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Chinese Chemical Letters 2016年第7期27卷 993-1003页

作者： Xian-Hua Meng Zhi-bo Jiang cheng-Gen Zhu Qing-Lan Guo cheng-bo xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Three new napelline-type C20-diterpenoid alkaloids,named aconicarmichinium A and B trifluoroacetates（1 and 2） and aconicarmichinium C chloride（3）,were isolated from an aqueous extract of ＂fu zi＂,the lateral roots of Aconitum *** structures were elucidated by extensive spectroscopic data *** 1-3 represent the first examples of napelline-type C20 diterpenoid alkaloid alcohol iminiums,of which the structures were fully *** addition,transformation and equilibration between the alcohol iminiums（1-3） and the aza acetals la-3a were investigated by measurements of the NMR spectra in protic and aprotic deuterium solvents including alkali pyridine-d5,along with evaporation under reduced pressure and gradual additions of TFA,AcOH,and *** results demonstrated that the transformation and equilibration were solvent-,base-,and ***,in aqueous biological fluid,these C20-diterpenoid alkaloids would more likely exist as the alcohol iminiums accompanied by anion counterparts in biosystems to increase their solubility, bioavailability, transportations, and *** absolute configurations of 1-3 were confirmed by X-ray crystallographic analysis of 2a.

关键词： Aconitum carmichaelii Ranunculaceae Napelline-type C20-diterpenoid alkaloid Aconicarmichiniums A–C Alcohol iminium and aza acetal forms of the diterpenoid alkaloid Transformation and equilibration

Isatindigodiphindoside,an alkaloid glycoside with a new diphenylpropylindole skeleton from the root of Isatis indigotica

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Chinese Chemical Letters 2018年第1期29卷 119-122页

作者： Ling-Jie Meng Qing-Lan Guo cheng-Gen Zhu cheng-bo xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sdences and Peking Union Medical College Belting 100050 China

A novel indole alkaloid glycoside with an unprecedented 2-（diphenylpropyl）indole skeleton, isatindigodiphindoside （1）, was isolated from an aqueous extract of the roots of lsatis indigotica. The structure was determined by extensive spectroscopic studies, especially by 2D NMR data analysis combined with enzymatic hydrolysis and ECD calculations. Plausible biosynthetic pathways of compound 1 are also discussed.

关键词： CruciferaeIsatis indigoticaBan lan genDiphenylpropylindoleAlkaloid glycosidelsatindigodiphindoside

Two pairs of unusual scalemic enantiomers from Isatis indigotica leaves

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Chinese Chemical Letters 2016年第12期27卷 1745-1750页

作者： Da-Wei Li Qing-Lan Guo Xian-Hua Meng cheng-Gen Zhu cheng-bo xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Two pairs of unusual scalemic enantiomers with a dimethoxyphenyl）ethyl]-2-methoxyindolin-3-one, novel carbon skeleton of 2-[1′-（4＂-hydroxy-3＂,5＂- named isatidifoliumindolinones A-D （1-4）, were isolated from an aqueous extract of lsatis indigotica leaves （da qing ye）. Their structures including absolute configurations were determined by spectroscopic data analysis combined with comparison of their experimental CD and calculated ECD spectra. Validity of the ECD spectra calculation to assign the absolute configurations is discussed. Plausible biosynthetic pathways of 1-4 are proposed. Stereochemistry-dependent activity against LPS-induced NO production in BY2 cells was observed, and among the stereoisomers compound 4 is most active.

关键词： Isatis indigotica Cruciferae 2-[ 1′-( 4″-Hydroxy-3″, 5″-dimethoxyphenyl)ethyl]-2-methoxyindolin-3-one Scalemic enantiomerlsatidifoliumindolinones A-D Bioactivity

Gastradefurphenol,a minor 9,9＇-neolignan with a new carbon skeleton substituted by two p-hydroxybenzyls from an aqueous extract of “tian ma”

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Chinese Chemical Letters 2017年第6期28卷 1185-1189页

作者： xue Zhou Qing-Lan Guo cheng-Gen Zhu cheng-bo xu Ya-Nan Wang Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

Gastradefurphenol（1）,a minor 9.9＇-neolignan with a novel carbon skeleton substituted by two phydroxybenzyls was isolated from an aqueous extract of the Gastrodia elata rhizomes（tian ma）.Its structure was determined by extensive spectroscopic data ***-dependent free rotational restriction of bonds and equilibrium of two molecular states are discussed by comparison of the NMR spectroscopic data of 1 in acetone-d6 with those in CD3OD.A biogenetic pathway of 1 is postulated to be associated with metabolic processes of L-tyrosine.

关键词： Gastrodia elata Orchidaceae 9 9'-Neolignan Gastradefurphenol Minor constituent

Gastrolatathioneine,an unusual ergothioneine derivative from an aqueous extract of "tian ma":A natural product co-produced by plant and symbiotic fungus

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Chinese Chemical Letters 2016年第10期27卷 1577-1581页

作者： Qing-Lan Guo Sheng Lin Ya-Nan Wang cheng-Gen Zhu cheng-bo xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

Gastrolatathioneine （1）, an unusual natural product derived from ergothioneine, a fungal amino acid containing an imidazole-2-thione moiety, was isolated from an aqueous extract of ＂tian ma＂（the Gastrodia elata rhizomes）. The structure of 1 including the absolute configuration was determined by extensive spectroscopic data analysis, combined with comparison of an experimental circular dichroism spectrum and calculated electronic circular dichroism spectra of stereoisomers, and confirmed by X-ray crystallography. The natural origin of 1 was proved by HPLC-ESIMS analysis of the crude extract. A biogenetic pathway of I is proposed on the basis of metabolic post-modification of ergothioneine that is biosynthesized by a symbiotic fungus. The plant and symbiotic fungus are co-uroducers of 1.

关键词： Gastrodia elataOrchidaceaeErgothioneine(+)-L-N N-bis(4-hydroxybenzyl)ergothioneineGastrolatathioneine

Research of CdZnTe detector based portable energy dispersive spectrometer

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Nuclear Science and Techniques 2006年第2期17卷 106-112页

作者： cheng cheng WEI Yong-bo xu Hui-Chao ZHAO Cui-Lan ZHANG Jin-Zhou PU Shi-Jie JIANG Da-Zhen Shanghai Institute of Applied Physics the Chinese Academy of Sciences Shanghai 201800 China

A kind of excellent CdZnTe crystal has been grown in Yinnel Tech, Inc. in recent years. Based on these CdZnTe crystals and some new techniques, a portable energy-dispersive spectrometer has been constructed which has yielded good results. CdZnTe detector has a 3% relative resolution in high-energy field and can detect gamma rays at room temperature. An integrated circuit based on preamplifier and shaping amplifier chips is connected to the detector. Voltage pulses are transformed into digital signals in MCA (multichannel analyzer) and are then transmitted to com- puter via USB bus. Data process algorithms are improved in this spectrometer. Fast Fourier transform (FFT) and nu- merical differentiation (ND) are used in energy peak’s searching program. Sampling-based correction technique is used in X-ray energy calibration. Modified Gaussian-Newton algorithm is a classical method to solve nonlinear curve fitting problems, and it is used to compute absolute intensity of each detected characteristic line.

关键词： CdZnTe探测器前置放大器能量弥散光谱仪光谱分析

Gastrodin Derivatives from Gastrodia elata

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Natural Products and Bioprospecting 2019年第6期9卷 393-404页

作者： cheng-bo xu Qing-Lan Guo Ya-Nan Wang Sheng Lin cheng-Gen Zhu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Nine new gastrodin derivatives,including seven p-hydroxybenzyl-modified gastrodin ethers(1-7),6′-O-acetylgastrodin(8),and 4-[α-d-glucopyranosyl-(1→6)-β-d-glucopyranosyloxy]benzyl alcohol(9),together with seven known derivatives,were isolated from an aqueous extract of Gastrodia elata(“tian ma”)*** structures were determined by spectroscopic and chemical methods as well as single crystal X-ray *** 1-4,7,10,and 11 were also isolated from a reaction mixture by refluxing gastrodin and p-hydroxybenzyl alcohol in *** both gastrodin and p-hydroxybenzyl alcohol exist in the plant,the reaction results provide evidence for the production and increase/decrease of potential effective/toxic components when“tian ma”is decocted solely or together with ingredients in Chinese traditional medicine formulations,though the isolates were inactive in the preliminarily cell-based assays at concentrations of 10μ***,using ultra-performance liquid chromatography high-resolution electrospray ionization mass spectrometry(UPLC-HRESIMS),4,7,10,and 11,as well as component variations,were detectable in the freshly prepared extracts of different types of samples,including the freeze-dried fresh *** rhizomes.

关键词： Orchidaceae Gastrodia elata Blume p-Hydroxybenzyl gastrodin ethers Reaction of gastrodin with p-hydroxybenzyl alcohol Component variation during decocting

Clinical Characteristics and Prognosis of Peri-strut Low-intensity Area Detected by Optical Coherence Tomography

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Chinese Medical Journal 2015年第23期128卷 3132-3137页

作者： De-Wei Wu Meng-Yue Yu Hai-Yang Gao Zhe He Jing Yao cheng Ding bo xu Li Zhang Fei Song Qing-Rong Liu Yong-Jian Wu Coronary Heart Disease Center State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Peri-strut low-intensity area （PLIA） is a typical image pattern ofneointima detected by optical coherence tomography （OCT） after stent implantation. However, few studies evaluated the predictors and prognosis of the PLIA; therefore, we aimed to explore the genesis and prognosis of PLIA detected by OCT in this study.Methods： Patients presenting neointimal hyperplasia documented by OCT reexamination after percutaneous coronary intervention were prospectively included from 2009 to 2011. Peri-strut intensity was analyzed and classified into two patterns： Low-intensity and high-intensity. Clinical characteristics were analyzed to assess their contribution to peri-strut intensity patterns. Follow-up were performed in patients who did not receive revascularization during OCT reexamination, and the prognosis of the patients was evaluated.Results： There were 128 patients underwent OCT reexamination after stent implantation included in the study. PLIA was detected in 22 （17.2%） patients. The incidence of PLIA was positively correlated with serum triglyceride （odds ratio [OR]： 2.11, 95% confidence interval [CI]： 1.14-3.90, P = 0.017）, low-density lipoprotein （OR： 2.61, 95% CI： 1.22-5.66, P = 0.015）, history of cerebrovascular disease （OR： 101.11, 95% CI： 6.54-1562.13, P 〈 0.001）, and initial clinical presentation of acute coronary syndrome （ACS, OR： 18.77, 95% CI： 2.73-128.83, P = 0.003） while negatively correlated with stent implantation time （OR： 0.57, 95% CI： 0.33-0.98, P = 0.043）. The median follow-up was longer than 3.8 years. Major adverse cardiovascular events （MACEs） occurred in 7 （7.3%） patients while showed no correlation with PLIA. A total of 17 （17.7%） patients experienced unstable angina （UA） and showed significant correlation with PLIA （hazard ratio： 6.16, 95% CI： 1.25-30.33, P = 0.025）.Conclusions： PLIA detected by OCT was positively correlated with higher serum lipid level, history ofcerebrovascular disease and initial presentation of ACS, and

关键词： Optical Coherence Tomography Peri-strut Low-intensity Area Unstable Angina

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan cheng Hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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隧道勘察效果中浅层地震折射波法的应用

山西建筑 2014年第33期40卷 179-180页

作者：程旭波山西省地勘局二一四地质队山西运城044000

结合工程实例,介绍了利用浅层地震波法对隧道围岩地质条件进行勘测的技术,并对浅层地震折射波法的完善措施作了讨论,促使地震折射波法在隧道勘测当中发挥更好的作用,为勘测设计提供准确的参考依据。

关键词：隧道勘测浅层折射资料准确