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Genetic variations of the ADIPOQ gene and risk of prostate cancer in Chinese Han men

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Asian Journal of Andrology 2014年第6期16卷 878-883页

作者： cheng-Yuan gu Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Shanghai Medical College Fudan University Shanghai China Cancer Institute Fudan University Shanghai Cancer Center Shanghai China Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering School of life Sciences Fudan University Shanghai China Fudan-Taizhou Institute of Health Sciences Taizhou China Duke Cancer Institute Duke University Medical Center Durham North Carolina USA

Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis. Genetic variations in ADIPOQare thought to influence the activity of adiponectin, thus relating to cancer occurrence. In this hospital-based case-control study of 917 prostate cancer （PCa） cases and 1036 cancer-free controls, we evaluated the association of single nucleotide polymorphisms in ADIPOQ with risk of PCa and adiponectin levels in Chinese Han men. Variants of ADIPOQ were genotyped by Taqman polymerase chain reaction method. The plasma adiponectin concentrations were measured by *** immunosorbent assay （ELISA） in a subset of cases and controls. We found that the ADIPOQ rs3774262 variant AA genotype was associated with both decreased PCa risk [adjusted odds ratio （OR）： 0.66, 95% confidence interval （CI） =0.48-0.92] and increased plasma adiponectin levels （P= 0.036 and 0,043）, with significant difference by tumor grade, clinical stage, and aggressiveness. A significant interaction between ADIPOQ rs3774262 and body mass index was observed in modifying the risk of PCa （P=6.7 × 10-3）. ADIPOQ rs266729 and rs182052 were not related to PCa risk or plasma adiponectin levels. Our data support that ADIPOQ rs3774262 may affect PCa risk in combination with plasma adiponectin levels in Chinese Han men. It may contribute to the molecular basis for the association between obesity and PCa.

关键词： adiponectin ADIPOQ polymorphism prostate cancer

Development and validation of abiotic ligand model for nickel toxicity to wheat(Triticum aestivum)

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Journal of Environmental Sciences 2017年第12期29卷 22-30页

作者： Yang Jiang Xueyuan gu Bojing Zhu cheng gu State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China.

A terrestrial biotic ligand model（t-BLM） was developed to predict nickel toxicity to wheat（Triticum aestivum） root elongation in hydroponic solutions. The competitive effects of five major cations（Ca^（2＋）, Mg^（2＋）, Na~＋, K~＋and H~＋） on Ni toxicity were investigated and Mg^（2＋）was found to be a strong competitor, while H＋showed less competing effect. Besides free Ni^（2＋）,the toxicity induced by the species NiHCO_3~＋ was non-neglect able at pH 〉 7 because NiHCO_3~＋ occupied a significant fraction of total Ni under such condition. Thus, a t-BLM including Ni^（2＋）, NiHCO_3~＋, Mg^（2＋）, and H＋could successfully predict the nickel toxicity to wheat root elongation and it performed better prediction than the conventional free ion activity *** addition, the model was examined with two sets of independent experiments, which contained multiple cations and low-molecular-weight organic acids to mimic the rhizosphere condition. The developed t-BLM well predicted nickel toxicity in both experiments since it can account in both complexation and competition effects, suggesting its potential to be used in a complicated matrix like soil solution. This study provides direct evidence that the t-BLM is a reliable method for the risk assessment of nickel in terrestrial system.

关键词： Model Nickel Wheat Toxicity Risk assessment

Three-dimensional visualization and quantification of microporosity in aluminum castings by X-ray micro-computed tomography

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Journal of Materials Science & Technology 2021年第6期65卷 99-107页

作者： cheng gu Yan Lu Alan A.Luo Department of Materials Science and Engineering The Ohio State University2041 College Rd N.ColumbusOhio 43210USA Department of Integrated Systems Engineering The Ohio State University1971 NeilAve.ColumbusOhio 43210USA

Porosity is a major issue in solidification processing of metallic *** this work,wedge die casting experiments were designed to investigate the effect of cooling rate on microporosity in an aluminum alloy *** information including dendrites and porosity were measured and observed by optical microscopy and X-ray micro-computed tomography(XMCT).The effects of cooling rate on secondary dendrite arm spacing(SDAS)and porosity were *** relationship between SDAS and cooling rate was established and validated using a mathematical ***-dimensional(3-D)porosity information,including porosity percentage,pore volume,and pore number,was determined by *** the cooling rate decreasing from a lower to a higher position of the wedge die,the observed pore number decreases,the porosity percentage increases,and the equivalent pore radius *** of the pores was discussed as an empirical criterion to distinguish the types of *** different cooling rates,the larger the equivalent pore radius is,the lower the sphericity of the *** research suggests that XMCT is a useful tool to provide critical 3-D porosity information for integrated computational materials engineering(ICME)design and process optimization of solidification products.

关键词： X-ray computed tomography Casting micropore Quantitative evaluation Al alloy

Photodegradation of Hexafluoropropylene Oxide Trimer Acid under UV Irradiation

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Journal of Environmental Sciences 2020年第11期32卷 132-140页

作者： Chen Li Na Mi Zhanghao Chen cheng gu State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

As a novel alternative to traditional perfluoroalkyl substances(PFASs),including perfluorooctanoic acid(PFOA)and perfluorooctane sulfonate(PFOS),hexafluoroproplyene oxide trimer acid(HFPO-TA)has been detected worldwide in surface ***,recent researches have demonstrated that HFPO-TA has stronger bioaccumulation potential and higher hepatotoxicity than *** treat these contaminants *** and PFOS,some photochemical techniques by adding exogenous substances had been ***,there is still no report for the behavior of HFPO-TA itself under direct UV *** current study investigated the photo-transformation of HFPO-TA under UV irradiation in aqueous *** 72 hr photoreaction,75%degradation ratio and 25%defluorination ratio were achieved under ambient *** active species,i.e.,hydrated electrons and active hydrogen atoms,generated from water splitting played dominant roles in degradation of HFPO-TA,which was confirmed by different effects of reaction atmospheres and quenching experiments.A possible degradation pathway was proposed based on the products identification and theoretical *** general,HFPO-TA would be transformed into shorter-chain PFASs,including hexafluoropropylene oxide dimer acid(HFPODA),perfluoropropionic acid(PFA)and trifluoroacetate(TFA).This research provides basic information for HFPO-TA photodegradation process and is essential to develop novel remediation techniques for HFPO-TA and other alternatives with similar structures.

关键词： HFPO-TA Photo-reductive Hydrated electrons Active hydrogen atoms Degradation pathway

Hemin associated to cetyltrimethylammonium broide micelles: a biomimetic catalyst for 2,4,6-trichlorophenol degradation

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Science China Chemistry 2015年第7期58卷 1220-1226页

作者： Lihui Zhang cheng gu Ran Hong Haiping Zhang State Key Laboratory of Pollution Control & Resource Reuse School of Environment Nanjing University School of Chemistry and Chemical Engineering Pingdingshan University

For the first time, an efficient, green, economical biomimetic catalyst （hemin-cetyltrimethylammonium bromide micelles） was discovered to degrade 2,4,6-trichlorophenol （TCP）. The degradation experiments indicate that pH, temperature, the addition of 2-methyIimidazole, and the amount of hydrogen peroxide influence the degradation process. Test of reusability revealed that CTAB micelles can protect hemin from destruction by H202 and that the materials can be recycled. This material can be of great use for waste-water treatment.

关键词： hemin-CTAB micelles biomimetic catalyst degrade TCP recycle

Cellular automaton simulation and experimental validation of eutectic transformation during solidification of Al-Si alloys

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npj Computational Materials 2022年第1期8卷 1245-1253页

作者： cheng gu Michael P.Moodispaw Alan A.Luo Department of Materials Science and Engineering The Ohio State UniversityColumbusOHUSA Department of Integrated Systems Engineering The Ohio State UniversityColumbusOHUSA

The morphology of eutectic silicon in solidification microstructure is critical to the performance of Al-Si-based *** eutectic Si phase formation has been a challenge in ICME (integrated computational materials engineering) based design and manufacturing of solidification products of Al-Si-based *** this study,our previous three-dimensional (3-D) cellular automaton (CA) model for α-Al dendritic growth was extended to include eutectic (α-Al + Si) transformation in multi-dendrite domains,providing a complete solidification simulation of critically important Al-Si based *** quantitative results of the Si phase in the eutectic microstructure were experimentally validated using scanning electron microscopy and deep etching *** simulation results show a good agreement with the experimental observations and calculations by the Scheil model and lever *** 3-D CA model is useful for predicting and optimizing the solidification microstructure including eutectic transformation during solidification processing such as casting,potentially welding,and additive manufacturing.

关键词： solidification eutectic transformation

Effect of HEA/Al composite interlayer on microstructure and mechanical property of Ti/Mg bimetal composite by solid-liquid compound casting

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China Foundry 2023年第1期20卷 1-11页

作者： Jin cheng Jian-hua Zhao Chun Wang Jing-jing Shangguan cheng gu Ya-jun Wang College of Materials Science and Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Beijing Power Machinery Research Institute Beijing 100074China

In this study,HEA/AI composite interlayer was used to fabricate Ti/Mg bimetal composites by solidliquid compound casting *** Al layer was prepared on the surface of TC4 alloy by hot dipping,and the FeCoNiCr HEA layer was prepared by magnetron sputtering onto the Al *** influence of the HEA layer thickness and pouring temperature on interface evolution was investigated based on SEM observation and thermodynamic *** indicate that the sluggish diffusion effect of HEA can effectively inhibit the interfacial diffusion between Al and Mg,which is conducive to the formation of solid solution,especially when the thickness of HEA is 800 *** the increase of casting temperature from 720 ℃ to 730 ℃,740℃,and 750 ℃,α-Al(Mg),α-Al(Mg)+Al3Mg2,Al3Mg2+Al12Mg17,and Al12Mg17+δ-Mg are formed at the interface of Ti/Mg bimetal,*** the thickness of the HEA layer is 800 nm and the pouring temperature is 720 ℃,the bonding strength of the Ti/Mg bimetal can reach the maximum of 93.6 MPa.

关键词： Ti/Mg bimetal composite microstructure solid-liquid compound casting HEA/Al composite interlayer mechanical property

Hemin-histamine-montmorillonite clay conjugate as a model biocatalyst to mimic natural peroxidase

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Science China Chemistry 2015年第4期58卷 731-737页

作者： Lihui Zhang cheng gu Jian Xiong Mei Yang Yong guo State Key Laboratory of Pollution Control & Resource Reuse School of the Environment Nanjing University

We successfully synthesized the first hemin-montmorillonite bio-conjugate with an amino acid residue to mimic natural peroxidase enzyme. Histamine was intercalated in montmorillonite by cation exchange, then a heroin molecule was loaded onto the histamine-montmorillonite with an adsorption capacity of 7.0 mg· g^-1. The hemin-histamine-montmorillonite conjugate shows high peroxidase activity as indicated by the oxidation of guaiacol, which is attributed to the activation of hemin by Fe-N complex formation between the imidazole group in histamine and the iron ion in the hemin molecule. Temperaturedependent peroxidase activity for this synthesized biomimetic material indicates that raising the reaction temperature could significantly enhance the activity of the conjugate. The biomimetic catalyst has good reusability; nearly 100% activity can be retained after three cycles. Because montmorillonite clay is widely distributed in the environment, this material offers great potential for in situ and ex situ remediation of many organic contaminants in surface/subsurface soils.

关键词： hemin-histamine-montmorillonite conjugates imidazole biomimetic catalyst peroxidase activity recycle

Effects of iron(hydr)oxides on the degradation of diethyl phthalate ester in heterogeneous(photo)-Fenton reactions

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Journal of Environmental Sciences 2019年第6期31卷 5-13页

作者： Wenjuan Shuai cheng gu guodong Fang Dongmei Zhou Juan Gao Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil Science Chinese Academy of Science University of Chinese Academy of Sciences State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University

This work studied the structural effects of hematite(α-Fe2 O3), 2-line ferrihydrite(HFO) and goethite(α-FeOOH) on diethyl phthalate ester(DEP) degradation. The results showed that the degradation of DEP was faster under 365 nm light irradiation than in the dark in the presence of iron(hydr)oxides. The apparent kinetic rates of DEP degradation followed the order HFO > goethite ≈ hematite in the dark and HFO > hematite > goethite under 365 nm light irradiation. Two pathways governed H2 O2 decomposition efficiency on iron(hydr)oxide surfaces:(1) forming UOH on inherent surface hydroxyl groups(Fe-OH) and(2) producing O2 and H2 O on the surface oxygen vacancies. X-ray photoelectron spectroscopy(XPS) analyses indicated that HFO not only has high Fe-OH content but also has high Vo content, resulting in its low H2 O2 utilization efficiency(η). DEP was degraded through hydrogen abstraction and deesterification, and the major products were(OH)2-DEP, mono-ethyl phthalate(MEP), OH-MEP,and phthalate acid(PA). The study is important in understanding the transformation of phthalate esters in top surface soils and surface waters under ultraviolet light.

关键词： Diethyl phthalate ester Iron(hydr)oxide Hydroxyl radical Heterogeneous Fenton reactions