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Microglial TRPV1 in epilepsy:Is it druggable for new antiepileptic treatment?

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BIOCELL 2023年第8期47卷 1689-1701页

作者： JIAO HU JIALU MO xianglin cheng The First Affiliated Hospital of Yangtze University Jingzhou434000China

Epilepsy is one of the most common neurological diseases worldwide with a high prevalence and unknown ***,its control is *** is generally accepted that an imbalance between the excitatory and inhibitory properties of the central nervous system(CNS)leads to a large number of abnormally synchronized neuronal discharges in the *** receptor potential vanilloid protein type 1(TRPV1)is a non-selective cation channel that contributes to the regulation of the nervous system and influences the excitability of the nervous *** includes the release of neurotransmitters,action potential generation due to alterations in ion channels,synaptic transmission,and the changes in glial *** is abundant evidence that TRPV1 is widely expressed in the central nervous system(including microglia)and is involved in the development of epilepsy through *** conclusion,microglial TRPV1 participates in neuroinflammatory reactions and functions as a potential proinflammatory *** presents a novel treatment approach to regulate seizures brought on by neuroinflammation.

关键词： TRPV1 Epilepsy Microglial Inflammation Synaptic plasticity

Derrick Safety Monitoring System Based on Fiber Bragg Grating Strain Sensors

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Photonic Sensors 2013年第3期3卷 237-240页

作者： Yang cheng xianglin LU Yuan GONG Yu WU Yunjiang RAO Key Laboratory of Optical Fiber Sensing & Communications (Ministry of Education) University of Electronic Science and Technology of China Chengdu 611731 China

The fiber Bragg grating （FBG） strain sensor is used in the oil and gas derricks for the health monitoring. The system consisted of the FBG strain sensors, optical interrogator and monitoring software. 64 sensors were installed on a derrick for loading and unloading tests. The results showed that the monitoring system had the advantages of the high accuracy, good repeatability, large capacity and real-time monitoring ability.

关键词： Fiber Bragg grating Derrick strain monitor

Analysis of Risk Factors Associated with Cognitive Dysfunction in Patients with Atrial Fibrillation

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Yangtze Medicine 2020年第4期4卷 319-330页

作者： Jiangfeng Tang xianglin cheng Department of Medicine Yangtze University Jingzhou China Rehabilitation Department of First Affiliated Hospital of Yangtze University Jingzhou China

Objective: To discuss the risk factors of cognitive dysfunction in patients with atrial fibrillation. Methods: The 150 cases of patients with atrial fibrillation were analyzed in the first affiliated hospital of Nanchang University who were treated in the cardiovascular department, general medicine department and gerontology department from August 2018 to June 2019. We used Mini-Mental State Examination (MMSE) score to evaluate cognitive function of patients with atrial fibrillation. According to the level of education and MMSE score, patients with atrial fibrillation were divided into three groups: normal cognitive function group, mild cognitive impairment group (MCI) and dementia group. And then the demographic data, the previous use of taking drugs, the results of ultrasonic cardiogram (UCG) and laboratory test were analyzed. Results: 1) The basic situation of research object: a total of 150 patients with atrial fibrillation were enrolled in the study, and the average age of these patients was 65.05 ± 8.74 years old, which included 78 males (52%) and 72 females (48%). The mean MMSE score was 23.42 ± 4.65. According to MMSE score, 86 cases (57.3%) of cognitive dysfunction occurred in 150 patients with atrial fibrillation, which included 41 cases (27.3%) of mild cognitive impairment and 45 cases (30%) of dementia. 2) The comparison of general clinical data: there were significant differences in age, smoking, level of education, left ventricular ejection fraction, left atrial diameter, D-dimer, fibrinogen, homocysteine, platelet and previous use of taking warfarin, dabigatran, CCB, statins among the three groups (P < 0.05). 3) The linear correlational analysis between risk factors of cognitive function and MMSE score in patients with atrial fibrillation: there was a positive correlation between left ventricular ejection fraction and MMSE score, but age, left atrial diameter, homocysteine, low density lipoprotein, pl

关键词： Atrial Fibrillation Cognitive Dysfunction Dementia Risk Factors

New Progress in the Treatment of Myasthenia Gravis

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Journal of Biosciences and Medicines 2023年第12期11卷 106-119页

作者： Yaping Sun xianglin cheng Department of Neurology Jingzhou First People’s Hospital Affiliated to Yangtze University Jingzhou China

In recent decades, the treatment of myasthenia gravis has been extensively developed, but a standardized standard still needs to be used. Its treatment strategy is associated with patient prognosis, economic costs, and complications. This article reviews the pathogenesis, treatment methods, and complications of myasthenia gravis, providing new ideas for diagnosing and treating myasthenia gravis and fully embodies the principle of safety and precision.

关键词： Myasthenia Gravis Thymusectomy Immunosuppressive Drug Biological Drug

Analysis of Etiology and Clinical Characteristics of 1170 Patients with Symptomatic Epilepsy in Jianghan Plain

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Yangtze Medicine 2020年第2期4卷 132-139页

作者： Yunyu Ding xianglin cheng Department of Neurology The First Clinical College of Yangtze University Jinzhou China

Objective: The etiology, clinical manifestations and treatment of 1170 patients with symptomatic epilepsy were retrospectively analyzed and provided guidance for further treatment of symptomatic epilepsy. Method: A retrospective analysis of 1170 cases of symptomatic epilepsy admitted to the First Affiliated Hospital of Yangtze University from January 2013 to June 2018 was conducted to analyze the etiology, clinical manifestations and treatment of different age groups. Results: Symptomatic epilepsy is high in the elderly, and men are more than women. Among the 1170 patients with symptomatic epilepsy, there were 81 (6.9%) cases of brain injury, 721 (61.6%) cases of cerebrovascular disease, 223 (19.0%) cases of tumor, 59 (5.0%) cases of central nervous system infection, 33 (2.8%) cases of immune metabolic disease, 11 (0.9%) cases of drugs, 6 (0.5%) cases of cortical dysplasia, 6 (0.5%) cases of neurodegenerative disease, 4 (0.3%) cases of parasites, 4 (0.3%) cases of poisons, and 22 (1.9%) cases of other diseases. Among them, central nervous system infection and cerebrovascular disease ranked first among the patients aged 0 - 18 years, followed by immune metabolic diseases;cerebrovascular disease ranked first among the patients aged 19 - 39 years, followed by tumors and brain trauma;cerebrovascular disease ranked first among the patients aged 40 - 65 years, followed by tumors and brain trauma;cerebrovascular disease ranked first among the patients aged over 65 years, followed by tumors, among the types of seizures, 74 (6.3%) cases of tonic seizures, 68 (5.8%) cases of clonic seizures, 856 (73.2%) cases of tonic-clonic seizures, 27 (2.3%) cases of myoclonic seizures, 12 (1.0%) cases of absence seizures, 116 (9.9%) cases of complicated partial seizures, and 17 (1.5%) cases of partial seizures, in addition to the etiology, 795 (67.9%) cases of sodium valproate, 152 (13.0%) cases of carbamazepine, 56 (4.8%) cases of topira

关键词： Symptomatic Epilepsy Etiology Clinical Features Treatment

Analysis of the Q-T Dispersion and T Wave Alternans in Patients with Epilepsy

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Yangtze Medicine 2017年第2期1卷 109-116页

作者： Dan Sheng xianglin cheng Department of Neurology the Clinical Medicine School of Yangtze University the First Affiliated Hospital of Yangtze

Objectives: There is a high rate of sudden death in epilepsy patients, part of which is sudden cardiac death. By investigating ECG T wave alternans and Q-T dispersion changes of epilepsy patients, we may predict the possibility of the occurrence of sudden death and provide basis for clinical prevention. Methods: Selecting 587 cases of epilepsy patients as the study group, 672 same period cases of healthy persons as the control group;Analyzing the effect of epilepsy on ECG T wave alternans and Q-T dispersion with the standard 12 lead ECG. Results: The study group had a significantly prolonged Q-T dispersion and an increased incidence of T wave alternans than that of the control group;Compared with other seizure types, tonic clonic seizure and absence seizure had a significantly prolonged Q-T dispersion and an increased occurrence rate of T wave alternans. Conclusions: Epilepsy patients ECG T wave alternans and Q-T dispersion has higher abnormal rate, and are prone to sudden cardiac death;Routine ECG(RECG) T wave alternans and Q-T dispersion changes can provide guidance for clinical prevention of sudden unexpected death in epilepsy (SUDEP).

关键词： Epilepsy T Wave Alternans Q-T Dispersion

The Influence of Gastrodin on Expression of IL-10, STAT3 and JAK2 in Epileptic Rats’ Hippocampus

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Yangtze Medicine 2018年第1期2卷 18-27页

作者： Xian Li xianglin cheng Department of Neurology The Clinical Medicine School of Yangtze University The First Affiliated Hospital of Yangtze University Jingzhou China

Objective: To explore the influence of gastrodin on IL-10, JAK2 and STAT3 in hippocampus of epileptic rats induced by pentylenetetrazol and the role of the IL-10 pathway in epilepsy. Methods: 50 adult male Wistar rats were randomly divided into 5 groups: normal control group (NC Group), epilepsy model group (EP Group), low doses of gastrodin + EP Group (GE1 Group), medium doses of gastrodin + EP Group (GE2 Group), high doses of gastrodin + EP Group (GE3 Group). EP group and GE Groups were injected subthreshold doses of pentylenetetrazole (PTZ) by intraperitoneal once a day until reaching the ignited standards. GE groups were respectively injected 4, 6, 8 mg/kg gastrodin by intraperitoneal. All groups were administered for 28 consecutive days. The behavioral changes of the rats were observed and recorded daily 1 hour after the injection. mRNAs of IL-10, STAT3 and JAK2 in hippocampus were measured by RT-qPCR, and proteins by Western blot. Results: Compared GE2 group with EP group, the incubation of seizure was significantly prolonged (P Conclusions: Gastrodin can increase the expression of IL-10, and reduce the expression of STAT3 and JAK2, which may play an antiepileptic effect through regulating JAK2/STAT3 signaling pathways by IL-10.

关键词： Gastrodin Epilepsy IL-10 STAT3/JAK2 Signal Pathway

Application of T-Wave Alternans in Evaluation of Prognosis in Patients with Intracerebral Hemorrhage

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Yangtze Medicine 2017年第3期1卷 127-132页

作者： Xian Li xianglin cheng Department of Neurology The Clinical Medicine School of Yangtze University The First Affiliated Hospital of Yangtze University Jingzhou China

Objective: To explore the application value of electrocardiograph (ECG) T-wave Alternans (TWA) anomaly in acute stage of intracerebral hemorrhage patients. Methods: We choose 1175 intracerebral hemorrhage patients whose conventional 12-lead ECG has TWA in our hospital from January 2011 to December 2015, 751 patients without TWA in the same period as the control group, compared the volume of intracerebral hemorrhage, bleeding site and mortality between the 2 groups. Results: In TWA group, 247 cases died, 361 cases with massive intracerebral hemorrhage, 298 cases with brain stem hemorrhage;in TWA negative group (control group), 41 cases died, 93 cases with massive brain hemorrhage, 64 cases with brain stem hemorrhage. There are statistical differences between two groups (P Conclusion: The occurrence of TWA is significantly related to the volume of bleeding, the bleeding site and mortality, and can be used as an important parameter in the prognosis of intracerebral hemorrhage.

关键词： Intracerebral Hemorrhage T-Wave Alternans Prognosis

The Analysis of the Treatment of Rhabdomyolysis by Snake Bites

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Yangtze Medicine 2018年第2期2卷 89-94页

作者： xianglin cheng Xin Zhang The Clinical Medicine School of Yangtze University (The First Affiliated Hospital of Yangtze University) Jingzhou China

Objective: To explore the treatment measure of rhabdomyolysis caused by snake bites, and provide guidance for further prevention and control of snake bites. Methods: To retrospectively analyze the 841 cases of serpentine bites in our hospital from January 2006 to July 2017;127 cases of patients with rhabdomyolysis syndrome were screened out, and their clinical manifestations, laboratory results, related treatment and prognosis were analyzed. Results: 127 cases patients were rhabdomyolysis out of 841 cases, 28 cases patients developed acute renal failure;treatment measures included local wound treatment, application of tetanus antitoxin, anti-snake venom serum, anti-infection, fluid “hydration” and diuretic, alkaline urine and hybrid renal replacement therapy. 112 cases were cured, improved conditions in 9 cases, 3 cases of death, 3 cases uncured. The improvement rate of is 95.26% after treatment. Conclusion: The rhabdomyolysis had a high incidence in snake bite patients, severe cases often developed acute renal failure. Serum myopsin and related biochemical blood tests could be used to diagnose rhabdomyolysis quickly. Combined treatment methods are the main measure to increase the cured rate and decrease the death rate.

关键词： Snake Bite Rhabdomyolysis Acute Renal Failure Combined Treatment