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The influences of wall Lorentz force and field Lorentz force on the cylinder drag reduction

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Acta Mechanica Sinica 2011年第5期27卷 668-674页

作者： Hui Zhang Bao-Chun Fan Zhi-hua chen yan-Ling Li Science and Technology on Transient Physics Laboratory Nanjing University of Science and Technology210094 Nanjing China

In this paper,the effects of Lorentz force on drag reduction for a circular cylinder have been studied experimentally and *** on its effects on drag reduction,the Lorentz force is found to be classified into two parts：one acts directly on the cylinder,named as the wall Lorentz force,and the other called the field Lorentz force acts on the fluid inside the boundary *** wall Lorentz force leads to the generation of a thrust,whereas the field Lorentz force results in drag *** the former dominates the drag variation,the drag would reduce accordingly and even turn into negative （thrust） with the application of Lorentz force.

关键词： Cylinder wake · Flow control · Lorentz force · Electromagnetic control

Using Lyapunov function to design optimal controller for AQM routers

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 113-118页

作者： ZHANG Peng YE cheng-qing MA Xue-ying chen yan-hua LI Xin School of Computer Science and Technology Zhejiang University Hangzhou 310027 China

It was shown that active queue management schemes implemented in the routers of communication networks sup-porting transmission control protocol (TCP) flows can be modelled as a feedback control system. In this paper based on Lyapunov function we developed an optimal controller to improve active queue management (AQM) router’s stability and response time, which are often in conflict with each other in system performance. Ns-2 simulations showed that optimal controller outperforms PI controller significantly.

关键词： TCP flows Active queue management (AQM) Lyapunov function Optimal controls

Colloidal Dispersion of Nano-Ru/SiO_2 in PEG and its Application for Hydrogenation of Benzene

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Chinese Chemical Letters 2006年第10期17卷 1413-1416页

作者： Yu Chuan yanG yan chen yan hua WANG Jing yang JIANG Zi Lin JIN State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012

Colloidal dispersion of nano-Ru/SiO2 in PEG （polyethylene glycol, M.W.=400） was used for benzene hydrogenation. The system has the features of easy catalyst＇s recycling and high catalyst stability.

关键词： Ru nanoparticles PEG benzene hydrogenation nano-Ru/SiO2

Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment

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World Journal of Gastroenterology 2009年第21期15卷 2638-2643页

作者： Yi-Bin Hou Min-hua chen Kun yan Jin-Yu Wu Wei yang Ultrasound Department Peking University School of Oncology Cancer Hospital & Institute No. 52 Fucheng Road Haidian District Beijing 100142 China

AIM:To evaluate the feasibility and efficacy of percutaneous radiofrequency ablation(RFA) of the feeding artery of hepatocellular carcinoma(HCC) in reducing the blood-flow-induced heat-sink effect of ***:A total of 154 HCC patients with 177 pathologically confirmed hypervascular lesions participated in the study and were randomly assigned into two ***-one patients with 75 HCCs(average tumor size,4.3 ± 1.1 cm) were included in group A,in which the feeding artery of HCC was identified by color Doppler flow imaging,and were ablated with multiple small overlapping RFA foci [percutaneous ablation of feeding artery(PAA)] before routine RFA treatment of the ***-three patients with 102 HCC(average tumor size,4.1 ± 1.0 cm) were included in group B,in which the tumors were treated routinely with ***-enhanced computed tomography was used as post-RFA imaging,when patients were followed-up for 1,3 and 6 ***:In group A,feeding arteries were blocked in 66(88%) HCC lesions,and the size of arteries decreased in nine(12%).The average number of punctures per HCC was 2.76 ± 1.12 in group A,and 3.36 ± 1.60 in group B(P = 0.01).The tumor necrosis rate at 1 mo post-RFA was 90.67%(68/75 lesions) in group A and 90.20%(92/102 lesions) in group *** recur-rence rate at 6 mo post-RFA was 17.33%(13/75) in group A and 31.37%(32/102) in group B(P = 0.04).CONCLUSION:PAA blocked effectively the feeding artery of *** of PAA and RFA significantly decreased post-RFA recurrence and provided an alternative treatment for hypervascular HCC.

关键词： Hepatocellular carcinoma Feeding artery Radiofrequency ablation Recurrence Color Dopplerflow imaging

The role of collateral related donors in haploidentical hematopoietic stem cell transplantation

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Science Bulletin 2018年第20期63卷 1376-1382页

作者： Xiao-Dong Mo Yuan-Yuan Zhang Xiao-Hui Zhang Lan-Ping Xu Yu Wang chen-hua yan huan chen Yu-Hong chen Ying-Jun Chang Kai-yan Liu Xiao-Jun huang Peking University People's Hospital Peking University Institute of hematologyBeijing 100044China Peking-Tsinghua Center for Life Sciences Beijing 100871China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China

A key issue in the haploiedntical hematopoietic stem cell transplantation(haplo-HSCT) setting is the search for the best donor, because donor selection can significantly impact the clinical outcomes. We aimed to identify the role of collateral related donors(CRDs) in donor selection for haplo-HSCT through comparing the clinical outcomes between CRDs(n = 60) and maternal donors(MDs, n = 296), which were the last choice of donor selection in immediate related donors(IRDs). The cumulative incidence of graft-versus-host disease was comparable between CRDs and MDs. The 5-year cumulative incidence of relapse and non-relapse mortality was 22.0%(95% CI, 11.3%–32.7%) versus 17.4%(95% CI, 13.0%–21.8%)(P = 0.455) and 25.0%(95% CI, 13.9%–36.1%) versus 23.1%(95% CI, 18.2%–28.0%)(P = 0.721) for the CRDs and MDs, respectively. The 5-year probabilities of disease-free survival and overall survival was 53.2%(95% CI, 40.4%–66.0%) versus 59.5%(95% CI, 53.8%–65.2%)(P = 0.406) and 56.5%(95% CI,43.8%–69.2%) versus 61.8%(95% CI, 56.1%–67.5%)(P = 0.458) for the CRDs and MDs, *** donor/male recipient(FDMR) CRDs were associated with the poorest clinical outcomes, and the clinical outcomes of non-FDMR CRDs were comparable to those of MDs. In summary, our results showed that CRDs did not showed superiority over MDs. Thus, IRDs should be the first choice of donor selection, and CRDs could only be the donors for those without IRDs.

关键词： Haploidentical Hematopoietic stem cell transplantation Collateral related donors Paternal donors Maternal donors

Application of Colloidal Gold to Fluorophotometric Determination of Human IgG

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Chemical Research in Chinese Universities 2010年第1期26卷 23-26页

作者： DENG Xin-yu GAO De-jiang TIAN Yuan chen yan-hua YU Ai-min ZHANG Han-qi WANG Xing-hua chen Ying College of Chemistry Jilin University Changchun 130012 P. R. China Jilin Province Center of Environmental Monitoring Changchun 130011 P R. China

A method for the determination of human immunoglobulin G（IgG） based on a colloidal gold label by fluorospectrophotometry was developed. The sandwich immunoreaction among goat-anti-human IgG, human IgG and goat-anti-human IgG labeled with colloidal gold nanoparticles was applied in this experiment. First, a sandwich im- munocomplex was formed on the surface of 96 well clear polystyrene high bind stripwellTM microplate. After the formation of the sandwich immunocomplex, a solution was added to dissociate the immunocomplex at room temperature. Then the solution of each well was transferred into the corresponding test tube. Thirdly, the rhodamine B solution was injected into each test tube. The rhodamine B chloraurate was extracted into ether that was measured with a spectrofluorometer. The experimental results indicate that the fluorescence intensity increased with the increase of human IgG concentration. The fluorescence intensity of rhodamine B chloraurate at 570 nm was proportional to the logarithm of human IgG concentration in a range from 10 to 5 × 10^5 ng/mL. It was shown that the determination of human IgG was easily made with the proposed fluorospectrophotometry.

关键词： Human IgG Colloidal gold Fluorospectrophotometry

Haploidentical stem cell transplantation in patients with chronic myelomonocytic leukemia

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Science China(Life Sciences) 2020年第8期63卷 1261-1264页

作者： Yu-Qian Sun chen Zhao Yu Wang chen-hua yan Xiao-Hui Zhang Lan-Ping Xu Kai-yan Liu Xiao-Jun huang Peking University People’s Hospital Peking University Institute of HaematologyNational Clinical Research Center for Hematologic diseaseBeijing Key Laboratory of Haematopoietic Stem Cell TransplantationBeijing 100044China Peking-Tsinghua Centre for Life Sciences Beijing 100871China

Dear Editor,Chronic myelomonocytic leukemia (CMML) is a rare clonal hematological malignancy with both myelodysplastic and myeloproliferative features. Patients with CMML have a very poor prognosis。

关键词： leukemia prognosis patients

Effects of TNF-α and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells

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Chinese Medical Journal 2005年第24期118卷 2052-2057页

作者： chen Wei-hua chen yan CUI Guo-hui Institute of Hematology Union Hospital Tongji Medical College ofHuazhong University of Science and Technology Wuhan 430022China

Background To better understand the possibilities of antiangiogenic tumor therapy and to assess possible side effects, we investigated the effect of tumour necrosis factor （TNF）-α and curcumin on the expression of vascular endothelial growth factor （VEGF） in U937 and Raji cell lines and their effect on angiogenesis in a human umbilical vein endothelial cell （HUVECs）-derived cell line （ECV304）, and also the relationship between Notchl and VEGF. The aim of this study was to elucidate potential mechanisms controlling tumor neovascularization. Methods VEGF secreted by U937 and Raji cell lines was determined by ELISA. Angiogenesis was tested by network formation of endothelial cells on Matrigel. Levels of VEGF mRNA in U937 and Raji cells and Notchl mRNA levels in EV304 cells were determined by RT-PCR. Results Secretion of VEGF by U937 and Raji cells was increased by TNF-α treatment and suppressed by curcumin （P 〈 0. 01 ）. The mRNA expression of VEGF165 and VEGF121 （containing 165 and 121 amino acid residues, respectively） were detected in any fractions. TNF-α augmented the expression of VEGF165 and VEGF121 mRNA and curcumin reduced the expression （P 〈0. 01 ）. No networks or cords formed in control and curcumin groups. There was tube formation on matrigel in the supernatants of the Raji culture group and the supernatants groups treated by VEGF group and TNF-α in Raji cell. Notch1 mRNA was detected but there was no significant change in the VEGF group compared with control （P 〉 0. 05）. Conclusions Expressions of VEGF mRNA in U937 and Raji cells were increased by TNF-α and suppressed by curcumin. VEGF and TNF-α can induce angiogenesis, and curcumin can inhibit angiogenesis in ECV304 cells.

关键词： tumour necrosis factors-α curcumin vascular endothelial growth factors Notch1

Pre-transplantation cytoreduction does not benefit advancedmyelodysplastic syndrome patients after myeloablative transplantation with grafts from family donors

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Cancer Communications 2021年第4期41卷 333-344页

作者： Yu-Qian Sun Lan-Ping Xu Kai-yan Liu Xiao-Hui Zhang chen-hua yan Jian Jin Xiao-Jun huang Yu Wang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic Disease BeijingKey Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044P.R.China Peking-Tsinghua Center for Life Sciences Beijing 100871P.R.China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100871P.R.China

Background:The role of pre-hematopoietic stem cell transplantation(HSCT)cytoreduction with either induction chemotherapy(IC)or hypomethylating agents(HMAs)in treating advanced myelodysplastic syndrome(MDS)remains *** aimed to evaluate pre-HSCT strategies by comparing the endpoints related to disease control between advanced MDS patients with pre-HSCT cytoreduction and those with best supportive ***:We described 228 consecutive advanced MDS patients who received HSCT from a haploidentical donor(HID,n=162)or matched related donor(MSD,n=66)with uniform myeloablative conditioning regimens between January 2015 and December *** these 228 patients,131(57.5%)were treated exclusively with pre-HSCT best supportive care(BSC),49(22.5%)were given HMA,and 48(21.1%)received both IC and *** score-matching analysis,multivariate analyses,and subgroup analyses were performed to elucidate the impact of pre-HSCT strategies on transplant ***:The 3-year relapse-free survival(RFS)rates were 78.2% and 70.0% for the BSC and cytoreduction cohorts(P=0.189)and were 78.2%,66.7%,and 73.2% for the BSC,HMA,and HMA+IC groups,respectively(P=0.269).A propensity score-matching analysis confirmed that the 3-year RFS rates were 81.9%,87.5%,and 66.9% for BSC,cytoreduction complete remission(CR),and cytoreduction non-CRgroups,respectively(P=0.051).Multivariate analyses demonstrated that pre-HSCT cytoreduction,older patient age,monosomal karyotype,and interval between diagnosis and HSCT were poor prognostic factors for *** the subgroup analyses,BSC was associated with longer RFS compared to cytoreduction among the younger patients,those with international prognostic scoring system intermediate-2/high risk at diagnosis,and those with intermediate/poor ***:Different pre-HSCT therapies did not yield discrepant post-HSCT *** benefit in terms of post-HSCT outcomes were correlated with pre-HSCT cytoreduction in advanced MDS even for cyt

关键词： myelodysplastic syndrome cytoreduction hypomethylating agent induction chemotherapy hematopoietic stem cell transplantation best supportive care