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Over-expression of LPTS-lin hepatocellular carcinoma cell line SMMC-7721 induces crisis

World Journal of Gastroenterology 2002年第6期8卷 1050-1052页

作者： cheng liao mu-jun zhao jing zhao di jia hai song zai-ping li,state key laboratory of molecular biology,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china state key laboratory of molecular biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences China.

AIM: To evaluate the function of the longer transcripts LPTS-lin hepatocellular carcinoma cell line ***: SMMC-7721 cells were transfected with LPTSL expression construct and stably transfected cells were selected by G418. multiple single clones formed and were checked for their phenotype. In the study of the effect on telomerase activity of LPTS-lin vitro, GST-LPTS-L fusion protein was expressed in *** and purified by glutathioneagarose column. Telomeric repeat amplification protocol (TRAP) assays were performed to study the influence of telomerase activity in SMMC-7721 ***: Over-expression of LPTS-L induced SMMC-7721 cells into crisis. LPTS-L could inhibit the telomerase activity in SMMC-7721 cellsin ***: LPTS-L is a potent telomeraseinhibitor. Over-expression of LPTS-L can induce hepatoma cells into crisis due to the reduction of telomerase activity.

关键词：肝细胞癌 SMMC-7721细胞系 LPTS-L基因表达过表达诱发危象

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio di Micco Ran ding Siqin dingl Yadong ding haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research institute Co. LtdBeijing Beijing institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(Amu/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue Huang Guang-cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei jia Fang-jun Lu Xiang Ma lian Tao Wei Zhang li Chen li-Ming song Ti-Pei li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan cheng-cheng Guo Da-Wei Han jia Huo Lu-Hua jiang Wei-Chun jiang jing Jin Yong-Jie Jin ling-Da Kong Bing li cheng-Kui li Gang li Mao-Shun li Wei li Xian li Xiao-Bo li Xu-Fang li Yang-Guo li Zheng-Wei li Xiao-Hua liang jing-Yuan liao Bai-Sheng liu Guo-Qing liu Hong-Wei liu Xiao-jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-cheng Shang Xin-Ying song liang Sun Ying Tan You-li Tuo Chen Wang Guo-Feng Wang Juan Wang ling-jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He Xu jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-jung Yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-Mei Zhang cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang zhao Zhang Zhi Zhang Zi-liang Zhang hai-Sheng zhao Xiao-Fan zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou Yu-Xuan Zhu Ren-lin Zhuang Yue Zhu key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China key laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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中国地层花粉数据集

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植物生态学报 2023年第10期47卷 1453-1463页

作者：周伯睿廖梦娜李凯徐德宇陈海燕倪健曹现勇孔昭宸许清海张芸 Ulrike HERZSCHUH 蔡永立陈碧珊陈敬安陈陵康程波高洋黄赐璇黄小忠李升峰李文漪廖淦标刘光琇刘平妹刘兴起马春梅宋长青孙湘君唐领余王曼华王永波夏玉梅徐家声阎顺羊向东姚轶锋叶传永张志勇赵增友郑卓朱诚浙江师范大学化学与生命科学学院浙江金华321004 浙江金华山亚热带森林生态系统野外科学观测研究站浙江金华321004 中国科学院青藏高原研究所青藏高原地球系统科学国家重点实验室北京100101 中国科学院植物研究所植被与环境变化国家重点实验室北京100093 河北师范大学资源与环境科学学院石家庄050027 Alfred Wegener institute Helmholtz Centre for Polar and Marine Research Potsdam 14473Germany 上海交通大学设计学院上海200240 岭南师范学院地理科学学院广东湛江524048 中国科学院地球化学研究所环境地球化学国家重点实验室贵阳550081 广东石油化工学院理学院广东茂名525000 华中师范大学城市与环境科学学院武汉430079 贵州师范大学喀斯特研究院贵阳550001 中国科学院地理科学与自然资源研究所北京100101 兰州大学环境资源学院兰州730000 南京大学地理与海洋科学学院南京210023 Department of Oceanography and Coastal sciences Louisiana State UniversityBaton RougeLA 70803USA 中国科学院西北生态环境资源研究院兰州730000 台湾大学地质科学系中国台北10617 首都师范大学资源环境与旅游学院北京100048 北京师范大学地表过程与资源生态国家重点实验室北京100875 同济大学海洋与地球科学学院上海200092 中国科学院南京地质古生物研究所南京210008 鲁东大学资源与环境工程学院山东烟台264025 中国科学院东北地理与农业生态研究所长春130102 自然资源部第一海洋研究所山东青岛266061 中国科学院新疆生态与地理研究所乌鲁木齐830011 中国科学院南京地理与湖泊研究所南京210008 中国科学院植物研究所系统与进化植物学国家重点实验室北京100093 中国地质科学院矿产资源研究所北京100037 中国科学院庐山植物园江西九江332900 西南大学地理科学学院重庆400715 中山大学地球科学与工程学院广州510275

地层孢粉数据是古植被和古气候重建等古环境研究的重要基础。孢粉数据库推动古环境研究从点到区域和全球尺度,从定性到定量,从而实现在大空间尺度和长时间序列上探索植被、气候和人类干扰的相互关系,以更好地理解地球系统的演变。该数... 详细信息

地层孢粉数据是古植被和古气候重建等古环境研究的重要基础。孢粉数据库推动古环境研究从点到区域和全球尺度,从定性到定量,从而实现在大空间尺度和长时间序列上探索植被、气候和人类干扰的相互关系,以更好地理解地球系统的演变。该数据集整合了全国第四纪末期(5万年以来)共372个地层花粉序列,涵盖790个花粉类群,样点分布于中国30个省级行政区与领海。数据集包含地层花粉采样点的地名、经纬度坐标和海拔高度、数据来源、样品类型、沉积物长度、样品数量、测年方法及测年数量、时间跨度和参考文献,以及每个采样点的花粉含量百分比。数据主要来源于20世纪80年代至今。采样点集中分布在温带和亚热带森林、温带草原和荒漠以及青藏高原高寒植被区域;在深海到青藏高原不同海拔高度都有分布,但集中在海拔2000 m之下。按照数据来源区分,原始数据样点178个,占47.8%;数值化数据194个,占52.2%。按照样品类型分类,多数样点为湖泊样品(151个)、冲积物/洪积物样品(99个)与泥炭样品(67个),占总样点数的85.2%。年代测定的主要方法为放射性碳同位素手段(占样品总数的93.8%),大部分记录有2-10个测年数据。采样点的平均花粉类群数量是19个,以4-30个花粉类群的采样点最多。代表性花粉类群(松属(Pinus)、栎属(Quercus)、蒿属(Artemisia)、禾本科)含量的时空分布格局表明,从末次盛冰期到全新世,这些花粉科属的分布范围扩大,含量也增加,但分布区域具有分异。半个多世纪以来,孢粉学工作者建立中国大部分地区的地层花粉记录,为探究古环境演变及其气候变化、人类活动驱动机制奠定了重要的基础。

关键词：花粉数据库地层花粉第四纪末期古植被古气候

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聚变堆安全特性评价研究

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核科学与工程 2016年第6期36卷 802-810页

作者：吴宜灿郁杰胡丽琴陈志斌王石生杨琪党同强朱志强梁参军聂保杰王大桂李亚洲王海霞金鸣倪木一贾江涛汪进王芳刘超蒋洁琼宋婧龙鹏程赵柱民汪建业 FDS团队中国科学院核能安全技术研究所中国科学院中子输运理论与辐射安全重点实验室合肥230031

确保核安全是未来聚变堆设计、建造和运行过程中必须坚持的最高原则,是聚变堆获得建造和运行许可的前提条件,也是聚变能得以吸引公众的主要理由之一。聚变堆具有高能中子、大量放射性氚、复杂结构、极端服役环境等特点,具有独特的潜在... 详细信息

确保核安全是未来聚变堆设计、建造和运行过程中必须坚持的最高原则,是聚变堆获得建造和运行许可的前提条件,也是聚变能得以吸引公众的主要理由之一。聚变堆具有高能中子、大量放射性氚、复杂结构、极端服役环境等特点,具有独特的潜在安全问题,因而必须开展针对性研究。本文将从聚变中子与放射性源项、热流体与能量传输、氚安全与环境影响、可靠性与风险管理、安全理念与公众接受度五个方面分别总结其安全特性,系统梳理其关键技术挑战,为建立聚变安全评价体系提供技术支持,进而服务于未来聚变堆的设计与建造。

关键词：聚变核安全安全特性安全体系

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