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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu Xiao-yu chen Jie Zhao Pin li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

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New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel yu chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

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醋酸与磷钨钼酸混合溶剂中甲烷部分氧化研究

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化学工程 2010年第7期38卷 58-61页

作者：李崇陈立宇张瑾雷涛雷鹏西北大学化工学院陕西西安710069

采用单因素考察法考察了以碘为催化剂,在醋酸和磷钨钼酸混合溶剂中各种工艺条件对甲烷液相部分催化氧化反应的影响。磷钨钼酸与醋酸的混合溶剂体系可用于甲烷部分氧化反应,以碘为催化剂有较好的催化效果。通过对液相产物的分析,提出了... 详细信息

采用单因素考察法考察了以碘为催化剂,在醋酸和磷钨钼酸混合溶剂中各种工艺条件对甲烷液相部分催化氧化反应的影响。磷钨钼酸与醋酸的混合溶剂体系可用于甲烷部分氧化反应,以碘为催化剂有较好的催化效果。通过对液相产物的分析,提出了在醋酸与磷钨钼酸混合溶剂中甲烷液相部分氧化反应属于亲电取代反应机理。反应条件为碘催化剂浓度0.04 mol/L,混合溶剂中醋酸50 mL,磷钨钼酸0.14 mol/L,氧化剂K2S2O80.20 mol/L,温度210℃,压力4.0 MPa时,甲烷转化率可达32.79%,目的产物选择性可达96.64%。

关键词：甲烷部分氧化醋酸与磷钨钼酸混合溶剂碘

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LC-MS/MS分析血浆中脂肪酸及代谢产物

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质谱学报 2018年第3期39卷 310-315页

作者：钟宇陈滨李健杨青锦文娟蔡春广东医科大学分析中心广东湛江524023

建立了高效液相色谱-串联质谱(LC-MS/MS)同时测定血浆中脂肪酸花生四烯酸(AA)及其代谢产物13-羟基十八碳烯酸(13-HODE)和9-羟基十八碳烯酸(9-HODE)的方法。采用Strata-X固相萃取柱净化,BEH C18色谱柱分离,以乙腈-水为流动相,流速0.2mL/m... 详细信息

建立了高效液相色谱-串联质谱(LC-MS/MS)同时测定血浆中脂肪酸花生四烯酸(AA)及其代谢产物13-羟基十八碳烯酸(13-HODE)和9-羟基十八碳烯酸(9-HODE)的方法。采用Strata-X固相萃取柱净化,BEH C18色谱柱分离,以乙腈-水为流动相,流速0.2mL/min,等度洗脱;电喷雾离子源负离子模式和多反应监测模式定量。结果表明,3种物质在0.5~50μg/L范围内线性关系良好,相关系数为0.994 2~0.996 0;低、中、高3个加标水平的平均回收率为97.42%~101.46%;日内相对标准偏差为2.72%~6.11%,日间相对标准偏差为3.87%~6.39%;AA、13-HODE和9-HODE定量限分别为0.5、0.5、1.0μg/L。该方法简单、灵敏、快速、可靠,可用于血浆中脂肪酸及其代谢产物的检测分析。

关键词：血浆 3-羟基十八碳烯酸(13-HODE) 9-羟基十八碳烯酸(9-HODE) 花生四烯酸(AA) 液相色谱-串联质谱(LC-MS/MS)

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糖尿病酮症酸中毒合并应激性溃疡的临床诊治分析

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中国全科医学 2010年第3期13卷 274-276页

作者：郝晓红陈宇俐李雨潮内蒙古乌兰察布市中心医院内分泌科 012000

目的探讨糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)合并应激性溃疡的临床特点及治疗方法。方法回顾性分析我院1998年1月—2008年1月诊治的20例DKA合并应激性溃疡患者的临床特点及治疗方法。结果20例DKA患者合并应激性溃疡均有上消... 详细信息

目的探讨糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)合并应激性溃疡的临床特点及治疗方法。方法回顾性分析我院1998年1月—2008年1月诊治的20例DKA合并应激性溃疡患者的临床特点及治疗方法。结果20例DKA患者合并应激性溃疡均有上消化道出血的表现,通过实验室检查及胃镜诊断明确。尽快纠正低血容量和酮症酸中毒,止血、降糖治疗后,除1例79岁老年患者合并急性心肌梗死死亡外,其余19例均治愈出院。结论DKA易合并应激性溃疡,应首先解除应激因素,积极处理DKA,抗感染,纠正酮症及酸碱代谢失调,抗休克治疗。

关键词：糖尿病酮症酸中毒消化性溃疡出血应激治疗

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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming li Jianfeng li Guoliang chen Tao lin Penghui Zhang Kuileung Tong Ningning chen Shaoyu liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

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Kirigami-Design-Enabled Hydrogel Multimorphs with Application as a Multistate Switch

Kirigami-Design-Enabled Hydrogel Multimorphs with Applicatio...

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中国力学大会-2021+1

作者： Xing Peng Hao Zhao Xu chen yu li Wei Hong Qiang Zheng Zi liang Wu Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Department of Mechanics and Aerospace Engineering Southern University of Science and Technology Global Station for Soft Matter Global Institution for Collaborative Research and Education Hokkaido University

Morphing materials have promising applications in soft robots,intelligent devices,and so *** the various design strategies,kirigami structures are recognized as a powerful tool to obtain sophisticated 3D configurations and unprecedented properties from planar designs on common ***,some kirigami designs are demonstrated for programmable,multistable 3D configurations from composite hydrogel sheets.

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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian li Xueer liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu li Yijia Lei Baozeng Sun Xiaoyu yu Zhe Wang College of Chemistry and life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

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Multiphase reaction spinning of high-temperature resistant weavable SiO_(2)-Kevlar hybrid aerogel fibers

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Nano Research 2025年第1期18卷 424-433页

作者： yunna chen Wenlu Zhang Qingyang li Wenbin li Chong He School of Textile Science and Engineering Wuhan Textile UniversityWuhan 430200China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Advanced aerogel fibers possess numerousadvantages amalgamating the attributes of aerogels and fibermaterials, rendering them invaluable in the realm of thermalmanagement and regulation. However, the achievement ofrobust mechanical properties and increased temperaturestability is still a major challenge for the majority of aerogelfibers. Herein, SiO_(2)-Kevlar hybrid aerogel fibers with bioniccore-shell structure were prepared by reaction spinning andweaved into fabric. Kevlar nanowires dispersion is pumpedinto a bath comprising a self-synthesized silica sol, whichfacilitates the hybridization of biphasic aerogels through thegel reaction. Precise control over the diameter (200-800 μm)and structure of the wet gel fibers was achieved throughmeticulous adjustment of the spinning solution composition and spinning parameters. Subsequent freeze-drying processfacilitates the formation of a core-shell hybrid structure, in which the SiO_(2) aerogel layer effectively encapsulate the Kevlaraerogel core fiber. Taking full advantage of the mechanical properties of the Kevlar core fiber, the resulting SiO_(2)-Kevlaraerogel fibers exhibit commendable weaving characteristics (51.8 MPa). Furthermore, SiO_(2)-Kevlar aerogel fabrics exhibitenhanced thermal insulation characteristics with a thermal conductivity of 0.037 W/(m·K). As a result of the presence ofexternal SiO_(2) aerogel layer, the overall temperature resistance performance of the SiO_(2)-Kevlar fabric reach up to 700 ℃.

关键词： aerogel fibers SiO_(2)aerogel Kevlar aerogel reaction spinning thermal protective performance

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