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Construction of nanoreactors on TiO_(2)nanotube arrays as a POCT device for sensitive colorimetric detection

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Chinese Chemical Letters 2023年第5期34卷 389-392页

作者： Jingwen Xu chenchen Liang Zhida Gao Yan-Yan song College of Sciences Northeastern UniversityShenyang 110004China

With increasing attention to personalized healthcare,miniaturized and easily implementable devices are desired for point-of-care testing(POCT).Herein,hydrophilic patterns were designed on freestanding TiO_(2)nanotube arrays(Ti NTs)as nanoreactors for a naked-eye colorimetric assay.With a high aspect ratio,TiN Ts can provide a long observation length combined with a limited volume.Moreover,by combining the photocatalytic property of TiO_(2)and spatiotemporal controllability of light,hydrophilic nanoreactors were fabricated with minimal volume,and thus the indicator and analyte are limited in a confined void by the hydrophobic surroundings,thus allowing a higher sensitivity for sensing.We believe the proposed sensing platform could provide a promising strategy in developing POCT devices for routine health monitoring.

关键词： Point-of-care testing TiO_(2)nanotube arrays Colorimetry Alkaline phosphatase Nano test tube

Characteristics of gut microbiota in representative mice strains:Implications for biological research

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Animal Models and Experimental Medicine 2022年第4期5卷 337-349,I0002页

作者： Jianguo Guo Chenchen Song Yunbo Liu Xuying Wu Wei Dong Hua Zhu Zhiguang Xiang Chuan Qin Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

Background:Experimental animals are used to study physiological phenomena,pathological mechanisms,and disease prevention.The gut microbiome is known as a potential confounding factor for inconsistent data from preclinical studies.Although many gut microbiome studies have been conducted in recent decades,few have focused on gut microbiota fluctuation among representative mouse strains.Methods:A range of frequently used mouse strains were selected from 34 isolation packages representing disease-related animal(DRA),immunity defect animal(IDA),or gene-editing animal(GEA)from the BALB/c and C57BL/6J backgrounds together with normal mice,and their microbial genomic DNA were isolated from mouse feces to sequence for the exploration of gut microbiota.Results:Mouse background strain,classification,introduced source,introduced year,and reproduction type significantly affected the gut microbiota structure(p<0.001 for all parameters),with background strain contributing the greatest influence(R^(2)=0.237).In normal groups,distinct gut microbiota types existed in different mouse strains.Sixty-four core operational taxonomic units were obtained from normal mice,and 12 belonged to Lactobacillus.Interestingly,the gut microbiota in C57BL/6J was more stable than that in BALB/c mice.Furthermore,the gut microbiota in the IDA,GEA,and DRA groups significantly differed from that in normal groups(p<0.001 for all).Compared with the normal group,there was a significantly higher Chao 1 and Shannon index(p<0.001 for all)in the IDA,GEA,and DRA groups.Markedly changed classes occurred with Firmicutes and Bacteroidetes.The abundances of Helicobacter,Blautia,Enterobacter,Bacillus,Clostridioides,Paenibacillus,and Clostridiales all significantly decreased in the IDA,GEA,and DRA groups,whereas those of Saccharimonas,Rikenella,and Odoribacter all significantly increased.

关键词： Bacteroidetes BALB/c mice C57BL/6J disease-related animal Firmicutes gene-editing animal gut microbiota i mmunity defect animal strains

LncRNA-CCAT5-mediated crosstalk between Wnt/β-Catenin and STAT3 signaling suggests novel therapeutic approaches for metastatic gastric cancer with high Wnt activity

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Cancer Communications 2024年第1期44卷 76-100页

作者： chenchen Liu Aiwen Shen Junquan song Lei Cheng Meng Zhang Yanong Wang Xiaowen Liu Department of Gastric Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Nephrology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pulmonary Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China

Background:Although the constitutively activated Wnt/β-catenin signaling pathway plays vital roles in gastric cancer(GC)progression,few Wnt inhibitors are approved for clinical use.Additionally,the clinical significance of long non-coding RNAs(lncRNAs)in GC intraperitoneal dissemination(IPD)remains elusive.Here,we investigated the function and therapeutic potential of Wnt-transactivated lncRNA,colon cancer-associated transcript 5(CCAT5),in GC metastasis.Methods:LncRNA-sequencing assay was performed to document abun-dance changes of lncRNAs induced by Wnt family member 3A(Wnt3a)and degradation-resistantβ-catenin(S33Y mutated)in ascites-derived GC cells with low Wnt activity.Luciferase reporter,Chromatin immunoprecipitation(ChIP)-re-ChIP assays were performed to determine how CCAT5 was tran-scribed.The clinical significance of CCAT5 was examined in 2 cohorts of GC patients.The biological function of CCAT5 was investigated through gain-and loss-of-function studies.The molecular mechanism was explored through RNA-sequencing,mass spectrometry,and CRISPR/Cas9-knocknout system.The therapeutic potential of CCAT5 was examined through RNAi-based cell xenograft model and patient-derived xenograft(PDX)model of IPD.Results:WeidentifiedanovelWnt-regulatedlncRNA,CCAT5,whichwastrans-activated by theβ-catenin/transcription factor 3(TCF3)complex.CCAT5 was significantly upregulated in GC and predicted poor prognosis.Functional studies confirmed the promotive role of CCAT5 in GC growth and metastasis.Mechanis-tically,CCAT5 bound to the C-end domain of signal transducer and activator of transcription 3(STAT3)and blocks Src homology 2 domain-containing protein tyrosine phosphatase 1(SHP-1)-mediated STAT3 Y705 dephosphorylation,leading to STAT3 nuclear entry and transactivation,thus accelerating GC progression.Furthermore,we demonstrated that both Wnt3a andβ-catenin acted as activa-tor of STAT3 signaling pathway,and the interplay between CCAT5 and STAT3 was functionally essential for Wnt-drived STAT3 signaling and tumor evolu-tion.Fina

关键词： CCAT5 gastric cancer intraperitoneal dissemination STAT3 Wnt/β-catenin

Comprehensive zoning of biomass energy heating in EU countries reference for China from European experience

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Chinese Journal of Population,Resources and Environment 2021年第4期19卷 321-329页

作者： Chenchen Song Jijiang He Haoran Zhang Energy Transformation and Social Development Research Center Tsinghua UniversityBeijing100084China Space Information Science Research Center Tokyo UniversityTokyo277-8568Japan

Heat is the largest energy end-use in the world,accounting for about 50%of global final energy consumption.In 2019,the International Energy Agency pointed out that the development of renewable energy heating has become a key way for the global response to climate change,environmental pollution control,energy transformation and sustainable development.Biomass energy as a priority for the development of renewable heat sources has been valued by countries around the world.Developed earlier in the EU countries,their biomass heating technology is more mature,and their policy system is more comprehensive.Accounting for 86%of the total renewable thermal energy consumption,biothermal energy in these countries has achieved significant effect and become an important driving force for the decarbonization of the heating industry.This practice has a very high demonstration effect globally.This paper constructs a comprehensive zoning theoretical framework of biomass energy heating and utilization in the EU countries.Based on the calculation of the supply and demand potential of biomass energy heating system,the FCM method is used to quantify the status of biomass resource utilization in 28 EU countries.The results show that there are significant differences in the utilization of biomass energy heating in the EU countries,which can be divided into five categories of comprehensive zones,which are the key development category(Finland,Sweden,Denmark,Estonia,Lithuania and Latvia),resource priority category(Austria,Croatia,Bulgaria,Romania,and Slovenia),policy-oriented category(Germany,Italy,Portugal,and Cyprus),good-potential category(Czech Republic,Hungary,Greece,Spain,Poland,France,and Slovakia)and under-developed category(UK,Netherlands,Belgium,Ireland,Luxembourg and Malta).At the same time,this paper discusses the characteristics and causes of biomass heating utilization of different types of EU countries,and summarizes the mature heating systems and rich experience in the EU countries with China’s current heating situation and

关键词： EU Biomass energy Heating Comprehensive zoning Supply and demand

Driving forces for ultrafast laser-induced sp^(2) to sp^(3) structural transformation in graphite

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npj Computational Materials 2023年第1期9卷 1591-1597页

作者： Chenchen Song Mengxue Guan Yunzhe Jia Daqiang Chen Jiyu Xu Cui Zhang Sheng Meng Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences100190 BeijingChina School of Physical Sciences University of Chinese Academy of Sciences100049 BeijingChina songshan Lake Materials Laboratory 523808 DongguanGuangdongChina Present address:Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education)School of PhysicsBeijing Institute of Technology100081 BeijingChina

Understanding the microscopic mechanism of photoinduced sp^(2)-to-sp^(3) structural transformation in graphite is a scientific challenge with great importance.Here,the ultrafast dynamics and characteristics of laser-induced structural transformation in graphite are revealed by non-adiabatic quantum dynamic simulations.Under laser irradiation,graphite undergoes an interlayer compression and sliding stage,followed by a key period of intralayer buckling and interlayer bonding to form an intermediate sp^(2)-sp^(3) hybrid structure,before completing the full transformation to hexagonal diamond.The process is driven by the cooperation of charge carrier multiplication and selective phonon excitations through electron-phonon interactions,in which photoexcited hot electrons scattered into unoccupied high-energy conduction bands play a key role in the introduction of in-plane instability in graphite.This work identifies a photoinduced non-adiabatic transition pathway from graphite to diamond and shows far-reaching implications for designing optically controlled structural phase transition in materials.

关键词： structural phonon interlayer

Differences in CO_(2)-Water-Rock Chemical Reactions among ’Sweet Spot’ Reservoirs:Implications for Carbon Sequestration

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地质学报:英文版 2023年第3期97卷 972-985页

作者： YANG Leilei song Ziyang LIU Yi WEI Guo ZHANG Xing MO chenchen FENG Bo LI Yaohua College of Carbon-Neutral Energy China University of Petroleum(Beijing)Beijing 102249China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing 102249China Petroleum Institute China University of Petroleum-Beijing at KaramayKaramayXinjiang 834000China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing 102249China Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China Oil and Gas Survey China Geological SurveyBeijing 100083China

The Lucaogou Formation,located in the Jimsar Sag,Junggar Basin,NW China,has great potential for shale oil resources.In the process of CO_(2)-EOR(CO_(2) enhance oil recovery),mineral dissolution,precipitation and transformation,leading to the local corrosion or blockage of reservoirs,have a significant influence on recovery.In this study,a combination of high-temperature and high-pressure laboratory experiments and coupled temperature/fluid-chemistry multifield numerical simulations are used to investigate CO_(2)-water-rock reactions under various reservoir conditions in the upper and lower ’sweet spots’,to reveal the mechanisms underlying CO_(2)-induced mineral dissolution,precipitation and transformation.In addition,we quantitatively calculated the evolution of porosity over geological timescales;compared and analyzed the variability of CO_(2) transformation in the reservoir under a variety of temperature,lithology and solution conditions;and identified the main factors controlling CO_(2)-water-rock reactions,the types of mineral transformation occurring during long-term CO_(2) sequestration and effective carbon sequestration minerals.The results demonstrate that the main minerals undergoing dissolution under the influence of supercritical CO_(2) are feldspars,while the main minerals undergoing precipitation include carbonate rock minerals,clay minerals and quartz.Feldspar minerals,especially the initially abundant plagioclase in the formation,directly affects total carbon sequestration,feldspar-rich clastic rocks therefore having considerable sequestration potential.

关键词： CO_(2) water-rock reactions mineral transformation carbon sequestration

Biocatalytic Buoyancy‑Driven Nanobots for Autonomous Cell Recognition and Enrichment

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Nano-Micro Letters 2023年第12期15卷 334-348页

作者： Ziyi Guo chenchen Zhuang Yihang song Joel Yong Yi Li Zhong Guo Biao Kong John MWhitelock Joseph Wang Kang Liang School of Chemical Engineering Australian Centre for NanoMedicineThe University of New South WalesSydneyNSW 2052Australia Medical College Northwest Minzu UniversityLanzhou 730000People’s Republic of China General Intensive Care Unit Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouPeople’s Republic of China School/Hospital of Stomatology Lanzhou UniversityLanzhou 730000People’s Republic of China Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438People’s Republic of China Graduate School of Biomedical Engineering The University of New South WalesSydneyNSW 2052Australia Department of Nanoengineering University of California San DiegoLa JollaCA 92093USA

Autonomously self-propelled nanoswimmers represent the nextgeneration nano-devices for bio-and environmental technology.However,current nanoswimmers generate limited energy output and can only move in short distances and duration,thus are struggling to be applied in practical challenges,such as living cell transportation.Here,we describe the construction of biodegradable metal-organic framework based nanobots with chemically driven buoyancy to achieve highly efficient,long-distance,directional vertical motion to“find-and-fetch”target cells.Nanobots surface-functionalized with antibodies against the cell surface marker carcinoembryonic antigen are exploited to impart the nanobots with specific cell targeting capacity to recognize and separate cancer cells.We demonstrate that the self-propelled motility of the nanobots can sufficiently transport the recognized cells autonomously,and the separated cells can be easily collected with a customized glass column,and finally regain their full metabolic potential after the separation.The utilization of nanobots with easy synthetic pathway shows considerable promise in cell recognition,separation,and enrichment.

关键词： Nanobots Surface functionalization Cell recognition Cell separation Metal-organic frameworks

Design and in-situ construct BiOI/Bi/TiO_(2)photocatalysts with metal-mediated heterostructures employing oxygen vacancies in TiO_(2)nanosheets

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Green Energy & Environment 2022年第4期7卷 680-690页

作者： chenchen Zhang Wenbin Chen Dairong Hu Hanjie Xie Yibing song Binbin Luo Yiwen Fang Wenhua Gao Ziyi Zhong Department of Chemistry Shantou UniversityGuangdong515063China Department of Chemical Engineering Guangdong Technion-Israel Institute of Technology(GTIIT)Guangdong515063China Technion-Israel Institute of Technology(IIT) Haifa32000Israel

The conventional p-n heterojunction photocatalysts suffer from the incompatibility between the interfacial charge transfer efficiency and the redox ability of charge carriers.To optimize the interfacial charge transfer of the conventional BiOI/TiO_(2) p-n photocatalyst,we synthesized the BiOI/Bi/TiO_(2) ternary photocatalyst with sandwiched metallic bismuth(Bi~0)by the oxygen-vacancy assisted method.The DFT calculation and structural characterizations confirmed the reaction of the electron-rich oxygen vacancies in the 2D-TiO_(2) nanosheets(TiO_(2)-NS)with the adsorbed BiO~+species.This reaction broke the Bi-O bonds to form Bi^(0) nanoparticles in-situ at the interface but still maintained the p-n heterojunction well.The NO-TPD and XRD analyses for samples correlated the Bi~0 formation with the oxygen vacancy concentrations well.The sandwiched Bi~0 functioned as an electronic transfer mediator like that in the Z-scheme heterostructure.Comparing with 0.20 BiOI/TiO_(2)-NP(NP,Nanoparticles),0.20 BiOI/Bi/TiO_(2)-NS-a(NS,Nanosheet)showed a much improved catalytic performance,i.e.,duplicated apparent quantum yield(AQY)and triplicated reaction rate constant(k).Also,the formation mechanism and the reaction mechanism were investigated in detail.This work provides a new strategy for the improving of the conventional p-n photocatalysts and new insights into the nature of the photocatalysis.

关键词： TiO_(2)nanosheets Oxygen vacancy Metallic bismuth Sandwiched heterostructure Photocatalysis

Pollution levels and characteristics of phthalate esters in indoor air of offices

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Journal of Environmental Sciences 2015年第2期27卷 157-162页

作者： Min song chenchen Chi Min Guo Xueqing Wang Lingxiao Cheng Xueyou Shen College of Environmental & Resource Sciences Zhejiang University Chinese Research Academy of Environmental Sciences The Xinhua Hospital of Zhejiang Province Zhejiang Provincial Key Laboratory of Organic Pollution and Control

The pollution status and characteristics of PAEs（phthalate esters） were investigated in indoor air of offices, and PAEs of both gas-phase and particulate-phase were detected in all the samples. The concentration（sum of the gas phase and the particulate phase） was4748.24 ng/m3, ranging between 3070.09 and 6700.14 ng/m3. Diethyl phthalate, dibutyl phthalate, and di（2-ethylhexyl） phthalate were the most abundant compounds, together accounting for 70% of the ∑ 6PAEs. Dividing the particulate-phase PAEs into four size ranges（〈 2.5, 2.5–5, 5–10, 〉 10 μm）, the result indicated that PAEs in PM2.5were the most abundant,with the proportion of 72.64%. In addition, the PAE concentration in PM2.5correlated significantly with the total particulate-phase PAEs（R2= 0.85）. Thus, the amount of PAEs in PM2.5can be estimated from the total amount of particulate-phase PAEs using this proportion. In a comparison between the offices and a newly decorated study room, it was found that pollution characteristics were similar between these two places. Thus, it is implied that the PAE concentration decreased by 50% 2 yr after decorating.

关键词： Phthalate esters Pollution status Particle size distribution Indoor air Office