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Efficacy and safety of berberine in the prophylactic treatment of acute radiation proctitis in postoperative patients with cervical cancer:a randomized controlled study

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Oncology and Translational Medicine 2021年第1期7卷 1-6页

作者： Kai Qin Yi cheng xianglin Yuan Jing Zhang Le Huang Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 30030China

Objective The aiom of this study was to study the efficacy and safety of berberine as a prophylactic treatment of acute radiation proctitis in postoperative patients with cervical *** A total of 120 postoperative patients with cervical cancer were enrolled between July 2016 and October 2019,and randomly divided into a treatment group(berberine 300 mg three times a day,n=60)and a control group(receiving vitamin C tablets,100 mg three times a day;n=60)using the random number table *** patients received pelvic intensity-modulated radiation therapy(IMRT)and concurrent sensitizing chemotherapy *** difference in the percentage of irradiation volume to the rectum and small intestine as well as the incidence,onset time,severity,and duration of acute radiation proctitis and cystitis during radiotherapy were compared between the two *** completion rate,completion time,number of chemotherapy sessions,and quality of life during radiotherapy were also *** There were no statistical differences in age,FIGO stage,pathological type,complications,highrisk factors,and rectum and small intestine irradiation dose distribution(V20,V30,V40,and V50)between the two groups(P>0.05).No acute radiation proctitis of grade 3 or above occurred in the two *** was no significant difference in the incidence of acute radiation cystitis,grade 2 acute radiation proctitis,completion rate of IMRT,and frequency of sensitization chemotherapy between the two *** prophylactic treatment with berberine,the incidence of grade 1 acute radiation proctitis,occurrence of grade 1 radiation proctitis,and completion time of radiotherapy in the treatment group were significantly lower than those in the control group(P<0.05).The SF-36 score of the treatment group after radiotherapy was 67.53±4.21,which was significantly better than that of the control group(64.90±6.32;P<0.05).The incidence of grade 3-4 neutropenia in the treatment group was 10%and lower than

关键词： berberine adjvuant therapy cervical cancer intensity-modulated radiation therapy(IMRT) acute radiation proctitis

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Prognostic risk model construction and prognostic biomarkers identification in esophageal adenocarcinoma based on immune-related long noncoding RNA

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Oncology and Translational Medicine 2020年第3期6卷 109-115页

作者： Kai Qin Yi cheng Jing Zhang xianglin Yuan Jianhua Wang Jian Bai Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective The aim of this study was to construct a prognostic model of esophageal adenocarcinoma(EAC)based on immune-related long noncoding RNAs(immune-related lncRNAs)and identify prognostic biomarkers using the Cancer Genome Atlas(TCGA)*** Whole genomic mRNA expression and clinical data of esophageal adenocarcinoma were obtained from the TCGA *** software Strawberry Perl,R and R packets were used to identify the immune-related genes and lncRNAs of esophageal adenocarcinoma,and for data processing and *** differentially expressed lncRNAs were detected while comparing esophageal adenocarcinoma and normal tissue *** key immune-related lncRNAs were screened using lasso regression analysis and univariate cox regression analysis,and used to construct the prognostic model using multivariate cox regression *** evaluate the accuracy of the risk prognostic model,all esophageal adenocarcinomas were divided into high-risk and low-risk groups according to the median risk score,after which Kaplan-Meier(K-M)survival curves,operating characteristic(ROC)curve and independent prognostic analysis of clinical traits were *** addition,statistically significant immune-related lncRNAs and potential prognostic biomarkers were identified using the prognostic model and multifactor cox regression analysis for k-m survival *** A total of 1322 differentially expressed immune-related lncRNAs were identified,28 of which were associated with prognosis via univariate cox regression *** addition,K-M survival analysis showed that the total survival time of the higher risk group was significantly shorter than that of the lower risk group(P=1.063e-10).The area under the ROC curve of 5-year total survival rate was *** risk score showed independent prognostic risk for esophageal adenocarcinoma via single factor and multifactorial independent prognostic *** addition,the HR and 95%CI of each key immune-related lncRNA

关键词： immune-related Cancer Genome Atlas(lncRNA) prognostic model prognostic biomarker esophageal adenocarcinoma(EAC) Cancer Genome Atlas(TCGA)database

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聚磁式场调制永磁风力发电机输出特性改善的研究

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中国电机工程学报 2015年第16期35卷 4198-4206页

作者：李祥林程明邹国棠东南大学电气工程学院江苏省南京市210096 香港大学电机电子工程系

根据场调制永磁风力发电机工作原理,推导其功率尺寸方程和电枢反应电抗压降表达式,提出改善此类场调制电机输出特性的方法。分析一种外转子聚磁式场调制电机结构,建立不同极槽数配合的聚磁式和传统永磁体表贴式场调制电机有限元模型,仿... 详细信息

根据场调制永磁风力发电机工作原理,推导其功率尺寸方程和电枢反应电抗压降表达式,提出改善此类场调制电机输出特性的方法。分析一种外转子聚磁式场调制电机结构,建立不同极槽数配合的聚磁式和传统永磁体表贴式场调制电机有限元模型,仿真分析磁路结构改变和极槽数配合对场调制电机相绕组电感和输出特性的影响。试制1台18槽/8极聚磁式场调制永磁电机样机,实验结果与仿真和理论分析一致,表明辐条嵌入式永磁体安排和合理的极槽数配合使得所提聚磁式场调制电机具有输出电压调整率小、外特性硬的特点。

关键词：聚磁磁场调制永磁风力发电机风力发电极槽配合输出特性

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聚磁式场调制永磁风力发电机工作原理与静态特性

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电工技术学报 2014年第11期29卷 1-9页

作者：李祥林程明邹国棠李顺东南大学电气工程学院南京210096 香港大学电机电子工程系

提出一种新型聚磁式场调制永磁(Flux-Concentrating Field-Modulated PermanentMagnet,FCFMPM)电机,该电机外转子采用聚磁式永磁体结构改善气隙磁通密度,定子采用开口槽结构提高空间利用率。基于磁齿轮效应,定子齿对转子永磁磁场进行调... 详细信息

提出一种新型聚磁式场调制永磁(Flux-Concentrating Field-Modulated PermanentMagnet,FCFMPM)电机,该电机外转子采用聚磁式永磁体结构改善气隙磁通密度,定子采用开口槽结构提高空间利用率。基于磁齿轮效应,定子齿对转子永磁磁场进行调制,产生极对数少、运行速度快的谐波磁场,由该谐波磁场作为有效励磁的FCFMPM电机具有低速、大转矩密度的特点。在深入分析电机工作原理的基础上,运用二维有限元方法计算了其静态特性,包括空载永磁磁链、空载感应电动势、电感、定位力矩和电磁转矩等。研制了一台5k W实验样机,并与商业化小型永磁直驱风力发电机做比较。仿真和实验结果表明,所提电机具有转矩密度大、定位力矩小、外特性硬等特点,特别适用于如风力发电等低速、直驱系统。

关键词：聚磁磁场调制永磁电机风力发电低速直驱

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Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial

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Cancer Communications 2019年第1期39卷 151-160页

作者： Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying cheng Jie Li Lu Wen xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo 17 Panjiayuan NanliChaoyang DistrictBeijing 100021P.R.China Department of Medical Oncology Henan Cancer HospitalZhengzhou 450008HenanP.R.China Department of Medical Oncology Taizhou People’s HospitalTaizhou 225300JiangsuP.R.China Department of Medical Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanP.R.China Department of Medical Oncology Tianjin Cancer HospitalTianjin 300060P.R.China Department of Medical Oncology Hunan Cancer HospitalChangsha 410006HunanP.R.China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150040HeilongjiangP.R.China Department of Medical Oncology Shandong Cancer HospitalJinan 250117ShandongP.R.China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009JiangsuP.R.China Department of Medical Oncology Jilin Cancer HospitalChangchun 130012JilinP.R.China Department of Radiotherapy Shanxi Cancer HospitalTaiyuan 030013ShanxiP.R.China Department of Medical Oncology Shanxi Cancer HospitalTaiyuan 030013ShanxiP.R.China Department of Medical Oncology Tongji HospitalWuhan 430030HubeiP.R.China Department of Medical Oncology Chifeng Municipal HospitalChifeng 024000Inner MongoliaP.R.China Department of Oncology The Second Xiangya Hospital of Central South UniversityChangsha 410011HunanP.R.China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052HenanP.R.China

Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been *** aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based ***:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across *** patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization *** primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both ***: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- o

关键词： Esophageal squamous cell carcinoma Recurrent Metastasis Multicenter open-label randomized trial Irinotecan S-1 Overall survival Progression-free survival Objective response rate Disease control rate

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新型外转子低速直驱永磁游标电机的损耗

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电工技术学报 2015年第2期30卷 14-20页

作者：朱洒程明李祥林李顺东南大学电气工程学院南京210096

对一种新型自增速永磁游标电机的损耗情况进行了分析,重点分析了永磁体和铝壳中的损耗。在电磁损耗计算中采用二维时步有限元法,阐明了采用二维有限元法计算永磁体中涡流损耗的原理和注意事项,并通过三维有限元法检验了二维有限元计算... 详细信息

对一种新型自增速永磁游标电机的损耗情况进行了分析,重点分析了永磁体和铝壳中的损耗。在电磁损耗计算中采用二维时步有限元法,阐明了采用二维有限元法计算永磁体中涡流损耗的原理和注意事项,并通过三维有限元法检验了二维有限元计算永磁体涡流损耗的误差。分析了铝壳损耗的主要影响因素以及减小方法。空载计算损耗与实测损耗基本一致,验证了损耗计算方法的正确性。最后研究了不同负载情况下损耗的变化情况,以及温度对损耗的影响。

关键词：永磁电机损耗计算电磁-热耦合分析游标电机

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A CLASS OF SINGULARLY PERTURBED EQUATIONS FOR LARGE PARAMETER WITH THREE TURNING POINTS

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Annals of Differential Equations 2012年第2期28卷 180-185页

作者： Huang Li (Hangzhou Dianzi University, Hangzhou 310018) xianglin Han , cheng Ouyang (Huzhou Teachers College, Huzhou 313000, Zhejiang)

A class of singularly perturbed problem of third order equation with two para-meters is studied. Using singular perturbation method, the structure of solutions to the problem is discussed in three different cases about two small parameters. The asymptotic solutions to the problem are given. The structure of solutions and the different limit behaviors are revealed. And the solutions are compared with the exact solutions to the equation in which the coefficients are constants and a relatively more perfect result is obtained.

关键词： singular perturbation turning point outer solution interior layer matching method

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我国省级公共图书馆读者违规处置政策比较分析

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图书馆 2015年第4期 44-46页

作者：朱向林程如烟中国科学技术信息研究所北京100038

通过访问我国31个省级公共图书馆网站对读者违规处置政策开展调查,从逾期不还、污损书刊和偷盗书刊3种读者违规行为入手,多维度分析读者违章的原因,并探讨公共图书馆在处理读者违章行为方面所采取的合理措施以及可行性办法。

关键词：省级图书馆公共图书馆读者违规处置政策

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交感神经系统在肝硬化及其并发症中的作用研究进展

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中国医学科学院学报 2024年第1期46卷 128-134页

作者：陈相林丁珺程翅喻田遵义医科大学附属医院麻醉科贵州遵义563000 遵义医科大学麻醉与器官保护基础研究省级重点实验室贵州遵义563000

交感神经系统(SNS)在维持器官正常功能和疾病发生发展中起着重要作用。目前研究发现交感神经与肝硬化、肝硬化心肌病和肝肾综合征(HRS)的发生发展密切相关,SNS也许可作为肝脏相关疾病的治疗靶点。为了深入理解交感神经在肝硬化及其并发... 详细信息

交感神经系统(SNS)在维持器官正常功能和疾病发生发展中起着重要作用。目前研究发现交感神经与肝硬化、肝硬化心肌病和肝肾综合征(HRS)的发生发展密切相关,SNS也许可作为肝脏相关疾病的治疗靶点。为了深入理解交感神经在肝硬化及其并发症的作用,本文综述了交感神经在肝硬化、肝硬化心肌病和HRS中的作用研究进展,以此为治疗肝硬化及其并发症提供新思路。

关键词：交感神经肝硬化进展机制

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基于信息增益的图像识别

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计算机工程与应用 2005年第15期41卷 51-52,190页

作者：秦相林程显毅哈尔滨商业大学计算机与信息工程学院江苏大学计算机科学与通信工程学院

模式是事物的本质,特征只是事物的表象,模式识别的任务就是要建立事物本质和表象之间的联系,传统模式识别是通过分类器建立这样的联系,模式识别的效率依赖于特征提取和选择。该文基于信息增益,通过动力学系统演化方程建立事物本质和表... 详细信息

模式是事物的本质,特征只是事物的表象,模式识别的任务就是要建立事物本质和表象之间的联系,传统模式识别是通过分类器建立这样的联系,模式识别的效率依赖于特征提取和选择。该文基于信息增益,通过动力学系统演化方程建立事物本质和表象之间的联系,该过程更符合人的认知过程。

关键词：模式识别信息增益动力学系统演化

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