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Acta Pharmacologica Sinica 2007年第1期28卷 98-104页

作者： cheng-liang zhang xiao-lei zou jia-bei peng ming xiang~2 Department of Pharmacology College of Pharmacy Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China DepartmentofPharmacology CollegeofPharmacyTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China

Aim:To investigate the effect and underlying mechanisms of immune-toleranceinduced by the adoptive transfer of bone marrow(BM)-derived dendritic cells(DC)in insulin-dependent diabetes mellitus(IDDM)***:The IDDMmodel was established by a low close of streptozotocin(STZ)in Balb/c *** subpopulations were generated from the BM cells with granulocyte-macroph-age colony-stimulating factor with or without *** purity and the Tcell stimulatory capability of DC were *** cells were used to modu-late autoimmune response in pre-diabetic *** glucose was examinedweekly;pancreas tissues were taken for histopathological analysis,and CD4~+ Tcells were isolated to detect lymphocyte proliferation by MTT assay and the ratioof CD4~+CD25+ T cells by fluorescence-activated cell sorting(FACS).The cytokinesecretion was determined by ELISA ***:Two DC subsets weregenerated from BM,which have phenotypes of mature DC(mDC)and immatureDC(iDC),*** level of blood glucose decreased significantly bytransferring iDC(Phan *** lymphocyte infiltration was ob-served in the islets,and pancreatic structure was *** vitro,proliferation oflymphocytes decreased and the proportion of CD4~+CD25~+ T cells increasedremarkably,compared with the mDC-treated groups(P<0.05),which were associ-ated with increased level of the Th2 cytokine and reduced level of the Th 1 cytokineafter iDC ***:Our data showed that iDC transfer was able toconfer protection to mice from STZ-induced *** immune-tolerance toIDDM may be associated with promoting the production of CD4~+CD25~+ T cellsand reducing regulatory Th2 responses in vivo.

关键词： dendritic cells insnlin-dependent diabetes mellitus streptozotocin immune tolerance regulatory T cells

Two symmetrical unsaturated acids isolated from Viscum album

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Chinese Journal of Natural Medicines 2019年第2期17卷 145-148页

作者： CAO Duo WANG Li-Qing han xiao-Min GUAN Hui-Rui lei Meng WEI Ya-Hui cheng liang YANG Pei-ming SUN Zheng-liang GAO Wen DAI jia-Kun College of Life Science Northwest University State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical Industry Shanghai University of Medicine&Health Sciences Affiliated Sixth People's Hospital South Campus Shineway Pharmaceutical Group Co. Ltd. Bio-Agricultue Institute of Shaanxi

In the present study,two new acetylene conjugate compounds,dibutyl(2Z,6Z)-octa-2,6-dien-4-yne dioate(1),and dibutyl(2E,6E)-octa-2,6-dien-4-yne dioate(2),were isolated from the dry stem leaves of Viscum album,along with nine known compounds(3–11).Their structures were confirmed on the basis of spectroscopic *** 1 and 8 showed antioxidant activity against xanthine oxidase(XOD)and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydroxyl(DPPH),with the IC_(50) of 1.22 and 1.33μmol·L^(–1),and the SC_(50 )of 4.34 and 8.22μmol·L^(–1),respectively.

关键词： Viscum album Symmetrical unsaturated acid Antioxidant activity

Protein microarray analysis of cytokine expression changes in distal stumps after sciatic nerve transection

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Neural Regeneration Research 2020年第3期15卷 503-511页

作者： xiao-Qing cheng Xue-Zhen liang Shuai Wei xiao Ding Gong-Hai han Ping Liu Xun Sun Qi Quan He Tang Qing Zhao Ai-jia Shang jiang peng beijing Key Laboratory of Regenerative Medicine in Orthopedics Institute of OrthopedicsChinese PLA General HospitalBeijingChina The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinanShandong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina

A large number of chemokines,cytokines,other trophic factors and the extracellular matrix molecules form a favorable microenvironment for peripheral nerve *** microenvironment is one of the major factors for regenerative ***,it is important to investigate the key molecules and regulators affecting nerve regeneration after peripheral nerve ***,the identities of specific cytokines at various time points after sciatic nerve injury have not been *** study was performed by transecting the sciatic nerve to establish a model of peripheral nerve injury and to analyze,by protein microarray,the expression of different cytokines in the distal nerve after *** showed a large number of cytokines were up-regulated at different time points post injury and several cytokines,e.g.,ciliary neurotrophic factor,were *** construction of a protein-protein interaction network was used to screen how the proteins interacted with differentially expressed *** Encyclopedia of Genes and Genomes pathway and Gene ontology analyses indicated that the differentially expressed cytokines were significantly associated with chemokine signaling pathways,Janus kinase/signal transducers and activators of transcription,phosphoinositide 3-kinase/protein kinase B,and notch signaling *** cytokines involved in inflammation,immune response and cell chemotaxis were up-regulated initially and the cytokines involved in neuronal apoptotic processes,cell-cell adhesion,and cell proliferation were up-regulated at 28 days after *** blot analysis showed that the expression and changes of hepatocyte growth factor,glial cell line-derived neurotrophic factor and ciliary neurotrophic factor were consistent with the results of protein microarray *** results provide a comprehensive understanding of changes in cytokine expression and changes in these cytokines and classical signaling pathways and biological function

关键词： cytokines distal stump gene ontology Kyoto Encyclopedia of Genes and Genomes pathway peripheral nerve injury protein microarray protein-protein interaction network Wallerian degeneration

树突状细胞和调节性T细胞在自身抗原所致小鼠免疫耐受模型中的作用

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世界华人消化杂志 2006年第7期14卷 687-692页

作者：向明张程亮邹晓蕾蔡晓寒彭佳蓓华中科技大学同济医学院药学院药理教研室湖北省武汉市430030

目的:探讨树突状细胞(DC)及CD4+CD25+调节性T细胞在胰岛素自身抗原sc所诱导的小鼠胰岛素依赖性糖尿病(IDDM)的免疫耐受中的重要作用．方法:低剂量链脲佐菌素(STZ)(40 mg／kg)ip 连续5次在Balb／c小鼠体内建立IDDM模型,胰岛素(100 μg)... 详细信息

目的:探讨树突状细胞(DC)及CD4+CD25+调节性T细胞在胰岛素自身抗原sc所诱导的小鼠胰岛素依赖性糖尿病(IDDM)的免疫耐受中的重要作用．方法:低剂量链脲佐菌素(STZ)(40 mg／kg)ip 连续5次在Balb／c小鼠体内建立IDDM模型,胰岛素(100 μg)与不完全弗氏佐剂(IFA,1:1)混合液sc 1次／wk,连续4 wk．模型建立后每周测定血糖,5 wk时处死动物,取胰腺进行病理组织学检查．分离骨髓DC前体及脾脏T淋巴细胞并进行体外培养．采用流式细胞术测定DC表型和CD4+CD25+调节性T细胞,以同种淋巴细胞刺激实验检测DC刺激淋巴细胞增殖功能．结果:胰岛素sc 4 wk后可明显降低小鼠的血糖,与模型对照组有极显著差异(13．79± 2．71 mmol/L vs 20．98±1．43 mmol／L,P<0．05), 胰岛内炎症细胞浸润减少,组织结构完整． IDDM模型建立后,小鼠骨髓来源树突状细胞CD11c表达为26．4％,DC分化异常,而正常小鼠CD11c表达为47．5％;混合淋巴细胞反应中DC刺激能力减弱,刺激指数分别为1．47± 0．01和1．32±0．01(刺激细胞和反应细胞比例分别为1:10和1:20),与正常小鼠相比,差别具有极显著性意义(P值均小于0．01)．脾脏 CD4+CD25+调节性T细胞减少到1．43％,而正常小鼠为5．09％．与此相反,胰岛素自身抗原连续应用后,不仅使血糖得到控制,表达 CD11c的树突状细胞数量增加,CD86和MHC- Ⅱ表面分子表达降低到26．6％和28．8％,刺激淋巴细胞反应的能力弱于正常DC,但强于模型小鼠的DC,刺激指数分别为2．30±0．06(1: 10)和2．17±0．02(1:20),CD4+CD25+调节性T 细胞数量上升到7．15％．结论:胰岛素sc可预防STZ所致小鼠IDDM的发生,自身抗原可以通过改善功能异常的树突状细胞．诱导CD4+CD25+调节性T细胞分化在模型小鼠体内建立免疫耐受．

关键词：自身抗原树突状细胞调节性T细胞 1型糖尿病小鼠胰岛素依赖性糖尿病

Correction of microwave pulse reflection by digital filters in superconducting quantum circuits

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Chinese Physics B 2024年第9期33卷 117-123页

作者： liang-liang Guo peng Duan lei Du Hai-Feng zhang Hao-Ran Tao Yong Chen xiao-Yan Yang Chi zhang Zhi-Long jia Wei-cheng Kong Zhao-Yun Chen Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

Reducing the control error is vital for high-fidelity digital and analog quantum *** superconducting circuits,one disagreeable error arises from the reflection of microwave signals due to impedance mismatch in the control ***,we demonstrate a reflection cancelation method when considering that there are two reflection nodes on the control *** propose to generate the pre-distortion pulse by passing the envelopes of the microwave signal through digital filters,which enables real-time reflection correction when integrated into the field-programmable gate array(FPGA).We achieve a reduction of single-qubit gate infidelity from 0.67%to 0.11%after eliminating microwave ***-time correction of microwave reflection paves the way for precise control and manipulation of the qubit state and would ultimately enhance the performance of algorithms and simulations executed on quantum processors.

关键词： reflection cancelation digital filter single-qubit gate superconducting circuit

髓源性树突状细胞过继转移诱导1型糖尿病小鼠免疫耐受及其机制

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世界华人消化杂志 2006年第33期14卷 3175-3179页

作者：张程亮向明邹晓蕾彭佳蓓华中科技大学同济医学院药学院药理室湖北省武汉市430030

目的:探讨髓源性树突状细胞(DC)过继转移诱导1型糖尿病(IDDM)小鼠免疫耐受的作用及其机制.方法:体外培养BALB/c小鼠骨髓来源DC,测定纯度,经ip小鼠体内.随后,采用少量多次链脲佐菌素(STZ)ip的方法建立IDDM小鼠模型.每周测定血糖,第4周时... 详细信息

目的:探讨髓源性树突状细胞(DC)过继转移诱导1型糖尿病(IDDM)小鼠免疫耐受的作用及其机制.方法:体外培养BALB/c小鼠骨髓来源DC,测定纯度,经ip小鼠体内.随后,采用少量多次链脲佐菌素(STZ)ip的方法建立IDDM小鼠模型.每周测定血糖,第4周时处死动物,分离脾脏淋巴细胞并进行体外培养,MTT法测定小鼠脾淋巴细胞增殖反应,采用流式细胞术检测CD4+CD25+调节性T细胞.ELISA法测定血清IL-2,IL-4含量.结果:过继转移表达CD11c+的DC4wk后,小鼠的血糖可明显降低,与模型对照组有极显著差异(8.32±1.05mmol/Lvs18.36±1.55mmol/L,P<0.01).与模型对照相比,过继转移DC可使小鼠脾淋巴细胞增殖能力降低(0.264±0.019vs0.489±0.012,P<0.05),流式细胞术测定结果显示CD4+CD25+T细胞亚群比例上升到5.28%,而模型对照组仅1.56%.DC过继可有效抑制IL-2分泌(121±19ng/Lvs195±32ng/L,P<0.05),而提高IL-4含量(187±36ng/Lvs76±30ng/L,P<0.01).结论:过继转移髓源性DC可以诱导免疫耐受防止IDDM的发生,其机制与促进体内CD4+CD25+T细胞亚群产生,重建Th1/Th2细胞因子平衡相关.

关键词：树突状细胞 1型糖尿病免疫耐受调节性 T细胞

The influence of the Insight-HXMT/LE time response on timing analysis

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Research in Astronomy and Astrophysics 2021年第1期21卷 45-52页

作者： Deng-Ke Zhou Shi-Jie Zheng Li-ming Song Yong Chen cheng-Kui Li xiao-Bo Li Tian-xiang Chen Wei-Wei Cui Wei Chen Da-Wei han Wei Hu jia Huo Rui-Can Ma Mao-Shun Li Tian-ming Li Wei Li He-Xin Liu Bo Lu Fang-Jun Lu Jin-Lu Qu You-Li Tuo Juan Wang Yu-Sa Wang Bai-Yang Wu Guang-cheng xiao Yu-peng Xu Yan-Ji Yang Shu zhang Zi-liang zhang xiao-Fan Zhao Yu-Xuan Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics Jilin UniversityChangchun 130012China

The LE is the low energy telescope that is carried on *** uses swept charge devices(SCDs)to detect soft X-ray ***’s time response is caused by the structure of the *** theoretical analysis and Monte Carlo simulations we discuss the influence of LE time response(LTR)on the timing analysis from three aspects:the power spectral density,the pulse profile and the time *** the LTR,the value of power spectral density monotonously decreases with the increasing *** power spectral density of a sinusoidal signal reduces by a half at frequency 536 *** corresponding frequency for quasi-periodic oscillation(QPO)signals is 458 *** root mean square(RMS)of QPOs holds a similar *** the LTR,the centroid frequency and full width at half maxima(FWHM)of QPOs signals do not *** LTR reduces the RMS of pulse profiles and shifts the pulse *** the time domain,the LTR only reduces the peak value of the cross-correlation function while it does not change the peak position;thus it will not affect the result of the time *** considering the time lag obtained from two instruments and one among them is LE,a 1.18 ms lag is expected caused by the *** time lag calculated in the frequency domain is the same as that in the time domain.

关键词： instrumentation:detectors methods:data analysis methods:analytical

The mini-GWAC optical follow-up of gravitational wave alerts – results from the O2 campaign and prospects for the upcoming O3 run

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Research in Astronomy and Astrophysics 2020年第1期20卷 107-123页

作者： Damien Turpin Chao Wu Xu-Hui han Li-Ping Xin Sarah Antier Nicolas Leroy Li Cao Hong-Bo cai Bertrand Cordier Jin-Song Deng Wen-Long Dong Qi-Chen Feng lei Huang lei jia Alain Klotz Cyril Lachaud Hua-Li Li En-Wei liang Shun-Fang Liu xiao-Meng Lu Xian-Min Meng Yu-lei Qiu Hui-Juan Wang Jing Wang Shen Wang xiang-Gao Wang jian-Yan Wei Bo-Bing Wu Yu-Jie xiao Da-Wei Xu Yang Xu Yuan-Gui Yang Pin-Pin zhang Ruo-Song zhang Shuang-Nan zhang Ya-Tong ZhengandSi-cheng zou Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayF-91898 OrsayFrance APC Univ Paris DiderotCNRS/IN2P3CEA/lrfuObs de ParisSorbonne Paris CiteFrance CEA Saclay DRF/IRFU/Departement d’astrophysique91191 Gif-sur-YvetteFrance School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Universite de Toulouse IRAP 14 Av.Edouard BelinF-31000 ToulouseFrance Institut de Recherche en Astrophysique et Planetologie(IRAP) UPS-OMPToulouseFrance Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Information Huaibei Normal UniversityHuaibei 235000China

The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons *** O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square *** them,six were finally confirmed as real astrophysical *** 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain *** GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next *** O2,only the mini-GWAC telescope network was fully *** to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event *** this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 *** observations provided the largest coverage of the GW localization areas with a short latency made by any optical *** found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger *** on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers.

关键词： gravitational waves methods:data analysis methods:observational (stars:)gammaray burst:general

A detector setup for the measurement of angular distribution of heavy-ion elastic scattering with low energy on RIBLL

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Nuclear Science and Techniques 2017年第7期28卷 85-89页

作者： Gao-Long zhang Yong-Jin Yao Guang-Xin zhang Zhen-Wei jiao cheng-jian Lin Ya-Zhou Niu Wei-Wei Qu lei Yang Nan-Rou Ma lei Zheng Hui-ming jia Li-Jie Sun Xing-Xing Liu xiao-Tong Chu Jie-cheng Yang jian-Song Wang Shi-Wei Xu peng Ma Jun-Bing Ma Shi-Lun Jin Zhen Bai Mei-Rong Huang Hong-liang Zang Biao Yang Yang Liu School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China China Institute of Atomic Energy Beijing 102413 China School of Radiation Medicine and Protection Medical College of Soochow University Soochow 215123 China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

A detector setup for the measurement of angular distribution of heavy-ion elastic scattering at energies around Coulomb barrier on the radioactive ion beam line in Lanzhou at the heavy-ion research facility in Lanzhou is *** beam profile and the scattering angles on the target are deduced by two parallel plate avalanche counters,and four sets of detector telescopes(including doublesided silicon strip detectors) are placed systematically with the beam line,incorporating with Monte Carlo *** data of ^(16)O on ^(89)Y target were analyzed to compare with the simulation *** is found that the simulated distribution is agreeable with the experimental *** assuming the pure Rutherford scattering at small scattering angles,the angular distribution of elastic scattering of^(16)O+^(89)Y at low energies can be reasonably *** indicates that this set of detector setup can be used for the measurement of angular distributions of heavy-ion elastic scattering at energies around Coulomb barrier.

关键词：兰州放射性束流线重离子研究装置探测器望远镜角分布测量弹性散射低能量设置平行板雪崩计数器