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Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

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World Journal of Stem Cells 2024年第4期16卷 444-458页

作者： cheng-jin Ai Ling-Juan Chen Li-Xuan Guo Ya-Ping Wang Zi-Yi Zhao Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Ophthalmology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Central Laboratory Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina

BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against conventional *** acetic acid(GAA),which is extracted from the seeds of cotton plants,exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting *** To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact *** In this study,LSCs were magnetically sorted from AML cell lines and the CD34+CD38-population was *** expression of leucine-rich pentatricopeptide repeat-containing protein(LRPPRC)and forkhead box M1(FOXM1)was evaluated in LSCs,and the effects of GAA on malignancies and mitochondrial RESULTS LRPPRC was found to be upregulated,and GAA inhibited cell proliferation by degrading *** induced LRPPRC degradation and inhibited the activation of interleukin 6(IL-6)/janus kinase(JAK)1/signal transducer and activator of transcription(STAT)3 signaling,enhancing chemosensitivity in LSCs against conventional chemotherapies,including L-Asparaginase,Dexamethasone,and *** was also found to downregulate FOXM1 indirectly by regulating ***,GAA induced reactive oxygen species accumulation,disturbed mitochondrial homeostasis,and caused mitochondrial *** inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC,GAA resulted in the elimination of ***,GAA induced oxidative stress and subsequent cell damage by causing mitochondrial *** Taken together,the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.

关键词： Leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling

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长三角区域大气污染协同治理网络结构及影响因素研究

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长江流域资源与环境 2024年第7期33卷 1529-1539页

作者：程进上海社会科学院生态与可持续发展研究所上海200020

基于长三角区域2018~2022年大气污染协同治理网络的数据样本,采用社会网络分析方法,对长三角区域大气污染协同治理网络结构进行研究。研究发现:(1)长三角区域大气污染协同治理网络密度总体上趋于增大,由最初的“强横向、弱纵向”的结构... 详细信息

基于长三角区域2018~2022年大气污染协同治理网络的数据样本,采用社会网络分析方法,对长三角区域大气污染协同治理网络结构进行研究。研究发现:(1)长三角区域大气污染协同治理网络密度总体上趋于增大,由最初的“强横向、弱纵向”的结构特点,逐渐演化出“强横向、强纵向”的特征。(2)长三角区域大气污染协同治理的行政主导特征显著,其网络结构具有明显的非梯度分布的层级特征,省级行政主体在网络结构中起关键主导作用。(3)区域大气污染协同治理网络结构受省级行政边界的影响较为明显,江苏、浙江和安徽三省范围内的城市各自形成了联系较为紧密的合作子集,省界内城市在开展大气污染协同治理方面表现出更加紧密的关系,跨省界的协同治理联系主要集中在省会城市或省界城市。(4)城市间距离、行政区划对大气污染协同治理关系的形成有显著影响。基于此,提出完善长三角区域合作“三级运作”结构模式、推动大气污染协同治理结构扁平化发展、增强跨区域大气污染协同治理纽带等政策建议。

关键词：长三角大气污染协同治理社会网络

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Assessment of climate damage in China based on integrated assessment framework

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Advances in Climate Change Research 2024年第1期15卷 124-133页

作者： Jie LIU Xiang-Zhen SHI Li YANG Chang-Yi LIU jin-cheng WANG Rui-Min ZHU Xue-Li SHI Qiu-Feng LIU International Business School Shanxi Normal UniversityXi'an 710062China University of Chinese Academy of Social Sciences Bejing 102488China School of Economics and Management Xinjiang UniversityUrumqi 830046China Global Energy Interconnection Development and Cooperation Organization(GEIDCO) Bejing 100031China Hubei Enshi College Enshi 445099China CMA Earth System Modeling and Prediction Centre China Meteorological AdministrationBeijing 100081China National Climate Centre China Meteorological AdministrationBeijing 100081China

Developing a localized and consistent model framework for climate loss and damage assessment is crucial for the policy-making of climate change mitigation and *** study introduces a comprehensive,multidisciplinary Integrated Assessment Model(IAM)framework for evaluating climate damage in China,utilizing BCC-SESM climate model and FUND sectoral climate damage model under the SSP2-RCPs *** a bottom-up approach,the research estimates climate damage across eight major sectors,recalibrates sectoral climate damage functions and parameters for China,and elucidates distinctions among direct climate loss,market climate loss,and aggregate climate *** findings reveal that the total climate damage function for China follows a quadratic pattern in response to temperature *** 2050,the estimated climate damage is projected to be 5.4%,5.7%,and 8.2%of GDP under RCP2.6,RCP4.5,and RCP8.5,***,both direct and market climate losses are projected to remain below 2%of GDP by 2050,while the aggregate climate loss could reach as high as 8.2%,which is predominantly attributed to non-market *** a sectoral perspective,under the RCP8.5 scenario,human health damage constitutes the largest share(61.9%)of the total climate loss by 2050,followed by sea-level rise damage(18.6%).This study sheds lights on the adaptation policy that should attach importance to the non-market sectors,particularly focusing on human health and sea-level rise.

关键词： Climate loss and damage Integrated assessment model(IAM) FUND model Representative concentration pathways(RCPs)scenario BCC-SESM

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Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome

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World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang Mei-Rou Liang Shi-jin cheng Xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics

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Cognitive impairment in patients with bipolar disorder alone versus those with bipolar disorder comorbid with borderline personality disorder

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World Journal of Psychiatry 2024年第8期14卷 1174-1181页

作者： Chao-Min Wang Hua Xue Bo Xin Kun Zhang Shuo Wang jin-cheng Wang Cui-Xia An Na Li Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental *** often coexists with borderline personality disorders,making the condition more *** To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality *** Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B,respectively,and 80 healthy volunteers were included as *** function in each group was evaluated using the Chinese version of the repeatable battery for the assess-ment of neuropsychological status(RBANS),the Stroop color-word test,and the Wechsler intelligence scale-revised(WAIS-RC).RESULTS The indices of the RBANS,Stroop color-word test,and WAIS-RC in groups A and B were significantly lower than those of the control group(P<0.05).Group A had significantly longer Stroop color-word test times for single-character,single-color,double-character,and double-color,lower scores of immediate memory,visual breadth,verbal function dimensions and total score of the RBANS,as well as lower scores of verbal IQ,performance IQ,and overall IQ of the WAIS-RC compared with group B(P<0.05).Compared to group B,group A exhibited significantly longer single-character time,single-color time,double-character time,and double-color time in the Stroop color-word test(P<0.05).CONCLUSION The cognitive function of patients with BD complicated with borderline personality disorder is lower than that of patients with BD.

关键词： Bipolar disorder Borderline personality disorder Cognitive impairment Chinese-version repeatable neuropsychological status test Stroop color-word test Wechsler intelligence scale

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Graphene oxide/Al_(2)O_(3)-based diffusive memristor cells:enabling robust crossbar arrays for multidisciplinary applications

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Rare Metals 2024年第8期43卷 3997-4005页

作者： Chen Liu Jun-cheng jin Yi-Ke Xiao Xin-Xin Wang Ping-Yuan Yan Yan-Qiang Cao Li-Yong Jiang Chuan-Xiang Sheng Ye-Feng Yu School of Microelectronics Nanjing University of Science and TechnologyNanjing 210094China School of Science Nanjing University of Science and TechnologyNanjing210094China School of Information Science and Technology Fudan UniversityShanghai 200433China

A memristor crossbar array (MCA) has emerged as a cutting-edge platform for advanced memory and neuromorphic computing hardware,offering unrivaled bit-level storage density.A diffusive memristor cell (DMC) is particularly well-suited for MCA integration due to its inherent threshold switching characteristics as a selector,effectively addressing current sneak path *** DMC's potential is acknowledged,it necessitates furtherexploration of their practical applicability.

关键词： crossbar arrays offering

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Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： YAN-NAN LI YUN-HONG XIU YAN-JUN TANG jinG-LONG CAO WEN-SHUANG HOU AN-QI WANG TIAN-ZHU LI cheng-HAO jin Department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina Department of Food Science and Engineering Heilongjiang Bayi Agricultural UniversityDaqingChina Department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals Engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

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面向聚变中子探测的宽禁带半导体探测器关键问题与研究挑战

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电子学报 2024年第8期52卷 2933-2938页

作者： SU Kai ZHANG jin-feng ZHANG Yi-yun JIANG Shu-qing GUO Hui ZHANG jin-cheng HAO Yue State Key Laboratory of Wide Band-gap Semiconductor Devices and Integrated Technology Faculty of Integrated CircuitXidian UniversityXi’anShaanxi 710071China National Engineering Research Center of Wide Band-gap Semiconductor Xidian UniversityXi’anShaanxi 710071China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyangSichuan 621900China

近年来国际聚变反应研究获得重大进展,选择抗位移能力强的宽禁带半导体探测器是推动聚变研究的关键技术之一.金刚石超宽禁带半导体具备卓越抗辐照和时间响应等特性,是聚变诊断特别是高能中子诊断的理想材料,碳化硅宽禁带半导体也可测量... 详细信息

近年来国际聚变反应研究获得重大进展,选择抗位移能力强的宽禁带半导体探测器是推动聚变研究的关键技术之一.金刚石超宽禁带半导体具备卓越抗辐照和时间响应等特性,是聚变诊断特别是高能中子诊断的理想材料,碳化硅宽禁带半导体也可测量中子,且大尺寸外延技术更成熟,可覆盖聚变研究装置上的大规模应用.通过这两种宽禁带半导体辐射探测器的研究并实现自主可控的高性能器件制备,将显著提高我国核聚变反应测量系统的性能,支持我国在未来的全球能源革命中处于领先优势.本文将对这两种宽禁带半导体探测器在聚变中子探测应用场景下研制的关键问题和研究挑战进行探讨,助力我国聚变能源开发和应用.

关键词：中子探测器金刚石碳化硅能量分辨脉冲响应

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In-situ Micro-CT analysis of deformation behavior in sandwich-structured meta-stable beta Ti−35Nb alloy

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2552-2562页

作者： Yu-jing LIU Zi-lin ZHANG jin-cheng WANG Xiang WU Xiao-chun LIU Wei-ying HUANG Lai-chang ZHANG Institute of Metals School of Materials Science and EngineeringChangsha University of Science&TechnologyChangsha 410004China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan UniversityJoondalupPerthWA 6027Australia College of Energy and Power Engineering Changsha University of Science&TechnologyChangsha 410004China

Beta Ti−35Nb sandwich-structured composites with various reinforcing layers were designed and produced using additive manufacturing(AM)to achieve a balance between light weight and high *** impact of reinforcing layers on the compressive deformation behavior of porous composites was investigated through micro-computed tomography(Micro-CT)and finite element method(FEM)*** results indicate that the addition of reinforcement layers to sandwich structures can significantly enhance the compressive yield strength and energy absorption capacity of porous metal structures;Micro-CT in-situ observation shows that the strain of the porous structure without the reinforcing layer is concentrated in the middle region,while the strain of the porous structure with the reinforcing layer is uniformly distributed;FEM analysis reveals that the reinforcing layers can alter stress distribution and reduce stress concentration,thereby promoting uniform deformation of the porous *** addition of reinforcing layer increases the compressive yield strength of sandwich-structured composite materials by 124%under the condition of limited reduction of porosity,and the yield strength increases from 4.6 to 10.3 MPa.

关键词： beta titanium alloy sandwich-structured composite in-situ micro-computed tomography finite element modeling compressive behavior

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南宋高宗朝两浙地区旱灾及官府应对探究

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农业考古 2024年第3期 142-147页

作者：金城淮南师范学院马克思主义学院

南宋高宗朝两浙地区旱灾多发,造成的损失极为严重。南宋初期,朝廷一方面在两浙地区采取发放粮米、蠲免租赋和借贷粮种等经济措施,以缓解灾情;另一方面,通过减常膳、决囚、祈雨和加强官员考核等政治措施,以稳定灾区社会秩序。此外,朝廷... 详细信息

南宋高宗朝两浙地区旱灾多发,造成的损失极为严重。南宋初期,朝廷一方面在两浙地区采取发放粮米、蠲免租赋和借贷粮种等经济措施,以缓解灾情;另一方面,通过减常膳、决囚、祈雨和加强官员考核等政治措施,以稳定灾区社会秩序。此外,朝廷还积极调动两浙地区民间力量参与救灾。以上措施对复苏两浙地区灾后经济,恢复民众正生活秩序起到了重要作用。

关键词：高宗朝两浙地区旱灾治理对策

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