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Krylov隐式积分因子法在火焰加速数值模拟中的应用

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北京理工大学学报 2017年第2期37卷 131-134页

作者：王成毕湧北京理工大学爆炸科学与技术国家重点实验室北京100081

基于描述可燃气体火焰加速及爆燃转爆轰的Navier-Stokes方程组,针对非刚性的对流扩散项及刚性的反应项之间的不同时间尺度,从而导致了直接数值模拟十分困难的问题,构造了Krylov隐式积分因子法(IIF)进行直接数值模拟,对刚性的反应项采用... 详细信息

基于描述可燃气体火焰加速及爆燃转爆轰的Navier-Stokes方程组,针对非刚性的对流扩散项及刚性的反应项之间的不同时间尺度,从而导致了直接数值模拟十分困难的问题,构造了Krylov隐式积分因子法(IIF)进行直接数值模拟,对刚性的反应项采用隐格式,非刚性的对流扩散项采用显格式,从而减少了计算步数,提高了计算效率,对于由隐格式带来的方程组,采用Krylov子空间映射来降低方程组的阶数使得计算量减小,数值模拟结果与实验结果相吻合.研究结果表明,IIF方法可以较好地应用于NS方程组的数值模拟中.

关键词：数值模拟火焰加速 Navier-Stokes方程隐式积分因子法 Krylov子空间

Cloning and Analysis of the Promoters of Two OsRhoGDIs Genes from Rice

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Agricultural Sciences in China 2008年第7期7卷 789-795页

作者： ZHANG Li-juan LIANG Wei-hong LIU Yue-xia LIU Xiao-fei HOU cheng-qian bi Jia-jia College of Life Science Henan Normal University Xinxiang 453007 P.R. China

OsRacD, belonging to rice （Oryza sativa L. ssp. japonica） Rho family of the small GTPases, is a pivotal gene involved in rice photoperiod fertility conversion of photoperiod sensitive genic male sterile rice which influences the rice fertility via controlling the pollen tube growth. Using OsRacD as bait, two GDP dissociation inhibitor genes designated as OsRhoGDI1 and OsRhoGDI2 were screened by yeast two-hybrid system. To further study the regulation mechanism of OsRhoGDIs, and also the relationships between OsRhoGDIs and OsRacD, the upstream regulation sequences of OsRhoGDI1 and OsRhoGDI2 were cloned by PCR, and the cis-elements in the promoters were predicted using internet tools in this study. The results showed that there were several kinds of response elements, such as phytohormone response elements, lightregulated elements and adversity induced elements in the promoters of OsRhoGDIs, some of which were similar. Comparing with the promoter of OsRacD, several pollen tube germination related elements were found. On one hand, the expression and regulation mechanism of OsRhoGDIs were complex, they may be regulated by several signaling pathways commonly, and the regulation mechanisms were similar to some extent. On the other hand, it was suggested that the fertility of photoperiod sensitive genic male sterile rice may be controlled by the cooperative expression of OsRhoGDIs and OsRacD.

关键词： rice OsRhoGDIs Rho OsRacD cis-acting elements

Effects of salinity and clonal integration on the amphibious plant Paspalum paspaloides:growth,photosynthesis and tissue ion regulation

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Journal of Plant Ecology 2019年第1期12卷 45-55页

作者： Ya-Ping Xing Guan-Wen Wei Fang-Li Luo Chao-Yang Li bi-cheng Dong Jie-Shan Ji Fei-Hai Yu School of Nature Conservation Beijing Forestry UniversityBeijing 100083China Central South University of Forestry and Technology Changsha 410004HunanChina Hydrographic Bureau of Jining Jining 272019ShandongChina Taizhou University Taizhou 318000ZhejiangChina

Aims Clonal integration can increase performance of clonal plants suffer-ing from environmental stress,and clonal plants in many wetlands commonly face stress of flooding accompanied by ***,few studies have tested roles of clonal integration in amphibious plants expanding from terrestrial to aquatic saline *** Basal(older)ramets of clonal fragments of Paspalum paspaloides were grown in soil to simulate terrestrial habitats,whereas their apical(younger)ramets were placed at the surface of saline water containing 0,50,150 and 250 mmol l^(−1)NaCl to mimic different salinity levels in aquatic *** connecting the apical and basal ramets were either intact(connected)to allow clonal integra-tion or severed(disconnected)to prevent *** Findings Increasing salinity level significantly decreased the growth of the apical ramets of ***,and such effects on the leaf growth were much higher without than with stolon connection after 60-day ***,leaf and total mass ratios of the connected to the disconnected apical ramets were higher at high than at low saline ***,Fv/Fm and F/Fm′of the apical ramets were higher with than without stolon connection in highly saline *** results suggest that clonal integration can benefit the spread of apical ramets from terrestrial soil into saline water,and that the positive effects increase with increasing ***,clonal integration did not significantly affect the growth of the whole *** to clonal integration,Na^(+)could be translocated from the apical to the basal ramets to alleviate ion toxicity in apical *** results suggest that clonal integration benefits the expansion of *** from terrestrial to aquatic saline habitats via maintained photosynthetic capacities and changed biomass allocation pattern.

关键词： amphibious clonal plant clonal integration Na^(+) salt stress wetland restoration

超导SIS混频器空间应用发射锁定机构热胀特性测量研究

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天文学报 2023年第4期64卷 58-67页

作者：张碧澄林镇辉姚骑均中国科学院紫金山天文台南京210023 中国科学技术大学天文与空间科学学院合肥230026

高灵敏度太赫兹探测模块(High Sensitivity Terahertz Detection Module,HSTDM)是中国空间巡天望远镜--巡天光学设施的后端模块之一,其核心探测器采用可工作于10K温区的氮化铌超导SIS(Superconductor Insulator Superconductor)混频器.超导SIS混频前端的锁定机构在力学和热学方面需相应的特殊设计,以应对发射阶段的力学振动以及工作运行阶段的隔热要求.为了确认在80K温区锁定机构与混频器前端有效分离,针对超导SIS混频前端发射锁定机构所用特氟龙材料热胀特性,开展基于低温LVDT(Linear Variable Differential Transformer)测量和标记划痕法测量以及两种测量方法交叉验证.LVDT实验测量结果表明特氟龙材料收缩率随温度变化与理论模型基本一致,在80K测得材料收缩率为1.86%.据此分析,超导SIS混频前端锁定机构在\lk 80K温度下可与10K冷级的超导SIS混频前端实现有效分离.

关键词：空间飞行器:仪器技术:低温杜瓦材料热胀特性

Risk factors for acute kidney injury in patients undergoing allogeneic hematopoietic stem cell transplantation

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Chinese Journal of Cancer 2010年第11期29卷 946-951页

作者： Zheng-Ping Yu Jia-Hua Ding Bao-An Chen bi-cheng Liu Hong Liu Yu-Feng Li Bang-He Ding Jun Qian Department of Hematology and Hematopoietic Cell Transplantation Zhongda Hospital Southeast University School of Medicine Nanjing Jiangsu 210009 P. R. China Institute of Nephrology Zhongda Hospital Southeast University School of Medicine Nanjing Jiangsu 210009 P. R. China Hematology Division Huaian Hospital Nanjing Medical University Huaian Jiangsu 223300 P. R. China Hematology Division Zhenjiang Hospital Zhenjiang Medical University Zhenjiang Jiangsu 212002 P. R. China

Background and Objective: Allogeneic hematopoietic cell transplantation (allo-HSCT) is a potent procedure for the treatment of hematologic diseases, yet it is associated with high risks of treatment-related complications. Except for transplant-related organ toxicities, renal insufficiencies which emerge earlier significantly limit patients' long survival. To analyze risk factors for acute kidney injury (AKI), we conducted a retrospective cohort study of 96 patients undergoing HSCT. Methods: During the first 100 days after allo-HSCT, all patients were evaluated for renal function by measuring serum creatinine clearance and glomerular filtration rate (GFR) with a classification below: Grade 0 (bility showed no striking increased risk for acute renal injury (HR = 1.684, 95% CI = 0.648-4.378). The survival rate was lower in patients with severe nephrotoxicity (21.4%) than in patients without nephrotoxicity (70.6%) (P = 0.001). Conclusions: Nephrotoxicity is the primary risk factor for AKI, severely imp

关键词：异基因造血干细胞移植风险因素移植治疗肾损伤患者急性肾功能不全血清肌酐

D-S证据理论的改进算法在时-空信息融合中的应用

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数据采集与处理 2005年第2期20卷 156-160页

作者：李茹李弼程信息工程大学信息工程学院信息科学系郑州450002

研究基于D-S证据理论的时-空信息融合,即多传感器多测量周期的信息融合,给出了三种时-空信息融合的方法:集中式、分布式无反馈和有反馈的融合算法。采用这些传统的时-空信息融合方法时,最终的融合结果会产生概率分配过分集中的现象,而... 详细信息

研究基于D-S证据理论的时-空信息融合,即多传感器多测量周期的信息融合,给出了三种时-空信息融合的方法:集中式、分布式无反馈和有反馈的融合算法。采用这些传统的时-空信息融合方法时,最终的融合结果会产生概率分配过分集中的现象,而且证据冲突时还会产生有悖常理的结果。本文在传统证据理论的合成公式的基础上给出了一个有效的合成规则,并由此提出了改进的融合方法。证据冲突的概率按照各个命题的平均支持程度加权进行分配,从而提高了融合结果的可靠性与合理性。

关键词： D—S证据理论传感器时-空信息融合改进算法

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原发性膜性肾病诊断及治疗新进展

中国实用内科杂志 2023年第3期43卷 183-187页

作者：伍敏魏青刘必成东南大学附属中大医院肾脏科东南大学肾脏病研究所江苏南京210009

原发性膜性肾病(pMN)是一种自身免疫性疾病,发病主要与磷脂酶A2受体(PLA2R)等多种足细胞抗原诱发机体免疫活化有关。尽管肾活检病理仍是pMN确诊的关键手段,越来越多研究提示,血清PLA2R抗体可作为生物标志物,在pMN诊断和临床疗效预测中... 详细信息

原发性膜性肾病(pMN)是一种自身免疫性疾病,发病主要与磷脂酶A2受体(PLA2R)等多种足细胞抗原诱发机体免疫活化有关。尽管肾活检病理仍是pMN确诊的关键手段,越来越多研究提示,血清PLA2R抗体可作为生物标志物,在pMN诊断和临床疗效预测中发挥重要作用。pMN常见临床表现为肾病综合征,免疫抑制剂是常用治疗方法,近年来多种生物制剂应用于pMN治疗,使部分难治性肾病综合征获得缓解。文章对pMN诊治新进展进行概述。

关键词：原发性膜性肾病磷脂酶A2受体免疫抑制剂

VEGF-A及其不同异构体在肾脏疾病中的研究进展

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生理学报 2022年第1期74卷 59-66页

作者：敬婧仲鑫刘必成吕林莉东南大学肾脏病研究所东南大学附属中大医院肾脏科南京210009

血管内皮生长因子-A(vascular endothelial growth factor-A,VEGF-A)是重要的血管生成因子,肾脏足细胞与上皮细胞是分泌VEGF-A的主要细胞类型,在肾脏病理生理过程中发挥重要作用。近年来随着对VEGF-A不同异构体功能的深入研究,以及对细... 详细信息

血管内皮生长因子-A(vascular endothelial growth factor-A,VEGF-A)是重要的血管生成因子,肾脏足细胞与上皮细胞是分泌VEGF-A的主要细胞类型,在肾脏病理生理过程中发挥重要作用。近年来随着对VEGF-A不同异构体功能的深入研究,以及对细胞外囊泡(extracellular vesicles,EVs)作为VEGF-A的新型分泌方式的认识,进一步关注和深入研究VEGF-A在肾脏损伤中的作用具有重要意义。本文主要从VEGF-A的表达、分泌、调控和生物学功能及VEGF-A不同异构体在肾脏病进展中的作用机制进行了综述,同时探讨了VEGF-A作为肾脏病诊断标志物和治疗靶点的研究进展。

关键词：血管内皮生长因子肾脏疾病内皮细胞细胞外囊泡外泌体

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi cheng Niang-mei LIU Wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO bi-xing LIU Cong-sheng LIU Xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(Pbited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein