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The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosis induced by hypoxia in rat cardiomyocyte

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The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosi...

第十三次全国心血管病学术会议

作者： SUN Guo-fang,LI Ju-xiang,DING Hao,HONG Kui, cheng Xiao-shu,cheng Xiao-shu Department of Cardiology,The second affiliated hospital of Nanchang university,Nanchang 330031,China

Objective It is well known that the apoptosis of cardiomyocyte involves the development of some cardiovascular diseases, such as heart failure,coronary heart disease and so ***-regulation of ROCK1(Rho—associated coiled-coil protein kinase-1) and ROCK2 could inhibit apoptosis of a variety of ***,shRNAs targeting ROCK1 and ROCK2 were transfected into rat cardiomyocytes to inhibit the expression of ROCK1 and *** effect of ROCK1 and ROCK2 on

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功率步进电动机系统电磁兼容性的研究

微电机 1999年第3期32卷 18-20页

作者：崔淑梅王铁成程树康哈尔滨工业大学

对功率步进电动机系统的电磁兼容性进行了研究，分析了功率步进电动机系统中产生电磁干扰的基本因素，研究了抑制干扰的方法，并实验验证了方法的可行性。

关键词：步进电动机电磁兼容性功率步进电动机

BEAM CHARACTERIZATIONS OF THE MINI-LIA

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BEAM CHARACTERIZATIONS OF THE MINI-LIA

The 17th International Conference on High-Power Particle Beams

作者： shu-Qing Liao cheng cheng shu-Xin Zheng Chuan-Xiang Tang Yu-Zheng Lin Department of Engineering Physics Tsinghua University Beijing China 100084 Key Laboratory of Particle & Radiation Imaging Ministry of Education Key Laboratory of High Energy Radiation Imaging Fundamental Science for National Defense Xiao-Bing Jing Fan Mu Hai-Feng Pang Institute of Fluid Physics CAEP Mianyang Sichuan China 621900

＜正＞A miniature electron linear induction accelerator （Mini-LIA）is designed and constructed at Tsinghua University under the CAEP/Tsinghua *** this paper we present the beam characterizations for the *** beam current is measured with a Faraday *** transverse beam profile is measured with a YAG *** beam energy is determined by observing the beam rotation angle in a solenoid,and the projected rms emittance is measured with the pepper-pot device.

关键词： Mini-LIA Beam diagnostics Pepper-pot YAG screen

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基于循环神经网络的微电网并网等效建模

电力科学与技术学报 2017年第1期32卷 43-48页

作者：蔡昌春赫卫国程述成江冰邓立华张建勇河海大学江苏省输配电装备技术重点实验室江苏常州213022 河海大学物联网工程学院江苏常州213022 中国电力科学研究院新能源研究所江苏南京210003

提出一种基于循环神经网络的微电网并网动态等效模型,利用人工神经网络的非线性映射特性,解决微电网系统并网接入的等效建模问题。根据微电网并网接入点的电压、电流、功率等测量数据,构建循环神经网络等效模型,将接入点电压和电流分别... 详细信息

提出一种基于循环神经网络的微电网并网动态等效模型,利用人工神经网络的非线性映射特性,解决微电网系统并网接入的等效建模问题。根据微电网并网接入点的电压、电流、功率等测量数据,构建循环神经网络等效模型,将接入点电压和电流分别作为神经网络的输入和输出,基于微电网和配电网的交换功率表征模型的准确性;并构建包含各种分布式发电系统的微电网系统,完成并网仿真实验;通过对比搭建的仿真模型和神经网络等效模型的输出动态特性,证明基于神经网络的微电网并网等效模型的准确性和适用性。

关键词：动态等效建模微电网循环人工神经网络分布式发电

240keV DOUBLE-PULSE LIA DEVICE

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240keV DOUBLE-PULSE LIA DEVICE

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

The 17th International Conference on High-Power Particle Beams

作者： JING Xiaobing~1 Mu Fan~1 Pang Haifeng~1 Zhang Kaizhi~1 Shi Jinshui~1 Deng Jianjun~1 1 :Institute of Fluid Physics CAEP P.O.Box 919-106 Mianyang 621900 China cheng cheng~2 Liao shu-qing~2 Lin Yu-zheng~2 Tang Chuan-xiang~2 Zheng shu-xin~2 2:Accelerator Lab. Dept.of Engineering Physics Tsinghua University Beijing 100084 China

＜正＞A small linear induction electron accelerator has been developed to explore the technology of generate intense electron beams in megahertz burst rate.A train of two 240keV,1.2A electron beams was obtained in the accelerator *** beam has a full width at half maximum of 80ns,with rise time of 30ns,and the duration time between two beams can be adjusted easily but not less than *** paper describes the physics design,development and experimental results of the *** key technology is analyzed.

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv shu-Meng Han Li-Yun He Zi-Yi Li Yu-cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

The Important Roles of Water in Protein Folding:an Approach by Single Molecule Force Spectroscopy

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Chinese Journal of Polymer Science 2018年第3期36卷 379-384页

作者： Bo cheng shu-Xun Cui School of Mechanical Engineering North University of ChinaTaiyuan 030051China Key Lab of Advanced Technologies of Materials Ministry of Education of ChinaSouthwest Jiaotong UniversityChengdu 610031China

The single-chain elasticity of a completely unfolded protein （027）8, modules of human cardiac titin） is studied in different liquid environments by the atomic force microscopy （AFM）-based single molecule force spectroscopy （SMFS）. The experimental results show that there is a clear deviation between the force curves obtained in the aqueous and nonaqueous environments. Such a deviation can be attributed to the additional energy consumed by the rearrangement of the bound water molecules around the chain of the completely unfolded （I27）s chain upon stretching in aqueous solution, which is very similar to the partial dehydration process from a denatured/unfolded to a native/folded protein. Through the analysis of the free energy changes involved in protein folding, we conclude that it is due to the weak disturbance of water molecules and the special backbone structures of proteins that the self-assembly of proteins can be achieved in physiological conditions. We speculate that water is likely to be an important criterion for the selection of self-assembling macromolecules in the prebiotic chemical evolution.

关键词： SMFS Protein Folding Water

Characteristics of shell thickness in a slab continuous casting mold

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International Journal of Minerals,Metallurgy and Materials 2009年第1期16卷 25-31页

作者： Di-feng Wu shu-sen cheng Zi-jian cheng School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Steelmaking Plant Jiuquan Iron and Steel Co. Ltd. Jiayuguan 735100 China

The key to reduce shell breakout in the continuous casting process is to control shell thickness in the mold. A numerical simulation on the turbulent flow and heat transfer coupled with solidification in the slab mold using the volume of fluid （VOF） model and the enthalpy-porosity scheme was conducted and the emphasis was put upon the flow effect on the shell thickness profiles in longitudinal and transverse directions. The results show that the jet acts a stronger impingement on the shell of narrow face, which causes a zero-increase of shell thickness in a certain range near the impingement point. The thinnest shell on the slab cross-section locates primarily in the center of the narrow face, and secondly near the comer of the wide face. Nozzle optimization can obviously increase the shell thickness and make it more uniform.

关键词： continuous casting slab mold shell thickness nozzle optimization

Characteristics of Deoxidation and Desulfurization during LF Refining Al-killed Steel by Highly Basic and Low Oxidizing Slag

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Journal of Iron and Steel Research International 2014年第2期21卷 166-173页

作者： Jing GUO shu-sen cheng Zi-jian cheng State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological EngineeringUniversity of Science and Technology of Beijing Jiuquan Iron and Steel (Group) Co. Ltd.

Steel and slag samples were taken at the start and the end of LF refining for steel plate cold common （SPCC）, in the compact strip production （CSP） process, and at the same time, the temperature and oxygen activity a[o] were measured by using an oxygen sensor. Furthermore, inclusions in steel samples were monitored by scanning electron microscopy （SEM） combined with energy dispersive spectroscopy （EDS）. It was confirmed that a [o] in liq- uid steel was in equilibrium with inclusion rather than with top slag during LF refining. Desulfurization was related to deoxidation since a[o] at slag-steel interface was clarified to be very close to that in liquid steel under the specific con- dition in LF with intense stirring by argon blowing and refined by highly basic low oxidizing slag for Al-killed steel. Sulfur partition ratio （Ls） was very sensitive to a[o]. Since a[o] increased rapidly with temperature rise, it not only offset promotion to desulfurization reaction with temperature rise but decreased Ls. For Al-killed steel, ***- tion of Al2O3 for lowering the activity of Al2O3 in inclusion was believed to be favorable for both deoxidation and desulfurization during LF refining.

关键词： deoxidation desulfurization inclusion sulfur partition ratio LF refining