检索结果-南通市图书馆

Posaconazole-associated severe hyperbilirubinemia in acute myeloid leukemia following chemotherapy: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2018年第16期6卷 1206-1209页

作者： Zai-Wei Song Yu-Chen Pan zhen-cheng Huang Wen-Xi Liu Rong-Sheng Zhao Hong-Mei Jing Fei Dong Department of Pharmacy Peking University Third Hospital Department of Hematology Peking University Third Hospital

BACKGROUND Posaconazole is a widely used azole antifungal agent, and posaconazole-associated severe hyperbilirubinemia is usually rare in clinical practice. We herein report a 58-year-old male with acute myeloid leukemia, who developed fungal infection following *** SUMMARY After administration of posaconazole oral suspension, the patient developed severe hyperbilirubinemia and jaundice(Common Terminology Criteria for Adverse Events, CTCAE-Grade 3) with a serum total bilirubin(T-BIL) peak level of 170 μmol/L, alkaline phosphatase level of 739 U/L, alanine aminotransferase level of 99 U/L, and gamma-glutamyl transpeptidase level of 638 U/L. After posaconazole withdrawal and symptomatic treatment with liver-protective agents, the level of T-BIL and other laboratory data decreased gradually, and related symptoms disappeared. After medication analysis and literature review, we consider that the patient had a cholestatic type of posaconazoleinduced liver injury, which was related to intracellular mitochondrial DNA damage. The case demonstrates that when patients with hematological malignancy develop severe infection following chemotherapy, combination of anti-infective drugs may contribute to ahigher risk of severe drug-induced liver injury. CONCLUSION This is the first thoroughly documented case report of posaconazole-associated severe hyperbilirubinemia. Therefore, in order to avoid severe adverse events, liver and renal function should be monitored closely before and during the administration of posaconazole.

关键词： Posaconazole Hyperbilirubinemia Liver injury Acute myeloid leukemia Case report

Interactions of Heavy Metal Ions with Paddy Soils as Inferred from Wien Effect Measurements in Dilute Suspensions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2006年第6期16卷 718-725页

作者： JIANG Jun LI cheng-Bao ZHAO An-zhen XU Ren-Kou WANG Yu-Jun S. P. FRIEDMAN Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China Institute of Soil Water and Environmental Sciences Agricultural Research Organization Voleani Center Bet Dagan 50250 Israel

Interactions of three heavy metal ions, Cu^2＋, Cd^2＋, and Pb^2＋, and, for comparison, Na^＋ with electrodialytic clay fractions （less than 2μm in diameter） of four paddy soils as well as a yellow-brown soil as a control soil were evaluated based on measurements of the Wien effect in dilute suspensions with a clay concentration of 10 g kg^-1 in four nitrate solutions of 2 × 10^-4/z mol L^-1, where z is the cation valence, and a nitric acid solution of 3 × 10^-5 mol L^-1, Field strengths ranging from 15 to 230 kV cm^-1 were applied for measuring the electrical conductivities （ECs） of the suspensions. The mean free binding energies between the various cations and all of the soils determined from exchange equilibrium increased in the order： Na^＋〈 Cd^2＋〈 Cu^2＋〈 Pb^2＋. In general, the ECs of the suspensions in the sodium nitrate solution were smaller than those of the suspensions in the heavy metal solutions because of the lower electrophoretic mobility of sodium compared to the divalent cations. In terms of relative electrical conductivity-field strength relationships, relative electrical conductivity （REC） of suspensions containing various cations at field strengths larger than about 50 kV cm^-1 were in the descending order： Na^＋〉 Cu^2＋〉 Cd^2＋〉 Pb^2＋ for all tested soils. A characteristic parameter of the REC-field strength curves, AREC200, REC at a field strength of 200 kV cm^-1 minus that at the local minimum of the concave segment of the REC-field strength curves, characterized the strength of adsorption of the cations stripped off by the applied strong electrical field, and for all soils the values of AREC200 were generally in the order： Na^＋〈 Cu^2＋ ≤ Cd^2＋〈 Pb^2＋.

关键词： binding energy electrical conductivity field strength heavy metal ions paddy soils

Genome-scale mRNA and miRNA transcriptomic insights into the regulatory mechanism of cucumber corolla opening

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2022年第9期21卷 2603-2614页

作者： SONG Xiao-fei GE Dan-feng XIE Yang LI Xiao-li SUN cheng-zhen CUI Hao-nan ZHU Xue-yun LIU Ren-yi YAN Li-ying Hebei Key Laboratory of Horticultural Germplasm Excavation and Innovative Utilization College of Horticultural Science and TechnologyHebei Normal University of Science and TechnologyQinhuangdao 066004P.R.China Center for Agroforestry Mega Data Science Haixia Institute of Science and TechnologyFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China

‘Corollas and spines’ is an important trait for fresh market cucumber. In a unique cucumber line, ‘6457’, the super ovary is much larger and corolla opening is delayed by 4–5 days, thus the resulting fruit has a flower that remains on the tip,which has a high commodity value. In this study, to better understand the molecular basis of corolla opening, mRNA and miRNA transcriptome analyses were performed during corolla development of the super and normal ovaries. A total of 234 differentially expressed miRNAs(DEMs) and 291 differentially expressed target genes(DE-target genes) were identified from four developmental stages, and the greatest number of DEMs was found at the yellow bud stage. Thirty of the DE-target genes were regulated by more than five DEMs, among which, CsHD-Zip was regulated by 28 DEMs,followed by DD2X(18). In addition, the expression patterns of miRNA_104, miRNA_157, miRNA_349, miRNA_242, and miRNA_98 were similar during corolla development, and they shared the same target gene, CsCuRX. Moreover, several critical candidate DEMs and DE-target genes were characterized and profiled by a qRT-PCR experiment. Three of the miRNAs, miRNA_157-CsCuRX, miRNA_411-CsGH3.6, and miRNA_161/297/257-CsHD-Zip, might be responsible for corolla opening in the cucumber super ovary. This integrated study on the transcriptional and post-transcriptional profiles can provide insights into the molecular regulatory mechanism underlying corolla opening in the cucumber.

关键词： cucumber miRNA corolla opening super ovaries

美国传教士与中国早期的西医护理学(1880—1930年)

在线全文

学校读者我要写书评

暂无评论

自然科学史研究 2006年第4期25卷 355-364页

作者：甄橙北京大学医史学研究中心北京100083

现代西方护理学伴随西方医学由传教士带到中国。传教士通过建立诊所、医院和护士学校,开始在中国传播西医护理学。主要回顾了1880—1930年的50年间,美国传教士在中国所做的工作,重点介绍了沃安娜(1890—?)和盖奇(1883—1946)两位传教士... 详细信息

现代西方护理学伴随西方医学由传教士带到中国。传教士通过建立诊所、医院和护士学校,开始在中国传播西医护理学。主要回顾了1880—1930年的50年间,美国传教士在中国所做的工作,重点介绍了沃安娜(1890—?)和盖奇(1883—1946)两位传教士护士的工作,以及中华护士会的建立和作用,并简要分析了影响西医护理学在中国发展的因素。

关键词：传教士护理学美国中国

DILUTION OF HORIZONTAL RADIAL JET IN A CURRENT

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 1992年第3期4卷 34-42页

作者： Guo zhen-ren Xu zhen-cheng Lin Kui Jiang Wei-qiang South China Institute for Environmental Sciences,Guangzhou 510655,P.R.China

A type of port with a movable cover is designed to increase initial dilution and prevent sea water and sediments from intruding into outfall *** radial jets pro- duced by this type of port in a current are investigated experimentally and *** analysis based on Reynolds'equations and self-similarity hypothesis shows that the maximum ve- locity of radial jets decays with r^(-1.5).The relationships between the width,thickness,average di- lution of a submerged wastefield along flow,and the parameters of the port,jet and ambient are established quantitatively and verified by *** is demonstrated that the dilution of horizontal radial jets is much higher than that of vertical round jets and the surface boil point of the former is much more distant than that of the latter.

关键词： dilution jet wastewater treatment turbulent mixing

Analysis of Meteorological Elements and Distribution Characters of Surface Solar Radiation in Guangxi

在线全文

学校读者我要写书评

暂无评论

Meteorological and Environmental Research 2012年第11期3卷 12-14,21页

作者： cheng Ai-zhen HUANG Ren-li Guangxi Meteorological Information Center Fangchenggang Meteorological Bureau in Guangxi

[Objective] The aim was to study the relation between solar radiation distribution and meteorological elements in Guangxi. [Method] Based on the observed data of solar radiation in Guangxi from 1995 to 2009, the total radiation, solar distribution and interannual changes in Guangxi were analyzed. By dint of observed data in Nanning station, the annual, seasonal and monthly changes of net radiation in Nanning and the linear relation between total radiation, solar distribution characteristics and interannual changes were discussed. [Result] The global radiation of surface solar radiation in the low latitude was higher tan the high latitude, as Beihai>Nanning>Guilin. The solar radiation changes and the seasonal changes in different places varied, as summer>autumn>spring>winter. The total radiation and solar radiation hours were consistent. The total solar radiation and the low cloud was in negative relation, but was in positive relation with sunny weather. The total solar radiation was in positive relation with ground temperature, except in winter. [Conclusion] The study provided effective theoretical basis and data reference to the study of climate and development of solar energy.

关键词： Total solar radiation Distribution characteristics Meteorology elements Analysis Guangxi China

The Clinical Value of NLR, D-D and CRP/ALB Ratio in the Diagnosis of Pulmonary Thromboembolism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2021年第10期9卷 65-73页

作者： Tiantian Shan[] zhen cheng[] Min Yan Xiangtao Pan Department of Hematology Taicang Hospital Affiliated to Soochow University Taicang China

Objective: To evaluate the clinical diagnostic value of C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR) and D-dimer (D-D) in patients with pulmonary thromboembolism (PTE). Methods: We conducted a retrospective analysis comparing hematology and coagulation in 362 PTCA-confirmed PTE patients with the control group and analyzing their relationships with CAR, NLR, and D-D. Receiver operating characteristic curve (ROC) was used to analyze the diagnostic threshold, area under the curve (AUC), diagnostic sensitivity and specificity of CAR, NLR and D-D for PTE. Results: 1) CAR, NLR and D-D levels in PTE patients were 2.13 ± 2.08, 8.96 ± 1.94 and 9.69 ± 8.61 respectively, significantly higher than those in control group (CAR = 0.03 ± 0.01, t = 20.7736, P 0.05). 3) The levels of HB, LY, PLT and AT in PTE patients were significantly lower than those in control group, while WBC, NE and FB were significantly higher than those in control group. 4) CAR was negatively correlated with Hb and AT (P all Conclusion: The levels of Hb, LY, PLT and AT were significantly decreased in PTE patients, while WBC, NE and FB were significantly increased. CAR, NLR and D-D were highly expressed in PTE patients, and were closely correlated with Hb, AT and FB. Combined detection of CAR, NLR and D-D can improve the diag

关键词： Pulmonary Thromboembolism CAR C-Reactive Protein/Albumin Ratio Neutrophil to Lymphocyte Ratio Plasma D-Dimer Clinical Diagnosis

Electrooxidative trifunctionalization of alkenes with N-chlorosuccinimide and ArSSAr/ArSH to α,β-dichloride arylsulfoxides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 131-135页

作者： Guohui Qin Renjie Wang zhen cheng Yonghong Zhang Bin Wang Yu Xia Weiwei Jin Chenjiang Liu Urumqi Key Laboratory of Green Catalysis and Synthesis Technology Key Laboratory of Oil and Gas Fine ChemicalsMinistry of Education&Xinjiang Uygur Autonomous RegionState Key Laboratory of Chemistry and Utilization of Carbon Based Energy ResourcesCollege of ChemistryXinjiang UniversityUrumqi 830017China

An unprecedented electrochemical oxidative trifunctionalization of olefins with diaryl disulfides/aryl thiols and N-chlorosuccinimide in an aqueous system is *** C-Cl bonds,one C-S bond,and one S=O bond are produced simultaneously in one step from simple and commercially available starting materials with clean *** tandem methodology features as mild reaction conditions,transition metal and additional oxidant free,broad substrate scope,good functional group compatibility,and gram scale preparation.

关键词： Electrooxidation Alkenes functionalization Vicinal dichlorination Sulfoxidation Tandem reaction

Construction of a high-density adzuki bean genetic map and evaluation of its utility based on a QTL analysis of seed size

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2021年第7期20卷 1753-1761页

作者： WANG Li-xia WANG Jie LUO Gao-ling YUAN Xing-xing GONG Dan HU Liang-liang WANG Su-hua CHEN Hong-lin CHEN Xin cheng Xu-zhen nstitute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute of Rice Research Guangxi Academy of Agricultural SciencesNanning 530007P.R.China Institute of Economic Crops Jiangsu Academy of Agricultural SciencesNanjing 210014P.R.China

Adzuki bean(Vigna angularis(Willd.)Ohwi&Ohashi)is an annual cultivated leguminous crop commonly grown in Asia and consumed ***,there has been limited research regarding adzuki bean genetics,which has prevented the efficient application of genes during *** the present study,we constructed a high-density genetic map based on whole genome re-sequencing technology and validated its utility by mining QTLs related to seed ***,we analyzed the sequences flanking insertions/deletions(In Dels)to develop a set of PCR-based markers useful for characterizing adzuki bean genetics.A total of 2904 markers were mapped to 11 linkage groups(LGs).The total length of the map was 1365.0 cM,with an average distance between markers of 0.47 *** the LGs,the number of markers ranged from 208(LG7)to 397(LG1)and the total distance ranged from 97.4 cM(LG9)to 155.6 cM(LG1).Twelve QTLs related to seed size were identified using the constructed *** two major QTLs in LG2 and LG9 explained 22.1 and 18.8%of the total phenotypic variation,*** minor QTLs in LG4,LG5 and LG6 explained 3.0–10.4%of the total phenotypic variation.A total of 9718 primer pairs were designed based on the sequences flanking In *** the 200 selected primer pairs,75 revealed polymorphisms in 24 adzuki bean *** genetic map constructed in this study will be useful for screening genes related to other ***,the QTL analysis of seed size and the novel markers described herein may be relevant for future molecular investigations of adzuki bean and will be useful for exploiting the mechanisms underlying legume seed development.

关键词： Vigna angularis genetic map QTL seed size PCR-based marker development