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ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway

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Journal of Genetics and Genomics 2024年第6期51卷 617-629页

作者： Ruihui Lu Jingwen Zhu Xin Li cheng zeng Yan Huang Chao Peng Yingfang Zhou Qing Xue Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China

Endometriosis refers to as an estrogen-dependent *** receptorβ(ERB),the main estrogen receptor subtype which is encoded by the estrogen receptor 2(ESR2)gene,can mediate the action of estrogen in *** selective estrogen receptor modulators can target the ERβ,they are not specific due to the wide distribution of ERβ.Recently,long noncoding RNAs have been implicated in ***,we aim to explore and validate the downstream regulatory mechanism of ERβ,and to investigate the potential role of long intergenic noncoding RNA 1018(LINC01018)as a nonhormonal treatment for *** study demonstrates that the expression levels of ESR2 and LINCo1018 are increased in ectopic endometrial tissues and reveals a significant positive correlation between the ESR2 and LINCo1018 ***,ERβdirectly binds to an estrogen response element located in the LINCO1018 promoter region and activates LINC01018 ***,ERβcan regulate the CDC25C/CDK1/CyclinB1 pathway and promote ectopic endometrial stromal cell proliferation via LINC01018 in *** with these findings,the knockdown of LINC01018 inhibits endometriotic lesion proliferation in *** summary,our study demonstrates that the ERβ/LINC01018/CDC25C/CDK1/CyclinB1 signaling axis regulates endometriosis progression.

关键词： Estrogen receptorβ Long intergenic noncoding RNA 1018 (LINC01018) Endometriosis Cell cycle Proliferation

NF-κB in biology and targeted therapy:new insights and translational implications

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1322-1358页

作者： Qing Guo Yizi Jin Xinyu Chen Xiaomin Ye Xin Shen Mingxi Lin cheng zeng Teng Zhou Jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly 40 ***,NF-κB signaling was identified as a pivotal pathway in mediating inflammatory ***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathways,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch,Hedgehog,and TLR *** physiological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety of human diseases,including cancers,inflammatory and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKls,non-coding RNAs,immunotherapy,and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKT diseases involvement

Design of artificial biomimetic channels with Na^(+)permeation rate and selectivity potentially outperforming the natural sodium channel

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Nano Research 2024年第9期17卷 8638-8646页

作者： Zhi Zhu Yan Zhao Chao Chang Shaojian Yan Tingyu Sun Shiyu Gu Yangmei Li Dengsong Zhang Chunlei Wang Xiao cheng zeng School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Physics Peking UniversityBeijing 100871China International Joint Laboratory of Catalytic Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Artificial ion channels that enable high-efficiency ion transport have important implications in nanofluidics and biomedical applications such as drug ***,we show a simulation-based chemical design of a biomimetic sodium channel that possesses permeation rate and selectivity potentially higher than those of the state-of-the-art natural vertebrate voltage-gated sodium ***,our theoretical findings have undergone empirical testing,aligning well with the Arrhenius law as derived from a diverse range of experimental *** high-efficiency ion transport is achieved by anchoring the carboxylate functional groups within the channel filter.A key chemical guiding principle underlying the ion channel design is that the free-energy barrier for the Na^(+)passage across the channel should be comparable to typical thermal energy at room *** the implementation of the chemical design,we found that the relatively low free-energy barrier can be attributed to the compensation effect of the carboxylate groups to the partially lost oxygen shell of the ion within the ion channel,as well as to the consonant vibration of the ions inside and outside the *** mechanistic understanding brings new insight,at the molecular level,into the high-efficiency ion transport across the designed membrane *** proof of principle achieved from the simulations will stimulate future experimental confirmation and potential applications of the high-performance artificial channels in nanofluidics and in bioinspired iontronics.

关键词： sodium channels anchoring carboxylate functional groups molecular dynamics simulations low free-energy barrier for ion passage thermal kinetic energy

Bioinspired design of integral molded Janus silk fibroin-MXene evaporator for efficient solar vapor generation

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Nano Research 2024年第4期17卷 2824-2835页

作者： Ling-Qing Kong Zhi-cheng zeng Guang-Zong Min Zhao-Hui Meng Guo-Qing Meng Xiao-Xiao Guo Nai-Bo Lin Xiang-Yang Liu The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005China The State Key Laboratory of Marine Environmental Science(MEL) College of Ocean and Earth SciencesXiamen UniversityXiamen 361005China

Solar vapor generation is a promising sustainable technology that uses solar distillation to produce fresh water from seawater and wastewater,helping relieve global water resource ***,inspired by naturally grown integrally molded mulberry leaves with a Janus hydrophilic and hydrophobic structure,a novel,simple,and efficient integrated molding method is proposed to break through the limitations of the traditional split manufacturing strategy and realizes the integrated formation of Janus *** on the spontaneous sedimentation characteristics of MXene in silk fibroin solution and its regulation of mesoscopic structure and hydrophilicity of silk fibroin,layered structures with different compositions and hydrophilicities were obtained in one ***,ethanol and glutaraldehyde were added to construct a physical crystallization-chemical crosslinking dual stabilization structure in silk *** evaporator has the evaporation rate of 3.07 kg·m^(-2)·h^(-1) and the efficiency of 86.8%under 1 sun and maintains high evaporation performance under various extreme test conditions including vigorous washing,repeated compression,and high-intensity ultraviolet(UV)***,the evaporator performs well in practical application scenarios,its evaporation rate in the simulated Dead Sea seawater exceeds 2.13 kg·m^(-2)·h^(-1),and more than 99.9%of the salt,heavy metal ions,oil pollution,and dyes are purified.

关键词： silk fibroin MXene bioinspired integrated molding Janus structure solar vapor generation

金属有机框架负载小干扰RNA克服乳腺癌的基质屏障

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中华肿瘤杂志 2024年第5期46卷 409-418页

作者：曾铖张剑复旦大学附属肿瘤医院肿瘤内科复旦大学上海医学院肿瘤学系上海200032

目的开发一种新型递送策略,利用金属有机框架(MOF)负载针对整合素αv(ITGAV)的小干扰RNA siITGAV,以克服基质屏障,进而增强乳腺癌内药物递送及免疫可及性。方法构建MOF@siITGAV颗粒,对其进行材料表征。通过细胞摄取实验观察乳腺癌4T1细... 详细信息

目的开发一种新型递送策略,利用金属有机框架(MOF)负载针对整合素αv(ITGAV)的小干扰RNA siITGAV,以克服基质屏障,进而增强乳腺癌内药物递送及免疫可及性。方法构建MOF@siITGAV颗粒,对其进行材料表征。通过细胞摄取实验观察乳腺癌4T1细胞对MOF@siITGAV的摄取情况,细胞计数试剂盒8法检测MOF@siITGAV的细胞毒性。设空白对照组、游离siITGAV组和MOF@siITGAV组,采用实时荧光定量聚合酶链反应检测各组4T1细胞中ITGAV mRNA的表达,采用Western blot检测ITGAV蛋白的表达,采用酶联免疫吸附试验检测TGF-β1的含量。采用3D球体穿透实验观察MOF@siITGAV穿透4T1细胞球的能力。建立三阴性乳腺癌小鼠模型,观察MOF@siITGAV对移植瘤生长及小鼠心、肝、脾、肺、肾等主要脏器的影响,采用免疫组化染色检测肿瘤组织中Ⅰ型胶原蛋白和CD8的表达。结果成功构建MOF@siITGAV颗粒,粒径为(198.0±3.3)nm,电位为-(20.2±0.4)mV。4T1细胞能有效摄取MOF@siITGAV,并触发siRNA的有效释放,MOF@siITGAV组细胞中ITGAV mRNA和蛋白表达水平、TGF-β1的表达水平均显著下调[相对于空白对照组,游离siITGAV组和MOF@siITGAV组4T1细胞中ITGAV mRNA相对表达水平分别为(109.9±19.0)%和(46.5±11.3)%;空白对照组、MOF@siNC组和MOF@siITGAV组TGF-β1浓度分别为(474.5±34.4)pg/ml、(437.2±16.5)pg/ml和(388.4±14.4)pg/ml]。MOF@siITGAV在4T1细胞球中的穿透能力更强,对4T1细胞无明显杀伤效应,0、10、20、40、80和160μg/ml MOF@siITGAV分别处理4T1细胞24 h,细胞活性分别为(99.7±3.5)%、(98.2±5.2)%、(97.3±6.6)%、(92.1±8.1)%和(92.4±4.1)%。MOF@siITGAV能有效抑制小鼠乳腺癌移植瘤的生长,给药15 d后,空白对照组、MOF@siNC组和MOF@siITGAV组小鼠的肿瘤体积分别为(691.1±193.0)mm^(3)、(652.7±306.5)mm^(3)和(135.3±41.9)mm^(3),MOF@siITGAV组小鼠的肿瘤体积小于空白对照组(P=0.025)。与空白对照组和MOF@siNC组相比,MOF@siITGAV组小鼠肿瘤组织中Ⅰ型胶原蛋白的含量明显减少,CD8阳性细胞明显增多,心、肝、脾、肺、肾等主要脏器未见明显异常。结论ITGAV可以破坏乳腺癌的ECM,改善药物瘤内递送,促进免疫细胞浸润。

关键词：乳腺肿瘤金属有机框架整合素αv 基因转染小干扰RNA 细胞外基质

A back analysis scheme for refined soil stratification based on integrating borehole and CPT data

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Geoscience Frontiers 2024年第1期15卷 1-16页

作者： Jiawei Xie cheng zeng Jinsong Huang Yuting Zhang Jianlin Lu Discipline of Civil Surveying&Environmental EngineeringPriority Research Centre for Geotechnical Science&EngineeringThe University of NewcastleCallaghanNSW 2308Australia

Utilizing both borehole and Cone Penetration Testing(CPT)data in soil stratification helps to get more convincing soil stratification ***,the soil classification results revealed by borehole(Unified Soil Classification System,USCS)and CPT tests(soil behavior type,SBT)are commonly not *** study proposes a feasible solution to integrate the borehole and CPT data with the tree-based *** tree-based method is naturally suitable for soil stratification tasks as it aims to divide the subsurface space into several clusters based on the similarities of the soil types.A novel boundary dic-tionary method is proposed to enhance the model performance on complex soil layer conditions.A prob-abilistic mapping matrix between the USCS-SBT system is built based on a collected municipal database with collocated borehole and CPT *** optimal soil stratification results can be selected based on considering multiple borehole information and pruning the structure of *** structure of the trees can be optimized in a back analysis perspective with the Sequential Model-Based Global Optimization(SMBO)algorithm which aims to maximize the possibility of observing the borehole information based on the USCS-SBT probabilistic mapping *** uncertainties of the optimal soil stratification results can be estimated based on a weighted Gini index *** performance of the proposed method is validated based on a real case in New Zealand with a cross-validation *** results indicate that the proposed method is robust and effective.

关键词： Soil stratification Data integration Borehole CPT Tree-based method

基于离散采样模型的三自由度双旋翼直升机的控制器设计

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系统科学与数学 2024年第9期44卷 2588-2602页

作者：迟楠曾诚贵州理工学院理学院贵阳550003

三自由度纵列式双旋翼直升机模型是动力学系统研究中的一类重要实验对象,也是研究直升机飞行控制技术的平台.文章首先针对非线性三自由度纵列式直升机模型的系统描述,在其标准形描述和一般采样保持条件下,导出了比经典的Euler模型更精... 详细信息

三自由度纵列式双旋翼直升机模型是动力学系统研究中的一类重要实验对象,也是研究直升机飞行控制技术的平台.文章首先针对非线性三自由度纵列式直升机模型的系统描述,在其标准形描述和一般采样保持条件下,导出了比经典的Euler模型更精确的非线性近似离散时间模型,并进一步计算可得出,它们的近似离散模型的局部截断误差和全局截断误差分别为T5和T2,其中T为采样周期.其次,文章对非线性三自由度双旋翼直升机进行了系统辨识及其相应的简单讨论.最后,在导出的近似直升机离散采样模型的基础上,对非线性三自由度双旋翼直升机,文章给出了连续时间输入控制设计和李雅普诺夫再设计两种方法来开展对比研究,并通过实例表明李雅普诺夫再设计可增强系统的控制性能.

关键词：三自由度双旋翼直升机离散采样分析系统辨识采样控制器设计

美国保守派智库涉台议题框架建构及中国对策--基于哈德逊研究所的分析

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智库理论与实践 2024年第3期9卷 136-145页

作者：曾诚刘蔚中国人民公安大学国家安全学院北京100038

[目的/意义]哈德逊研究所(Hudson Institute)作为美国典型的保守派智库,是影响美国涉台政策的重要机构。对哈德逊研究所涉台议题的框架建构进行剖析和总结,有助于中国智库更好地研判和评估美国涉台政策走向。[方法/过程]本文以哈德逊研... 详细信息

[目的/意义]哈德逊研究所(Hudson Institute)作为美国典型的保守派智库,是影响美国涉台政策的重要机构。对哈德逊研究所涉台议题的框架建构进行剖析和总结,有助于中国智库更好地研判和评估美国涉台政策走向。[方法/过程]本文以哈德逊研究所发布的40余份涉台研究成果作为研究样本,结合诊断式框架、预后式框架及促动式框架总结其涉台议题的观点与特征,发现“以台制华”战略贯穿于哈德逊研究所对台湾问题的制造到炒作过程。[结果/结论]哈德逊研究所涉台议题的框架建构的本质是贯彻美国“以台制华”的对华战略,维护美国的国际霸权地位。两岸智库应在认清其本质的同时,加深彼此良性互动,提升中国国际话语权,为抵御美国保守派智库干扰中美关系走向正常化、巩固两岸和平发展贡献力量。

关键词：哈德逊研究所美国智库涉台议题国家安全 “以台制华”

Opening the“Black Box”:How Out-of-Class Use of Duolingo Impacts Chinese Junior High School Students'Intrinsic Motivation for English

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ECNU Review of Education 2024年第2期7卷 283-307页

作者：曾成 Linda Fisher 184 Hills Road Cambridge CB28PQUK

Purpose:Mobile-assisted language learning(MALL)apps such as Duolingo have great potential for promoting learners'motivation to learn a second language(L2).However,little research has investigated how this motivational impact takes ***,despite the flexibility of mobile learning,most existing studies are conducted in classroom settings,with less attention paid to out-of-school technology ***/Approach/Methods:To address these gaps,we present a model based on self-determination theory and propose the idea of“motivational transfer”to explain the psychological mechanism underpinning the impact of *** examine the model,we conducted a case study with 20 Year 8 Chinese junior school students who used Duolingo to learn English as a foreign language(EFL)after school for 6 ***:Questionnaire and group interview data support our hypothesized mechanism:learners'activity-specific intrinsic motivation(IM)for using Duolingo and their underlying psychological need for autonomy and competence can be transferred to a more general level,thereby enhancing learners'global ***:The proposed theoretical model expands our understanding of how digital technology stimulates learners'L2 motivation;it can help L2 educators design better technological affordances to promote learners'motivation both in and outside the classroom.

关键词： Digital game-based learning L2 motivation MALL self-determination theory