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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na yang Lu Lv Shu-Meng Han Li-Yun He Zi-Yi Li Yu-cheng yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

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Block Turbo code modulation for MB-OFDM-based cognitive radio to suppress its side-band interferences

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 29-34页

作者： yang cheng Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China Wireless Network Laboratory Beijing University of Posts and Telecommunications Beijing 100876 China

To suppress the side-band interferences caused by multiband orthogonal frequency division multiplexing （MB-OFDM）-based cognitive radio systems, a mathematical expression of the side-band signal is derived. Based on this expression, the constraints among the transmitted symbols, which help to suppress the interferences, are obtained. Combined with the constraints, a type of block Turbo code modulation scheme is proposed. In the modulation scheme, the side-band interferences are attenuated quickly. Compared with other techniques, in this scheme, the interference suppression is implemented more easily and sufficiently. Simultaneously, the bit error rate （BER） performance can be improved. Theoretical analyses and simulation results show that it is highly applicable for MB-OFDM-based cognitive radio systems to suffer from Rayleigh fading.

关键词： MB-OFDM cognitive radio block Turbo code modulation BER performance

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Recent progress in supramolecular chiral photochemistry

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Chinese Chemical Letters 2013年第6期24卷 437-441页

作者： cheng yang College of Chemistry Sichuan University

Chiral photochemistry appears to be a highly challenging topic and still very much in its infancy, especially if comparing to its well-developed thermochemical *** efforts have been devoted in order to improve stereoselectivity of chiral photoreactions,among which,the supramolecular strategy proven the most *** present review,motivated by the rapid progress in the supramolecular chiral photochemistry,concentrates on advancements achieved mainly in the last *** features and advantages of supramolecular chiral photochemistry are exemplified by representative photoreactions in terms of the chiral hosts/assemblies.

关键词： Supramolecular chemistry Photochemistry Stereochemistry Photochirogenesis

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Multiple Positive Solutions for Semi-positone m-point Boundary Value Problems

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 419-426页

作者： cheng-bo Zhai cheng yang School of Mathematical Science Shanxi University Shanxi 030006 China Business College of Shanxi University Shanxi 030031 China

In this article, we establish the existence of at least two positive solutions for the semi-positone m-point boundary value problem with a parameter u （t）＋ λf （t, u） = 0, t ∈ （0, 1）, u （0） = sum （biu （ξ i ）） from i=1 to m-2, u（1）= sum （aiu（ξ i ）） from i=1 to m-2, where λ 〉 0 is a parameter, 0 〈 ξ 1 〈 ξ 2 〈 ··· 〈 ξ m 2 〈 1 with 0 〈sum ai from i=1 to m-2 〈 1, sum bi from i=1 to m-2 =1 b i 〈 1, a i , b i ∈ [0, ∞） and f （t, u） ≥ M with M is a positive constant. The method employed is the Leggett-Williams fixed-point theorem. As an application, an example is given to demonstrate the main result.

关键词： Multiple positive solutions cone semi-positone m-point boundary value problem,concave functional parameter

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Charmed baryons circa 2015

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Frontiers of physics 2015年第6期10卷 23-49页

作者： Hai-yang cheng Institute of Physics Academia Sinica Taipei

This is essentially an update of Ref. [1] [H. Y. cheng, Int. J. Mod. Phys. A 24 （Suppl. 1）, 593 （2009）], a review of charmed baryon physics around 2007. Topics covered in this review include the spectroscopy, stro... 详细信息

关键词： charmed baryons spectroscopy decays of baryons chiral Lagrangian

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On the Norm of a Self-Adjoint Operator and a New Bilinear Integral Inequality

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Acta Mathematica Sinica,English Series 2007年第7期23卷 1311-1316页

作者： Bi cheng yang Department of Mathematics Guangdong Institute of Education

In this paper, the expression of the norm of a self-adjoint integral operator T ： L^2（0, ∞） → L^2 （0, ∞） is obtained. As applications, a new bilinear integral inequality with a best constant factor is establis... 详细信息

关键词： norm self-adjoint bilinear inequality Beta function

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Progress and performance evaluation of Bei Dou global navigation satellite system： Data analysis based on BDS-3 demonstration system

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Science China Earth Sciences 2018年第5期61卷 614-624页

作者： Yuanxi yang yangyin XU Jinlong LI cheng yang State Key Laboratory of Geo-information Engineering Xi'an 710054 China Institute of Geographical Spatial Information Information Engineering University Zhengzhou 450001 China Beijing Satellite Navigation Center Beijing 100094 China School of Land Science and Geomatics China University of Geosciences Beijing 100083 China

The first two Medium Earth Orbit(MEO) satellites of the third generation of Bei Dou satellite navigation System(BDS-3) were successfully launched on November 5, 2017. This historical launch starts the new era of the global navigation satellite system of Bei Dou. Before the first two satellites of BDS-3, a demonstration system for BDS-3 with five satellites,including two Inclined Geosynchronous Orbit satellites(IGSO) and three MEO satellites, was established between 2015 and2016 for testing the new payloads, new designed signals and new techniques. In the demonstration system, the new S frequency signal and satellite hydrogen clock as well as inter-satellite link(ISL) based on Ka-band signals with time-division multiple addresses(TDMA) were tested. This paper mainly analyzes the performances of the demonstration system, including the signalto-noise ratios, pseudorange errors and the multipath errors of the civilian signals of BDS-3. The qualities of signals in space,time synchronization and timing precision were tested as well. Most of the performances were compared with those of the regional Bei Dou satellite navigation system(BDS-2). At last, the performances of positioning, navigation and timing(PNT) of the future Bei Dou global system(BDS-3) were evaluated based on the signal quality of the present demonstration satellite system.

关键词： Bei Dou-3 Demonstration satellite Signal Timing Signal-to-noise ratios

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Practical integrated navigation fault detection algorithm based on sequential hypothesis testing

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Journal of Systems Engineering and Electronics 2011年第1期22卷 146-149页

作者： Feng yang cheng cheng Quan Pan Gongyuan Zhang Department of Automation Northwestern Polytechnical University Xi'an 710072 R R. China

In detecting system fault algorithms,the false alarm rate and undectect rate generated by residual Chi-square test can affect the stability of *** paper proposes a fault detection algorithm based on sequential residual Chi-square test and applies to fault detection of an integrated navigation *** simulation result shows that the algorithm can accurately detect the fault information of global positioning system（GPS）,eliminate the influence of false alarm and missed detection on filter,and enhance fault tolerance of integrated navigation systems.

关键词： residual Chi-square test integrated navigation fault detection.

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Performance of Polyaniline-coated Short Carbon Fibers in Electromagnetic Shielding Coating

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Journal of Materials Science & Technology 2007年第4期23卷 529-534页

作者： Dongxiu YU Jiang cheng Zhuoru yang School of Chemical and Energy Engineering South China University of Technology Guangzhou 510640 China

Combined nitric acid oxidation method and polyaniline （PANI）-coated method were applied to modify the surface properties of short carbon fibers （SCF）. The electrical and mechanical properties of acrylic coatings with 50 wt pct PANI-coated carbon fiber were investigated by using scanning electron microscope （SEM）, UV-Vis spectrophotometer, four-probe method and the coaxial cable method. The results of the pH measurement and XPS （X-ray photoelectron spectroscopy） patterns showed that the oxygen functional groups, such as -OH and -COOH, were attached on the carbon fiber surfaces after oxidation treatment. The XPS analysis of PANl-coated oxidized SCF （PAOSCF） revealed that PANI may bond on the surface of oxidized SCF with chemical bonds. SEM images and surface roughness analyses showed that PANl-coated layer changed the surface morphology. Compared with SCF/acrylic coating, the surface resistivity of PAOSCF/acrylic coating decreased from17.1 to 5.3 Ω/sq and the shielding efficiency （SE） value increased from 1.54 to 23.3 dB.

关键词： Carbon fibers Polyaniline Surface treatment Dispersion stability Shielding effectiveness

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