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Metabolism regulation of TD26 in hepatocellular carcinoma: mechanistic links and potential clinical implication

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Cancer Biology & Medicine 2018年第S1期15卷 15-16页

作者： chenchen Wang Jie Cai Hailong Wu xiaoni Kong Qiang xia Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Collaborative Research Center Shanghai University of Medicine and Health SciencesShanghaiChina

Objective:Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths worldwide,and HCC cells metabolically distinct from normal *** lipogenesis has been reported to play a critical role in HCC *** study ... 详细信息

关键词： Metabolism regulation implication

Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin

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Cellular & Molecular Immunology 2019年第5期16卷 483-494页

作者： Yankai Wen chenchen Wang Jinyang Gu Chang Yu Kaixia Wang Xuehua Sun Yun Sun Hailong Wu Ying Tong Qiang xia xiaoni Kong Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Transplantation Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Liver Diseases Shuguang Hospital affiliated to Shanghai University of Chinese Traditional MedicineShanghaiChina Department of Rehabilitation Medicine The First Affiliated HospitalZhejiang UniversityHangzhouChina Department of Hyperbaric Oxygen The First Affiliated HospitalZhejiang UniversityHangzhouChina State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInnovation Center for Cell Signaling NetworkInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina

Induction of osteopontin(OPN),a well-known pro-inflammatory molecule,has been observed in acetaminophen(APAP)-induced ***,the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully *** employing a hepatotoxic mouse model induced by APAP overdose,we demonstrate that both serum and hepatic OPN levels were significantly elevated in response to APAP *** in vivo and in vitro studies clearly indicated that the induced expression of hepatic OPN was mainly located in necrosis areas and produced by dying or dead *** experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1(CYP2E1).Interestingly,this inhibition of CYP2E1 expression did not occur in unfasted Opn−/−mice,but was significant in fasted Opn−/−mice and maintained for 2hours after APAP challenge in fasted Opn−/−*** addition,despite the early protective role of OPN deficiency on APAP-induced hepatotoxicity,OPN deficiency retarded injury resolution by sensitizing hepatocytes to apoptosis and impairing liver ***,we demonstrated that a siRNA-mediated transient hepatic Opn knockdown could sufficiently and significantly protect animals from APAP-induced hepatotoxicity and *** conclusion,this study clearly defines the cell source of OPN induction in response to APAP treatment,provides a novel insight into the metabolic role of OPN to APAP overdose,and suggests an Opn-targeted therapeutic strategy for the treatment or prevention of APAP-induced hepatotoxicity.

关键词： acetaminophen CYP2E1 hepatotoxicity ketone body osteopontin

Dahuang Fuzi decoction reduces inflammation levels and alleviates intestinal mucosal barrier damage in septic rats

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Journal of Traditional Chinese Medical Sciences 2020年第1期7卷 37-44页

作者： Fusheng Liu Chunyue Yu Jin Liu Nadia Johnson Yin Zhang Zeqi Su chenchen Sun xia Ding Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China International School Beijing University of Chinese MedicineBeijing100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective:To investigate the protective effect of Dahuang Fuzi Decoction(DHFZD),a traditional Chinese prescription,at alleviating sepsis-induced inflammation and gut barrier damage in ***:Forty clean-grade male Sprague-Dawley rats were divided randomly into three groups:normal control group(NCG,n?10),model control group(MCG,n?15)and DHFZD-treated group(DHFZDG,n?15).NCG rats were sham operated on and used as the controls,whereas MCG and DHFZDG rats were used to replicate the rat sepsis model using cecal ligation and puncture(CLP).The DHFZDG rats received DHFZD by gavage(4.5 mg/g of body weight)2 h prior to CLP and after its successful induction,while the NCG and MCG rats received equivalent amounts of sterilized water by *** rat groups were starved and had free access to *** 24 h post-experimental set up,the mortality of rats in each group was recorded,and peritoneal inflammation assessment and pathological changes related to the intestinal mucosal injury index(IMII)in the surviving rats were evaluated.D-lactic acid,tumor necrosis factor(TNF)-a,interleukin(IL)-6 and IL-10 peripheral blood concentrations,along with secretory immunoglobulin A(sIgA)in the intestinal mucosa were evaluated by enzyme-linked immunosorbent *** microbes were detected using 16S rRNA gene ***:DHFZD reduced sepsis-related mortality in the ***,it alleviated peritoneal inflammation and pathological changes according to the *** reduced serum procalcitonin,TNF-a and IL-6 concentrations,but not the IL-10 *** also reduced serum D-lactic acid and increased sIgA concentrations in intestinal ***,DHFZDG restored gut microbiota diversity and regulated the decrease in Bacteroidetes induced by sepsis,compared with the MCG ***:DHFZDG may play a protective role in sepsis by alleviating sepsis-induced inflammation and gut barrier damage in rats.

关键词： Dahuang Fuzi decoction Inflammation Intestinal mucosal barrier Sepsis

Guanine-assisted N-doped ordered mesoporous carbons as efficient capacity decaying suppression materials for lithium–sulfur batteries

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Journal of Materials Science & Technology 2022年第6期101卷 155-164页

作者： Riguang Cheng Yanxun Guan Yumei Luo chenchen Zhang Yongpeng xia Sheng Wei Mengmeng Zhao Qi Lin Hao Li Shiyou Zheng Federico Rosei Lixian Sun Fen Xu Hongge Pan School of Material Science&Engineering Guangxi Key Laboratory of Information Materials and Guangxi Collaborative Innovation Center of Structure and Property for New Energy and MaterialsGuilin University of Electronic TechnologyGuilin 541004China School of Mechanical&Electrical Engineering Guilin University of Electronic TechnologyGuilin 541004China School of Material Science&Engineering University of Shanghai for Science&TechnologyShanghai 200093China CentreÉnergie Matériaux et TélécommunicationsInstitut National de la Recherche Scientifique1650 Boul.Lionel BouletVarennesJ3×1S2QuébecCanada School of New Energy Science and Technology Xi’an Technological UniversityChina

Lithium–sulfur(Li–S)batteries are considered promising next-generation energy storage devices due to their high weight capacities and theoretical energy densities,which are significantly higher than those of conventional lithium-ion ***,the sulfur cathode presents two major drawbacks,specifically low specific capacity caused by the poor electrical conductivities of the active materials and fast capacity decay caused by polysulfide dissolution/***,a high-rate and high-stability dendritic material consisting of N-doped ordered mesoporous carbons(NOMCs)was successfully synthesized via a facile and low-cost calcination *** highly ordered mesoporous carbon skeleton limited the growth of the sulfur nanofiller within its channels and provided the necessary electrical contact with the insulating ***,N-doped heteroatoms presented strong binding sites for trapping polysulfide intermediates,achieving high electrochemical activity,which promoted polysulfide conversion *** a result,the prepared NOMC-2/S cathode material with 1.2-1.5 mg cm^(-2)of sulfur displayed excellent electrochemical performance with a high-rate capability of 460.5 m Ah g^(-1)at 1 C,a high specific capacity of 530.9 m Ah g^(-1)after 200 cycles at 0.1 C,and a decay rate of~0.19%per cycle.

关键词： Lithium–sulfur batteries N-doped ordered mesoporous carbons Electrochemistry

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植物乳杆菌对肠道吸收短链脂肪酸的调控作用

食品与发酵工业 2024年第18期50卷 24-32页

作者：徐海燕程月郭聪聪夏滋涵申菲菲孔晨曦印伯星关成冉张臣臣顾瑞霞郑英明陈大卫扬州大学食品科学与工程学院江苏省乳品生物技术与安全控制重点实验室江苏扬州225127 扬州市中医院江苏扬州225127 中国农业大学食品科学与营养工程学院北京100083 江苏省乳业生物工程技术研究中心江苏扬州225004 江苏宇航食品科技有限公司江苏盐城224000

短链脂肪酸(short-chain fatty acids,SCFAs)是肠道微生物发挥益生作用的重要物质基础,但当肠道微生态发生紊乱时,会缺失或过多地吸收SCFAs,对机体健康产生不利的影响。该文利用肠上皮Caco-2细胞建立肠道吸收混合SCFAs模型,探究植物乳... 详细信息

短链脂肪酸(short-chain fatty acids,SCFAs)是肠道微生物发挥益生作用的重要物质基础,但当肠道微生态发生紊乱时,会缺失或过多地吸收SCFAs,对机体健康产生不利的影响。该文利用肠上皮Caco-2细胞建立肠道吸收混合SCFAs模型,探究植物乳杆菌对肠道吸收SCFAs的调控作用及可能的作用机制。结果表明,培养至第21天时,肠上皮Caco-2细胞单层表面被微绒毛覆盖,具有良好的致密性和完整性;当模型中混合SCFAs(乙酸∶丙酸∶丁酸=3∶1∶1,摩尔比)为5.0 mmol/L时,模型中的细胞存活率较高。植物乳杆菌f28、f2及f5均显著促进了细胞对乙酸、丙酸和丁酸的吸收(P<0.05);菌株f5促细胞吸收乙酸的作用显著高于其他菌株(P<0.05),而菌株f16则起到显著抑制作用(P<0.05),但促细胞吸收丙酸和丁酸的作用均显著高于其他菌株(P<0.05);菌株f19显著抑制细胞对丁酸的吸收(P<0.05)。菌株f2和f19显著上调了细胞中单羧酸转运蛋白(monocarboxylate transporter 1,MCT 1)蛋白和基因的表达水平(P<0.05),而菌株f28和f5则起到显著下调作用(P<0.05);菌株f28、f5、f16和f19显著上调了Na^(+)耦合单羧酸转运蛋白-1(sodium-coupled monocarboxylate transporter,SMCT1)蛋白和基因的表达水平(P<0.05);菌株f16显著上调了Na^(+)/H^(+)交换泵3(Na^(+)-H^(+)exchanger 3,NHE3)蛋白和基因的表达水平(P<0.05),而菌株f2、f5和f19则起到显著下调作用(P<0.05)。试验的植物乳杆菌能够通过上调或下调肠上皮Caco-2细胞SCFAs转运体的表达水平来调控其对SCFAs的吸收,研究为改善机体对SCFAs的生物利用度及相关制品的开发应用提供理论依据。

关键词：植物乳杆菌肠上皮Caco-2细胞短链脂肪酸转运体表达水平

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Wide-range color-tunable afterglow emission by the modulation of triplet exciton transition processes based on buckybowl structure

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聚集体(英文)

聚集体(英文) 2023年第4期4卷 93-99页

作者： Yongfeng Zhang chenchen Xiong Wenbo Wang Wenbo Dai Yue Ren Junming xia Gengchen Li Jianbing Shi Bin Tong xiaoyan Zheng xiangfeng Shao Zhengxu Cai Yuping Dong Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouChina Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science of the Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijingChina

Buckybowl structures as non-uniform electrostatic potential distributions of poly-cyclic aromatic materials show a unique photoelectric *** this work,OTC was utilized for dynamic modulation of triplet exciton transition *** host molecules with different functional units were selected,thus providing dif-ferent intermolecular interactions in the host/guest ***,the delayed emissions were regulated from 536 to 624 nm via the tuning of the triplet exciton transition processes of OTC in different *** data and theoretical calculations revealed that the varied triplet transition behaviors resulted from the competition between the intersystem crossing(ISC)process of OTC-monomer and the reverse intersystem crossing(RISC)process of *** work proves the superior structure of buckybowl-based luminophore for controlling triplet exciton transition processes and supplies a new perspective for persistent afterglow luminophore design.

关键词： buckybowl structure dynamic modulation host/guest doping systems room temperature phosphores-cence triplet exciton transition processes

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臣辰诸器新考

湖北美术学院学报 2024年第3期 22-30页

作者：夏虞南中国社会科学院古代史研究所、“古文字与中华文明传承发展工程”协同攻关创新平台

陕西近年新出“臣辰”铭青铜器,具有明显的商晚期风格。通过重新梳理分析臣辰诸器纹饰、器型并明确断代,结合铭文及传世文献,可推断“臣辰”所属族群在商周之际的世官性质和作为史官、小臣的历史地位。在铜器纹饰、器型风格、铭文所见... 详细信息

陕西近年新出“臣辰”铭青铜器,具有明显的商晚期风格。通过重新梳理分析臣辰诸器纹饰、器型并明确断代,结合铭文及传世文献,可推断“臣辰”所属族群在商周之际的世官性质和作为史官、小臣的历史地位。在铜器纹饰、器型风格、铭文所见历史活动和政治地位等方面皆体现出商周之际的连续性与传承性,该类型青铜器当为商晚期至西周早期的产物。臣辰或为商周之际活跃于洛阳等地区,具有一定地位及影响力、直接听从于王命、履行史官职能的世官家族。

关键词：臣辰纹饰器型士上卣殷礼

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质心侧偏角对车辆稳定性影响的研究

汽车工程 2011年第4期33卷 277-282页

作者：张晨晨夏群生何乐清华大学汽车安全与节能国家重点实验室北京100084 上海汽车股份有限公司技术中心上海201805

分别采用β方法和相平面法分析质心侧偏角对车辆稳定性的影响,重点分析各种不同因素对质心侧偏角质心侧偏角速度相平面的稳定性边界的影响。最终确定质心侧偏角控制准则,并通过道路试验进行了验证。

关键词：车辆稳定性质心侧偏角 β法相平面控制准则

Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury

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Chinese Medical Journal 2023年第11期136卷 1349-1357页

作者： Tingting Wang Jinmin Liu chenchen Hu Xin Wei Linlin Han Afang Zhu Rong Wang Zhijun Chen Zhengyuan xia Shanglong Yao Weike Mao Department of Anesthesiology Institute of Anesthesiology and Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Anesthesiology Wuhan No.1 HospitalWuhanHubei 430022China State Key Laboratory of Pharmaceutical Biotechnology Department of MedicineThe University of Hong KongHong KongChina

Background:Dysfunction of the gap junction channel protein connexin 43(Cx43)contributes to myocardial ischemia/reperfusion(I/R)-induced ventricular ***43 can be regulated by small ubiquitin-like modifier(SUMO)*** inhibitor of activated STAT Y(PIASy)is an E3 SUMO ligase for its target ***,whether Cx43 is a target protein of PIASy and whether Cx43 SUMOylation plays a role in I/R-induced arrhythmias are largely ***:Male Sprague-Dawley rats were infected with PIASy short hairpin ribonucleic acid(shRNA)using recombinant adeno-associated virus subtype 9(rAAV9).Two weeks later,the rats were subjected to 45 min of left coronary artery occlusion followed by 2 h *** was recorded to assess *** ventricular tissues were collected for molecular biological ***:Following 45 min of ischemia,QRS duration and QTc intervals statistically significantly increased,but these values decreased after transfecting PIASy *** downregulation ameliorated ventricular arrhythmias induced by myocardial I/R,as evidenced by the decreased incidence of ventricular tachycardia and ventricular fibrillation,and reduced arrythmia *** addition,myocardial I/R statistically significantly induced PIASy expression and Cx43 SUMOylation,accompanied by reduced Cx43 phosphorylation and plakophilin 2(PKP2)***,PIASy downregulation remarkably reduced Cx43 SUMOylation,accompanied by increased Cx43 phosphorylation and PKP2 expression after I/***:PIASy downregulation inhibited Cx43 SUMOylation and increased PKP2 expression,thereby improving ventricular arrhythmias in ischemic/reperfused rats heart.

关键词： Connexin 43 Myocardial reperfusion injury PIASy PKP2 SUMOylation Arrhythmias