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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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静电喷射纳米铝热剂的微推进性能

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含能材料 2016年第12期24卷 1136-1144页

作者：汝承博王飞许建兵代骥沈云叶迎华朱朋沈瑞琪南京理工大学化工学院江苏南京210094

纳米铝热剂可用作基于微机电系统(MEMS)的固体化学微推进器的装药。添加含能粘结剂可以增强纳米铝热剂的推进性能表现。选择硝化棉(NC)和聚偏二氟乙烯(PVDF)作为含能粘结剂,利用静电喷射的方式制备纳米铝热剂,从理论和实验系统地研究了... 详细信息

纳米铝热剂可用作基于微机电系统(MEMS)的固体化学微推进器的装药。添加含能粘结剂可以增强纳米铝热剂的推进性能表现。选择硝化棉(NC)和聚偏二氟乙烯(PVDF)作为含能粘结剂,利用静电喷射的方式制备纳米铝热剂,从理论和实验系统地研究了燃料/氧化剂的平衡配比、粘结剂含量对推进性能的影响,并与相同条件下机械混合纳米铝热剂的推进性能比较。结果表明:静电喷射较机械混合纳米铝热剂的固体颗粒分布均匀;Al/CuO的计算最佳平衡配比为0.9,最佳实验平衡配比为1.8;当NC含量为2.5%时,比冲可以达到250.2 m·s^(-1),与无粘结剂的Al/CuO相比增加比例为8.0%;PVDF的加入降低了实验比冲值。粘结剂的分解产物将纳米颗粒分开,增加了凝聚相反应的特征传质长度,导致燃烧持续时间从2.9 ms显著地增加到87.8 ms。

关键词：纳米铝热剂固体化学微推进器比冲静电喷射含能粘结剂

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Dynamical Behavior of V^2C Control boost Converter

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Journal of Southwest Jiaotong University(English Edition) 2010年第1期18卷 32-38页

作者：包伯成许建平 School of Electrical and Information Engineering Jiangsu Teachers University of Technology School of Electrical Engineering Southwest Jiaotong University

A discrete iterative map model of V^2C control boost converter was established to study the dynamical behaviors of the converter. By using parameter space map and bifurcation diagram, the effects of circuit parameters on the bifurcation behaviors of V^2C control and current-mode control boost converters were analyzed. The phase portraits and time-domain waveforms of the V^2C control boost converter were obtained by Runge-Kutta algorithm through piecewise smooth switching model. The research results indicate that V^2C control boost converters can evolve into periodic and chaotic behaviors, and show weaker nonlinear behaviors than current-mode control boost converters.

关键词： Bifurcation Chaos Discrete iterative map Parameter space V^2C control boost converter

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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng xu Jing-Kai Wang bo Chen Hao xu Deng Pan Yu-Yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

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A high torque dual 3-phase permanent magnet vernier machine with strong fault-tolerance

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Science China(Technological Sciences) 2024年第10期67卷 3275-3284页

作者： xu YuWen WANG bo WANG RongXin cheng Ming HUA Wei School of Electrical Engineering Southeast UniversityNanjing 210096China

The field modulation effect has been proposed and investigated in various electric machine *** them,permanent magnet vernier machines(PMVMs)have attained intensive research due to the high torque density and simple ***,the performance of PMVMs in terms of fault tolerance is seldom *** article proposes a novel dual 3-phase fault-tolerant PMVM with segregated concentric *** from the field modulation effect,the PMVM can generate high torque with low PM *** low PM flux also implies small fault currents in the short-circuit ***,the PMVM exhibits inherent good fault-tolerant capability without sacrificing torque *** independent 3-phase modular winding sets are adopted to improve *** realize the physical and electrical isolation,each winding set is controlled by a standard 3-phase *** healthy performance and fault tolerance of the proposed machine are evaluated by finite element analysis and verified by experimental *** results infer its advantages in healthy conditions and various fault scenarios,including open-circuit,short-circuit,and interturn short-circuit conditions.

关键词： fault-tolerant capability segregated windings field modulation permanent magnet vernier machine

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Postsynthetic Modification of Metal-Organic Frameworks through Click Chemistry

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Chinese Journal of Chemistry 2016年第2期34卷 186-190页

作者： bo Gui Xiangshi Meng Hai xu cheng Wang Key Laboratory of Biomedical Polymers (Ministry of Education) College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China College of Chemistry and Chemical Engineering Central South University Changsha Hunan 410083 China

The postsynthetic modification （PSM） of metal-organic frameworks （MOFs） has emerged as a powerful tool to chemically tailor the interior of MOFs. In this review, we summarize the research progress of PSM of MOFs t... 详细信息

关键词： postsynthetic modification metal-organic frameworks click chemistry azide-alkyne click reaction thiol-ene reaction

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Data-driven flatness intelligent representation method of cold rolled strip

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Journal of Iron and Steel Research International 2023年第5期30卷 994-1012页

作者： Yang-huan xu Dong-cheng Wang bo-wei Duan Hong-min Liu National Engineering Research Center for Equipment and Technology of Cold Rolling Strip Yanshan UniversityQinhuangdao 066004HebeiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an 710032ShaanxiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina

A high-accuracy flatness prediction model is the basis for realizing flatness *** flatness is typically reflected as the strain distribution,which is a ***,it is difficult to obtain ideal results if the real flatness is directly used as the output value of the flatness intelligent prediction ***,it is necessary to seek an abstract representation method of real *** this reason,two new intelligent flatness representation models were proposed based on the autoencoder of unsupervised learning theory:the flatness autoencoder representation(FAR)model and the flatness stacked sparse autoencoder representation(FSSAR)*** with the traditional Legendre fourth-order polynomial representation model,the representation accuracies of the FAR and FSSAR models are significantly improved,better representing the flatness defects,like the double tight *** optimal number of bottleneck layer neurons in the FAR and FSSAR models is 5,which means that five basic patterns can accurately represent real *** with the FAR model,the FSSAR model has higher representation accuracy,although the flatness basic pattern is more abstract,and the physical meaning is not clear ***,the accuracy of the FAR model is slightly lower than that of the FSSAR ***,it can automatically learn the flatness basic pattern with a very clear physical meaning for both the theoretical and real flatness,which is an optimal intelligent representation method for flatness.

关键词： Cold rolling flatness Data-driven model Unsupervised learning Representation learning Autoencoder bottleneck layer

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A new high-pressure die casting Mg-Gd-Sm-Al alloy with high strength-ductility synergy

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Journal of Rare Earths 2024年第12期42卷 2239-2248页

作者： Shuhui Lv Youwei cheng bo Deng Tao xu Xin Qiu Qiang Yang School of Materials Science and Engineering Changchun University of Science and Technology State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Kashui International Holdings Limited

A high-pressure die casting（HPDC） Mg-5Gd-1.5Sm-0.7Al alloy was newly developed and exhibits outstanding strength-ductility synergy, with the yield strength and the tensile elongation to fracture being approximately 200 MPa and 8.5%, respectively. This alloy has two types of a-Mg grains: coarse a1-Mg(（46 ± 18） μm) and fine a2-Mg(（9.2 ± 2.3） μm) grains, and various Al-GS（GS = Gd and Sm） particles located at grain boundaries while clear solute-atom segregation near grain boundaries with limited or free intermetallic particles. Characterizations using Cs-corrected high-angle annular dark-field scanning transmission electron microscopy（HAADF-STEM） indicate the crystal structures of Al-GS phases. After aging, dense β'precipitates and chain-shaped β''-like structures precipitated near grain boundaries while a high density of ultrafine β''-（Mg,Al）3Sm precipitates and Al-GS clusters formed in grain center. Relatively fine grains, Al-GS primary particles, solute-atom segregation near grain boundaries, and/or multiple precipitates contribute to the high strength of the studied alloy, while the multi-scale a-Mg grains,variety of intermetallic particles but discontinuous skeleton, and the multi-typed precipitated lead to its satisfactory ductility.

关键词： Intermetallic phases Magnesium alloys Precipitate Rare earths Scanning/transmission electron microscopy (STEM) Strength-ductility synergy

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Microstructure and properties of hybrid additive manufacturing 316L component by directed energy deposition and laser remelting

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Journal of Iron and Steel Research International 2020年第7期27卷 842-848页

作者： Xiao-hui Chen bo Chen xu cheng Guo-chao Li Zheng Huang National Engineering Laboratory of Additive Manufacturing for Large Metallic Components and Engineering Research CenterMinistry of Education on Laser Direct Manufacturing for Large Metallic ComponentsSchool of Materials Science and EngineeringBeihang UniversityBeijing 100191China Research Center for Processing AECC Shanghai Commercial Aircraft Engine Manufacturing Co.Ltd.Shanghai 201306China

Arc additive manufacturing is a high-productivity and low-cost technology for directly fabricating fully dense metallic ***,this technology with high deposit rate would cause degradation of dimensional accuracy and surface quality of the metallic component.A novel hybrid additive manufacturing technology by combining the benefit of directed energy deposition and laser remelting is *** hybrid technology is successfully utilized to fabricate 316L component with excellent surface *** show that laser remelting can largely increase the amount ofδphases and eliminateσphases in additive manufacturing 316L component surface due to the rapid *** leads to the formation of remelting layer with higher microhardness and excellent corrosion resistance when compared to the steel made by directed energy deposition *** laser remelting power can improve surface quality as well as corrosion resistance,but degrade microhardness of remelting layer owing to the decrease inδphases.

关键词： Hybrid additive manufacturing Laser remelting Directed energy deposition Microstructure Corrosion resistance

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Intelligent representation method of image flatness for cold rolled strip

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Journal of Iron and Steel Research International 2024年第5期31卷 1177-1195页

作者： Yang-huan xu Dong-cheng Wang Hong-min Liu bo-wei Duan National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710018ShaanxiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina

Real flatness images are the bases for flatness detection based on machine vision of cold rolled *** characteristics of a real flatness image are analyzed,and a lightweight strip location detection(SLD)model with deep semantic segmentation networks is *** interference areas in the real flatness image can be eliminated by the SLD model,and valid information can be *** this basis,the concept of image flatness is proposed for the first *** image flatness representation(IFAR)model is established on the basis of an autoencoder with a new *** optimal structure of the bottleneck layer is 16×16×4,and the IFAR model exhibits a good representation ***,interpretability analysis of the representation factors is carried out,and the difference and physical meaning of the representation factors for image flatness with different categories are *** flatness with new defect morphologies(bilateral quarter waves and large middle waves)that are not present in the original dataset are generated by modifying the representation factors of the no wave ***,the SLD and IFAR models are used to detect and represent all the real flatness images on the test *** average processing time for a single image is 11.42 ms,which is suitable for industrial *** research results provide effective methods and ideas for intelligent flatness detection technology based on machine vision.

关键词： Cold rolled strip Image flatness Location detection Representation learning bottleneck layer

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