检索结果-南通市图书馆

CHINA＇S OUTBOUND MERGERS AND ACQUISITIONS IN THE U.S.

在线全文

学校读者我要写书评

暂无评论

Frontiers of Law in China-Selected Publications from Chinese Universities 2014年第3期9卷 464-489页

作者： sheng chen zhang Li 1University of Illinois College of Law Champaign Illinois U.S. 2Lu Chau Law Firm LLP Anyang Henan China

Although scholars have long studied the acquisition by American firms of Chinese firms in China, surprisingly little research has been undertaken about Chinese firms acquiring American firms in the U.S. The significance of Chinese outbound M＆A deals in the U.S. lies in its demonstration that no all-encompassing, reductive theory can apply to all M＆A deals. This is because in each M＆A deal considerations vary widely, and these variations are the result of different acquiring firms, target firms, and jurisdictions. China＇s outbound M＆A deals in the U.S. illustrate this point well for two reasons. Firstly, most cross-border M＆A activities involve acquiring firms from developed markets and target firms from emerging markets,＂ by contrast, Chinese M＆A activities in the U.S. exemplify emerging-market firms intending to acquire firms in a developed market. Secondly, and more importantly, while the objective among American firms in acquiring Chinese firms is acquiring market share for the most part, the goals of Chinese firms, by contrast, revolve around the more advanced technology and better management offered by American firms. Because China＇s outbound M＆A activities in the U.S. is a relatively new phenomenon, this article covers some important issues in this generally untapped area based on limited cases, data, and scholarly articles that are available.

关键词：

Expression of Obesity Hormone Leptin in Human Colorectal Cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2009年第2期21卷 142-146页

作者： Jin-chun Cong Xian-wei Dai Ming-yang Shen Jun-jiang Wang Chun-sheng chen Hong zhang Lei Qiao Department of Colorectal Surgery Shengjing Hospital China Medical University Shenyang 110004 China

Objective： The obesity hormone, leptin, has been found to participate in the development and proliferation of normal and malignant tissues. The aim of this study was to evaluate the role of leptin in human colorectal cancer. Methods： Serum leptin levels were measured via ABC-ELLSA in 30 colorectal cancers and 24 normal controls. Leptin concentration in colorectal cancer was analyzed in terms of selected clinicopathological features and some oncogenes. Results： The mean concentration of leptin was significantly higher for colorectal cancers（3.54±1.46 ng/ml） than normal controls（2.27±0.99 ng/ml）, no gender difference was observed in this study. Leptin expression in poorly differentiated tumors was obviously lower than those in moderately and well differentiated tumors. There were no statistically significant correlations between leptin and the serum CEA and CA199 in colorectal cancers （P〉0.05）, and between leptin and the expressions of K-RAS, P53, APC, DCC genes in tumor tissues （P〉0.05）. Conclusion： Leptin is overexpressed in human colorectal cancer, which is related to the differentiation degrees of the tumor. There is no correlation between leptin expression and changes of oncogenes in colorectal cancers.

关键词： Colorectal cancer Leptin

Assessing food security performance from the One Health concept:an evaluation tool based on the Global One Health Index

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2023年第5期12卷 98-99页

作者： Si-Yu Gu Fu-Min chen chen-sheng zhang Yi-Bin Zhou Tian-Yun Li Ne Qiang Xiao-Xi zhang Jing-Shu Liu Shu-Xun Wang Xue-chen Yang Xiao-Kui Guo Qin-Qin Hu Xiao-Bei Deng Le-Fei Han School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University-The University of Edinburgh Shanghai China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) Shanghai China Minhang District Center for Disease Control and Prevention Shanghai China School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China

Background Food systems instantiate the complex interdependencies across humans,physical environments,and other *** One Health approaches for agri-food system transformation,which adopts integrated and unifying approaches to optimize the overall health of humans,animals,plants,and environments,is crucial to enhance the sustainability of food *** study develops a potential assessment tool,named the global One Health index-Food Security(GOHI-FS),aiming to evaluate food security performance across countries/territories from One Health perspective and identify relevant gaps that need to be improved for sustainable food *** We comprehensively reviewed existing frameworks and elements of food *** indicator framework of GOHI-FS was conceptualized following the structure-process-outcome model and confirmed by expert *** available data in 2020 was collected for each *** weighting strategy was determined by the Fuzzy Analytical Hierarchy *** data for each indicator was normalized and aggregated by weighted arithmetic *** regressions were performed to evaluate the associations of GOHI-FS with health and social-economic *** The GOHI-FS includes 5 first-level indicators,19 second-level indicators and 45 third-level *** were 146 countries/territories enrolled for *** highest average score of first-level indicators was Nutrition(69.8)and the lowest was Government Support and Response(31.3).There was regional heterogeneity of GOHI-FS *** median scores with interquartile range(IQR)were shown in North America(median:76.1,IQR:75.5-76.7),followed by Europe and Central Asia(median:66.9,IQR:60.1-74.3),East Asia and the Pacific(median:60.6,IQR:55.5-68.7),Latin America and the Caribbean(median:60.2,IQR:57.8-65.0),Middle East and North Africa(median:56.6,IQR:52.0-62.8),South Asia(median:51.1,IQR:46.7-53.8),and sub-Saharan Africa(median:41.4,IQR:37.2-46.5).We

关键词： Food security One Health Index Indicator framework Assessment

A versatile cloning vector facilitates target geneexpression in prokaryotic and eukaryotic cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Medical Colleges of PLA(China) 2011年第4期26卷 204-212页

作者： Wang sheng chen Jinhui zhang Baozhong Liu Dabin zhang Xin Mi Zhiqiang An Xiaoping Tong Yigang State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China

Objective： To facilitate manipulation of gene expression in different host cells, we used pEGFP-N1 as backbone to construct a versatile vector that can drive foreign gene expression in prokaryotic and eukaryotic cells. Methods： A cloning and expression vector, pEGFP-NI-lac, was constructed by inserting the prokaryotic lac promoter of pUC 19 into the eukaryotic expression vector, pEGFP-N1, between the eukaryotic PCMV promoter and enhanced green fluorescent protein （EGFP） open reading frames. To assess the function of pEGFP-NI-lac, the nucleotide sequence encoding the hepatitis C virus （HCV） core protein was cloned into the multiple cloning sites. Western blotting analysis was used to detect the expression of the HCV core protein in Escherichia coli DH5a and HepG2 cells. Results： Restriction enzyme digestion and sequence analysis indicated that pEGFP-NI-lac was successfully constructed and the HCV core gene was cloned into this vector. The Western blotting results showed that pEGFP-NI-lac promoted expression of HCV core gene in prokaryotic E. coli DH5a and eukaryotic HepG2 cells. Conclusion： The pEGFP-NI-lac vector has been successfully constructed and functions in both prokaryotic and eukaryotic cells. The EGFP reporter can be used as an insert-inactivation marker for clone selection or as an expression tag. This vector can be used for cloning and expression of genes in both prokaryotic and eukaryotic cells, making gene cloning, expression and functional studies convenient as well as time- and labor-efficient

关键词： Cloning Gene expression: Versatile vector

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin zhang Xiaoxuan chen Weiqiang chen Kangsheng Li Jiangtao sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

在线全文

学校读者我要写书评

暂无评论

基于光学图像的多粒度随动环境感知算法

软件学报 2016年第10期27卷 2661-2675页

作者：陈昊升张格叶阳东郑州大学信息工程学院河南郑州450052

针对快速三维建模中的室内外随动环境感知问题,提出一种基于光学图像的多粒度随动环境感知算法.该算法根据多种光学图像生成拟合真实三维环境的多粒度点云模型,然后通过概率八叉树压缩并统一表示已生成的多粒度三维模型.进而伴随相机轨... 详细信息

针对快速三维建模中的室内外随动环境感知问题,提出一种基于光学图像的多粒度随动环境感知算法.该算法根据多种光学图像生成拟合真实三维环境的多粒度点云模型,然后通过概率八叉树压缩并统一表示已生成的多粒度三维模型.进而伴随相机轨迹每个时间节点,通过卡尔曼滤波动态融合多粒度点云模型的概率八叉树表示.最终生成唯一的时态融合概率八叉树三维模型,简称TFPOM,使TFPOM能够在较少的噪声影响下以任意粒度动态拟合真实环境.该算法配合剪枝和归并策略能够适应多粒度融合和多粒度表示的环境建模要求,有效压缩环境模型存储空间,实现鲁棒的随动环境感知,便于基于环境模型的视觉导航,增强现实等应用.实验结果表明,该算法能够在以可穿戴设备为代表的内含多种异构光学图像传感器、低计算效能的平台上实时地得到充分拟合真实动态环境的多粒度TFPOM,基于该模型的视觉导航具有较小的轨迹误差.

关键词：随动环境感知概率八叉树多粒度快速三维建模

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng zhang chenyang zhang Linlin Wu Wei Sun Hongliang zhang Jianhua chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor