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Frontiers of Medicine 2015年第4期9卷 478-486页

作者： Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen zhibin Hu Guangfu Jin Hongbing Shen Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 211166 China Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing 211166 China Department of Cardiothoracic Surgery the Affiliated Wuxi People's Hospital of Nanjing Medical University Wuxi 214043 China Department of Medical Oncology the Affiliated Huai 'an First People 's Hospital of Nanjing Medical University Huai'an 223300 China

Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma （ESCC） was still uncertain. Several telomere length-related single nucleotide polymorphisms （TL- SNPs） in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study （1045 ESCC cases and 1433 controls） to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length （RTL）（median： 1.34） than controls （median： 1.50, P 〈 0.001）. More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk （P 〈 0.001）, with odds ratios （95% confidence interval） equal to 2.40 （1.84- 3.14）, 1.36 （1.03-1.79）, 1.01 （0.76-1.35）, and 1.37 （1.03-1.82） for individuals in the 1st （the shortest）, 2nd, 3rd, and 5th （the longest） quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.

关键词： esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association study

Rise and decline of ancient salt industry revealed by Na and Ca concentrations in sediments at Zhongba site, Chongqing

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Journal of Geographical Sciences 2008年第3期18卷 328-340页

作者： ZHU cheng JIANG Fengqing MA Chunmei XU Weifeng HUANG Linyan ZHENG Chaogui LI Lan SUN zhibin School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China Xinjiang Institute of Ecology and Geography CAS Urumqi 830011 China Department of Geography College of Chuzhou Chuzhou 239012 Anhui China Sichuan Provincial Institute of Archeology Chengdu 610041 China

Based on dynastic period division and AMS ^14 C dating performed on the sedimentary layers at Zhongba and Yuxi sites,and also the analysis of Na,Ca and Mg of 201 sedimentary samples from Zhongba site and that of Ca and Na in 47 sedimentary samples from Yuxi by using an inductively coupled plasma-mass spectrometry（ICP）,we found that there were 35 time periods when the contents of Ca and Na were reversely correlated,*** the content of Ca was the highest,the content of Na was the lowest,and vice versa. Among them,there were 21 time periods when the content of Ca was the highest,and Na was the lowest,indicating that there were about 21 prosperous periods of ancient salt production at Zhongba site since *** 14 time periods with the peak values of Na while the low values of Ca indicate 14 declined periods of salt production at Zhongba site since *** conclusion obtained from the reverse relationship between Ca and Na contents in this paper is consistent with that＂the salt production at Zhongba site started in the new stone age,developed in the Xia and Shang dynasties,reached at the heyday in periods from the Western Zhou to the Han Dynasties,maintained stable to develop in the Tang and the Song dynasties,and gradually declined after the Song Dynasty because the sea salt were conveyed into Sichuan region,however,still had production in the 1970s-1980s＂,educed from archeological *** the above mentioned results indicate that there is a reverse relationship obviously between the contents of Na and Ca in sediments at Zhongba site for ancient salt production,which can be used to reveal the process of rise and decline of ancient salt industry at Zhongba site.

关键词： Zhongba site Zhongxian County reverse relationship between contents of Na and Ca rise and decline of early salt production

Short Pulse Width and High Peak Power 457 nm Deep Blue Laser with V-Type Cavity

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Journal of Applied Mathematics and Physics 2021年第11期9卷 2987-2994页

作者： zhibin Zhao cheng cheng Hao Chen Quan Li Yi Qu Guojun Liu Zhongliang Qiao Baoxue Bo College of Opto-Electronic Engineering Changchun University of Science and Technology Changchun China Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province College of Physics and Electronic Engineering Hainan Normal University Haikou China

An intracavity frequency doubling acousto-optically Q-switched Neodymium-doped Yttrium Orthvanadate (Nd:YVO4) 457 nm blue laser by employing a three-mirror folded cavity was demonstrated. With the incident pump power of 40.4 W, the maximum average output power of 439 mW 457 nm laser, and the minimum pulse duration of 86.14 ns and the maximum peak power of 510 W were achieved at 10 kHz. The M2 factors are 1.23 and 1.61 in X and Y directions, respectively. The power stability in two hours is better than 2%.

关键词： Laser All-Solid-State Laser Pulse Wave Deep Blue Laser 457 nm Laser

Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma

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Science China(Life Sciences) 2022年第1期65卷 19-32页

作者： cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personized MedicineNanjing Medical UniversityNanjing 211166China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in ***,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA *** global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across *** high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD ***,the new classification was independent of classic molecular subtypes based on gene expression or DNA *** further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our *** model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy *** findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer.

关键词： lung adenocarcinoma A-to-I RNA editing cancer molecular type

Bone mineral density value evaluation based on photoacoustic spectral analysis combined with deep learning method

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Chinese Optics Letters 2020年第4期18卷 63-66页

作者： Xue Zhou zhibin Jin Ting Feng Qian cheng Xueding Wang Yao Ding Hongchen Zhan Jie Yuan Jinling College Nanjing UniversityNanjing 210089China School of Electronic Science and Engineering Nanjing UniversityNanjing 210008China Nanjing Drum Tower Hospital Nanjing 210093China Institution of Acoustics Tongji UniversityShanghai 200092China

The diagnosis of osteoporosis is eventually converted to the measurement of bone mineral density(BMD)in clinical *** our previous work had proved the ability of using photoacoustic spectral analysis(PASA)to efficiently detect osteoporosis,in this contribution,we proposed a fully connected multi-layer deep neural network combined with PASA to semi-quantify BMD values corresponding to varying degrees of bone loss and to further evaluate the degree of *** were carried out on swine femur heads,and the performance of our proposed method is satisfying for future clinical screening.

关键词： photoacoustics osteoporosis neural network

TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L

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Advances in Bioscience and Biotechnology 2017年第9期8卷 311-323页

作者： cheng An Guangjing Zhu Suzanne N. Martos Xue Feng Haimou Zhang Yankai Jia zhibin Wang Guang’an Men Hospital China Academy of Chinese Medical Sciences Beijing China Laboratory of Human Environmental Epigenomes Department of Environmental Health Sciences Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA School of Life Sciences Hubei University Wuhan China GENEWIZ Suzhou Suzhou China Fenxian Central Hospital Shanghai China Department of Oncology and Sidney Kimmel Comprehensive Cancer Center School of Medicine Johns Hopkins University Balti-more MD USA

Histone modification including H3 lysine 79 methylation (H3K79me) plays a key role during gene transcription and DNA damage repair. DOT1L, the sole methyltransferase for three states of H3K79me, is implicated in leukemia, colorectal cancer, and dilated cardiomyopathy. However, understanding of DOT1L and H3K79me in these pathways and disease pathogenesis has been limited due to the difficulty of working with DOT1L protein. For instance, locus-specific or genome-wide binding sites of DOT1L revealed by chromatin immunoprecipitation (ChIP)-based methods are necessary for inferring its functions, but high-quality ChIP-grade antibodies are currently not available. Herein we have developed a knock-in approach to tag endogenous DOT1L with 3 × Flag at its C-terminal domain to follow functional analyses. The knock-in was facilitated by using TALENs to induce a targeted double-strand break at the endogenous DOTIL to stimulate local homologous recombination at that site. The single cell colonies with successful knock-in were isolated and verified by different methods. We also demonstrated that tagged DOT1L maintains its normal function in terms of methylation and that the engineered cells would be very useful for further studies.

关键词： DOT1L Flag TALEN Knock-In

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可多线程测量的模拟钻杆四分量力虚拟仪器

清华大学学报（自然科学版） 2006年第8期46卷 1414-1417页

作者：李成丁天怀傅志斌王鹏清华大学精密仪器与机械学系北京100084

为分析钻杆的井下受力状态,应用直梁应变片式测力传感器,研制了一种基于虚拟仪器平台的钻杆四分量力测量系统。传感器系统随钻柱同轴旋转,终端单片机定时采集试件所承受的径向力、轴向力和扭矩等参数。L abV IEW调用串口A ctiveX控件的M... 详细信息

为分析钻杆的井下受力状态,应用直梁应变片式测力传感器,研制了一种基于虚拟仪器平台的钻杆四分量力测量系统。传感器系统随钻柱同轴旋转,终端单片机定时采集试件所承受的径向力、轴向力和扭矩等参数。L abV IEW调用串口A ctiveX控件的M SComm中断通讯模式,并结合I/O子系统设置和数据同步方法,实现了串口无线采集和钻杆转角测量的多线程检测。实验结果表明,该系统能够实现模拟钻杆在低钻速条件下(<180 r/m in)的实时测量,为钻杆振动特性的理论分析提供了实验依据。

关键词：直梁应变式力传感器钻杆四分量力虚拟仪器

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标签箱粒子概率假设密度群目标跟踪算法

系统工程与电子技术 2019年第8期41卷 1677-1685页

作者：程轩宋骊平姬红兵邹志彬西安电子科技大学电子工程学院

针对现有的箱粒子概率假设密度(probability hypothesis density,PHD)群目标跟踪算法计算量大、在群数目较多时状态提取不稳定以及无法获得群的航迹等问题,提出标签箱粒子PHD群目标跟踪算法。该算法首先对量测进行预处理,剔除其中的杂... 详细信息

针对现有的箱粒子概率假设密度(probability hypothesis density,PHD)群目标跟踪算法计算量大、在群数目较多时状态提取不稳定以及无法获得群的航迹等问题,提出标签箱粒子PHD群目标跟踪算法。该算法首先对量测进行预处理,剔除其中的杂波量测,以降低量测更新的计算量。然后,通过为箱粒子添加标签,区分不同的群目标,获得不同群的航迹。最后,依据不同标签提取群目标的状态,有效避免k-means聚类不稳定带来的影响。仿真实验表明,所提算法具有运算量小,在漏检环境下仍能很好地维持不同群的航迹,并在群数目较多时可准确提取群目标状态等优点。

关键词：群目标跟踪概率假设密度滤波箱粒子滤波标签航迹

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可组装轻质空间结构技术研究进展

宇航学报 2022年第11期43卷 1429-1443页

作者：熊健龚程韦兴宇李志彬哈尔滨工业大学航天学院复合材料与结构研究所哈尔滨150001 哈尔滨工业大学特种环境复合材料技术国家级重点实验室哈尔滨150080

概述了当前可组装轻质空间结构的构建技术方法,具体包含嵌锁组装、堆叠组装、折叠成型、充气成型和张拉整体成型五种主流技术;以太空建造、月面栖息地和近空间飞行器为典型应用,介绍了现有可组装轻质空间结构技术的航空航天应用。最后,... 详细信息

概述了当前可组装轻质空间结构的构建技术方法,具体包含嵌锁组装、堆叠组装、折叠成型、充气成型和张拉整体成型五种主流技术;以太空建造、月面栖息地和近空间飞行器为典型应用,介绍了现有可组装轻质空间结构技术的航空航天应用。最后,对比分析了各空间结构技术,讨论了现有挑战和技术难点,并对其未来发展方向进行了展望,旨在为今后航空航天任务中所需的轻量化空间结构研究提供参考。

关键词：可组装空间结构太空建造月面栖息地近空间飞行器