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Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie fan Jia-qi zhan. Jia-qi zhan.Li HU Li-li chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan national High Magnetic Field Center Wuhan430074China The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of nanjing Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

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Fibroblast-localized lncRnA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy

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Science China(Life Sciences) 2024年第6期67卷 1155-1169页

作者： Shuai yuan Xudong zhan. Jiabing zhan.Rong Xie Jiahui fan Beibei Dai yanru Zhao Zhongwei yin Qian Liu Dao Wen Wang Huaping Li chen chen Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

CFIRL is a long noncoding RnA(lnc RnA),we previously identified as the most significantly upregulated lnc RnA in the failing hearts of patients with dilated cardiomyopathy(DCM).In this study,we determined the function of CFIRL and its role in ***-time polymerase chain reaction and in situ hybridization assays revealed that CFIRL was primarily localized in the nucleus of cardiac fibroblasts and robustly increased in failing *** knockdown or fibroblast-specific knockout of CFIRL attenuated transverse aortic constriction(TAC)-induced cardiac dysfunction and fibrosis in *** of CFIRL in vitro promoted fibroblast proliferation and aggravated angiotensin II-induced differentiation to *** knockdown attenuated these ***,RnA pull-down assay and gene expression profiling revealed that CFIRL recruited EnO1,a newly identified noncanonical transcriptional factor,to activate ***-6 exerted a paracrine effect on cardiomyocytes to promote cardiac hypertrophy,which can be prevented by CFIRL *** findings uncover the critical role of CFIRL,a fibroblast-associated lnc RnA,in heart failure by facilitating crosstalk between fibroblasts and *** knockdown might be a potent strategy to prevent cardiac remodeling in heart failure,particularly in DCM.

关键词： lncRnA fibroblast fibrosis dilated cardiomyopathy heart failure

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Plasma-assisted aerogel interface engineering enables uniform Zn^(2+)flux and fast desolvation kinetics toward zinc metal batteries

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Journal of Energy Chemistry 2024年第8期95卷 29-38,I0002页

作者： Zijian Xu Zhenhai Shi zhan.Chang fan Feng Zhuanyi Liu Dongkun Chu Jianguo Ren Zi-Feng Ma Suli chen Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material EngineeringJiangnan UniversityWuxi 214122JiangsuChina Shanghai Electrochemical Energy Devices Research Center Department of Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China BTR new Material Group Co. LTD.Shenzhen 518000GuangdongChina

The poor reversibility of Zn anodes induced by dendrite growth,surface passivation,and corrosion,severely hinders the practical applicability of Zn metal *** address these issues,a plasmaassisted aerogel(PAG)interface engineering was proposed as efficient ion transport modulator that can simultaneously regulate uniform Zn^(2+)flux and desolvation behavior during battery *** PAG with ordered mesopores acted as an ion sieve to homogenize Zn deposition and accelerate Zn^(2+)flux,which is favorable for corrosion resistance and dendrite ***,the plasma-assisted aerogel with abundant hydrophilic groups can facilitate the desolvation kinetics of Zn^(2+)due to the multiple hydrogen-bonding interaction with the activated water molecules,thus accelerating the Zn^(2+)migration ***,the Zn/Zn cell assembled with PAG-modified separator demonstrates stable plating and stripping behavior(over 1400 h at 1 mA cm^(-2))and high Coulombic efficiency(99.8%at1 mA cm^(-2)after 1100 cycles),and the Zn‖MnO_(2)full cell shows excellent long-term cycling stability and maintains a high capacity of 154.9 mA h g^(-1)after 1000 cycles at 1 A g^(-1).This study provides a feasible approach for the large-scale fabrication of aerogel functionalized separators to realize ultra-stable Zn metal batteries.

关键词： Zn metal batteries Aerogel interface Plasma Zn^(2+)migration kinetics Dendrite growth

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2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng Minru Liao Wenke Jin Wei Liu Zixiang Li Zhichao fan Ling Zou Siwei chen Lingjuan Zhu Qian Zhao Gu zhan.Liang Ouyang cheng Peng Bo Han Jin zhan. Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(nAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun n-terminal kinase(JnK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RnA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PyCR1)axis was closely assoiated with *** activating PyCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism

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Preliminary Model Study for Forecasting a Hot Weather Process in Guangdong Province Using CMA-TRAMS

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Atmospheric and Climate Sciences 2024年第1期14卷 101-117页

作者： Wenfan Wang Jiemin zhan.Dehui chen Zitong chen yanxia zhan. Qing fan Guangfeng Dai yingying Luo Aifen ye Department of Applied Mechanics and Engineering Shenzhen Campus of Sun Yat-sen University Shenzhen Guangdong China Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional numerical Weather Prediction CMA Guangzhou China

In this paper, the CMA-TRAMS tropical high-resolution system was used to forecast a typical hot weather process in Guangdong, China with different horizontal resolutions and surface coverage. The results of resolutions of 0.02° and 0.06° were presented with the same surface coverage of the GlobeLand30 V2020, companies with the results of resolution 0.02° with the USGS global surface coverage. The results showed that, on the overall assessment the 2 km model performed better in forecasting 2 m temperature, while the 6 km model was more accurate in predicting 10 m wind speed. In the evaluation of representative stations, the 2 km model performed better in forecasting 2 m temperature and 2 m relative humidity at the coastal stations, and the 2 km model was also better in forecasting 2 m pressure at the representative stations. However, the 6 km model performed better in forecasting 10 m wind speed at the representative stations. Furthermore, the 2 km model, owing to its higher horizontal resolution, presented a more detailed stratification of various meteorological field maps, allowing for a more pronounced simulation of local meteorological element variations. And the use of the surface coverage data of the GlobeLand30 V2020 improved the forecasting of 2 m temperature, and 10 m wind speed compared to the USGS surface coverage data.

关键词： High-Resolution numerical Model CMA-TRAMS Model Test Evaluation Surface Coverage numerical Simulation

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探寻式搜索中用户满意度状态识别与演化规律研究

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数据分析与知识发现 2024年第1期8卷 90-103页

作者：赵一鸣陈湛张帆武汉大学信息资源研究中心武汉430072 武汉大学信息管理学院武汉430072 武汉大学大数据研究院武汉430072 武汉大学图书情报国家级实验教学示范中心武汉430072 武汉大学科教管理与评价中心武汉430072

【目的】识别探寻式搜索中的用户满意度状态,揭示用户满意度与用户查询式重构模式之间的相互作用关系和动态演化规律。【方法】利用用户查询、时序等特征,基于4种有监督学习算法进行用户满意度预测;通过挖掘用户满意度与查询式重构模式... 详细信息

【目的】识别探寻式搜索中的用户满意度状态,揭示用户满意度与用户查询式重构模式之间的相互作用关系和动态演化规律。【方法】利用用户查询、时序等特征,基于4种有监督学习算法进行用户满意度预测;通过挖掘用户满意度与查询式重构模式之间的相互影响规律,指导探寻式搜索智能辅助中的查询式重构推荐策略。【结果】在开放基准数据集上,所构建的满意度预测模型的预测准确率最高达到74%,优于已有基线模型;同时,相关性分析的结果表明用户满意度与查询式重构模式之间的关联关系显著。【局限】用户满意度仅代表搜索状态的一种视角,未来需要针对探寻式搜索中的用户状态构建完善统一的描述和分类体系。【结论】利用探寻式搜索中的用户搜索行为,优化了模型特征,进一步提升用户满意度预测模型的性能,并结合用户满意度演化规律,为探寻式搜索中的智能搜索辅助策略提供了有效的理论支撑。

关键词：探寻式搜索用户满意度用户满意度预测查询式重构

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Establishment of naLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： yi Tian Zhiguang Fu Xiaosheng Zhu Chunjing zhan.Jinwei Hu Li fan Chaojun Song Qian yang yu Wang Mei Shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize naLuF_(4):15%Tb^(3+)(nLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system nLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when nLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the nLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFn-γand TnF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFn-γand TnF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFn-γand TnF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

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Will the Globe Encounter the Warmest Winter after the Hottest Summer in 2023?

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Advances in Atmospheric Sciences 2024年第4期41卷 581-586页

作者： Fei ZHEnG Shuai HU Jiehua MA Lin WAnG Kexin LI Bo WU Qing BAO Jingbei PEnG Chaofan LI Haifeng ZOnG yao yAO Baoqiang TIAn Hong chen Xianmei LAnG fangxing fan Xiao DOnG yanling zhan.Tao ZHU Tianjun ZHOU Jiang ZHU International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China nansen-Zhu International Research Centre(nZC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Monsoon System Research(CMSR) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China CAS Key Lab of Regional Climate-Environment for Temperate East Asia(RCE-TEA) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

In the boreal summer and autumn of 2023,the globe experienced an extremely hot period across both oceans and *** consecutive record-breaking mean surface temperature has caused many to speculate upon how the global temperature will evolve in the coming 2023/24 boreal *** this report,as shown in the multi-model ensemble mean(MME)prediction released by the Institute of Atmospheric Physics at the Chinese Academy of Sciences,a medium-to-strong eastern Pacific El niño event will reach its mature phase in the following 2−3 months,which tends to excite an anomalous anticyclone over the western north Pacific and the Pacific-north American teleconnection,thus serving to modulate the winter climate in East Asia and north *** some uncertainty due to unpredictable internal atmospheric variability,the global mean surface temperature(GMST)in the 2023/24 winter will likely be the warmest in recorded history as a consequence of both the El niño event and the long-term global warming ***,the middle and low latitudes of Eurasia are expected to experience an anomalously warm winter,and the surface air temperature anomaly in China will likely exceed 2.4 standard deviations above climatology and subsequently be recorded as the warmest winter since ***,the necessary early warnings are still reliable in the timely updated mediumterm numerical weather forecasts and sub-seasonal-to-seasonal prediction.

关键词： winter climate El niño seasonal forecast GMST

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A proton-catalyzing prodrug for PDT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions

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Science China Chemistry 2024年第9期67卷 3162-3178页

作者： Miao Li Xueying Sun Xiuqin Ma yang Tan Xiaoyi Jin yi Wang fan yang Qian Li Honglei zhan.Xiaojun Peng School of Biological Engineering Dalian Polytechnic UniversityDalian 116034China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

The reactive oxygen species(ROS)generation from photosensitizer in photodynamic therapy(PDT)is limited by tumor *** type-I photosensitizers,e.g.,sulfur-substituted nile blue,still rely on oxygen as the main center for transferring electrons to generate *** off the pathway of oxygen consumption in tumor can help photosensitizers overcome the limitation of low oxygen,in order to efficiently generate more *** is known that glycolysis inhibitor 3-bromopyruvic acid(3-BP),which could specially target mitochondria,can provide more oxygen by inhibiting oxidative ***,we successfully designed and synthesized a new 3-BP-coupled sulfur-substituted nile blue as prodrug(nBBP)for chemical/photodynamic synergistic *** results indicated that the protons in tumor catalyzed the hydrolysis of nBBP,inhibited photoinduced electron transfer between 3-BP and the photosensitizer in nBBP and further assisted the photosensitizer to be localized in mitochondria,utilizing local oxygen as much as possible and kill tumor cells more ***,the glycolysis inhibition-induced autophagy was combined with PDT-induced autophagy,which could promote the deaths of tumor *** other remedies exploiting nanomaterials,this construction method of nBBP achieves the efficient synergy of photodynamic therapy and glycolysis inhibition,stronger than their theoretical addition,in spatiotemporal *** study provides not only a highly efficient platform for tumor therapy but also a design approach for prodrugs with synergistic effects.

关键词： photodynamic therapy prodrug glycolysis inhibition autophagy tumor synergistic therapy

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The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via nLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： fan Luo Han Li Wenjuan Ma Jiaxin Cao Qun chen Feiteng Lu Miaozhen Qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua zhan.Ting Zhou Qiuyun Luo Wentao Pan Lin zhan. Chaozhuo Lin yan Huang Li zhan. Dajun yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RnA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2575 directly binds to nF-κB p65 to activate nLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-nF-κB p65 and nLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages nLRP3

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