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Prediction of cell-cell communication patierns of dorsal root ganglion cells:single-cell RNA sequencing data analysis

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Neural Regeneration Research 2024年第6期19卷 1367-1374页

作者： Yanna Lian cheng wu Li Liu Xiangyao Li National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuZhejiang ProvinceChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineZhejiang UniversityHainingZhejiang ProvinceChina Biomedical Sciences College of Medicine and Veterinary MedicineThe University of EdinburghEdinburghUK Core Facilities of the School of Medicine Zhejiang UniversityHangzhouZhejiang ProvinceChina

Dorsal root ganglion neurons transmit peripheral somatic information to the central nervous system,and dorsal root ganglion neuron excitability affects pain *** root ganglion stimulation is a new approach for managing pain *** of the cell-cell communication among dorsal root ganglion cells may help in the development of new pain and itch management ***,we used the single-cell RNA-sequencing(scRNA-seq)database to investigate intercellular communication networks among dorsal root ganglion *** collected scRNA-seq data from six samples from three studies,yielding data on a total of 17,766 *** on genetic profiles,we identified satellite glial cells,Schwann cells,neurons,vascular endothelial cells,immune cells,fibroblasts,and vascular smooth muscle *** analysis revealed that eight types of dorsal root ganglion neurons mediated proprioceptive,itch,touch,mechanical,heat,and cold ***,we predicted several distinct forms of intercellular communication among dorsal root ganglion cells,including cell-cell contact,secreted signals,extracellular matrix,and neurotransmitter-mediated *** data mining predicted that Mrgpra3-positive neurons robustly express the genes encoding the adenosine Adora2b(A2B)receptor and glial cell line-derived neurotrophic factor family receptor alpha 1(GFRα-1).Our immunohistochemistry results confirmed the coexpression of the A2B receptor and GFRα-*** injection of the A2B receptor antagonist PSB-603 effectively prevented histamine-induced scratching behaviour in a dose-dependent *** results demonstrate the involvement of the A2B receptor in the modulation of itch ***,our findings provide insight into dorsal root ganglion cell-cell communication patterns and *** results should contribute to the development of new strategies for the regulation of dorsal root ganglion excitability.

关键词： cell-cell communications CellChat dorsal root ganglion scRNA-Seq database

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Geometry-Aware ICP for Scene Reconstruction from RGB-D Camera

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Journal of Computer Science & Technology 2019年第3期34卷 581-593页

作者： Bo Ren Jia-cheng wu Ya-Lei Lv Ming-Ming cheng Shao-Ping Lu College of Computer Science Nankai UniversityTianjin 300350China

The Iterative Closest Point (ICP) scheme has been widely used for the registration of surfaces and point ***, when working on depth image sequences where there are large geometric planes with small (or even without) details,existing ICP algorithms are prone to tangential drifting and erroneous rotational estimations due to input device *** this paper, we propose a novel ICP algorithm that aims to overcome such drawbacks, and provides significantly stabler registration estimation for simultaneous localization and mapping (SLAM) tasks on RGB-D camera inputs. In our approach,the tangential drifting and the rotational estimation error are reduced by: 1) updating the conventional Euclidean distance term with the local geometry information, and 2) introducing a new camera stabilization term that prevents improper camera movement in the calculation. Our approach is simple, fast, effective, and is readily integratable with previous ICP algorithms. We test our new method with the TUM RGB-D SLAM dataset on state-of-the-art real-time 3D dense reconstruction platforms, i.e., ElasticFusion and Kintinuous. Experiments show that our new strategy outperforms all previous ones on various RGB-D data sequences under different combinations of registration systems and solutions.

关键词： ICP(iterative closest point) RGB-D tangential drifting rotational estimation covariance matrix

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Thermal transport in lithium-ion battery: A micro perspective for thermal management

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Frontiers of physics 2022年第1期17卷 143-153页

作者： Changqing Xiang cheng-Wei wu wu-Xing Zhou Guofeng Xie Gang Zhang College of Information Science and Engineering Jishou UniversityJishou416000China School of Materials Science and Engineering&Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Hunan University of Science and TechnologyXiangtan411201China Institute of High Performance Computing A*STAR Singapore138632Singapore

In recent years, lithium ion (Li-ion) batteries have served as significant power sources in portable electronic devices and electric vehicles because of their high energy density and rate capability. There are growing concerns towards the safety of Li-ion batteries, in which thermal conductivities of anodes, cathodes, electrolytes and separator play key roles for determining the thermal energy transport in Li-ion battery. In this review, we summarize the state-of-the-art studies on the thermal conductivities of commonly used anodes, cathodes, electrolytes and separator in Li-ion batteries, including both theoretical and experimental reports. First, the thermal conductivities of anodes and cathodes are discussed, and the effects of delithiation degree and temperature of materials are also discussed. Then, we review the thermal conductivities of commonly used electrolytes, especially on solid electrolytes. Finally, the basic concept of interfacial thermal conductance and simulation methods are presented, as well as the interfacial thermal conductance between separator and cathodes. This perspective review would provide atomic perspective knowledge to understand thermal transport in Li-ion battery, which will be beneficial to the thermal management and temperature control in electrochemical energy storage devices.

关键词： lithium ion batteries thermal management phonon transport interfacial thermal transport amorphous materials

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Transient ventricular arrhythmia as a rare cause of dizziness during exercise:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9205-9210页

作者： Li-Li Gao cheng-Han wu Department of Neurology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003Fujian ProvinceChina

BACKGROUND Dizziness is a common symptom in adults and usually due to peripheral causes affecting semicircular canal function or central causes affecting the pons,medulla,or *** is a recognized cause of dizziness in people with structural or ischemic heart *** report a case of exercise-induced transient ventricular tachycardia and dizziness in a man with no evidence of organic heart *** SUMMARY A 42-year-old man presented with a 6 mo history of transient exercise-induced dizziness and prodromal *** patient was otherwise *** examination,otoscopy,vestibular tests,cerebellar tests,laboratory investigations,and imaging investigations were all ***-four hour Holter monitoring revealed four episodes of transient ventricular tachycardia during *** patient was started on metoprolol and subsequently underwent radiofrequency catheter *** patient reported a full recovery and no dizziness during daily *** results were maintained at the 6 mo *** Ventricular tachycardia is an uncommon but potentially serious cause of *** outcome of this case illustrates the benefits of careful clinical examination and communication with specialized *** clinical suspicion of arrhythmia in a patient with dizziness merits consultation with a cardiologist and referral to a specialized center to ensure timely diagnosis and treatment.

关键词： Dizziness Cardiac arrhythmia Ventricular tachycardia Catheter ablation Organic heart disease Case report

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Subgradient-based feedback neural networks for non-differentiable convex optimization problems

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Science in China(Series F) 2006年第4期49卷 421-435页

作者： LI Guocheng SONG Shiji wu cheng Center of Intelligent and Networked Systems Department of Automation Tsinghua University Beijing100084 China

This paper developed the dynamic feedback neural network model to solve the convex nonlinear programming problem proposed by Leung et al. and introduced subgradient-based dynamic feedback neural networks to solve non-differentiable convex optimization problems. For unconstrained non-differentiable convex optimization problem, on the assumption that the objective function is convex coercive, we proved that with arbitrarily given initial value, the trajectory of the feedback neural network constructed by a projection subgradient converges to an asymptotically stable equilibrium point which is also an optimal solution of the primal unconstrained problem. For constrained non-differentiable convex optimization problem, on the assumption that the objective function is convex coercive and the constraint functions are convex also, the energy functions sequence and corresponding dynamic feedback subneural network models based on a projection subgradient are successively constructed respectively, the convergence theorem is then obtained and the stopping condition is given. Furthermore, the effective algorithms are designed and some simulation experiments are illustrated.

关键词： projection subgradient non-differentiable convex optimization convergence feedback neural network.

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Formal verification technique for grid service chain model and its application

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Science in China(Series F) 2007年第1期50卷 1-20页

作者： XU Ke WANG YueXuan wu cheng Automation Department Tsinghua University Beijing 100084 China

Ensuring the correctness and reliability of large-scale resource sharing and complex job processing Is an Important task for grid applications. From a formal method perspective, a grid service chain model based on state PI calculus Is proposed In this work as the theoretical foundation for the service composition and collaboration in grid. Following the Idea of the Web Service Resource Framework （WSRF）, state PI calculus enables the life-cycle management of system states by associating the actions in the original PI calculus with system states. Moreover, model checking technique is exploltad for the design-time and run-time logical verification of grid service chain models. A grid application scenario of the dynamic analysis of material deformation structure is also provided to show the effectiveness of the proposed work.

关键词： grid grid service chain formal method model checking state Pi calculus

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Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance Li-ion battery anodes

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Rare Metals 2024年第2期43卷 599-611页

作者： Xue-Ru Zhang Qiong wu Yong Zhang Xi-Fei Li Ting Xie Yu-cheng wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox ***,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical *** overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization *** a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon *** integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer *** MnCo_(2)O_(4)@C/Cu possesses slightly longer Li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in Li-ion *** rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase *** a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible Li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in Li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials Lithium-ion batteries

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Robust LS-SVM regression for ore grade estimation in a seafloor hydrothermal sulphide deposit

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Acta Oceanologica Sinica 2013年第8期32卷 16-25页

作者： ZHANG Xunan SONG Shiji LI Jiabiao wu cheng Department of Automation Tsinghua University Second Institute of Oceanography State Oceanic Administration

Due to the geological complexities of ore body formation and limited borehole sampling, this paper propos- es a robust weighted least square support vector machine （LS-SVM） regression model to solve the ore grade estimation for a seafloor hydrothermal sulphide deposit in Solwara 1, which consists of a large proportion of incomplete samples without ore types and grade values. The standard LS-SVM classification model is applied to identify the ore type for each incomplete sample. Then, a weighted K-nearest neighbor （WKNN） algorithm is proposed to interpolate the missing values. Prior to modeling, the particle swarm optimiza- tion （PSO） algorithm is used to obtain an appropriate splitting for the training and test data sets so as to eliminate the large discrepancies caused by random division. Coupled simulated annealing （CSA） and grid search using 10-fold cross validation techniques are adopted to determine the optimal tuning parameter- s in the LS-SVM models. The effectiveness of the proposed model by comparing with other well-known techniques such as inverse distance weight （IDW）, ordinary kriging （OK）, and back propagation （BP） neural network is demonstrated. The experimental results show that the robust weighted LS-SVM outperforms the other methods, and has strong predictive and generalization ability.

关键词： weighted LS-SVIVl.grade estimation incomplete samples data division

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Fermion dynamical symmetry and strongly-correlated electrons:A comprehensive model of high-temperature superconductivity

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Frontiers of physics 2020年第4期15卷 35-99页

作者： Mike Guidry Yang Sun Lian-Ao wu cheng-Li wu Department of Physics and Astronomy Universilty of TenesseeKnorilleTN 37996USA School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China IKERBASQUE Basque Foundation for Science48011 BilbaoSpainand Department of Theoretical Physics and History of ScienceBasque Country University(EHU/UPV)Post Office Bor 64448080 BilbaoSpain Department of Physics Chung-Yuan Christian UniversityChungliTaiwan 320China

We review application of the SU(4)model of strongly-correlated electrons to cuprate and iron-based superconductors.A minimal self-consistent generalization of BCS theory to incorporate antiferromag-netism on an equal footing with pairing and strong Coulomb repulsion is found to account system-atically for the major features of high-temperature superconductivity,with microscopic details of the parent compounds entering only *** provides a systematic procedure to separate es-sential from peripheral,suggesting that many features exhibited by the high-Te data set are of interest in their own right but are not central to the superconducting *** generally,we propose that the surprisingly broad range of conventional and unconventional superconducting and superfluid behavior observed across many fields of physics results from the systemnatic appearance of similar al-gebraic structures for the emergent ffoctive Harmiltonians,even though the microscopic Harmiltonians of the corresponding parent states may differ radically from each other.

关键词： strongly-correlated electrons SU(4)model fermian dynamical symmetry high-temperature superconductivity

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On the Growth of Solutions of Second Order Linear Differential Equations with Extremal Coefficients

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Acta Mathematica Sinica,English Series 2013年第2期29卷 365-372页

作者： Jian Ren LONG Peng cheng wu Zheng ZHANG School of Mathematics and Computer Science Guizhou Normal University

In this paper, we consider the differential equation f＂＋ A（z）f＇＋ B（z）f = 0, where A and B= 0 are entire functions. Assume that A is extremal for Yang＇s inequality, then we will give some conditions on B whi... 详细信息

关键词： Entire function deficient value Borel direction order

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