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Science China Chemistry 2024年第5期67卷 1624-1635页

作者： Shuxin liu Jinjuan Ma xiang Xu Aiguo Wang Nan Zheng School of Chemical Engineering Dalian University of TechnologyDalian 116024China Department of Comparative Medicine Laboratory Animal Center Dalian Medical UniversityDalian 116000China Cancer Hospital of Dalian University of Technology Shenyang 116000China

Carbon monoxide(CO) is an endogenous therapeutic gas with an anti-tumor effect. The precise delivery and controlled release of CO in tumor tissues play crucial roles in anti-cancer treatment. However, efficient in situ generation of CO from metal-free COreleasing molecules(CORMs) remains a formidable challenge. Herein, we develop ultrasound(US)-driven self-decomposition porphyrin as organic and metal-free US-CORMs, which can spatiotemporally control the CO release(347 mmol CO/mol porphyrin) efficiently under physiologically harmless US conditions(1.0 MHz, 1.5 W/cm^(2), 50% duty cycle, 50 min). Moreover,porphyrin as a sonosensitizer can also generate reactive oxygen species(ROS) under US treatment to achieve sonodynamic therapy(SDT). Advanced functions of such porphyrin-based CORMs in CO gas-sonodynamic synergistic treatment have been demonstrated by evaluating the in vitro and in vivo anti-tumor effects.

关键词： porphyrin sonodynamic therapy metal-free CO precursors ultrasound-driven gas therapy

Finite Element Method for Transient Electric Field by Using Indirect Laplace Transform with High Accuracy

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 401-411页

作者： Teng Wen xiang Cui Xuebao Li Sijia liu Zhibin Zhao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China China Electric Power Planning&Engineering Institute Beijing 100120China

This paper focuses on the finite element method in the complex frequency domain(CFD-FEM)for the transient electric ***,the initial value and boundary value problem of the transient electric field under the electroquasistatic field in the complex frequency domain is *** addition,the finite element equation and the constrained electric field equation on the boundary are ***,the indirect algorithm of the numerical inverse Laplace transform is *** on it,the calculation procedures of the CFD-FEM are illustrated in ***,the step response,zero-state response under the positive periodic square waveform(PPSW)voltage,and the zero-input response by the CFD-FEM with direct algorithm and indirect algorithm are ***,the reason for the numerical oscillations of the zero-state response under the PPSW voltage is analyzed,and the method to reduce oscillations is *** results show that the numerical accuracy of the indirect algorithm of the CFD-FEM is more than an order of magnitude higher than that of the direct algorithm when calculating the step response of the transient electric *** proposed method can significantly reduce the numerical oscillations of the zero-state response under the PPSW *** proposed method is helpful for the calculation of the transient electric field,especially in the case of frequency-dependent parameters.

关键词： Electroquasistatic field transient electric field finite element method complex frequency domain numerical Laplace transform

Recent advances in fabrication and functions of neuromorphic system based on organic field effect transistor

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International Journal of Extreme Manufacturing 2024年第2期6卷 273-295页

作者： Yaqian liu Minrui Lian Wei chen Huipeng chen School of Physics and Electronic Engineering Zhengzhou University of Light IndustryHenan 450002People’s Republic of China Institute of Optoelectronic Display National&Local United Engineering Lab of Flat Panel Display TechnologyFuzhou UniversityFuzhou 350002People’s Republic of China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207People’s Republic of China Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore Department of Physics National University of Singapore3 Science Drive 3Singapore 117543Singapore

The development of various artificial electronics and machines would explosively increase the amount of information and data,which need to be processed via in-situ *** synapse devices can store and process signals in a parallel way,thus improving fault tolerance and decreasing the power consumption of artificial *** organic field effect transistor(OFET)is a promising component for bioinspired neuromorphic systems because it is suitable for large-scale integrated circuits and flexible *** this review,the organic semiconductor materials,structures and fabrication,and different artificial sensory perception systems functions based on neuromorphic OFET devices are ***,a summary and challenges of neuromorphic OFET devices are *** review presents a detailed introduction to the recent progress of neuromorphic OFET devices from semiconductor materials to perception systems,which would serve as a reference for the development of neuromorphic systems in future bioinspired electronics.

关键词： organic field effect transistor neuromorphic systems synaptic transistor sensory perception systems device fabrication

Migration Networks Pattern of China’s Floating Population from the Perspective of Complex Network

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Chinese Geographical Science 2024年第2期34卷 327-341页

作者： liu Wangbao chen Ranran College of Geography Science South China Normal UniversityGuangzhou 510631China

Since China’s reform and opening-up,the growing disparity between urban and rural areas and regions has led to massive *** China’s Rural Revitalization Strategy and the industrial transfer from the eastern coastal areas to the inland,the migration direction and pattern of the floating population have undergone certain *** the 2017 China Migrants Dynamic Survey(CMDS),excluding Hong Kong,Macao,and Taiwan regions of China,organized by China’s National Health Commission,the relationship matrix of the floating population is constructed according to the inflow place of the interviewees and their outflow place(the location of the registered residence)in the questionnaire *** then apply the complex network model to analyze the migration direction and network pattern of China’s floating population from the city *** migration network shows an obvious hierarchical *** first-,second-,third-and fourth-tier distribution cities are municipalities directly under the central government,provincial capital cities,major cities in the central and western regions and ordinary cities in all provinces,*** migration trend is from the central and western regions to the eastern coastal *** migration network has‘small world’characteristics,forming nine *** shows that most node cities in the same community are closely linked and geographically close,indicating that the migration network of floating population is still affected by geographical *** the urban-rural and regional differences will promote the rational distribution this *** is necessary to strengthen the reform of the registered residence system,so that the floating population can enjoy urban public services comparable to other populations,and allow migrants to live and work in peace.

关键词： complex network floating population migration network spatial pattern community structure

Late Triassic Intracontinental Deformation of South Tianshan,Central Asia:Evidence from Syn-tectonic Sedimentation and Detrital Zircon Provenances of the Kuqa Depression

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 548-568页

作者： QIN xiang chen Xuanhua SHAO Zhaogang ZHANG Yiping WANG Yongchao LI Bing SU He WANG Ye liu Kui HAN Lele China Aero Geophysical Survey and Remote Sensing Center for Natural Resources Beijing 100083China Key Laboratory of Airborne Geophysics and Remote Sensing Geology MNRBeijing 100083China Chinese Academy of Geological Sciences Beijing 100037China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China

The Tianshan range,a Paleozoic orogenic belt in Central Asia,has undergone multiple phases of tectonic activities characterized by the N-S compression after the early Mesozoic,including the far-field effects of the Cenozoic Indian-Asian ***,there are limited reports on the tectonic deformation and initiation of Triassic intracontinental deformation in the Tianshan *** this structural context is crucial for interpreting the early intracontinental deformation history of the Eurasian continent during the early *** strata and syn-tectonic sediments provide a rich source of information on tectonic activities and have been extensively used in the studies of orogenic *** on detail fieldwork conducted in this study,the middle-late Triassic Kelamayi Formation of the northern Kuqa Depression in the southern Tianshan fold-thrust belt has been identified as the typical syn-tectonic growth *** youngest detrital zircon component in two lithic sandstone samples from the bottom and top of the Kelamayi growth strata yielded U-Pb ages of 223.4±3.1 and 215.5±2.9 Ma,respectively,indicating that the maximum depositional age of the bottom and top of the Kelamayi growth strata is 226-220 and 218-212 *** geochronological distribution of detrital samples from the Early-Middle Triassic and Late Triassic revealed abrupt changes,suggesting a new source supply resulting from tectonic activation in the Tianshan *** coupling relationship between the syn-tectonic sedimentation of the Kelamayi Formation and the South Tianshan fold-thrust system provides robust evidence that the Triassic intracontinental deformation of the South Tianshan range began at approximately 226-220 Ma(during the Late Triassic)and ended at approximately 218-212 *** findings provide crucial constraints for understanding the intraplate deformation in the Tianshan range during the Triassic.

关键词： growth strata basin-mountain coupling Triassic Indosinian event Kuqa Depression South Tianshan

Updated Lagrangian Particle Hydrodynamics (ULPH)Modeling of Natural Convection Problems

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 151-169页

作者： Junsong Xiong Zhen Wang Shaofan Li Xin Lai Lisheng liu xiang liu Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics Wuhan University of TechnologyWuhan430070China Department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhan430070China Department of Civil and Environmental Engineering The University of CaliforniaBerkeleyCA 94720USA

Natural convection is a heat transfer mechanism driven by temperature or density differences,leading to fluid motion without external *** occurs in various natural and engineering phenomena,influencing heat transfer,climate,and fluid mixing in industrial *** work aims to use the Updated Lagrangian Particle Hydrodynamics(ULPH)theory to address natural convection *** Navier-Stokes equation is discretized using second-order nonlocal differential operators,allowing a direct solution of the Laplace operator for temperature in the energy *** numerical simulations,including cases such as natural convection in square cavities and two concentric cylinders,were conducted to validate the reliability of the *** results demonstrate that the proposed model exhibits excellent accuracy and performance,providing a promising and effective numerical approach for natural convection problems.

关键词： Updated Lagrangian particle hydrodynamics(ULPH) natural convection meshless methods higher order Laplacian model

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1359-1388页

作者： Qian Zhou Yu Meng Daishi Li Lei Yao Jiayuan Le Yihuang liu Yuming Sun Furong Zeng xiang chen Guangtong Deng Department of Dermatology Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Furong Laboratory 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya Hospital87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of General Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Plastic and Cosmetic Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Oncology Xiangya HospitalCentral South University87Xiangya RoadChangsha 410008Hunan ProvinceChina

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membranelocalized lipid *** acts as an innate tumor suppressor mechanism and participates in the biological processes of ***,mesenchymal and dedifferentiated cancer cells,which are usually resistant to apoptosis and traditional therapies,are exquisitely vulnerable to ferroptosis,further underscoring its potential as a treatment approach for cancers,especially for refractory ***,the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor *** induction not only inhibits cancer but also promotes cancer development due to its potential negative impact on anticancer ***,a comprehensive understanding of the role of ferroptosis in cancer is crucial for the successful translation of ferroptosis therapy from the laboratory to clinical *** this review,we provide an overview of the recent advancements in understanding ferroptosis in cancer,covering molecular mechanisms,biological functions,regulatory pathways,and interactions with the tumor *** also summarize the potential applications of ferroptosis induction in immunotherapy,radiotherapy,and systemic therapy,as well as ferroptosis inhibition for cancer treatment in various *** finally discuss ferroptosis markers,the current challenges and future directions of ferroptosis in the treatment of cancer.

关键词： cancer mechanisms treatment

An Updated Lagrangian Particle Hydrodynamics (ULPH)-NOSBPD Coupling Approach forModeling Fluid-Structure Interaction Problem

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 491-523页

作者： Zhen Wang Junsong Xiong Shaofan Li Xin Lai xiang liu Lisheng liu Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics Wuhan University of TechnologyWuhan430070China Department of Civil and Environmental Engineering The University of CaliforniaBerkeleyCA 94720USA Department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhan430070China

A fluid-structure interaction approach is proposed in this paper based onNon-Ordinary State-Based Peridynamics(NOSB-PD)and Updated Lagrangian Particle Hydrodynamics(ULPH)to simulate the fluid-structure interaction problem with large geometric deformation and material failure and solve the fluid-structure interaction problem of Newtonian *** the coupled framework,the NOSB-PD theory describes the deformation and fracture of the solid material *** is applied to describe the flow of Newtonian fluids due to its advantages in computational *** framework utilizes the advantages of NOSB-PD theory for solving discontinuous problems and ULPH theory for solving fluid problems,with good computational stability and robustness.A fluidstructure coupling algorithm using pressure as the transmission medium is established to deal with the fluidstructure *** dynamic model of solid structure and the PD-ULPH fluid-structure interaction model involving large deformation are verified by numerical *** results agree with the analytical solution,the available experimental data,and other numerical ***,the accuracy and effectiveness of the proposed method in solving the fluid-structure interaction problem are *** fluid-structure interactionmodel based on ULPH and NOSB-PD established in this paper provides a new idea for the numerical solution of fluidstructure interaction and a promising approach for engineering design and experimental prediction.

关键词： Fluid-structure interaction(FSI) updated lagrangian particle hydrodynamics peridynamics meshfree method

A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

A new species of Discostella guiyangensis ***.(Bacillariophyta,Stephanodiscales)from Guiyang,China:morphology and phylogeny

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Journal of Oceanology and Limnology 2024年第4期42卷 1312-1324页

作者： Yandan xiang Fangru NAN Xudong liu Shulian XIE John Patrick KOCIOLEK Qi liu School of Life Science Shanxi UniversityTaiyuan 030006China Department of Ecology and Evolutionary Biology and Museum of Natural History University of ColoradoBoulder CO 80309USA

We describe a new species of Discostella from Guiyang based on light and scanning electron microscopic observations,as well as molecular *** species is morphologically distinguished from other species by a relatively smooth and slightly recessed central area with marginal striae of unequal lengths forked near the *** fultoportulae and a single rimoportula are situated between every two costae or on the *** morphological characters and the concatenated data of rbc L and SSU rDNA indicate that Discostella guiyangensis is a unique and new *** to divergence time estimation analysis,Discostella guiyangensis is the oldest species among the Discostella species sequenced *** addition,we complement molecular data of Discostella asterocostata and Discostella stelligera.

关键词： Discostella morphology molecular analysis divergence time estimation new species