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Animal diversities and characteristics of environmental change revealed by skeletons unearthed at Zhongba Site of Chongqing City,China

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Chinese Science Bulletin 2008年第S1期53卷 74-86页

作者： ZHU cheng MA ChunMei OUYANG Jie LI ZhongXuan YIN Qian SUN zhibin HUANG YunPing R.K.FLAD LI Lan LI YuMei School of Geographic and Oceanographic Sciences of Nanjing University Nanjing 210093China Cultural Relic and Archaeology Research Institute of Sichuan Province Chengdu 610041China Faculty of Archaeology and Museology Peking UniversityBeijing 100871China Department of Anthropology Peabody MuseumHarvard UniversityCambridgeMA 02138USA Graduate University of Chinese Academy of Sciences Beijing 100049China

Nearly 200000 animal skeletons are unearthed in the Unit T0202 from Zhongba Site of Zhongxian *** to the analysis of 129165 specimens,these skeletons may be classified into 5 kinds, namely,Mammalia,Osteichthys,Aves,Amphibian and Reptilia,which belong to 13 orders,28 families and 42 *** this paper,based on archeological dating and AMS 14 C data,through statistically analyzing the unearthed skeletons and studying the change of the smallest individual numbers,these research results detected the following:1)In almost all the time of 2370―200 BC,in Zhongba region, some animals distributed widely,such as Muntiacus sp,Elaphodus cephalophus and Muntiacus sp. inhabiting in glade and grassland,Scrofa *** Canis familiaris raised by the ancient people,rodentia rabbit and Rattus rattus,which suggested that a fairly good ecological environment of forest and grassland was preserved at that period and the predecessors began to raise domestic animals from 1750 to 1000 BC,which has lasted until today.2)Rhinoceros only lived during 2000―1750 BC,1000― 700 BC and 700―500 BC,which indicates that the ecological environment of grassland and wetland might be better in these phases.3)Macaca *** Ursus arctos appeared only after 1750―1000 BC, which may show that the forest condition is better for animals to live during 1750―200 BC.4)The smallest individual numbers of Bublus sp.,bos *** otters emerged during about 2370―1750 BC, which perhaps infers that water area during the early period was wider than that of the late period.5) Since skeletons of rhinoceros are discovered in strata of Zhongba Site during 2000―1750 BC and 1000―500 BC,according to the climate and ecology environment which rhinoceros live in now,the average annual temperature and precipitation during 2000―1750 BC and 1000―500 BC are supposed to be probably higher than that of *** Zhu Kezhen considered that the first low temperature period in the past 5000 years of China was between 1100 BC a

关键词： Zhongba Site animal skeletons animal diversity climate and ecological environment change 2370 BC—200 BC

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RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer

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The Journal of Biomedical Research 2020年第2期34卷 129-138页

作者： Fei Chen Yuancheng Li Na Qin Fengliang Wang Jiangbo Du cheng Wang Fangzhi Du Tao Jiang Yue Jiang Juncheng Dai zhibin Hu cheng Lu Hongbing Shen Department of Breast Surgery Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211116China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211116China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211116China Department of Clinical Management National Center for STD ControlInstitute of DermatologyChinese Academy of Medical SciencesNanjingJiangsu 210042China

Triple negative breast cancer(TNBC) is an aggressive subtype of breast cancer that currently lacks effective biomarkers and therapeutic targets required to investigate the diagnosis and treatment of TNBC. Here we performed a comprehensive differential analysis of 165 TNBC samples by integrating RNA-seq data of breast tumor tissues and adjacent normal tissues from both our cohort and The Cancer Genome Atlas(TCGA). Pathway enrichment analysis was conducted to evaluate the biological function of TNBC-specific expressed genes. Further multivariate Cox proportional hazard regression was performed to evaluate the effect of these genes on TNBC prognosis. In this report, we identified a total of 148 TNBC-specific expressed genes that were primarily enriched in mammary gland morphogenesis and hormone levels related pathways, suggesting that mammary gland morphogenesis might play a unique role in TNBC patients differing from other breast cancer types. Further survival analysis revealed that nine genes(FSIP1, ADCY5, FSD1, HMSD, CMTM5, AFF3, CYP2 A7, ATP1 A2,and C11 orf86) were significantly associated with the prognosis of TNBC patients, while three of them(ADCY5,CYP2 A7, and ATP1 A2) were involved in the hormone-related pathways. These findings indicated the vital role of the hormone-related genes in TNBC tumorigenesis and may provide some independent prognostic markers as well as novel therapeutic targets for TNBC.

关键词： RNA-seq triple negative breast cancer prognosis differential expression

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The cancer-testis gene,MEIOB,sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency

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Cancer Biology & Medicine 2021年第1期18卷 74-87页

作者： Yayun Gu cheng Wang Rongxuan Zhu Jianshui Yang Wenwen Yuan Yanhui Zhu Yan Zhou Na Qin Hongbing Shen Hongxia Ma Hongxia Wang Xiaoan Liu zhibin Hu State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentJiangsu Collaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211116China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Breast Surgery The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029China

Objective:The newly defined cancer-testis(CT)gene,MEIOB,was previously found to play key roles in DNA double-strand break(DSB)*** this study,we aimed to investigate the effects and mechanisms of MEIOB in the carcinogenesis of triple-negative breast cancers(TNBCs).Methods:The Cancer Genome Atlas database was used to quantify the expression of *** regression analysis was used to evaluate the association between MEIOB expression and the prognosis of human *** effects of MEIOB on cell proliferation and migration in TNBCs were also assessed in ***-derived xenograft(PDX)models were used to assess the sensitivity of breast cancers with active MEIOB to PARP1 ***:We confirmed MEIOB as a CT gene whose expression was restricted to the testes and breast tumors,especially *** activation was significantly associated with poor survival in breast cancer patients[overall,hazard ratio(HR)=1.90(1.16–2.06);TNBCs:HR=7.05(1.16–41.80)].In addition,we found that MEIOB was oncogenic and significantly promoted the proliferation of TNBC *** analysis showed that MEIOB participated in DSB repair in ***,in contrast to its function in meiosis,it mediated homologous recombination deficiency(HRD)through the activation of poly ADP-ribose polymerase(PARP)1 by interacting with ***,activated MEIOB was shown to confer sensitivity to PARP inhibitors,which was confirmed in PDX ***:MEIOB played an oncogenic role in TNBC through its involvement in *** addition,dysregulation of MEIOB sensitized TNBC cells to PARP inhibitors,so MEIOB may be a therapeutic target of PARP1 inhibitors in TNBC.

关键词： Cancer-testis gene MEIOB triple-negative breast cancer PARP1 inhibitor cell proliferation

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全固态Nd:GdVO_(4)四倍频228 nm深紫外激光器

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海南师范大学学报（自然科学版） 2024年第1期37卷 30-36页

作者：程成金秦隆赵志斌李权沈惟含徐东昕陈浩刘国军乔忠良曲轶海南师范大学海南省激光技术与光电功能材料重点实验室海南海口571158 海南师范大学物理与电子工程学院海南海口571158 吉林大学超硬材料国家重点实验室吉林长春130012

在室温下实现全固态Nd:GdVO_(4)激光器四倍频228 nm深紫外脉冲输出。本文采用LD端面泵浦912 nm Nd:GdVO_(4)、声光调Q技术和LBO/BBO级联倍频产生228 nm脉冲激光,并通过理论和实验优化激光器参数设计,最终在LD泵浦功率为23.5 W时,重复频... 详细信息

在室温下实现全固态Nd:GdVO_(4)激光器四倍频228 nm深紫外脉冲输出。本文采用LD端面泵浦912 nm Nd:GdVO_(4)、声光调Q技术和LBO/BBO级联倍频产生228 nm脉冲激光,并通过理论和实验优化激光器参数设计,最终在LD泵浦功率为23.5 W时,重复频率在10 kHz下,获得了平均功率为14 mW的228 nm深紫外光输出,其脉冲宽度为59 ns,光斑呈椭圆形。

关键词：全固态激光器 Nd:GdVO_(4)晶体四倍频 228 nm激光

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复合非淀粉多糖酶制剂产品对肉鸡养殖生产效率及经济效益影响的研究

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饲料博览 2021年第7期31卷 5-9,18页

作者：陈德近王乙茹赵平王春羲白华毅杨明华钱锦花屈娥程志斌云南农业大学昆明650201 昆明三正生物科技(集团)有限公司昆明650217 达州职业技术学院四川达州635001 玉溪农业职业技术学院云南玉溪653100

本研究旨在从养殖生产效率和养殖经济效益角度评估几种市售复合非淀粉多糖(Non-starch polysaccharide, NSP)酶制剂产品在肉鸡养殖生产中的应用效果,选择21日龄健康AA肉鸡500只,随机分成5个处理组,正对照组(PC)饲喂"玉米-豆粕"型日粮,... 详细信息

本研究旨在从养殖生产效率和养殖经济效益角度评估几种市售复合非淀粉多糖(Non-starch polysaccharide, NSP)酶制剂产品在肉鸡养殖生产中的应用效果,选择21日龄健康AA肉鸡500只,随机分成5个处理组,正对照组(PC)饲喂"玉米-豆粕"型日粮,负对照组(NC)饲喂"杂粮-杂粕"型日粮,3个试验组(NC+E1、NC+E2、NC+E3)分别在NC基础上添加3种复合NSP酶制剂(E1、E2和E3)。结果显示:与PC组比,NC组肉鸡料重比、平均日采食量、饲料便发生率显著增加(P0.05)。养殖生产效率依次为PC>NC+E2>NC+E3>NC+E1>NC,养殖经济效率依次为NC+E2>PC>NC+E3>NC>NC+E1。结果表明养殖生产效率和养殖经济效益指标有助于全面评价不同市售NSP酶制剂产品在肉鸡养殖中的应用效果及其价值。

关键词：肉鸡复合非淀粉多糖酶制剂养殖生产效率养殖经济效益

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解淀粉芽孢杆菌对畜禽肠道有害菌、有益菌抑菌性能的研究初报

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饲料博览 2021年第8期31卷 1-5,9页

作者：王政露肖明霞王乙茹柳成东赵平钱锦花杨保和屈娥程志斌云南农业大学昆明650201 达州职业技术学院四川达州635001 玉溪农业职业技术学院云南玉溪653100 云南快大多畜牧科技有限公司云南玉溪653100

为了评估一株解淀粉芽孢杆菌(Bacillus amyloliquefaciens,菌株编号YNAU 6172)对畜禽肠道主要有害菌(大肠杆菌K88、大肠杆菌K99、猪霍乱沙门氏菌、鸡白痢沙门氏菌)及肠道有益菌(罗伊氏乳酸杆菌、嗜热双歧杆菌)的抑制作用,采用牛津杯体... 详细信息

为了评估一株解淀粉芽孢杆菌(Bacillus amyloliquefaciens,菌株编号YNAU 6172)对畜禽肠道主要有害菌(大肠杆菌K88、大肠杆菌K99、猪霍乱沙门氏菌、鸡白痢沙门氏菌)及肠道有益菌(罗伊氏乳酸杆菌、嗜热双歧杆菌)的抑制作用,采用牛津杯体外抑菌试验法,以抑菌圈直径值判定解淀粉芽孢杆菌对以上6个指示菌的抑制作用。结果显示:解淀粉芽孢杆菌对4个肠道有害菌的抑制作用均判定为不敏感,对肠道有益菌嗜热双歧杆菌判定也为不敏感,但对肠道有益菌罗伊氏乳酸杆菌的抑制作用为敏感。说明解淀粉芽孢杆菌作为饲用微生态制剂开发需进一步筛选和验证。

关键词：解淀粉芽孢杆菌抑菌性能牛津杯法肠道有害菌肠道有益菌

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Natural variation of GmFATA1B regulates seed oil content and composition in soybean

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Journal of Integrative Plant Biology 2023年第10期65卷 2368-2379页

作者： Zhandong Cai Peiqi Xian Yanbo cheng Yuan Yang Yakun Zhang Zihang He Chuwen Xiong zhibin Guo Zhicheng Chen Huiqian Jiang Qibin Ma Hai Nian Liangfa Ge Guangdong Sub‐center of National Center for Soybean Improvement South China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region Shaoguan UniversityShaoguan 512000China Department of Grassland Science College of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

Soybean(Glycine max) produces seeds that are rich in unsaturated fatty acids and is an important oilseed crop worldwide. Seed oil content and composition largely determine the economic value of soybean. Due to natural genetic variation, seed oil content varies substantially across soybean cultivars. Although much progress has been made in elucidating the genetic trajectory underlying fatty acid metabolism and oil biosynthesis in plants, the causal genes for many quantitative trait loci(QTLs) regulating seed oil content in soybean remain to be revealed. In this study, we identified Gm FATA1B as the gene underlying a QTL that regulates seed oil content and composition, as well as seed size in soybean. Nine extra amino acids in the conserved region of Gm FATA1B impair its function as a fatty acyl–acyl carrier protein thioesterase, thereby affecting seed oil content and composition. Heterogeneously overexpressing the functional Gm FATA1B allele in Arabidopsis thaliana increased both the total oil content and the oleic acid and linoleic acid contents of seeds. Our findings uncover a previously unknown locus underlying variation in seed oil content in soybean and lay the foundation for improving seed oil content and composition in soybean.

关键词： GmFATA1B natural variation QTL seed oil content soybean

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美洲大蠊人工养殖高效产卵与孵化研究进展

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饲料博览 2019年第3期29卷 14-16,21页

作者：白华毅苏子峰万德生李琦华段治尚舒积杨秀云程志斌云南农业大学昆明650201 大理大学农学与生物科学学院云南大理671003 云南腾药制药股份有限公司云南腾冲679199

文章从提高人工养殖美洲大蠊产卵数量与孵化效率的目的出发,分析了人工养殖环境温度、湿度、光照、营养与饲料、病虫害与天敌防控等因素对改善美洲大蠊人工养殖效应的影响。

关键词：美洲大蠊人工养殖产卵孵化

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CircAST:Full-length Assembly and Quantification of Alternatively Spliced Isoforms in Circular RNAs

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Genomics, Proteomics & Bioinformatics 2019年第5期17卷 522-534页

作者： Jing Wu Yan Li cheng Wang Yiqiang Cui Tianyi Xu Chang Wang Xiao Wang Jiahao Sha Bin Jiang Kai Wang zhibin Hu Xuejiang Guo Xiaofeng Song Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Center of Pathology and Clinical Laboratory Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Center for Cellular and Molecular Therapeutic Children’s Hospital of PhiladelphiaPhiladelphiaPA 19104USA

Circular RNAs(circ RNAs),covalently closed continuous RNA loops,are generated from cognate linear RNAs through back splicing events,and alternative splicing events may generate different circ RNA isoforms at the same ***,the challenges of reconstruction and quantification of alternatively spliced full-length circ RNAs remain *** the basis of the internal structural characteristics of circ RNAs,we developed Circ AST,a tool to assemble alternatively spliced circ RNA transcripts and estimate their expression by using multiple splice *** studies showed that Circ AST correctly assembled the full sequences of circ RNAs with a sensitivity of 85.63%–94.32%and a precision of 81.96%–87.55%.By assigning reads to specific isoforms,Circ AST quantified the expression of circ RNA isoforms with correlation coefficients of 0.85–0.99 between theoretical and estimated *** evaluated Circ AST on an in-house mouse testis RNA-seq dataset with RNase R treatment for enriching circ RNAs and identified 380 circ RNAs with full-length sequences different from those of their corresponding cognate linear ***-PCR and Sanger sequencing analyses validated 32 out of 37 randomly selected isoforms,thus further indicating the good performance of Circ AST,especially for isoforms with low *** also applied Circ AST to published experimental data and observed substantial diversity in circular transcripts across samples,thus suggesting that circ RNA expression is highly *** AST can be accessed freely at https://***/xiaofengsong/CircAST.

关键词： Circular RNA Full-length reconstruction Isoform quantification Multiple splice graph model Transcriptome

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饲用凝结芽孢杆菌对断奶仔猪生产性能的影响

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饲料博览 2017年第12期27卷 6-10页

作者：余冬友胡小波钟伟杨保和王春李亚平刘兴能柳成东夏涛程志斌云南农业大学昆明650201 玉溪市正和养殖场云南玉溪653100 云南快大多畜牧科技有限公司云南玉溪653100 昆明三正生物科技(集团)有限公司昆明650217

试验将28日龄断奶仔猪132头(杜×长×大)分为3个处理组:对照组(组合抗生素组)、试验组1(组合抗生素组+凝结芽孢杆菌1×10~7cfu·g^(-1))、试验组2(组合抗生素组+凝结芽孢杆菌2×10~7cfu·g^(-1)),研究含有组合抗生素的商业仔猪饲料额外... 详细信息

试验将28日龄断奶仔猪132头(杜×长×大)分为3个处理组:对照组(组合抗生素组)、试验组1(组合抗生素组+凝结芽孢杆菌1×10~7cfu·g^(-1))、试验组2(组合抗生素组+凝结芽孢杆菌2×10~7cfu·g^(-1)),研究含有组合抗生素的商业仔猪饲料额外添加饲用凝结芽孢杆菌对断奶仔猪生产性能的影响。试验结果表明,在末体重指标方面,试验组1和2分别比对照组提高了3.2%和4.2%,但3个处理组之间差异不显著(P>0.05)。在平均日增重指标方面,试验组1和2分别比对照组提高了5.5%和7.0%,但3个处理组之间差异也不显著(P>0.05)。试验期为28 d,对照组仔猪腹泻头数最多,试验组2腹泻头数最少。试验结果表明,在断奶仔猪日粮组合使用多种常规饲用抗生素的基础上,额外添加饲用凝结芽孢杆菌2×10~7cfu·g^(-1)(全价配合饲料),具有进一步减少仔猪腹泻、提高生长速度的作用。

关键词：凝结芽孢杆菌断奶仔猪生产性能

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