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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong Shu cheng Xiao Gao Shan-He yu yu-Ting Dai Xin-yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-Mei Yi hao Zhang wei-guo Cao Rong Li wei Tang Yan Zhao Peng-Peng Xu Li Wang wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

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Chinese Hα Solar Explorer(CHASE)——a complementary space mission to the ASO-S

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Research in Astronomy and Astrophysics 2019年第11期19卷 110-114页

作者： Chuan Li cheng Fang Zhen Li Ming-De Ding Peng-Fei Chen Zhe Chen Liang-Kui Lin Chang-Zheng Chen Chang-Ya Chen Hong-Jiang Tao wei You Qi hao yu Dai Xin cheng Yang guo Jie Hong Min-Jie An wei-Qiang cheng Jian-Xin Chen wei Wang wei Zhang School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory for Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China Changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China Shanghai Institute of Satellite Engineering Shanghai 201109China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar *** scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hα*** paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,*** CHASE mission is scheduled to launch in *** will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S).

关键词： instrumentation spectrographs-Sun atmosphere-Sun activity

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GATIS score for predicting the prognosis of rectal neuroendocrine neoplasms:A Chinese multicenter study of 12-year experience

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World Journal of Gastroenterology 2024年第28期30卷 3403-3417页

作者： Xin-yu Zeng Ming Zhong guo-Le Lin cheng-guo Li wei-Zhong Jiang wei Zhang Li-Jian Xia Mao-Jun Di Hong-Xue Wu Xiao-Feng Liao yue-Ming Sun Min-hao yu Kai-Xiong Tao Yong Li Rui Zhang Peng Zhang Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Gastrointestinal Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Colorectal Surgery Fujian Medical UniversityFuzhou 350401Fujian ProvinceChina Department of Colorectal Surgery Changhai HospitalShanghai 200433China Department of Gastrointestinal Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250118Shandong ProvinceChina Department of Gastrointestinal Surgery Taihe HospitalHubei University of MedicineShiyan 442099Hubei ProvinceChina Department of Gastrointestinal Surgery I Section Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of General Surgery Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina Department of Colorectal Surgery Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery School of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Department of Colorectal Surgery Liaoning Cancer HospitalShenyang 110042Liaoning ProvinceChina

BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large *** Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in *** forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were *** A total of 1408 patients with R-NENs were *** grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for *** GATIS score was calculated based on these five *** overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival *** to decision curve analysis,net benefit of the GATIS score was higher than that of a single *** time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time *** The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival

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纳秒脉冲激光斜入射辐照铝靶等离子体羽流及微冲量特性研究

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光谱学与光谱分析 2023年第3期43卷 933-939页

作者：于程浩叶继飞周伟静常浩郭威航天工程大学宇航科学与技术系激光推进及其应用国家重点实验室北京101416

为研究脉冲激光斜入射烧蚀铝靶冲量耦合机理,直接测量其宏观冲量耦合特性是其中一种手段,但激光烧蚀包含多种物理过程,仅仅研究其宏观力学性能难以深入分析冲量形成机理,脉冲激光烧蚀形成的等离子体羽流喷射是诱发力学效应的重要过程,因... 详细信息

为研究脉冲激光斜入射烧蚀铝靶冲量耦合机理,直接测量其宏观冲量耦合特性是其中一种手段,但激光烧蚀包含多种物理过程,仅仅研究其宏观力学性能难以深入分析冲量形成机理,脉冲激光烧蚀形成的等离子体羽流喷射是诱发力学效应的重要过程,因此,在研究宏观力学性能的基础上,通过开展脉冲激光斜入射烧蚀铝靶等离子体羽流及发射光谱特性测量研究,深入分析脉冲激光烧蚀冲量耦合机理。围绕单脉冲1064nm激光斜入射烧蚀铝靶开展研究,首先通过构建高速摄影测量系统和发射光谱测量系统,获得了典型激光能量密度斜入射烧蚀铝靶产生的等离子体羽流图像、等离子体光谱图像和等离子体发射光谱,基于等离子体发射光谱,利用Boltzmann作图法和Stark展宽法,分别研究了脉冲激光多种斜入射角度下等离子体温度、电子数密度随能量密度的变化关系;通过搭建扭摆微冲量测量系统,研究了脉冲激光多种斜入射角度下,沿着激光入射方向的冲量耦合系数随能量密度的变化。研究中遵循从羽流微尺度演化过程到冲量宏观力学性能测量分析的研究思路。实验结果表明,随着能量密度的增加,等离子体羽流发光强度增强,羽流离化程度增加,等离子体温度、电子数密度均先迅速增加,冲量耦合系数也迅速增加;当能量密度大于15 J·cm^(-2)时,由于等离子体屏蔽效应,等离子体温度、电子数密度均逐渐趋于饱和,最终导致冲量耦合系数随着能量密度的增加而减小;此外,随着入射角度的增加,等离子体温度、电子数密度均逐渐减小,导致冲量耦合系数也随之减小。研究结果表明,利用高速摄影和发射光谱可较好地分析脉冲激光烧蚀冲量耦合机理,研究结果可为激光空间碎片清除、空间微推力器、空间非合作目标消旋等空间应用的关键参数优化提供参考。

关键词：激光烧蚀斜入射等离子体羽流高速摄影发射光谱等离子体屏蔽冲量耦合

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Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography

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Asian Journal of Andrology 2016年第4期18卷 633-638页

作者： guo-Peng yu Rong Na Ding-wei Ye Jun Qi Fang Liu Hai-Tao Chen Yi-Shuo Wu Gui-Ming Zhang Jie-Lin Sun Yao Zhu Li-Qun Huang Shan-cheng Ren De-Ke Jiang S Lilly Zheng hao-WenJiang Ying-hao Sun Qiang Ding Jianfeng Xu Fudan Institute of Urology Huashan Hospital Fudan University Shanghai China Department of Urology Huashan Hospital Fudan University Shanghai China Department of Urology Fudan University Shanghai Cancer Center and Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Urology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Genetic Engineering School of Life Salience Fudan University Shanghai China Center for Cancer Genomics Wake Forest School of Medicine Winston-Salem North Carolina USA Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai China Program for Personalized Cancer Care NorthShore University HealthSystem Evanston IL USA.

The [-2]proPSA （p2PSA） and its derivatives, the p2PSA-to-free PSA ratio （%p2PSA）, and the Prostate Health Index （PHI） have greatly improved discrimination between men with and without prostate cancer （PCa） in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination （DRE） and transrectal ultrasonography （TRUS） are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen （tPSA）, free PSA, and p2PSA. For each patient, the free-to-total PSA ratio （%fPSA）, PSA density （PSAD）, p2PSA-to-free PSA ratio （%p2PSA）, and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve （AUC） and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml-1. Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China.

关键词： [-2]proPSA prostate cancer Prostate Health Index prostate-specific antigen receiver operating curve

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Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-wei Yang Yong-hao Chen Rong Liu Bang-Jiao Ye Jie Wen Hai-Rui guo Zi-Jie Han Qi-Ping Chen Zhong-wei Wen wei-Li Sun Han Yi Xing-Yan Liu Tao Ye Jiang-Bo Bai Qi An Jie Bao yu Bao Ping Cao hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-hao Gu Chang-Cai Han guo-Zhu He Yong-cheng He Yang Hong Yi-wei Hu Han-Xiong Huang Xi-Ru Huang hao-yu Jiang wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Shu-Bin Liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-yu Tang Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-yun Yang Li yu Tao yu Yong-Ji yu guo-Hui Zhang Lin-hao Zhang Qi-wei Zhang Xian-Peng Zhang yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan Ming He Qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning Li Xiao-Fei Wang Jian-cheng Liu Zhao-Hua Peng Zhuo Liang Ai-Ling Li Jian Zheng Qi-Wen Fan yun-Ju Li You-Bao Wang Zhi-Hong Li Yang-Ping Shen Ding Nan wei Nan yu-Qiang Zhang Jia-Ying-hao Li Jun-Wen Tian Jiang-Lin Hou Chang-Xin guo Zhi-cheng Zhang Ming-hao Zhu yu-Wen Chen yu-Chen Jiang Tao Tian Jin-Long Ma Yi-Hui Liu Jing-yu Dong Run-Long Liu Mei-yue-Nan Ma Yong-Shou Chen wei-Ping Liu Bing guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

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连续激光辐照对三结砷化镓电池散射光谱的特性影响

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光谱学与光谱分析 2023年第12期43卷 3674-3681页

作者：郭威常浩徐灿周伟静于程浩姬刚航天工程大学研究生院北京101416 航天工程大学宇航科学与技术系北京101416 航天工程大学航天指挥学院北京101416

太阳能电池作为一种高效的光电转化器,被广泛地应用于光伏发电系统中。激光作为一种高亮度光源辐照电池时,会导致其出现损伤,可利用电池的表面散射光谱特性,对其损伤程度进行判别。通过目标表面散射光谱测量系统,对激光辐照后的三结砷... 详细信息

太阳能电池作为一种高效的光电转化器,被广泛地应用于光伏发电系统中。激光作为一种高亮度光源辐照电池时,会导致其出现损伤,可利用电池的表面散射光谱特性,对其损伤程度进行判别。通过目标表面散射光谱测量系统,对激光辐照后的三结砷化镓电池散射光谱进行测量,并计算双向反射分布函数(BRDF)。其中测量系统主要由FX 2000和NIR 17型光纤光谱仪组成,针对电池表面的强镜反射特性,在实验中采用了入射角和反射角为30°的测量几何模型。原始三结砷化镓太阳能电池的结构主要包括减反射膜DAR层、顶电池GaInP层、中电池GaAs层和底电池Ge层,其散射光谱特征包括可见光谱段(500~900 nm)的吸收特性及近红外谱段(900~1 200 nm)的类周期振荡特性,在对连续激光辐照损伤后电池的光谱特性进行实验测量后,得到了损伤电池光谱BRDF的变化,并结合基于薄膜干涉理论的电池散射光谱模型,对各膜层损伤后的特征进行了分析。结果表明:DAR层的主要作用是降低光谱反射能量,对光谱曲线的特性影响较小;Ge层对光谱曲线形状基本无影响;电池散射光谱吸收和干涉等特征主要由GaInP层和GaAs层所引起,其中,GaInP层主要影响可见光谱段的吸收特性,并对近红外谱段内的干涉特性起到调制作用,而GaAs层主要影响近红外谱段的干涉特性,当其损伤到一定程度后,会导致可见光谱段内出现干涉特性。最后,在实验结果分析的基础上,通过模型研究了电池各层对散射光谱特性的影响,并讨论了基于散射光谱特性的电池损伤程度判别,研究结果可为电池激光损伤判别提供参考。

关键词：激光辐照三结砷化镓电池散射光谱表面形貌损伤特性

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Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen Wang Fan-lian Zeng Ya-wen Hu Xiao-yan Wang Fu-lei Zhao Pei Zhou Jing Hu yuan-yuan Xiao Zhong-lan Hu Ming-feng guo Xiao-qiong wei Xiao Liu Nong-yu Huang Jun Zhang Shu-wen Chen Juan cheng Hua-ping Zheng Hong Zhou Qi-xiang Zhao Chen Zhang Yan hao Song Zou Yi-yue Gui Jia-dong yu Lin-na Gu cheng-cheng yue hao-zhou Zhang Wen-ling Wu Yi-fan Zhou Xi-kun Zhou guo-bo Shen Xiu Teng Jiong Li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

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In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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Nuclear Science and Techniques 2024年第10期35卷 149-160页

作者： Jin-cheng Wang Jie Ren wei Jiang Xi-Chao Ruan Ying-Yi Liu hao-Lan Yang Kuo-Zhi Xu Xin-Yi Pan Qi Sun Jie Bao Han-Xiong Huang hao-Fan Bai Jiang-Bo Bai Ping Cao Qi-Ping Chen Yong-hao Chen Wen-hao Duan An-Chuan Fan Rui-Rui Fan Chang-Qing Feng Min-hao Gu Chang-Cai Han Zi-Jie Han guo-Zhu He Yong-cheng He Yang Hong Yi-wei Hu Zhi-Jie Jiang Ling Kang Chang-Lin Lan Bo Li Feng Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Yi-Na Liu Guang-yuan Luan Chang-Jun Ning Yi-Jia Qiu Wen-Kai Ren Zhi-Zhou Ren Zhao-Hui Song Kang Sun Zhi-Xin Tan Jing-yu Tang Sheng-Da Tang Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Zhong-wei Wen Xiao-Guang Wu Xuan Wu Ze-Peng Wu Cong Xia Li-Kun Xie Han Yi Tao yu Yong-Ji yu guo-Hui Zhang Hang-Chang Zhang Qi-wei Zhang Xian-Peng Zhang yu-Liang Zhang Zhi-Yong Zhang Mao-yuan Zhao Zhi-hao Zhou Ke-Jun Zhu Chong Zou Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230027China

The back-streaming white-neutron beamline(Back-n)of the China Spallation Neutron Source is an essential neutronresearch platform built for the study of nuclear data,neutron physics,and neutron *** types of cross-sectional neutron-reaction measurements have been performed at Back-n since early *** measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron *** gamma rays,commonly referred to as in-beam gamma rays,can induce a non-negligible experimental background in neutron-reaction *** the characteristics of in-beam gamma rays is important for understanding the experimental ***,measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons;thus,discriminating between neutron-induced signals and those from in-beam gamma rays is *** this study,we propose the use of the black resonance filter method and a CeBr_(3) scintillation detector to measure the characteristics of the in-beam gamma rays of *** types of black resonance filters,^(181)Ta,^(59)Co,^(nat)Ag,and^(nat)Cd,were used in this *** time-of-flight(TOF)technique was used to select the detector signals remaining in the absorption region of the TOF spectra,which were mainly induced by in-beam gamma *** energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr_(3) scintillation detector and using Monte Carlo *** on the results of this study,the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated,which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n CeBr_(3)scintillator Black filter resonance technique

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