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Double[5]carbohelicene:facile synthesis,chiroptical properties,isomerization study,and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang xiao-Li Zhao Lin Xu Linlin Liu xiaodong Li Junfeng Fang Zhiwei Fang Ya cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Physics and Electronic Science Engineering Research Center of Nanophotonics&Advanced InstrumentMinistry of EducationEast China Normal UniversityShanghai 200241China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Institute of Polymer Optoelectronic Materials&Devices State Key Laboratory of Luminescent Materials&DevicesSouth China University of TechnologyGuangzhou 510640China

Double carbohelicenes have attracted considerable attention due to their aesthetic structures,distinctπ-conjugation extension,inherent chirality,and intriguing optical and electronic ***,the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties,isomerization process and lasing application is presented.1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key *** is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM,which were successfully isolated and unambiguously confirmed by Xray *** optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography(HPLC),and 1-PP and 1-MM were characterized by circular ***,it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating,and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated.1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%.Consequently,we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously,which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm^(-2).We believe that our studies,including the facile synthesis methodology,detailed isomerization studies,and lasing application,will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu xiao Shangru Zhai Chuang Xue Guangping Zheng Deqing Zhang Renchao Che Junye cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosis induced by hypoxia in rat cardiomyocyte

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The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosi...

第十三次全国心血管病学术会议

作者： SUN Guo-fang,LI Ju-xiang,DING Hao,HONG Kui, cheng xiao-shu,cheng xiao-shu Department of Cardiology,The second affiliated hospital of Nanchang university,Nanchang 330031,China

Objective It is well known that the apoptosis of cardiomyocyte involves the development of some cardiovascular diseases, such as heart failure,coronary heart disease and so ***-regulation of ROCK1(Rho—associated coiled-coil protein kinase-1) and ROCK2 could inhibit apoptosis of a variety of ***,shRNAs targeting ROCK1 and ROCK2 were transfected into rat cardiomyocytes to inhibit the expression of ROCK1 and *** effect of ROCK1 and ROCK2 on

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cnki会议

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监护人责任的实体法与程序法问题

北京理工大学学报（社会科学版） 2025年第1期27卷 21-34页

作者：程啸清华大学法学院北京100084

监护人责任属于替代责任。监护人是侵权责任的主体,应当直接向被侵权人承担全部的侵权责任,而非相应的责任或补充责任。《民法典》第1188条第2款要求从有财产的被监护人的财产中支付赔偿费用,不足的部分才由监护人赔偿,该规定过于保护... 详细信息

监护人责任属于替代责任。监护人是侵权责任的主体,应当直接向被侵权人承担全部的侵权责任,而非相应的责任或补充责任。《民法典》第1188条第2款要求从有财产的被监护人的财产中支付赔偿费用,不足的部分才由监护人赔偿,该规定过于保护被侵权人以及监护人,忽视对被监护人的保护。父母作为未成年子女的法定监护人应当共同承担监护人责任即承担的是连带责任。离异夫妻中未与未成年人子女共同生活的一方也应当承担全部的监护人责任。没有与继子女形成抚养教育关系的继父母不承担监护人责任。继父母收养继子女后,应当承担监护人责任,被监护人的生父母不再承担监护人责任。教唆人、帮助人的侵权责任与未尽到监护职责的监护人承担的相应的责任以及监护人与有过错的受托履行监护职责的人所承担的侵权责任的关系都属于部分的连带责任。在监护人责任诉讼中监护人与被监护人属于共同被告。

关键词：民法典监护人责任补充责任相应的责任部分连带责任

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Pronounced impact of size and shape effects on creep rupture life of a K439B superalloy combustion chamber casting simulator

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China Foundry 2025年

作者： Wen-tong Liu Yi-dong Wu Lei Gao Jing-yang Chen cheng-bo xiao Xi-dong Hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The size and shape effect(SSE) of components has become a critical issue for mechanical properties, application reliability, and processing. In this study, the creep rupture life(CRL) of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated. The intrinsic mechanisms of the SSE were explored from the dendrite structure, volume fraction and size of the γ' phase, and element segregation, etc. It is shown that this casting exhibits a strong SSE of creep rupture life, characterized by a significant difference in the CRL values up to 60% with the variation of wall thickness and position in the casing. In terms of casting technology, the influence of SSE on CRL is actually determined by the cooling rate. The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing), volume fraction size of the γ' phase in the dendrite trunk, and elements segregation rate. This work may have implications for the design and application of engineering components with large sizes and complex structures.

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河西走廊西段及邻区早白垩世盆地的重新厘定

石油学报 2004年第6期25卷 18-22页

作者：何光玉杨树锋陈汉林肖安成程晓敢浙江大学理学院地球科学系浙江杭州310027

对河西走廊西段及邻区的地震剖面进行了解释 ,结合钻井资料对其早白垩世时期的沉积与构造特征进行了系统分析 ,对盆地的原型进行了新的厘定。在早白垩世时期 ,该区中部并未发育宽台山黑山隆起与天泉寺合黎山隆起 ,原酒西盆地与花海... 详细信息

对河西走廊西段及邻区的地震剖面进行了解释 ,结合钻井资料对其早白垩世时期的沉积与构造特征进行了系统分析 ,对盆地的原型进行了新的厘定。在早白垩世时期 ,该区中部并未发育宽台山黑山隆起与天泉寺合黎山隆起 ,原酒西盆地与花海、酒东和金塔盆地应同属统一的酒泉盆地。其中 ,原花海、酒西盆地应同属统一的酒西坳陷 ,内含青西、赤金、石大花海 3个凹陷 ,后者又可以进一步分为花海次凹、石北次凹和大红圈次凹。原金塔、酒东盆地应同属统一的酒东坳陷 ,内含金塔、盐池、营尔和马营 4个凹陷。 2个大坳陷间以嘉峪关隆起作为分隔 ,而原始盆地的南部边界应位于现今边界以南 3 0～ 5 0km处。

关键词：酒泉盆地盆地原型早白垩世河西走廊构造特征

经皮二尖瓣夹合术治疗二尖瓣关闭不全合并心力衰竭患者疗效的Meta分析

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中国循证医学杂志 2016年第4期16卷 409-414页

作者：蒋至智刘增长程小成重庆医科大学附属第二医院心血管内科重庆401320

目的系统评价经皮二尖瓣夹合术（MitraClip）治疗二尖瓣关闭不全合并心力衰竭患者的疗效。方法计算机检索PubMed、The Cochrane Library（2014年第11期）、EMbase、CBM、CNKI、VIP和WanFang Data数据库,搜集二尖瓣关闭不全合并心力衰竭... 详细信息

目的系统评价经皮二尖瓣夹合术（MitraClip）治疗二尖瓣关闭不全合并心力衰竭患者的疗效。方法计算机检索PubMed、The Cochrane Library（2014年第11期）、EMbase、CBM、CNKI、VIP和WanFang Data数据库,搜集二尖瓣关闭不全合并心力衰竭患者行MitraClip治疗的自身前后对照试验,检索时限均从2005年10月至2015年10月。由2位评价员独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用RevMan 5.2软件进行Meta分析。结果最终纳入9个研究,共计782例患者,患者术前NYHA分级均大于Ⅰ级,其中86.2%为Ⅲ~Ⅳ级。Meta分析结果显示,行MitraClip术后,患者NYHA分级Ⅲ~Ⅳ级所占比例显著下降[RD=0.72,95%CI（0.60,0.85）,P〈0.000 01],左室射血分数（LVEF）显著提高[MD=–2.97,95%CI（–5.06,–0.89）,P〈0.005],六分钟步行试验（6-MWT）的步行距离增大[MD=–88.73,95%CI（–157.16,–20.31）,P=0.01]。结论 Mitra Clip治疗能在一定程度上改善二尖瓣关闭不全合并心力衰竭患者心功能,但其在改善患者远期生存率方面是否有优势尚待进一步研究证实。

关键词：经皮二尖瓣夹合术二尖瓣关闭不全心力衰竭 Meta分析

Metastasizing to the colon from triple-negative breast cancer:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 443-455页

作者： Ben-Quan Wang Xing-Gui Fang Ben-Hong Xiang xiao-Jiao Wang Ming Cao cheng-Le Zhuang Zhong-Chen Liu Zheng Wang Department of Gastrointestinal Surgery The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Breast Surgery The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Pathology The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Gastrointestinal Surgery Colorectal Cancer CenterShanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200000China

BACKGROUND Breast cancer(BC)metastasis to the gastrointestinal tract is uncommon,colonic metastasis from BC(CMBC)is even *** SUMMARY This report describes a 44-year-old female patient with metastatic triple-negative BC in the ascending colon who underwent laparoscopic radical right *** patient had undergone left modified radical mastectomy only 15 months ago and stopped chemotherapy just 3 months *** diagnosis of CMBC was made based on the previous history of BC and positive results of several specific immunohistochemical markers(gross cystic disease fluid protein 15,mammaglobin,GATA-binding protein 3,and cytokeratin 7)for breast *** CMBC should be highly cautious in patients with a previous history of BC,especially triple-negative BC,and further examination to aid in diagnosis.

关键词： Breast cancer Colon metastasis Colonoscopy Pathology Surgery Review Case report

SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells

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World Journal of Gastroenterology 2025年第10期31卷 118-133页

作者： Jia-Nan Chen Li Wang Yu-Xin He xiao-Wei Sun Long-Jiao cheng Ya-Nan Li Sei Yoshida Zhong-Yang Shen School of Medicine Nankai UniversityTianjin 300071China Department of Organ Transplant Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesFrontiers Science Center for Cell ResponsesNankai UniversityTianjin 300071China Research Institute of Transplant Medicine Nankai UniversityTianjin 300192China Nankai International Advanced Research Institute Shenzhen 518045Guangdong ProvinceChina Tianjin Key Laboratory for Organ Transplantation Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Proteins play a central role in regulating biological functions,and various pathways regulate their synthesis and *** reticulum-associated protein degradation(ERAD)is crucial for monitoring protein synthesis and processing unfolded or misfolded proteins in actively growing tumor ***,the role of the multiple ERAD complexes in liver cancer remains *** To elucidate the effects of SEL1L-mediated ERAD on Huh7 and explore the underlying mechanisms in vivo and in *** Huh7 cells were treated with ERAD inhibitor to identify ERAD’s *** counting kit-8,5-ethynyl-2’-deoxyuridine and colony formation experiments were *** level and migration ability were assessed using fluorescence activated cell sorting and Transwell assay,***7 SEL1L knockout cell line was established via clustered regularly interspaced short palindromic repeats,proliferation,apoptosis,and migration were assessed through previous *** role of SEL1L in vivo and the downstream target of SEL1L were identified using Xenograft and mass spectrometry,*** The ERAD inhibitor suppressed cell proliferation and migration and promoted ***1L-HRD1 significantly influenced Huh7 cell ***1L knockout suppressed tumor cell proliferation and migration and enhanced *** spectrometry revealed EXT2 is a primary substrate of ***1L knockout significantly increased the protein expression of ***,EXT2 knockdown partially restored the effect of SEL1L *** ERAD inhibition suppressed the proliferation and migration of Huh7 and promoted its ***2 plays an important role and ERAD might be a potential treatment for Huh7 hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Endoplasmic reticulum stress Endoplasmic reticulum-associated protein degradation SEL1L EXT2