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Interfacial oxidized Pd species dominate catalytic hydrogenation of polar unsaturated bonds

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Nano Research 2024年第1期17卷 228-234页

作者： Pengyao You Shaoqi zhan.Pengpeng Ruan Ruixuan Qin Shiguang mo Yazhou zhan. Kunlong Liu Lansun Zheng Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Chemistry BMCUppsala UniversityBMC Box 576Uppsala S-75123Sweden Department of Chemistry University of OxfordOxford OX13QZUK

The determination of catalytically active sites is crucial for the design of efficient and stable catalysts toward desired ***,the complexity of supported noble metal catalysts has led to controversy over the locations of catalytically active sites(e.g.,metal,support,and metal/support interface).Here we develop a structurally controllable catalyst system(Pd/SBA-15)to reveal the catalytic active sites for the selective hydrogenation of ketones to alcohol using acetophenone hydrogenation as model *** investigations demonstrated that unsupported Pd nanocrystals have no catalytic activity for acetophenone ***,oxidized Pd species were catalytically highly active for acetophenone *** catalytic activity decreased with the decreased oxidation state of *** work provides insights into the hydrogenation mechanism of ketones but also other unsaturated compounds containing polar bonds,e.g.,nitrobenzene,N-benzylidene-benzylamine,and carbon dioxide.

关键词： oxidized Pd metal/oxide interface constant particle size Pd/SBA-15 acetophenone hydrogenation

N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2769-2780页

作者： Xin-zhan.zhan. Xiao-Chuan mo Zhu-Ting Wang Rong Sun Da-Quan Sun Department of Biochemistry and molecular Biology&Research Center for Basic Medical Sciences Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina

BACKGROUND Wnt/FZD-mediated signaling pathways are activated in more than 90%of hepatocellular carcinoma(HCC)cell *** a well-known secretory glycoprotein,Wnt3 can interact with FZD receptors on the cell surface,thereby activating the Wnt/β-catenin signaling ***,the N-glycosylation modification site of Wnt3 and the effect of this modification on the biological function of the protein are still *** To investigate the effect of Wnt3 N-glycosylation on the biological function of HCC *** Site-directed mutagenesis was used to verify the Wnt3 N-glycosylation sites,actinomycin D treatment was used to detect the stability of Wnt3 after site-directed mutation,the binding of the N-glycosylation site-directed mutant Wnt3 to FZD7 was observed by laser confocal microscopy,and the effects of the N-glycosylation site-directed mutation of Wnt3 on the Wnt/β-catenin signaling pathway and the progression of HCC cells were detected by western blot and cell function *** Wnt3 has two N-glycosylation-modified sites(Asn90 and Asn301);when a single site at amino acid 301 is mutated,the stability of Wnt3 is weakened;the binding ability of Wnt3 to FZD7 decreases when both sites are mutated simultaneously;and the level of proteins related to the Wnt/β-catenin signaling pathway is *** proliferation,migration and invasion are also weakened in the case of single 301 site and double-site *** These results indicate that by inhibiting the N-glycosylation of Wnt3,the proliferation,migration,invasion and colony formation abilities of liver cancer cells can be weakened,which might provide new therapeutic strategies for clinical liver cancer in the future.

关键词： Wnt3 N-glycosylation Hepatocellular carcinoma Liver cancer Wnt/β-catenin FZD7

Deep electrical structures of Qinzhou-Fangcheng Junction Zone in Guangxi and seismogenic environment of the 1936 Lingshan M6^(3/4)earthquake

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Science China Earth Sciences 2024年第2期67卷 584-603页

作者： Bin ZHOU Chunheng YAN Yan zhan.Xiangyu SUN Sha LI Xiang WEN Yajun mo Yongdong YUAN Yuan YUAN Meili HUANG Earthquake Agency of Guangxi Zhuang Autonomous Region Nanning530022China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100029China Guangxi Geophysical Survey Institute Liuzhou545005China

The tectonic position of the southwest section of the Qinzhou Bay-Hangzhou Bay Tectonic Junction Zone(QHTJZ)can be determined by examining the Qinzhou-Fangcheng Junction Zone(QFJZ)in *** zone is significant because it was the location of the largest earthquake ever recorded in the inland region of South China,specifically the 1936 Lingshan M6^(3/4)earthquake in ***,this region serves as an optimal location for researching the origins of intraplate earthquakes in South *** study presents a display of a broadband magnetotelluric(MT)prospecting profile that traverses the Guangxi QFJZ and the Lingshan earthquake zone,extending from the northwest(NW)to the southeast(SE).A resistivity structure model was generated using three-dimensional(3D)inversion technology along the *** main faults in QFJZ were analyzed in terms of their deep extension forms and tectonic *** analysis was performed by integrating the results obtained from geology,gravity,wave velocity ratio,Global Position System(GPS),and geothermal *** results showed that(1)the Dongzhong-Xiaodong fault(DXf),the eastern Fangcheng-Lingshan fault(FLf2),and the eastern Hepu-Beiliu fault(HBf2)were all trans-crustal deep faults,and crust-mantle ductile shear zones developed in the deep *** electrical boundary zones,DXf and HBf2,were *** inclined towards the northwest,while HBf2 inclined towards the *** FangchengLingshan fault(FLf)exhibits a tectonic style resembling a“flower”shape in the upper *** the deeper section,it is characterized by an electrical boundary zone that gradually slopes towards the southeast direction.(2)The Hunan-Guangxi Passive Continental Margin(HGPCM)on the NW side of DXf had a stratified resistivity structure and relatively stable Bouguer gravity anomalies,which conformed to the quasi-craton tectonic attribute of the local failure at the southeastern margin of the Yangtze Block(YB).The southeastern side of this bloc

关键词： South China Block Qinzhou-Fangcheng Junction Zone Magnetotelluric 1936 Lingshan M6^(3/4)earthquake Deep seismogenic environment

A highly reduced mo_(74) polyoxometalate featuring high proton conductivity accessed by building block strategy

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Science China Chemistry 2024年第3期67卷 862-868页

作者： Shi-Yi Liu Xue-Xin Li Wei-Chao chen Kui-zhan.Shao Xin-Long Wang Chao Qin Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Highly reduced polyoxometalates(POMs) are predicted to be used as rather high energy density materials;however,it still suffers from the limited cluster species and reduction *** we demonstrate that it is possible to employ the building block strategy to generate a highly reduced polyoxomolybdate(C_(2)H_(8)N)_(14)(NH_(4))_(4)H_(14)[mo_(48)-Ⅴmo_(26)ⅥO_(202)(OH)_(12)(SO_(4))_(6)]·46H_(2)O(mo_(74)).The fundamental mo-based{mo_x}(x=4,5,and 6) building blocks,which are templated by tetra-coordinated anions{moO_(4)}or{SO_(4)},not only lay foundation for the formation of mo_(74) featuring an unprecedented reduction ratio of 65%,but also give rise to SBBs-mediated(secondary building blocks) supramolecular dense packing interactions among the isolated mo_(74) clusters that are favorable for proton ***,high proton conductivity(2.04×10^(-2)S cm^(-1)) had been realized at 50℃ and 90% relative humidity,revealing one of the well-known POMs-based crystalline proton conducting *** result highlights that this building block approach possesses great potential in producing highly reduced POM systems that can achieve controllable reduced ratio and desirable properties.

关键词： polyoxometalate building block molybdenum highly reduced state proton conduction

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强聚焦高阶时空涡旋的生成方法及其传播特性

光学学报 2024年第10期44卷 338-346页

作者：于自强莫德威于飞詹其文陈建上海理工大学光电信息与计算机工程学院上海200093 上海理工大学上海市现代光学系统重点实验室上海200093 中国科学院上海光学精密机械研究所高功率激光单元技术实验室上海201800 国科大杭州高等研究院物理与光电工程学院浙江杭州310024

主要研究了经高数值孔径物镜强聚焦生成高阶时空涡旋的方法及高度局域时空涡旋在焦平面前后的传播特性。根据模式转换理论,对入射波包进行预处理,利用Richards Wolf矢量衍射公式仿真计算预处理后的入射波包以及经透镜强聚焦后在焦平面... 详细信息

主要研究了经高数值孔径物镜强聚焦生成高阶时空涡旋的方法及高度局域时空涡旋在焦平面前后的传播特性。根据模式转换理论,对入射波包进行预处理,利用Richards Wolf矢量衍射公式仿真计算预处理后的入射波包以及经透镜强聚焦后在焦平面及焦平面前后传播的时空波包的三维时空分布,并对其强度和相位进行了分析。结果表明,强聚焦波包具有预定的高阶时空螺旋相位,且在透镜焦平面前后传播过程中,时空波包的总拓扑荷数保持不变,波包强度分布发生旋转,波包内部演化出若干个一阶时空相位奇点。

关键词：物理光学轨道角动量时空光涡旋强聚焦光束传播拓扑荷数

Dimensional regulation in gigantic molybdenum blue wheels featuring{(W)mo_(5)}motifs for enhanced proton conductivity

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Nano Research 2024年第9期17卷 8261-8268页

作者： Yu-Lun Wu Jing Du Hai-Ying zhan. Ming-Jun Hou Qiao-Yue Li Wei-Chao chen Kui-zhan.Shao Bo Zhu Chao Qin Xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China Hebei Key Laboratory of Organic Functional molecules National Demonstration Center for Experimental Chemistry EducationTesting and Analysis CenterCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Dimensional regulation in polyoxometalates is an effective strategy during the design and synthesis of polyoxometalates-based high proton conductors,but it is not available to ***,the precise regulation of dimensionality has been realized in an unprecedented gigantic molybdenum blue wheel family featuring pentagonal{(W)mo5}motifs through optimizing the molar ratio of mo/W,including[Gd_(2)mo_(124)W_(14)O_(422)(H_(2)O)62]38-(0D-{mo_(124)W_(14)},1),[mo_(126)W_(14)O441(H_(2)O)51]^(70-)(1D-{mo_(126)W_(14)}n,2),and[mo_(124)W_(14)O_(430)(H_(2)O)50]60-(2D-{mo_(124)W_(14)}n,3).Such important{(W)mo5}structural motif brings new reactivity into gigantic mo blue *** are different numbers and sites of{mo2}defects in each wheel-shaped monomer in 1-3,which leads to the monomers of 2 and 3 to form 1D and 2D architectures via mo-O-mo covalent bonds driven by{mo2}-mediated H_(2)O ligands substitution process,respectively,thus achieving the controllable dimensional *** expected,the proton conductivity of 3 is 10 times higher than that of 1 and 1.7 times higher than that of *** continuous proton hopping sites in 2D network are responsible for the enhanced proton conductivity with lower activation *** study highlights that this dimensional regulation approach remains great potential in preparing polyoxometalates-based high proton conductive materials.

关键词： polyoxometalate molybdenum blue wheels mo/W mixed-addenda polyoxometalates dimensional regulation proton conduction

A bibliometric analysis of molybdenum-based nanomaterials in the biomedical field

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Tungsten 2024年第1期6卷 17-47页

作者： Zhi-Qiang Wang Ya-Wen Pan Jing Wu Hong-Bin Qi Shuang Zhu zhan.Jun Gu School of Science China University of GeosciencesBeijing 100083China CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy PhysicsBeijing 100049China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaChinese Academy of SciencesBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China

molybdenum(mo)-based nanomaterials have been widely used in biomedical fields due to their various nanostructures and unique physical/chemical *** various reviews have described the development of mo-based materials in the biomedical field,an objective and comprehensive summary and analysis of research trends in this field is still ***,we used the bibliometric analysis method to analyze all relevant literature on the biological application of mobased nanomaterials in recent ***,we use bibliometric tools to analyze the dataset by year,country/region,institution and research hotspot to obtain the research ***,based on objectively identified research hotspots,the biomedical applications of mo-based nanomaterials are reviewed comprehensively,mainly including sensors,cancer imaging/therapy and antibacterial ***,we discussed the application prospects and challenges of mo-based *** article provides a new perspective to understand the current research progress and further promote the development of mobased nanomaterials in biomedical research.

关键词： molybdenum Nanomaterial Biomedicine Bibliometric analysis

Multi-performance evaluation of high-throughput accelerated corrosion test for high-strength low-alloy 921A steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1260-1278页

作者： Cong-cong Du Ming-hua Qin zhan.fang Wu Dong-ling Li Lei Zhao Xiang-yang Li Hai-zhou Wang Beijing Advanced Innovation Center for Materials Genome Engineering National Center for Materials Service SafetyUniversity of Science and Technology BeijingBeijing100083China China Iron and Steel Research Institute Group Co. Ltd.Beijing100081China Beijing Advanced Innovation Center for Materials Genome Engineering Central Iron and Steel Research InstituteBeijing100081China

The corrosion behavior of high-strength low-alloy 921A steel in a simulated marine atmospheric environment was studied using a high-throughput experimental *** corrosion behavior,corrosion morphology,and corrosion products of 921A steels were analyzed using various techniques,including corrosion mass loss method,polarization curve,white-light interferometry,scanning electron microscopy,energy-dispersive spectrometry,microbeam X-ray fluorescence spectrometry,X-ray diffraction technique,and X-ray photoelectron *** test results indicated that 921A steel exhibits better corrosion resistance than Q450NQR1 steel in simulated harsh atmospheric environments,as evidenced by a lower corrosion mass loss rate throughout the corrosion *** corrosion products of both steels consisted ofα-FeOOH,Fe_(3)O_(4),andγ-FeOOH,withα-FeOOH being more prevalent in the rust layer of 921A steel than in Q450NQR1 *** inner rust layer of 921A steel also exhibited an appositional enrichment region of Cr,Ni,mo,and V,leading to its superior corrosion resistance compared to that of Q450NQR1 *** efficacy of high-throughput accelerated corrosion experimental methods was highlighted for evaluating the corrosion resistance of steel materials in harsh environmental *** findings suggest that 921A steel exhibits better corrosion resistance compared to Q450NQR1 steel and has the potential to be more suitable in harsh marine atmospheric *** characterization of the rust layer structures and composition reveals the parallel enrichment of certain elements in the inner rust layer of 921A steel,which enhances its corrosion resistance.

关键词： Atmospheric corrosion High-throughput experimental method High-strength low-alloy steel Corrosion characteristics Rust layer Element enrichment

泛癌分析揭示SPP1与多种肿瘤的临床预后相关性

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中国临床药理学杂志 2024年第12期40卷 1827-1831页

作者：陈洁张默门展宇陈琳汪露庞晓丛徐州医科大学药学院江苏徐州221009 北京大学第一医院临床药理研究所北京100034 北京大学第一医院中西医结合科北京100034 北京大学第一医院药学部北京100034 海南科技职业大学化学与材料工程学院海南海口571137

目的通过生物信息学方法分析分泌性磷酸蛋白(SPP1)在肿瘤中的功能作用,评估在人类泛癌中的差异表达和预后价值。方法癌症样本数据来自the Cancer Genome Atlas(TCGA)、Genetype-tissue Expression(GTEx)数据库,利用CPTAC数据库研究SPP1... 详细信息

目的通过生物信息学方法分析分泌性磷酸蛋白(SPP1)在肿瘤中的功能作用,评估在人类泛癌中的差异表达和预后价值。方法癌症样本数据来自the Cancer Genome Atlas(TCGA)、Genetype-tissue Expression(GTEx)数据库,利用CPTAC数据库研究SPP1在泛癌中的基因差异表达,利用GEPIA2数据库研究SPP1与患者生存预后之间的相关性,利用CbioPortal工具评估SPP1在32种肿瘤中的基因突变改变形式。结果在32种肿瘤类型中,SPP1 mRNA表达在8种癌症中有差异,仅在肾透明细胞癌中蛋白表达下降,其余癌症中蛋白表达均增加,基因的表达在肿瘤分期中具有特异性;SPP1 mRNA的表达与患者的总生存期(OS)和无病生存期(DFS)呈负相关;SPP1在肿瘤中的基因活性与低甲基化相关,即低甲基化可以激活致癌基因进而影响肿瘤细胞的生成、凋亡、增生,进一步影响肿瘤的发生发展;SPP1以错义突变为主要基因突变形式,基因的改变与前列腺癌、胃癌患者较差的预后相关。结论基于泛癌分析成功验证了SPP1在人类癌症中的特异性,特异性表达与癌症患者的临床预后紧密相关,说明SPP1可以作为癌症预后的靶点。

关键词：分泌性磷酸蛋白预后 DNA甲基化基因突变泛癌分析