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Study of the blocking mechanism in gravel packing based on CFD-DEM

Particuology 2024年第7期90卷 164-178页

作者： Fucheng Deng Lei Wen Gang Li Baitao fan Ning Gong Shenghong chen Yangtze University Jingzhou434023China Guangzhou Institute of Energy Conversion Chinese Academy of Sciences510640China CNOOC Research Institute Ltd Beijing100028China Tianjin Branch of CNOOC Ltd Tianjin300459China CNOOC Ener Tech-Drilling&Production Co Tianjin300457China

Gravel packing sand control(GPSC),as the optimization of mechanical sand control technology,is widely used in the deep water completion and sand control of loose sandstone heavy oil reservoirs and highly *** explore the blocking mechanism of GPSC,the influence of its structural parameters on the blocking of GPSC is *** paper establishes a particle element model based on computational fluid dynamics-discrete element method coupling using the discrete element method and establishes a fluid flow model combined with computational fluid dynamics to realize their full coupling *** sand control experiments were carried out using a micro visual sand control simulation device to verify the blocking *** blocking mechanism is analyzed from the microscopic point of view,and then,the influence of sand control structure parameters on the blocking in GPSC design is *** results show the following:(1)the blocking process of GPSC can be divided into three stages:an initial stage,sand accumulation stage,and equilibrium stage.(2)There are two main types of gravel packing *** first type of blocking is blocking on the surface of the gravel *** particles on the surface of gravel layer mainly exist in the form of large particle size blocking gravel pores and sand particles bridging each *** second type of blockage is the blockage inside the gravel *** particles mainly exist in the form of internal mud cakes and adsorption on gravels inside the gravel layer.(3)To ensure the sand control performance of the gravel layer,the gravel layer thickness is designed between 23 and 28 *** displacement or pressure of the on-site packing pump should be increased to ensure that the gravel layer packing solidity ranges between 59%and 62%.In the design of GPSC,it should be ensured that the median particle size of gravel is 5–6 times the median particle size of *** study provides an effective technical reference for the

关键词： CFD-DEM Blocking the process Blocking mechanism Structural parameter

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Solubility determination and comparison ofβ-HMX and RDX in two binary mixed solvents(acetonitrile+water,nitric acid+water)

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Chinese Journal of Chemical Engineering 2024年第5期69卷 238-249页

作者： Yuehua Yao fan Wang Yinguang Xu Zishuai Xu Lizhen chen Jianlong Wang School of Chemistry and Chemical Engineering North University of ChinaTaiyuan 030051China Gansu Yinguang Chemical Industry Group Co.Ltd. Baiyin 730900China

In order to remove hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX),the main impurity,in process of polymorphic transformation of octrahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),the solubility ofβ-HMX and RDX in acetonitrile(ACN)+water in the temperature range of 288.15-333.15 K and in nitric acid(HNO_(3))+water in the temperature range of 298.15-333.15 K were measured by laser dynamic *** results showed that the solubility of bothβ-HMX and RDX in binary mixed solvents increased monotonously as the temperature increase at a given solvent composition or with increasing of mole fraction of solvent(ACN and nitric acid).Solubility data were well correlated by the modified Apelblat equation,Jouyban-Acree model,Yaws equation and van't Hoff equation,and the Yaws equation achieved the best fitting results according to the relative error and the mean square error ***,the solubility ofβ-HMX and RDX in binary mixed solvent was compared,based on the solubility difference and the solvent's own properties,the best separation degree ofβ-HMX and RDX was found when the mole fraction of nitric acid was 0.22 at room temperature,which provided data support for HMX crystallization in mixed *** solubility differences between RDX andβ-HMX in mixed solvents were explained from the formation of intermolecular and intramolecular hydrogen bonds.

关键词： Solubility Octrahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine Hexahydro-1,3,5-trinitro-1,3,5-triazine Separation Model Hydrogen bond

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Preparation of PrFe_(x)Co_(1-x)O_(3)/Mt catalyst and study on degradation of 2-hydroxybenzoic acid wastewater by catalytic wet peroxide oxidation

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Chinese Journal of Chemical Engineering 2024年第1期65卷 286-297页

作者： Binxia Zhao Yijia Gao Tiancheng Hun Xiaoxiao fan Nan Shao Xiaoqian chen School of Chemical Engineering Northwest UniversityXi'an 710069China

In this study,the perovskite nanocomposite PrFe_(x)Co_(1-x)O_(3)(Pr(S))was successfully synthesized by the sol-gel method;PrFe_(x)Co_(1-x)O_(3)/Al-pillared montmorillonite(Pr(S)/Mt)catalysts were prepared by impregnation(D)method and solid-melting(G)method,respectively,with Pr(S)as the active component and Al-pillared montmorillonite as the *** catalysts were applied to treat the 2-hydroxybenzoic acid(2-HA)-simulated wastewater by catalytic wet peroxide oxidation(CWPO)technique,and the chemical oxygen demand(COD)removal rate and the 2-HA degradation rate were used as indicators to evaluate the catalytic *** results of the experiment indicated that the solid-melting method was more conducive to preparing the catalyst when the Co/Fe molar ratio of 7:3 and the optimal structural properties of the catalysts were *** influence of operating parameters,including reaction temperature,catalyst dosage,H_(2)O_(2)dosage,pH,and initial 2-HA concentration,were optimized for the degradation of 2-HA by *** results showed that 97.64%of 2-HA degradation and 75.23%of COD removal rate were achieved under more suitable experimental *** addition,after the catalyst was used five times,the degradation rate of 2-HA could still reach 76.93%,which implied the high stability and reusability of the *** high catalytic activity of the catalyst was due to the doping of Co into PrFeO_(3),which could promote the generation of HO·,and the high stability could be attributed to the loading of Pr(S)onto Al-Mt,which reduced the leaching of reactive *** study of reaction mechanism and kinetics showed that the whole degradation process conformed to the pseudo-firstorder kinetic equation,and the Langmuir-Hinshelwood method was applied to demonstrate that catalysis was dominant in the degradation process.

关键词： Montmorillonite Perovskite Catalytic wet peroxide oxidation(CWPO) 2-Hydroxybenzoic acid

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GRU-integrated constrained soft actor-critic learning enabled fully distributed scheduling strategy for residential virtual power plant

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Global Energy Interconnection 2024年第2期7卷 117-129页

作者： Xiaoyun Deng Yongdong chen Dongchuan fan Youbo Liu Chao Ma College of Electrical Engineering Sichuan UniversityChengdu 610065P.R.China State Grid Sichuan Comprehensive Energy Service Co.Ltd. Chengdu 610072P.R.China

In this study,a novel residential virtual power plant(RVPP)scheduling method that leverages a gate recurrent unit(GRU)-integrated deep reinforcement learning(DRL)algorithm is *** the proposed scheme,the GRU-integrated DRL algorithm guides the RVPP to participate effectively in both the day-ahead and real-time markets,lowering the electricity purchase costs and consumption risks for *** Lagrangian relaxation technique is introduced to transform the constrained Markov decision process(CMDP)into an unconstrained optimization problem,which guarantees that the constraints are strictly satisfied without determining the penalty ***,to enhance the scalability of the constrained soft actor-critic(CSAC)-based RVPP scheduling approach,a fully distributed scheduling architecture was designed to enable plug-and-play in the residential distributed energy resources(RDER).Case studies performed on the constructed RVPP scenario validated the performance of the proposed methodology in enhancing the responsiveness of the RDER to power tariffs,balancing the supply and demand of the power grid,and ensuring customer comfort.

关键词： Residential virtual power plant Residential distributed energy resource Constrained soft actor-critic Fully distributed scheduling strategy

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How Do Chinese Exporting Firms Respond to Environment-related Notifications? A Green Innovation Perspective

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China & World Economy 2024年第5期32卷 1-27页

作者： Wen chen Yinzi fan Professor School of Economics Xiamen University China PhD Candidate School of Economics Xiamen University China

Environment-related notifications play an important role in the coordinated development of trade and environment protection. In this paper, we examine how Chinese exporting enterprises responded to environment-related notifications implemented by the US through green innovation practices. These notifications significantly encouraged exporting firms to increase green innovation, as evidenced particularly by the number of green utility model patents granted. This effect was most pronounced in non-foreign-invested enterprises, high-total-factor-productivity firms, technology-intensive industries, and nongreen industries. These notifications also increased the probability of enterprises exiting the market while reducing the probability of new enterprises entering it. The innovation motivation of surviving firms was higher than that of the new entrants. Our analysis also suggests that environment-related notifications had a crowding-out effect on other innovation rather than a leverage effect. This study offers important empirical evidence that helps enterprises to respond to green non-tariff measures effectively, enrich the existing literature, and provide practical guidance for both policymaking and corporate development.

关键词： difference-in-differences environment-related notification green innovation trade and environment

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Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 321-334页

作者： Rangrang fan Linrui Cai Hao Liu Hongxu chen Caili chen Gang Guo Jianguo Xu Department of Neurosurgery and Institute of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China NMPA Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOENational Drug Clinical-Trial InstitutionWest China Second HospitalSichuan UniversityChengdu610041China Department of Immunology School of Basic Medical SciencesXinxiang Medical UniversityXinxiangHenan453000China

Despite decades of laboratory and clinical trials,breast cancer remains the main cause of cancer-related disease burden in *** the metabolism destruction effect of metformin(Met)and cancer cell starvation induced by glucose oxidase(GOx),after their efficient delivery to tumor sites,GOx and Met may consume a large amount of glucose and produce sufficient hydrogen peroxide in ***,a pH-responsive epigallocatechin gallate(EGCG)-conjugated low-molecular-weight chitosan(LC-EGCG,LE)nanoparticle(Met–GOx/Fe@LE NPs)was *** coordination between iron ions(Fe3+)and EGCG in this nanoplatform can enhance the efficacy of chemodynamic therapy via the Fenton ***–GOx/Fe@LE NPs allow GOx to retain its enzymatic activity while simultaneously improving its ***,this pH-responsive nanoplatform presents controllable drug release *** in vivo biodistribution study showed that the intracranial accumulation of GOx delivered by this nanoplatform was 3.6-fold higher than that of the free *** in vivo anticancer results indicated that this metabolism destruction/starvation/chemodynamic triple-combination therapy could induce increased apoptosis/death of tumor cells and reduce their *** triple-combination therapy approach is promising for efficient and targeted cancer treatment.

关键词： Metformin Glucose oxidase Metabolism disruption Tumor starvation Combination cancer therapy

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Miniature tunable Airy beam optical meta-device

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Opto-Electronic Advances 2024年第2期7卷 5-12页

作者： Jing cheng Zhang Mu Ku chen Yubin fan Qinmiao chen Shufan chen Jin Yao Xiaoyuan Liu Shumin Xiao Din Ping Tsai Department of Electrical Engineering City University of Hong KongKowloonHong Kong SAR 999077China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SAR 999077China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China

Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser *** research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation *** this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy *** approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two *** validity of the proposed strategy has been confirmed through simulation and experimental *** proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc.

关键词： metasurface miniature device tunable Airy beam tunable meta-device

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Binary Program Vulnerability Mining Based on Neural Network

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Computers, Materials & Continua 2024年第2期78卷 1861-1879页

作者： Zhenhui Li Shuangping xing Lin Yu Huiping Li fan Zhou Guangqiang Yin Xikai Tang Zhiguo Wang School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu611731China School of Electrical and Computer Engineering University ofWaterlooWaterlooN2L 3G1Canada

Software security analysts typically only have access to the executable program and cannot directly access the source code of the *** poses significant challenges to security *** it is crucial to identify vulnerabilities in such non-source code programs,there exists a limited set of generalized tools due to the low versatility of current vulnerability mining ***,these tools suffer from some *** terms of targeted fuzzing,the path searching for target points is not streamlined enough,and the completely random testing leads to an excessively large search ***,when it comes to code similarity analysis,there are issues with incomplete code feature extraction,which may result in information *** this paper,we propose a cross-platform and cross-architecture approach to exploit vulnerabilities using neural network obfuscation *** leveraging the Angr framework,a deobfuscation technique is introduced,along with the adoption of a VEX-IR-based intermediate language conversion *** combination allows for the unified handling of binary programs across various architectures,compilers,and compilation ***,binary programs are processed to extract multi-level spatial features using a combination of a skip-gram model with self-attention mechanism and a bidirectional Long Short-Term Memory(LSTM)***,the graph embedding network is utilized to evaluate the similarity of program *** on these similarity scores,a target function is determined,and symbolic execution is applied to solve the target *** solved content serves as the initial seed for targeted *** binary program is processed by using the de-obfuscation technique and intermediate language transformation method,and then the similarity of program functions is evaluated by using a graph embedding network,and symbolic execution is performed based on these similarity *** approach facilitates

关键词： Vulnerability mining de-obfuscation neural network graph embedding network symbolic execution

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Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia

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Virologica Sinica 2024年第1期39卷 31-43页

作者： Dongyan Zhang Xiulin Wu xing Xue Wenshi Li Ping Zhou Zhao Lv Kexin Zhao fan Zhu State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan UniversityWuhan430071China Hubei Province Key Laboratory of Allergy&Immunology Wuhan UniversityWuhan430071China

Human endogenous retroviruses(HERVs)are remnants of retroviral infections in human germline cells from millions of years *** these,ERVW-1(also known as HERV-W-ENV,ERVWE1,or ENVW)encodes the envelope protein of the HERV-W family,which contributes to the pathophysiology of ***,neuropathological studies have revealed cell death and disruption of iron homeostasis in the brains of individuals with ***,our bioinformatics analysis showed that differentially expressed genes in the human prefrontal cortex RNA microarray dataset(GSE53987)were mainly related to ferroptosis and its associated *** data demonstrated significantly lower expression levels of ferroptosis-related genes,particularly Glutathione peroxidase 4(GPX4)and solute carrier family 3 member 2(SLC3A2),in schizophrenia patients compared to normal *** in-depth analyses revealed a significant negative correlation between ERVW-1 expression and the levels of GPX4/SLC3A2 in *** indicated that ERVW-1 increased iron levels,malondialdehyde(MDA),and transferrin receptor protein 1(TFR1)expression while decreasing glutathione(GSH)levels and triggering the loss of mitochondrial membrane potential,suggesting that ERVW-1 can induce *** research has shown that ERVW-1 reduced the expression of GPX4 and SLC3A2 by inhibiting their promoter ***,Ferrostatin-1(Fer-1),the ferroptosis inhibitor,reversed the iron accumulation and mitochondrial membrane potential loss,as well as restored the expressions of ferroptosis markers GSH,MDA,and TFR1 induced by *** conclusion,ERVW-1 could promote ferroptosis by downregulating the expression of GPX4 and SLC3A2,revealing a novel mechanism by which ERVW-1 contributes to neuronal cell death in schizophrenia.

关键词： ERVW-1 Glutathione peroxidase 4(GPX4) Solute carrier family 3 member 2(SLC3A2) Ferroptosis Schizophrenia

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Integrated schedule of order picking and delivery for instant delivery

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Journal of Management Science and Engineering 2024年第1期9卷 88-100页

作者： Qiuchen Gu Tijun fan Jingyi chen School of Business East China University of Science and TechnologyShanghai200237China Research Center for Operations and Supply Chain Management East China University of Science and TechnologyShanghai200237China Economics and Management School Minjiang UniversityFuzhou350108China

In this study,we introduce an integrated schedule of order picking and delivery for instant *** picking,including order batching and picking sequencing,is scheduled online under real-time order arrival,which integrates order delivery by depicting order location dispersion in an online order picking *** delivery,including delivery person assignment and route planning,is modeled to minimize the total duration of order fulfillment by considering the influence of the order picking completion time.A rule-based online order picking strategy is established,and a customized ant colony optimization(ACO)algorithm is proposed to optimize order *** on 16 simulated instances of different scales demonstrate that our online order picking schedule considering order delivery outperforms existing approaches and that the customized ACO algorithm for order delivery is effective.

关键词： Online scheduling Order picking Delivery routing Integrated order picking and delivery Instant delivery

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