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Radio frequency conditioning of an S-band accelerating structure prototype for compact proton therapy facility

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Nuclear Science and Techniques 2021年第6期32卷 94-107页

作者： Yu Zhang Wen-cheng Fang xiao-Xia Huang Jian-Hao Tan Shao-Peng Zhong cheng-cheng xiao Jun-Qiang Zhang cheng Wang Yu-Qing Yang Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Tech University Shanghai 201210China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

The development of a high-gradient accelerating structure is underway to construct a compact proton linear accelerator for cancer *** experiments and numerous studies are being conducted to develop compact linear accelerators for proton *** of the electromagnetic and mechanical design has been performed to simplify the manufacturing process and reduce costs.A novel high-gradient structure with a low relativistic proton velocity(β),v/c=0.38,was designed,fabricated,and tested at high *** first full-scale prototype was also successfully tested with high radio frequency(RF)power,a repetition rate of 50 Hz,and pulse length of 3μs to reach a high-gradient of 46 MV/m using a 50 MW S-band klystron power supply obtained from the Shanghai Soft X-ray Free Electron Laser *** is the first high-power test in China,which is in line with the expected experimental *** study presents preliminary high-power testing of S-band standing wave accelerating structures with 11 *** work aims to verify the feasibility of using a high-gradient RF accelerating structure in compact proton therapy *** cold test of the prototype cavity was completed in *** of the high-power RF test setup,the process of RF conditioning,and the high-power results are described.

关键词： S-band Standing wave(SW) High-gradient Accelerating structure RF conditioning

An S-band solid-state radio frequency power amplifier used at Shanghai soft X-ray FEL facility

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Nuclear Science and Techniques 2016年第6期27卷 86-92页

作者： Hong-Li Ding Ming-Hua Zhao cheng-cheng xiao Shao-Peng Zhong Jun-Qiang Zhang Shanghai Institute of Applied Physics Chinese Academy of SciencesZhangjiangShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

In this paper,we present the general design methods and parameter measurements of a 1-k W solidstate radio frequency(RF) power amplifier at 2856 MHz,for the soft X-ray free electron laser ***-stage amplification with a 4-way combination is *** RF switch module is integrated with the solid-state RF power amplifier to convert the continuous wave(CW) signal into pulse signal,with adjustable pulse *** power gain is measured at 57.7 d B at 60 d Bm *** RF phase noise,which is measured by the low-level RF system,is\0.015 degree(RMS),while the pulse frontier jitter is\5 ns.

关键词：射频功率放大器激光装置自由电子软X射线固态 S波段上海参数测量

Proton linac-based therapy facility for ultra-high dose rate (FLASH) treatment

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Nuclear Science and Techniques 2021年第4期32卷 1-9页

作者： Wen-cheng Fang xiao-Xia Huang Jian-Hao Tan Chao-Peng Wang cheng-cheng xiao Yi-Xing Lu Yu Zhang Yu-Qing Yang Yi-Ming Xu Han-Yu Gong Jun-Qiang Zhang Shao-Peng Zhong Zhen-Tang Zhao Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China University of Chinese Academy of Sciences Beijing 100049China Shanghai APACTRON Particle Equipment Company Limited Shanghai 201800China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

As an advanced treatment method in the past five years,ultra-high dose rate(FLASH)radiotherapy as a breakthrough and milestone in radiotherapy development has been verified to be much less harmful to healthy tissues in different *** treatments require an instantaneous dose rate as high as hundreds of grays per second to complete the treatment in less than 100 *** proton therapy facilities with the spread-out of the Bragg peak formed by different energy layers,to our knowledge,cannot easily achieve an adequate dose rate for FLASH treatments because the energy layer switch or gantry rotation of current facilities requires a few seconds,which is relatively long.A new design for a therapy facility based on a proton linear accelerator(linac)for FLASH treatment is proposed *** is designed under two criteria:no mechanical motion and no magnetic field *** new therapy facility can achieve an ultrahigh dose rate of up to 300 Gy/s;however,it delivers an instantaneous dose of 30 Gy within 100 ms to complete a typical FLASH *** design includes a compact proton linac with permanent magnets,a fast beam kicker in both azimuth and elevation angles,a fixed gantry with a static superconducting coil to steer proton bunches with all energy,a fast beam scanner using radio-frequency(RF)deflectors,and a fast low-level RF *** relevant principles and conceptual proposals are presented herein.

关键词： Proton therapy FLASH Proton linac Deflector Superconducting coil Fast scanner

初诊多发性骨髓瘤患者外周血淋巴细胞绝对数分析及其临床意义

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中国实验血液学杂志 2012年第3期20卷 624-627页

作者：程骁赪张晓黎叶娴石晓菁苏州市立医院东区血液科江苏苏州215001

本研究旨在探讨多发性骨髓瘤(MM)患者初发时淋巴细胞绝对数(ALC)与临床特征和预后的相关性。回顾性分析本院2002年1月-2011年8月间收治的34例初诊MM患者资料,根据入院时ALC分为ALC0.05)。结论:MM患者初诊时ALC可作为疗效及预后判断的重... 详细信息

本研究旨在探讨多发性骨髓瘤(MM)患者初发时淋巴细胞绝对数(ALC)与临床特征和预后的相关性。回顾性分析本院2002年1月-2011年8月间收治的34例初诊MM患者资料,根据入院时ALC分为ALC0.05)。结论:MM患者初诊时ALC可作为疗效及预后判断的重要指标。

关键词：淋巴细胞绝对数多发性骨髓瘤 T淋巴细胞亚群

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen Heng xiao Hai-Yang Hu Xing-Yu Chen cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-Jian Wu Ying cheng xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu xiao Shangru Zhai Chuang Xue Guangping Zheng Deqing Zhang Renchao Che Junye cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosis induced by hypoxia in rat cardiomyocyte

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The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosi...

第十三次全国心血管病学术会议

作者： SUN Guo-fang,LI Ju-xiang,DING Hao,HONG Kui, cheng xiao-shu,cheng xiao-shu Department of Cardiology,The second affiliated hospital of Nanchang university,Nanchang 330031,China

Objective It is well known that the apoptosis of cardiomyocyte involves the development of some cardiovascular diseases, such as heart failure,coronary heart disease and so ***-regulation of ROCK1(Rho—associated coiled-coil protein kinase-1) and ROCK2 could inhibit apoptosis of a variety of ***,shRNAs targeting ROCK1 and ROCK2 were transfected into rat cardiomyocytes to inhibit the expression of ROCK1 and *** effect of ROCK1 and ROCK2 on

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河西走廊西段及邻区早白垩世盆地的重新厘定

石油学报 2004年第6期25卷 18-22页

作者：何光玉杨树锋陈汉林肖安成程晓敢浙江大学理学院地球科学系浙江杭州310027

对河西走廊西段及邻区的地震剖面进行了解释 ,结合钻井资料对其早白垩世时期的沉积与构造特征进行了系统分析 ,对盆地的原型进行了新的厘定。在早白垩世时期 ,该区中部并未发育宽台山黑山隆起与天泉寺合黎山隆起 ,原酒西盆地与花海... 详细信息

对河西走廊西段及邻区的地震剖面进行了解释 ,结合钻井资料对其早白垩世时期的沉积与构造特征进行了系统分析 ,对盆地的原型进行了新的厘定。在早白垩世时期 ,该区中部并未发育宽台山黑山隆起与天泉寺合黎山隆起 ,原酒西盆地与花海、酒东和金塔盆地应同属统一的酒泉盆地。其中 ,原花海、酒西盆地应同属统一的酒西坳陷 ,内含青西、赤金、石大花海 3个凹陷 ,后者又可以进一步分为花海次凹、石北次凹和大红圈次凹。原金塔、酒东盆地应同属统一的酒东坳陷 ,内含金塔、盐池、营尔和马营 4个凹陷。 2个大坳陷间以嘉峪关隆起作为分隔 ,而原始盆地的南部边界应位于现今边界以南 3 0～ 5 0km处。

关键词：酒泉盆地盆地原型早白垩世河西走廊构造特征