system,cardiovascular system,and nervous *** also discuss the underlying molecular mechanisms associated with the regenerative effects of exercise and emerging therapeutic exercise mimetics for regeneration,as well as the associated opportunities and *** aim to describe an integrated perspective on the current advances of distinct physiological mechanisms associated with exercise-induced tissue regeneration on various organs and facilitate the development of drugs that mimics the benefits of exercise.

关键词： organs mechanisms exercise

SnS_2 nanosheets arrays sandwiched by N-doped carbon and TiO_2 for high-performance Na-ion storage

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Green Energy & Environment 2018年第1期3卷 42-49页

作者： Weina ren Haifeng Zhang Cao Guan Chuanwei cheng Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji University Department of Materials Science and Engineering National University of Singapore The Institute of Dongguan-Tongji University

In this paper, SnS_2 nanosheets arrays sandwiched by porous N-doped carbon and TiO_2(TiO_2@SnS_2@N-C) on flexible carbon cloth are prepared and tested as a free-standing anode for high-performance sodium ion batteries. The as-obtained TiO_2@SnS_2@N-C composite delivers a remarkable capacity performance(840 mA h g^(-1) at a current density of 200 mA g^(-1)), excellent rate capability and long-cycling life stability(293 mA h g^(-1) at 1 A g^(-1) after 600 cycles). The excellent electrochemical performance can be attributed to the synergistic effect of each component of the unique hybrid structure, in which the SnS_2 nanosheets with open framworks offer high capacity, while the porous N-doped carbon nanoplates arrays on flexible carbon cloth are able to improve the conductivity and the TiO_2 passivation layer can keep the structure integrity of SnS_2 nanosheets.

关键词： Sandwich structure SnS2 nanosheets N-doped carbon TiO2 Sodium-ion battery

DYNAMIC CHARACTERISTICS IN INCOMPRESSIBLE HYPERELASTIC CYLINDRICAL MEMBRANES

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Acta Mechanica Solida Sinica 2010年第5期23卷 420-427页

作者： datian Niu Xuegang Yuan Changjun cheng Jiusheng ren School of Science Dalian Nationalities University Dalian 116600 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

In this paper, the dynamic characteristics are examined for a cylindrical membrane composed of a transversely isotropic incompressible hyperelastic material under an applied uniform radial constant pressure at its inner surface. A second-order nonlinear ordinary differential equation that approximately describes the radial oscillation of the inner surface of the membrane with respect to time is obtained. Some interesting conclusions are proposed for different materials, such as the neo-Hookean material, the Mooney-Rivlin material and the Rivlin-Saunders material. Firstly, the bifurcation conditions depending on the material parameters and the pressure loads are determined. Secondly, the conditions of periodic motion are presented in detail for membranes composed of different materials. Meanwhile, numerical simulations are also provided.

关键词： incompressible hyperelastic material cylindrical membrane dynamical character- istic nonlinear periodic oscillation

COUPLING EFFECTS OF VOID SHAPE AND VOID SIZE ON THE GROWTH OF AN ELLIPTIC VOID IN A FIBER-REINFORCED HYPER-ELASTIC THIN PLATE

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Acta Mechanica Solida Sinica 2012年第3期25卷 312-320页

作者： Jiusheng ren Hanhai Li Changjun cheng Xuegang Yuan Department of Mechanics Shanghai UniversityShanghai 200444China Shanghai Key Laboratory of Mechanics in Energy and Environment Engineering Shanghai 200444China College of Science Dalian Nationalities UniversityDalian 116600China

The growth of a prolate or oblate elliptic micro-void in a fiber reinforced anisotropic incompressible hyper-elastic rectangular thin plate subjected to uniaxial extensions is studied within the framework of finite elasticity. Coupling effects of void shape and void size on the growth of the void are paid special attention to. The deformation function of the plate with an isolated elliptic void is given, which is expressed by two parameters to solve the differential equation. The solution is approximately obtained from the minimum potential energy principle. Deformation curves for the void with a wide range of void aspect ratios and the stress distributions on the surface of the void have been obtained by numerical computation. The growth behavior of the void and the characteristics of stress distributions on the surface of the void are captured. The combined effects of void size and void shape on the growth of the void in the thin plate are discussed. The maximum stresses for the void with different sizes and different void aspect ratios are compared.

关键词： fiber reinforced hyper-elastic material rectangular thin plate with void void shapeand void size potential energy principle growth of void

Application of Near-Infrared Reflectance Spectroscopy to the Evaluation of D-chiro-Inositol,Vitexin,and Isovitexin Contents in Mung Bean

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Agricultural Sciences in China 2011年第12期10卷 1986-1991页

作者： YAO Yang cheng Xu-zhen ren Gui-xing Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Mung bean （Vigna radiata L.） is rich in D-chiro-inositol （DCI）, vitexin, and isovitexin, which has beneficial effects on antidiabetic and inhibits the formation of advanced glycation end-products. In this study, near-infrared reflectance spectroscopy （NIRS） was used to predict the contents of DCI, vitexin, and isovitexin in mung bean. The spectra data were linearized with those determined by high-performance liquid chromatography （HPLC）. The models for predicting the DCI, vitexin, and isovitexin contents in mung bean were developed using partial least-squares （PLS） algorithm. Cross-validation procedures indicated good correlations between HPLC data and NIRS predictions （R2=0.90 for DCI, R2=0.81 for vitexin, and R2=0.90 for isovitexin）. The predictive contents of DCI, vitexin, and isovitexin ranged from 2.082 to 3.084%, 1.277 to 1.307%, and 0.5998 to 0.6286%, respectively. The results showed that NIRS, a well-established and widely applied technique, could be applied to rapid detection of DCI, vitexin, and isovitexin contents in mung bean.

关键词： D-chiro-inositol, vitexin, isovitexin, NIRS, mung beanMun bean is an imoortant natural so

Soil hydraulic conductivity as affected by vegetation restoration age on the Loess Plateau,China

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Journal of Arid Land 2016年第4期8卷 546-555页

作者： ren Zongping ZHU Liangjun WANG Bing cheng Shengdong State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi'an University of Technology State Key Laboratory of Soil Erosion and Dryland Farming on Loess Plateau Institute of Soil and Water ConservationChinese Academy of Science State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences

The Loess Plateau of China has experienced extensive vegetation restoration in the past several decades, which leads to great changes in soil properties such as soil bulk, porosity, and organic matter with the vegetation restoration age. And these soil properties have great effect on the soil infiltration and soil hydraulic conductivity. However, the potential changes in soil hydraulic conductivity caused by vegetation restoration age have not been well understood. This study was conducted to investigate the changes in soil hydraulic conductivity under five grasslands with different vegetation restoration ages （3, 10, 18, 28 and 37 years） compared to a slope farmland, and further to identify the factors responsible for these changes on the Loess Plateau of China. At each site, accumulative infiltration amount and soil hydraulic conductivity were determined using a disc permeameter with a water supply pressure of -20 mm. Soil properties were measured for analyzing their potential factors influencing soil hydraulic conductivity. The results showed that the soil bulk had no significant changes over the initial 20 years of restoration （P〉0.05）; the total porosity, capillary porosity and field capacity decreased significantly in the grass land with 28 and 37 restoration ages compared to the slope farmland; accumulative infiltration amount and soil hydraulic conductivity were significantly enhanced after 18 years of vegetation restoration. However, accumulative infiltration amount and soil hydraulic conductivity fluctuated over the initial 10 years of restoration. The increase in soil hydraulic conductivity with vegetation restoration was closely related to the changes in soil texture and structure. Soil sand and clay contents were the most influential factors on soil hydraulic conductivity, followed by bulk density, soil porosity, root density and crust thickness. The Pearson correlation coefficients indicated that the soil hydraulic conductivity was affected by multiply

关键词： disc permeameter effect factors soil infiltration vegetation restoration Loess Plateau

Contents of D-chiro-Inositol,Vitexin,and Isovitexin in Various Varieties of Mung Bean and Its Products

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Agricultural Sciences in China 2011年第11期10卷 1710-1715页

作者： YAO Yang cheng Xu-zhen ren Gui-xing Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China

Mung bean （Vigna radiata L.） is rich in bioactive compounds including D-chiro-inositol （DCI）, vitexin, and isovitexin, which have beneficial effects on patients with diabetes. To find a better source for these valuable chemicals, we have collected 110 varieties of mung bean seed samples and 8 mung bean products to determine the levels of these bioactive compounds. We also measured the DCI content in mung bean sprouts at different germination stages. Content of DCI, vitexin, and isovitexin in all mung bean varieties ranged from 0.43 to 5.79, 0.12 to 3.00, and 0.03 to 1.16 mg g-~, respectively. The varieties of C0001321, C0003522, and C0004485 have the highest DCI, vitexin, and isovitexin contents, respectively. The mung bean products in the market contained relatively lower level of these bioactive components. Contents of DCI, vitexin, and isovitexin in all mung bean products ranged from 0.119 to 0.717, 0 to 0.547, and 0 to 0.923 mg g-~, respectively. During the 112 h of germination test, DCI level steadily increased at first stage and reached the highest level at 80 h of germination （4.79 mg g-~）. These results provide useful information for the selection of suitable varieties and proper germination stages to obtain functional ingredients from mung beans.

关键词： D-chiro-inositol vitexin isovitexin mung bean

An Interactive Collaborative Creation System for Shadow Puppets Based on Smooth Generative Adversarial Networks

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Computers, Materials & Continua 2024年第6期79卷 4107-4126页

作者： cheng Yang Miaojia Lou Xiaoyu Chen Zixuan ren Department of Industrial Design Hangzhou City UniversityHangzhou310000China College of Computer Science and Technology Zhejiang UniversityHangzhou310000China

Chinese shadow puppetry has been recognized as a world intangible cultural ***,it faces substantial challenges in its preservation and advancement due to the intricate and labor-intensive nature of crafting shadow *** ensure the inheritance and development of this cultural heritage,it is imperative to enable traditional art to flourish in the digital *** paper presents an Interactive Collaborative Creation System for shadow puppets,designed to facilitate the creation of high-quality shadow puppet images with greater *** system comprises four key functions:Image contour extraction,intelligent reference recommendation,generation network,and color adjustment,all aimed at assisting users in various aspects of the creative process,including drawing,inspiration,and content ***,we propose an enhanced algorithm called Smooth Generative Adversarial Networks(SmoothGAN),which exhibits more stable gradient training and a greater capacity for generating high-resolution shadow puppet ***,we have built a new dataset comprising high-quality shadow puppet images to train the shadow puppet generation *** qualitative and quantitative experimental results demonstrate that SmoothGAN significantly improves the quality of image generation,while our system efficiently assists users in creating high-quality shadow puppet images,with a SUS scale score of *** study provides a valuable theoretical and practical reference for the digital creation of shadow puppet art.

关键词： Shadow puppets deep learning image generation co-create