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Esophagectomy for locally advanced esophageal cancer, followed by chemoradiotherapy and adjuvant chemotherapy

World Journal of Gastroenterology 2005年第34期11卷 5367-5372页

作者： hung-Chang Liu Shih-Kai hung Cham-Jer Huang Chung-Chu chen Ming-Jen chen Chun-Chao Chang cheng-Jeng Tai Chi-Yuan Tzen Li-Hua Lu Yu-Jen chen Departments of Thoracic Surgery Radiation OncologyGastroenterology and Pathology Mackay Memorial HospitalTaipei Taiwan China Taipei Medical University Hospital Taipei Taiwan China Mackay Junior College of Nursing Taipei Taiwan

AIM： To compare the efficacy and toxicity of a three-step combination therapy with post-operative radiation alone for locally advanced esophageal cancer.METHODS： Patients with T3-4 and N0-1 esophageal carcinoma from a number of institutions were non-randomly, prospectively enrolled in the study. All patients underwent single-stage curative en bloc esophagectomy. The patients were then assigned into one of two treatment groups based on treatment consisting of either post-operative concurrent chemoradiotherapy （CCRT） with weekly cisplatin 30 mg/m^2 followed by systemic adjuvant chemotherapy （four monthly cycles of cisplatin 20 mg/m^2 and 5-fluorouracil 1 000 mg/m^2 for five consecutive days）, or, post-operative radiation alone. The radiotherapy dose was 55-60 Gy for all patients. Primary end-point of this study was to assess the per-protocol patients＇ improvement of overall survival benefit. Secondary end-point was designed to evaluate both the per-protocol and intent-totreat patients＇ outcome of survival. RESULTS： A total of 60 patients （n=30 per group） were enrolled in this study. The two groups were generally comparable for demographic characteristics and hematological and non-hematological toxicities. The CCRT with weekly cisplatin was well tolerated, with significantly better overall survival （30.9 mo vs 20.7 mo; 95% CI, 27.5-36.4 vs 15.2-26.1） and 3-year survival （70.0% vs 33.7%; P=0.003）. Low histological grade of tumor （P〈0.001） was associated with favorable survival in these locally advanced patients. CONCLUSION： For locally advanced esophageal cancer, the combination of esophagectomy, post-operative CCRT with weekly cisplatin and systemic adjuvant chemotherapy is well tolerated and effective. A large-scale, prospective randomized trial of this regimen is in progress.

关键词： Curative esophagectomy Concurrent chemoradiotherapy Cisplatin

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Serum hepatitis B surface antigen levels predict treatment response to nucleos(t)ide analogues

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World Journal of Gastroenterology 2014年第24期20卷 7686-7695页

作者： Chien-hung chen Yi-Chun Chiu Sheng-Nan Lu Chuan-Mo Lee Jing-Houng Wang Tsung-Hui Hu Chao-hung hung Division of Hepato-Gastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Quantification of hepatitis B surface antigen(HBsAg)has been suggested to be helpful in the management of chronic hepatitis B(CHB)***(t)ide analogs(NAs)are the therapy of choice for CHB and are used in the majority of CHB *** are able to induce hepatitis B virus(HBV)viral suppression,normalization of alanine aminotransferase(ALT)levels,and improvement in liver *** quantitative assays for serum HBsAg have recently become available,facilitating standardized quantification of serum *** has led to increased interest in the clinical application of quantitative serum HBsAg for predicting therapeutic response to *** studies have shown that a decline in serum HBsAg levels in patients receiving peginterferon may signal successful induction of immune control over HBV,and can therefore be used to predict therapeutic *** treatment typically induces a less rapid decline in HBsAg than interferon treatment;it has been estimated that full HBsAg clearance can require decades of NA ***,a rapid HBsAg decline during NA therapy may identify patients who will show clearance of ***,there is no consensus on the clinical utility of serum HBsAg monitoring for evaluating patient responses to NA *** review focuses on recent findings regarding the potential application of HBsAg quantification in the management of CHB patients receiving NA therapy.

关键词： Alanine aminotransferase Hepatitis B virus Hepatitis B surface antigen Nucleos(t)ide analogs Virological response

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Fracture behavior of hybrid epoxy nanocomposites based on multi-walled carbon nanotube and core-shell rubber

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Nano Materials Science 2022年第3期4卷 251-258页

作者： Zewen Zhu Hengxi chen Qihui chen Cong Liu Kwanghae Noh Haiqing Yao Masaya Kotaki hung-Jue Sue Department of Materials Science and Engineering Texas A&M UniversityCollege StationTX77843-3003USA School of Materials Science and Engineering North University of ChinaTaiyuan030051PR China Kaneka US Materials Research Center FremontCA94555USA

The dispersion of nanoparticles plays a key role in enhancing the mechanical performance of polymer *** this work,one hybrid epoxy nanocomposite reinforced by a well dispersed,zinc oxide functionalized,multi-wall carbon nanotube (Zn O-MWCNT) and core-shell rubber (CSR) was prepared,which possesses both high modulus and fracture toughness while maintaining relatively high glass transition temperature (Tg).The improved fracture toughness from 0.82 MPa mfor neat epoxy to 1.46 MPa mfor the ternary epoxy nanocomposites is resulted from a series of synergistic toughening mechanisms,including cavitation of CSR-induced matrix shear banding,along with the fracture of MWCNTs and crack *** implication of the present study for the preparation of high-performance polymer nanocomposites is discussed.

关键词： Carbon nanotube Core-shell rubber Epoxy nanocomposites Fracture toughness Synergistic toughening effect

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Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent

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Cellular & Molecular Immunology 2011年第5期8卷 415-423页

作者： Mobolaji O Olurinde Ching-hung Shen Adam Drake Ailin Bai Jianzhu chen Harvard-MIT Division of Health Sciences and Technology CambridgeMAUSA Koch Institute for Integrative Cancer Research Massachusetts Institute of TechnologyCambridgeMAUSA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMAUSA Department of Biology Massachusetts Institute of TechnologyCambridgeMAUSA

How tumor-infiltrating lymphocytes(TILs)that are tumor-specific but functionally tolerant persist in the antigen-expressing tumor tissue is largely *** have previously developed a modified TRansgenic Adenocarcinoma of the Mouse Prostate(TRAMP)model where prostate cancer cells express the T-cell epitope SIYRYYGL(SIY)recognized by CD8 T cells expressing the 2C T-cell receptor(TCR)(referred to as TRP-SIY mice).In TRP-SIY mice,activated 2C T cells rapidly become tolerant following infiltration into the prostate *** this study,we show that tolerant 2C T cells persist in the prostate tumor of TRP-SIY mice by proliferating slowly in a tumor-dependent,but antigen-,interleukin(IL)-7-and IL-15-independent *** also show that disappearance of 2C T cells from the lymphoid organs of TRP-SIY mice are due to antigen-induced T-cell contraction rather than altered trafficking or generalized T-cell depletion in the ***,we show that clonal T cells unreactive to SIY are equally capable of persisting in the prostate *** findings suggest that while functional tolerance of TILs is induced by antigen,persistence of tolerant TILs in the tumor tissue is mediated by a novel mechanism:slow proliferation independent of antigen and homeostatic *** results also allow CD8 T-cell survival in the tumor environment to be compared with T-cell survival in chronic infection.

关键词： antigen cytokines tolerance tumor-associated factors tumor-infiltrating lymphocytes

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Single daily amikacin versus cefotaxime in the short-course treatment of spontaneous bacterial peritonitis in cirrhotics

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World Journal of Gastroenterology 2005年第43期11卷 6823-6827页

作者： Tai-An chen Gin-Ho Lo Kwok-hung Lai Whey-Jen Lin Division of Gastroenterology

AIM: To compare the efficacy and safety of single daily amikacin vs. cefotaxime in the 5-d treatment of spontaneous bacterial peritonitis (SBP).METHODS: Thirty-seven cirrhotic patients with SBP,19 in group A and 18 in group B, were studied. Group A received 1 g of cefotaxime every 6 h, and group B received 500 mg of amikacin qd. Both antibiotics were administered up to 5 d and the responses were ***: Infection was cured in 15 of 19 patients (78.9%) treated with cefotaxime and in 11 of 18 (61.1%)treated with amikacin. Four patients of the Cefotaxime group (21.1%) and five patients of the Amikacin group (27.8%) died. Two in each group (10.5% vs 11.1%)had renal impairment during study period. One in each group (5.3% vs 5.6%) may be considered to suffer from nephrotoxicity due to increased urinary β2-microglobulin ***: In this study, single daily doses of amikacin in the treatment of SBP in cirrhotics were not associated with an increased incidence of renal impairment or nephrotoxicity. However, a 5-d regimen of amikacin is less effective than a 5-d regimen of cefotaxime in the SBP treatment.

关键词： Spontaneous bacterial peritonitis Amikacin Cefotaxime

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Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection

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World Journal of Gastroenterology 2010年第18期16卷 2265-2271页

作者： Chao-hung hung Jing-Houng Wang Tsung-Hui Hu Chien-hung chen Kuo-Chin Chang Yi-Hao Yen Yuanhung Kuo Ming-Chao Tsai Chuan-Mo Lee Division of Hepatogastroenterology Department of Internal MedicineChang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of Medicine

AIM:To elucidate the role of insulin resistance(IR) and serum adiponectin level in hepatocellular carcinoma(HCC) associated with chronic hepatitis ***:Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed *** model assessment of IR(HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus(HCV) ***:Among HCC patients,type 2 diabetics(DM) was more prevalent in HCV subjects(35.6%,n = 59) compared to hepatitis B virus(HBV;12.7%,n = 63) or non-HBV,non-HCV cases(7.1%,n = 28).In patients with chronic hepatitis C,HCC subjects had higher blood sugar(P < 0.001),insulin level(P = 0.003) and HOMAIR(P = 0.018) than those with chronic hepatitis and advanced ***,male sex and body mass index were significantly associated with serum adiponectin level,whereas HOMA-IR was *** on stepwise logistic regression analysis,age(OR:1.124,P < 0.001),serum insulin level(OR:1.585,P < 0.001),HOMA-IR(OR:0.495,P = 0.001),DM(OR:11.601,P = 0.002) and male sex(OR:3.877,P = 0.016) were independently associated with *** result was similar even if the diabetic subjects were excluded for ***:Insulin resistance measured by HOMAIR,regardless of the presence of diabetes,is significantly associated with HCC development in patients with chronic HCV infection.

关键词： Hepatitis C virus Hepatocellular carcinoma Insulin resistance Diabetes Adiponectin

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Theoretical and Experimental Study of Breaking Wave on Sloping Bottoms

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China Ocean Engineering 2013年第6期27卷 737-750页

作者： YANG Kuei-Sen chen Yang-Yih LI Meng-Syue HSU hung-Chu Department of Marine Environment and Engineering National Sun Yat-Sen University International Wave Dynamics Research Center National Cheng Kung University Tainan Hydraulics Laboratory National Cheng Kung University

This paper studies the continuous evolution of breaking wave for the surface water waves propagating on a sloping beach. A Lagrangian asymptotic solution is derived. According to the solution coupled with the wave breaking criteria and the equations of water particles motion, the wave deformation and the continuous wave breaking processes for the progressive water waves propagating on a sloping bottom can be derived. A series of experiments are also conducted to compare with the theoretical solution. The results show that the present solution can reasonably describe the plunging or spilling wave breaking phenomenon.

关键词： Eulerian Lagrangian waves breaking plunging spilling

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Exploring the mechanisms of magnolol in the treatment of periodontitis by integrating network pharmacology and molecular docking

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BIOCELL 2023年第6期47卷 1317-1327页

作者： DER-JEU chen chenG-hung LAI Department of Veterinary Medicine National Chung Hsing UniversityTaichungTaiwan

Background:Magnolol,a bioactive extract of the Chinese herb Magnolia officinalis has a protective effect against *** study is aimed to explore the mechanisms involved in the functioning of magnolol against periodontitis and provide a basis for further ***:Network pharmacology analysis was performed based on the identification of related targets from public *** Protein-protein interaction(PPI)network was constructed to visualize the significance between the targets of magnolol and ***,Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis were performed to predict the functions and the signal regulatory pathways involved in the action of magnolol against ***“functiontarget-pathway”networks were constructed to analyze the core targets and pathways of magnolol against *** docking was used to verify the interaction of magnolol and core ***:A total of 58 active targets of magnolol and 644 periodontitis-related targets were collected from public databases.A total of 25 targets of magnolol against periodontitis were identified based on the Venn *** analysis showed that magnolol has a role in the response to oxidative stress,nicotine,and *** enrichment analysis indicated that the mechanism of magnolol against periodontitis was mainly related to the tumor necrosis factor(TNF),phosphoinositide 3-kinase(PI3K/Akt),and mitogen-activated protein kinase(MAPK)signaling *** with PPI network and molecular docking results,the core targets of magnolol against periodontitis included AKT1,MAPK8,MAPK14,TNF,and ***:To summarize,the anti-periodontitis mechanisms of magnolol are potentially through regulating the TNF,PI3K/Akt,and MAPK signaling pathways.

关键词： Magnolol Periodontitis Network pharmacology Molecular docking

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Particle Trajectories in Nonlinear Water Wave on Uniform Current

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China Ocean Engineering 2008年第4期22卷 611-621页

作者： hung-Chu HSU Yang-Yih chen Chia-Yan chenG Wen-Jer TSENG Tainan Hydraulics Laboratory National Cheng Kung University Department of Marine Environment and Engineering National Sun Yat-Sen University Coastal and Offshore Resources Research Center Fisheries Research Institute Department of Civil Engineering Cheng Shiu University

The study in this paper is focusing on trajectories of particles in the irrotational progressive water waves coexisting with uniform current. The parametric equations of particle trajectories over a range of levels in a Lagrangian type of description are developed analytically via the Euler-Lagrange transformation. The Lagrangian wave period of particle motion differing from the Eulerian wave period and the mass transport can also be obtained directly. The third-order solution of particle trajectory exhibits that they do not move in closed orbital motion but represent a net movement that decreases exponentially with the water depth. Uniform current is found to have significant effect on the trajectories and drift velocity of gravity waves. Overall, the influence of increased uniform current is to increase the relative horizontal distance traveled by a particle, as well as the magnitude of the time-averaged drift velocity on the free surface. For adverse current cases, a reverse behavior is found. The obtained third-order solutions satisfy the irrotational condition contrasted to the Gerstner waves and are verified by reducing to those of two-dimensional gravity waves in Lagrangian coordinates.

关键词： wave current Lagrangian Euler- Lagrange transformation particle trajectory

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Long-Term Impact of Extra Sediment on Notches and Incised Meanders in the Hoshe River, Taiwan

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Journal of Mountain Science 2013年第5期10卷 716-723页

作者： Su-Chin chen Chun-hung WU Yi-Chiung CHAO Pei-Yu SHIH Dept. of Soil and Water Conservation National Chung Hsing University Water Resources Engineering and Conservation Feng Chia University

The extra sediment load induced by typhoons and rainstorms in the Heshe River, Taiwan, are the principal reason for severe sediment-related disasters. The total sediment load during Typhoon Morakot in 9009 was 31 x lo6 m3, accounting for 95% of the annual sediment discharge. Large amounts of sediment load entered the Hoshe River, causing the braiding index （BI） to increase. Subsequently, the BI became positively correlated with the channel width in the Hoshe River. The specific typhoon and rainstorm events decreased after Typhoon Morakot, the sediment input decreased, inducing the fluvial morphology of the braided river to develop into a meandering river. The extra sediment load induced the deposition depth to increase and produce a headward deposition in the main channel and its tributaries. In addition, the river bend and the topographical notch restrained the sediment from moving downstream and being stored locally, indirectly increasing the erosion density of the river banks from 2.5 to lo.5 times.

关键词： Extra sediment load River morphology Braiding index

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