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Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis

Acta Pharmaceutica Sinica B 2024年第8期14卷 3493-3512页

作者： Longhao cheng Xiaoxue Wang Aijun liu Ying Zhu Hu cheng Jiangling Yu Lili Gong Honglin liu Guolin Shen Lihong liu Institute of Clinical Medical Sciences ChinaeJapan Friendship HospitalCapital Medical UniversityBeijing 100029China Department of Pharmacy ChinaeJapan Friendship HospitalBeijing 100029China Beijing Chao-Yang Hospital Capital Medical UniversityBeijing 100020China Institute of Chemicals Safety Chinese Academy of Inspection and QuarantineBeijing 100020China

Amino acid metabolic remodeling is a hallmark of cancer,driving an increased nutritional demand for amino *** acids are pivotal for energetic regulation,biosynthetic support,and homeostatic maintenance to stimulate cancer ***,the role of phenylalanine in multiple myeloma(MM)remains ***,we demonstrate that phenylalanine levels in MM patients are decreased in plasma but elevated in bone marrow(BM)*** the treatment,phenylalanine levels increase in plasma and decrease in *** suggests that changes in phenylalanine have diagnostic value and that phenylalanine in the BM microenvironment is an essential source of nutrients for MM *** requirement for phenylalanine by MM cells exhibits a similar *** phenylalanine utilization suppresses MM cell growth and provides a synergistic effect with Bortezomib(BTZ)treatment in vitro and murine ***,phenylalanine deprivation induces excessive endoplasmic reticulum stress and leads to MM cell apoptosis through the ATF3eCHOPeDR5 *** with ATF3 significantly affects phenylalanine deprivation *** conclusion,we have identified phenylalanine metabolism as a characteristic feature of MM metabolic *** is necessary for MM proliferation,and its aberrant demand highlights the importance of lowphenylalanine diets as an adjuvant treatment for MM.

关键词： Multiple myeloma Phenylalanine Amino acid metabolism Nutrient deprivation Cancer therapy Endoplasmic reticulum stress ATF3 Apoptosis

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Early Cretaceous Metasomatized Lithospheric Mantle beneath the Central Jiangnan Orogen in South China:Geochemical and Sr-Nd Isotope Evidence from the Tuanshanbei Dolerite

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 602-616页

作者： WANG cheng WEI Hantao liu Qingquan YANG Zhao Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-sen UniversityGuangzhou 510275China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Development and Research Centre China Geological SurveyBeijing 100037China School of Environmental Studies China University of GeosciencesWuhan 430074China

It is well established that Cretaceous magmatism in the South China Block(SCB)is related to the Paleo-Pacific ***,the starting time and the associated deep crust-mantle processes are still *** dike swarms carry important information on the deep earth(including mantle)geodynamics and geochemical *** the Jiangnan Orogen(South China).there is no information on whether the Mesozoic magmatic activities in this region are also directly related to the Pacific subduction or *** this study,we present detailed zircon U-Pb geochronological,wholerock element and Sr-Nd isotope data for Early Cretaceous Tuanshanbei dolerite dikes,and provide new constraints on the condition of the lithospheric mantle and mantle dynamics of the SCB during that ***-ICP-MS zircon U-Pb dating suggests that this dolerite erupted in the Early Cretaceous(~145 Ma).All samples have alkaline geochemical affinities with K_(2.O+Na_(2.O=3.11-4.04 wt%,K_(2.O/Na_(2.O=0.50-0.72.and Mg^(#)=*** are enriched in LILE but depleted in HFSE with higher initial^(87)Sr/^(86)Sr ratio(0.706896-0.714743)and lower ε_(Nd)(t)(-2.61 to-1.67).They have high Nb/U,Nb/La,La/Sm and Rb/Sr,and low La/Nb,La/Ta,Ce/Pb,Ba/Rb,Tb/Yb and Gd/Yb *** geochemical signatures suggest that the fractional crystallization is obvious but crustal contamination play a negligible role during magmatic *** dolerite were most likely derived from low-degree(2.-5%)partial melting of a phlogopite-bearing mantle material consisted of~85% spinel peridotite and~15% garnet peridotite previously metasomatized by asthenospherederived fluids/melts with minor subduction-derived fluids/***-rollback generally lead to the upwelling of the hot *** upwelling of asthenosphere consuming the lithospheric mantle by thermo-mechanical-chemical *** lithospheric mantle may have partially melted due to the heating by the upwelling asthenosphere and lithospheric extension.I

关键词： Early Cretaceous mafic dike metasomatized lithospheric mantle Tuanshanbei dolerite Jiangnan Orogen South China

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Prediction of cell-cell communication patierns of dorsal root ganglion cells:single-cell RNA sequencing data analysis

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Neural Regeneration Research 2024年第6期19卷 1367-1374页

作者： Yanna Lian cheng Wu Li liu Xiangyao Li National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuZhejiang ProvinceChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineZhejiang UniversityHainingZhejiang ProvinceChina Biomedical Sciences College of Medicine and Veterinary MedicineThe University of EdinburghEdinburghUK Core Facilities of the School of Medicine Zhejiang UniversityHangzhouZhejiang ProvinceChina

Dorsal root ganglion neurons transmit peripheral somatic information to the central nervous system,and dorsal root ganglion neuron excitability affects pain *** root ganglion stimulation is a new approach for managing pain *** of the cell-cell communication among dorsal root ganglion cells may help in the development of new pain and itch management ***,we used the single-cell RNA-sequencing(scRNA-seq)database to investigate intercellular communication networks among dorsal root ganglion *** collected scRNA-seq data from six samples from three studies,yielding data on a total of 17,766 *** on genetic profiles,we identified satellite glial cells,Schwann cells,neurons,vascular endothelial cells,immune cells,fibroblasts,and vascular smooth muscle *** analysis revealed that eight types of dorsal root ganglion neurons mediated proprioceptive,itch,touch,mechanical,heat,and cold ***,we predicted several distinct forms of intercellular communication among dorsal root ganglion cells,including cell-cell contact,secreted signals,extracellular matrix,and neurotransmitter-mediated *** data mining predicted that Mrgpra3-positive neurons robustly express the genes encoding the adenosine Adora2.(A2.)receptor and glial cell line-derived neurotrophic factor family receptor alpha 1(GFRα-1).Our immunohistochemistry results confirmed the coexpression of the A2. receptor and GFRα-*** injection of the A2. receptor antagonist PSB-603 effectively prevented histamine-induced scratching behaviour in a dose-dependent *** results demonstrate the involvement of the A2. receptor in the modulation of itch ***,our findings provide insight into dorsal root ganglion cell-cell communication patterns and *** results should contribute to the development of new strategies for the regulation of dorsal root ganglion excitability.

关键词： cell-cell communications CellChat dorsal root ganglion scRNA-Seq database

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Morphological characteristics and evolution model of slope units along loess gully cross section

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Frontiers of Earth Science 2024年第1期18卷 17-29页

作者： Lulu liu Fayuan LI Xue YANG Jianhua cheng School of Geography Nanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China

Gully morphology is an important part of loess landform *** with gully development,the variation of its cross section is the most significant,and it can intuitively reflect the characteristics of the lateral widening of the gully ***,in-depth research of the variation of the cross-sectional morphology of the gully is helpful to understanding the development process of the loess *** on the DEMs(Digital Elevation Model)of nine periods of an indoor simulated loess small watershed,this paper studies the evolution model of a complete branch ditch in the watershed using the digital terrain analysis theory and *** show that with the development of the gully,the average gradient of the gully slope continuously decreases,and the slope morphology is mostly a concave slope along the slope *** degree of downward concave first increases and then gradually tends to be *** gully erosion mode is gradually transformed from downward cutting erosion to lateral *** more mature the gully development,the lower the depth of gully bottom cutting is compared with the width of gully ***,the surface cutting depth tends to be stable and the slope is ***,the transformation law of the slope morphology of the gully cross section with the development of the gully is studied,and the prediction model of the transformation of the slope morphology of the gully cross section is established by using the Markov *** Markov model can better reflect the dynamic change of the slope morphology of the gully cross section,which is of great significance to revealing the external performance and internal mechanism of the gully morphology.

关键词： gully cross section slope morphology Markov chain digital elevation model

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Influence of meteorological factors on open biomass burning at a background site in Northeast China

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Journal of Environmental Sciences 2024年第4期138卷 1-9页

作者： Yulong Wang Linlin Liang Wanyun Xu Chang liu Hongbing cheng Yusi liu Gen Zhang Xiaobin Xu Dajiang Yu Peng Wang Qingli Song Jiumeng liu Yuan cheng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological SciencesBeijing 100081China Longfengshan Regional Background Station China Meteorological AdministrationHeilongjiang 150200China Heilongjiang Climate Center Heilongjiang 150030China

Biomass burning(BB)is a very important emission source that significantly adversely impacts regional air *** produces a large number of primary organic aerosol(POA)and black carbon(BC).Besides,BB also provides many precursors for secondary organic aerosol(SOA)*** this work,the ratio of levoglucosan(LG)to organic carbon(OC)and the fire hotspots map was used to identify the open biomass burning(OBB)events,which occurred in two representative episodes,October 13 to November 30,2.2.,and April1 to April 30,*** ratio of organic aerosol(OA)to reconstructed PM_(2.5)concentration(PM_(2.5)^(*))increased with the increase of LG/*** LG/OC ratio is higher than 0.03,the highest OA/PM_(2.5)^(*)ratio can reach 80%,which means the contribution of OBB to OA is *** to the ratio of LG to K^(+),LG to mannosan(MN)and the regional characteristics of Longfengshan,it can be determined that the crop residuals are the main *** occurrence of OBB coincides with farmers’preferred choices,i.e.,burning biomass in“bright weather”.The“bright weather”refers to the meteorological conditions with high temperature,low humidity,and without *** factors indirectly affect regional biomass combustion pollution by influencing farmers’active choices.

关键词： Air pollution Biomass burning Meteorological factors Organic trace Agricultural fires

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Effects of Additives on the Microstructure and Tribology Performance of Ta-12. Alloy Micro-Arc Oxidation Coating

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 142-149页

作者：刘玲 HU Changgang cheng Wendong 刘兴泉 School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China

Oxide ceramic coatings were fabricated on tantalum alloys by micro-arc oxidation (MAO) to improve their hardness and tribological properties. The MAO coatings were manufactured in a mixed silicatephosphate electrolyte containing NaF and/or EDTA (ethylene diamine tetraacetic acid). The surface morphology,cross-sectional view, chemical composition, hardness, and wear performance of the coatings were analysed. As revealed by the scanning electron microscopy, silica-rich nodules appear on the MAO coating obtained in the silicate-phosphate electrolyte, but the formation of nodules is inhibited with NaF and/or EDTA in the ***, they reduce the roughness and improve the compactness of the coatings, which are composed of Ta_(2.O_(5),(Ta, O), and TaO. A thick and hard coating is obtained in the NaF-containing electrolyte, and the tribology performance is effectively improved. With additives, the nodule structure is detached from the coating surface and dissolved in the electrolyte. By using NaF as an electrolyte additive, the abrasion performance of the MAO coating is enhanced by decreasing the nodule structure, increasing the size of micropores, and improving the coating hardness.

关键词： micro-arc oxidation tantalum alloy additives tribology performance

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Diversity and ecological assembly process of aerobic anoxygenic phototrophic bacteria in a low irradiation area,Three Gorges Reservoir

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Journal of Environmental Sciences 2024年第9期143卷 116-125页

作者： Lixin Huo Anran Ma Hong liu Xingzu Wang cheng Song Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Chongqing School University of Chinese Academy of SciencesCollege of Resources and EnvironmentChongqing 400714China Key Laboratory of Reservoir Aquatic Environment Chinese Academy of SciencesChongqing 400714China University of Chinese Academy of Sciences Beijing 100049China

Aerobic anoxygenic phototrophic bacteria(AAPB)are significant bacterial groups in aquatic ecosystems,known for their rapid growth and photoheterotrophic ***,the distribution and ecological assembly process of AAPB in low irradiation freshwater basins remain unclear,warranting further *** this study,we present the diversity,abundance,spatial variations,ecological process,and community interaction of AAPB in sediment of Three Gorges Reservoir(TGR)under low *** findings demonstrate the dominant genera of AAPB community that exist in the TGR area also are appeared in different waters,with some regional ***,the concentration of pufM gene,an indicator for AAPB,maintains a consistently high numerical level ranging from(2.2.±0.44)×10^(4)to(9.98±0.30)×10^(7)gene copies/*** solar irradiation is suggested as the major factor affecting AAPB,it remains unclear whether and how AAPB differ between regions due to varying solar irradiation *** results show spatial differences between total bacteria and AAPB communities,with significant differences observed only in *** and environmental factor contributed less than 10%to the spatial difference of community,with sediment type and environmental factors being the key factors influencing microbial community *** stochastic process plays a dominant role in the aggregation and replacement of AAPB communities,among which the most contribution is dispersal *** AAPB network,Yoonia and Gemmobacter are the hubs for *** results valuable insights into the AAPB communities in TGR with low irradiation.

关键词： Three Gorges Reservoir(TGR) Aerobic anoxygenic phototrophic bacteria(AAPB) Bacterial community Null model Community assembly

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Jellyfish bio-inspired Fe@CNT@CuNC derived from ZIF-8 for cathodic oxygen reduction

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Nano Research 2024年第4期17卷 2352-2359页

作者： Kai cheng Zequan liu Demin Jiang Min Song Yuqiao Wang Research Center for Nano Photoelectrochemistry and Devices School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Yangtze River Delta Carbon Neutrality Strategy Development Institute Southeast UniversityNanjing 210096China School of Energy and Environment Southeast UniversityNanjing 210096China

Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells(MFCs).Herein,jellyfish-inspired Fe clusters on carbon nanotubes connected with CuNC(Fe@CNT@CuNC)were designed and prepared by using zeolitic imidazolate framework(ZIF)-8 precursors to imitate the organic texture and function of *** antibacterial effect of Cu^(+)ions depressed the growth of cathode biofilm to ensure rapid mass *** clusters and CuNC connected by CNTs accelerated the electron transfer from Fe to *** optimization of oxygen adsorption was caused by electron redistribution between sites of Fe and ***-like catalysts achieved a half-wave potential of 0.86 V and onset potential of 0.95 V *** hydrogen electrode(RHE).MFCs gained the maximum power density of 1600 mW·m^(-2. after 500 h *** work provides insights into the special design of advanced catalysts based on bio-inspiration and biomimetics.

关键词： bio-inspiration oxygen reduction reaction antibacterial ability microbial fuel cells density functional theory(DFT)rational design

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Development of sustainable and efficient recycling technology for spent Li-ion batteries: Traditional and transformation go hand in hand

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Green Energy & Environment 2024年第5期9卷 802-830页

作者： Zejian liu Gongqi liu Leilei {2. Jing Gu Haoran Yuan Yong Chen Yufeng Wu Guangzhou Institute of Energy Conversion Chinese Academy of Sciences(CAS)Guangzhou510640China School of Engineering Science University of Science and Technology of ChinaHefei230026China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou510640China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China

Clean and efﬁcient recycling of spent lithium-ion batteries(LIBs)has become an urgent need to promote sustainable and rapid development of human ***,we provide a critical and comprehensive overview of the various technologies for recycling spent LIBs,starting with lithium-ion power *** research on raw material collection,metallurgical recovery,separation and puriﬁcation is highlighted,particularly in terms of all aspects of economic efﬁciency,energy consumption,technology transformation and policy *** and pathways for transformative full-component recovery of spent LIBs are explored,revealing a clean and efﬁcient closed-loop recovery *** methods are proposed for future recycling technologies,with a focus on how future research directions can be ***,based on life-cycle assessment,the challenges of future recycling are revealed from the LIBs supply chain and stability of the supply chain of the new energy battery industry to provide an outlook on clean and efﬁcient short process recycling *** work is designed to support the sustainable development of the new energy power industry,to help meet the needs of global decarbonization strategies and to respond to the major needs of industrialized recycling.

关键词： Spent LIBs Transformative recycling LCA analysis Policy guidance High value utilization

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Design strategy and relevant flow mechanisms of highly loaded 3D compressor tandem cascades

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Chinese Journal of Aeronautics 2024年第7期37卷 220-235页

作者： Xiaochen MAO Yunyu WANG Zhihua DING Hao cheng Bo liu School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China The National Key Laboratory of Science and Technology on Aerodynamic Design and Research Xi’an 710129China Xi’an Thermal Power Research Institute Co.Ltd Xi’an 710072China

To investigate the design strategy of highly loaded tandem cascades at both the midspan and endwall,the overall performance and flow mechanisms of four typical tandem cascades based on the optimization were analyzed from multiple perspectives *** results show that the interference effects on the Front Blade(FB)and Rear Blade(RB)should not be overlooked during the design phase,and the design strategies at the midspan and endwall are completely *** the midspan,the optimization aims to increase the interference effects and the strength of the gap jet while maintaining the same load on the FB and ***,the endwall optimal airfoil exhibits weakening interference effects,advancement of the gap jet location,and load transfer from the FB to *** further analysis of flow characteristics,the midspan optimal airfoil is beneficial for inhibiting the low-energy fluid from interacting with the suction surface of RB under the design condition,but results in earlier occurrence of corner *** endwall optimal airfoil helps suppress the development of the secondary flow and delay the onset of corner ***,by combining the benefits of these two design approaches,additional forward sweep effects are achieved,further enhancing the performance of the tandem cascade.

关键词： Tandem cascade Interference effect Vortex structure Load split Compressor

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