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Gastrointestinal discomforts and dietary intake in Chinese urban elders:A cross-sectional study in eight cities of China

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World Journal of Gastroenterology 2019年第45期25卷 6681-6692页

作者： Ai Zhao mei-chen wang Ignatius Man-Yau Szeto Li-Ping Meng Yan wang Ting Li Yu-mei Zhang School of Public Health Peking UniversityBeijing 100191China Yili Innovation Center Inner Mongolia Yili Industrial Group Co.Ltd.Hohhot 010110Inner Mongolia Autonomous RegionChina Inner Mongolia Dairy Technology Research Institute Co. Ltd.Hohhot 010110Inner Mongolia Autonomous RegionChina

BACKGROUND Gastrointestinal(GI)discomforts are common in the elderly population;however,whether such discomforts are associated with dietary intake has not been *** To evaluate GI discomforts in Chinese urban elders and the associated *** The gastrointestinal symptom rating scale(GSRS)was used to identify GI discomforts in 688 elders from eight cities of *** semi-quantitative food frequency questionnaire and one time of 24 h dietary recall were used to access the food intake,identify dietary pattern,and calculate the nutrients *** About 83%of studied elders experienced at least one of GI discomforts in the past 6 mo;dyspepsia was the most commonly reported(66.7%),followed by reflux(44.8%),abdominal pain(35.9%),constipation(35.8%),and diarrhea(34.7%).Female gender,lower education level,and lower family income were associated with a higher GSRS *** who were diagnosed with a GI-related disease had a higher score of constipation,but a lower score of *** diseases were positively associated with certain GI *** dietary patterns were identified by the method of principal component analysis,which were characterized as high intake of salt and tea;more frequent intake of tubers,fruits,aquatic products,and soybeans;and high intake of cereal,vegetables,and meat,***,no associations between dietary patterns and GSRS score were *** elders with a higher GSRS score had significantly lower intake of bean *** elders whose GSRS score was≥21 and 18-20 decreased their bean production intake by 7.2(0.3,14.3)g/d and 14.3(1.2,27.3)g/d,respectively,compared with those who had a GSRS score≤*** were no differences in other food categories,calories,or nutrients intake among elders with different GSRS *** GI discomforts are common in Chinese urban *** discomforts might be associated with the choice of food.

关键词： Gastrointestinal discomforts Nutrition Dietary intake Nutrients Elderly population

Possibility of reaching the predicted center of the“island of stability”via the radioactive beam-induced fusion reactions

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Nuclear Science and Techniques 2024年第9期35卷 186-195页

作者： Ming-Hao Zhang Ying Zou mei-chen wang Gen Zhang Qing-Lin Niu Feng-Shou Zhang The Key Laboratory of Beam Technology of Ministry of Education School of Physics and AstronomyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China School of Physical Science and Technology Guangxi UniversityNanning 530004China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of LanzhouLanzhou 730000China

Based on the dinuclear system model,the synthesis of the predicted double-magic nuclei^(298)Fl and 304120 was investigated via neutron-rich radioactive beam-induced fusion *** reaction^(58)Ca+^(244)Pu is predicted to be favorable for producing^(298)Fl with a maximal ER cross section of 0.301 *** of the entrance channel effect reveal that the^(244)Pu target is more promising for synthesizing^(298)Fl than the neutron-rich targets^(248)Cm and^(249)Bk,because of the influence of the Coulomb *** the synthesis of 304120,the maximal ER cross section of 0.046 fb emerges in the reaction^(58)V+^(249)Bk,indicating the need for further advancements in both experimental facilities and reaction mechanisms.

关键词： Superheavy nuclei Dinuclear system model Fusion reaction Double-magic nucleus Radioactive beam

Deposition of crackless freestanding diamond films on Mo substrates with Zr interlayer

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 246-250页

作者： Zheng Liu cheng-ming Li Liang-xian chen Li-mei wang Li-fu Hei Fan-xiu Lu School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

The Mo substrate with Zr interlayer,namely composite substrate,was employed to solve the problem of crack formation in the freestanding diamond film *** diamond films deposited on the composite substrates by the direct current arc plasma jet chemical vapor deposition（CVD） method were investigated with scanning electron microscopy（SEM）,X-ray photoelectron spectroscopy （XPS）,X-ray diffraction（XRD）,and Raman *** addition,the stress distribution during the large area freestanding diamond film deposition on the composite substrate was analyzed based on the finite element model *** results reveal that Zr interlayer can be easily destroyed during the post-deposition cooling process,which is helpful for stress release and crack avoiding in diamond films.

关键词： chemical vapor deposition diamond film interlayer thermal stress finite element analysis

Scorpion Venom Heat-Resistant Peptide is Neuroprotective against Cerebral Ischemia-Reperfusion Injury in Association with the NMDA-MAPK Pathway

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Neuroscience Bulletin 2020年第3期36卷 243-253页

作者： Xu-Gang wang Dan-Dan Zhu Na Li Yue-Lin Huang Ying-Zi wang Ting Zhang chen-mei wang Bin wang Yan Peng Bi-Ying Ge Shao Li Jie Zhao Liaoning Provincial Key Laboratory of Cerebral Diseases Department of PhysiologyCollege of Basic Medical SciencesDalian Medical UniversityDalian 116044China National-Local Joint Engineering Research Center for DrugResearch and Development of Neurodegenerative Diseases Dalian Medical UniversityDalian 116000China The Second Hospital of Dalian Medical University Dalian 116023China

Scorpion venom heat-resistant peptide(SVHRP)is a component purified from Buthus martensii Karsch scorpion venom. Our previous studies have shown that SVHRP is neuroprotective in models of Alzheimer’s disease and Parkinson’s disease. The present study aimed to explore the potential neuroprotective effects of SVHRP on cerebral ischemia/reperfusion(I/R) injury, using a mouse model of middle cerebral artery occlusion/reperfusion(MCAO/R) and a cellular model of oxygen-glucose deprivation/reoxygenation(OGD/R). Our results showed that SVHRP treatment decreased the neurological deficit scores, edema formation, infarct volume and neuronal loss in the MCAO/R mice, and protected primary neurons against OGD/R insult. SVHRP pretreatment suppressed the alterations in protein levels of N-methyl-D-aspartate receptors(NMDARs) and phosphorylated p38 MAPK as well as some proinflammatory factors in both the animal and cellular models. These results suggest that SVHRP has neuroprotective effects against cerebral I/R injury, which might be associated with inhibition of the NMDA-MAPKmediated excitotoxicity.

关键词： Scorpion venom heat-resistant peptide Cerebral ischemia/reperfusion injury Neuroprotection NMDARs p38 MAPK

Cerebroprotective effect of Huanglian Jiedu decoction on amyloid protein precursor/presenilin-1 double transgenic mice

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Neural Regeneration Research 2011年第9期6卷 645-650页

作者： Xin Qiu Guohua chen Gui mei Yuegu wang Kaixin wang Tao wang Pei Feng Department of Neurology Integrated Traditional Chinese and Western Medicine Hospital Huazhong University of Science and TechnologyWuhan 430022 Hubei Province China

Huanglian Jiedu decoction （HLJDD） has been shown to improve cerebral blood flow, and reduce lipid peroxidation damage to the brain and its energy metabolism. The present study was designed to observe the cerebroprotective effect of *** on an Alzheimer＇s disease rodent model, presenilin-1/amyloid protein precursor double transgenic mice. HLJDD reduced serum interleukin-6 and interleukin-113 levels, decreased [3-amyloid precursor protein gene and senile plaque expression, resisted oxidation, and reduced free radical-induced injury, thereby improving the learning and memory of these mice. Moreover, HLJDD at 433 mg/kg per day exhibited better effects compared with that at 865 or 216 mg/kg per day, and donepezil hydrochloride at 30 mg/kg per day. Thus, these results suggest that HLJDD may have protective effects against Alzheimer＇s disease.

关键词： Huanglian Jiedu decoction amyloidprotein precursorlpresenilin-1 double transgenic mice effect hippocampus neural regeneration

Interaction of methylenetetrahydrofolate reductase C677T,cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population

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World Journal of Gastroenterology 2008年第45期14卷 6986-6992页

作者： Jiang-mei Qin Lei Yang Bo chen Xiu-mei wang Feng Li Pei-Hua Liao Lin He Laboratory of Xinjiang Endemic and Ethnic Diseases School of Medicine Shihezi University Shihezi 832002 Xinjiang Uygur Autonomous Region China

AIM： To evaluate the association and interaction of genetic polymorphisms in methylenetetrahydrofolate reductase （MTHER） and cytochrome P4502E1 （CY- P4502E1）, environment risk factors with esophageal cancer （EC） in Kazakh, a high EC incidence area of Xinjiang Uygur Autonomous Region, China. METHODS： A 1：2 matched case-control study was conducted with 120 cases of EC and 240 populationor hospital-based controls. The controls were matched for sex, nationality, area of residence and age within a 5-year difference. MTHER and CYP4502E1 genotypes were identified by PCR-based restriction fragment length polymorphism （RFLP）. A conditional logistic regression model was established to identify risk factors. The strata method was adopted in interaction analysis. RESULTS： Low consumption of green vegetables and fresh fruits, alcohol drinking, and unsafe water （shallow well, or river） were found to be the risk factors for EC. Individuals with the MTHFR677 （C/T ＋ T/T） genotype had a 2.62-fold （95% CI： 1.61-4.28） risk of developing EC compared with those who carried the C/C genotype. Individuals with the CYP4502EIC1/C1 genotype had a 3.00-fold （95% CI： 1.82-4.96） risk compared with those who carried the CYP4502E1 （C1/C2 ＋ C2/C2） genotype. Gene-environment interaction analysis showed that MTHFR677 gene polymorphism was correlated with consumption of green vegetables and fresh fruit, while CYP4502E1 C1/C1 was correlated with alcohol drinking and unsafe drinking water. MTHFR and CYP4502E1 analysis of gene-gene interaction showed that individuals with the MTHFR677 （C/T ＋ T/T） and CYP4502EIC1/ C1 genotypes had a 7.41-fold （95% CI： 3.60-15.25） risk of developing EC compared with those who carried the MTHFR677C/C and CYP4502E1 RsaI C1/C2 ＋ C2/C2 genes, and the interaction rate was higher than that of the two factors alone. CONCLUSION： Low consumption of green vegetables and fresh fruits, alcohol drinking, and unsafe water （shallow well, or river） and polymorphisms in MTHFR and CYP4502E1

关键词： Kazakh Esophageal Cancer Methylenetet-rahydrofolate reductase C677T Cytochrome P4502E1 Genetic polymorphism Environment risk factors Interaction Case control study

1,3-Dinitro-2-chloro-5-trifluorotoluene and its bridged derivatives Ⅰ.An investigation on the displacement reactions of bidentate nucleophiles towards aromatic rings

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Chinese Journal of Chemistry 1991年第4期9卷 343-350页

作者： JI,Jing-Shun chen,mei-Jin wang,Qi-Wen SHENG,Wei Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai 200032

The reactions of 1,3-dinitro-2-chloro-5-trifluorotoluene(DNCTT)(1)and its bridged com- pounds with bidentate nucleophiles have been *** or secondary diamines and diethylene glycol react with 1 and its bridged derivatives by replacing the substituent grouppara to CF_3, whereas ethanedithiol reacts either by replacing the substituent group para to CF_3 or by displacing both groups and a nitro *** results have been rationalized in terms of electronic effects and nucleophilicity of the nucleophiles.

关键词： An investigation on the displacement reactions of bidentate nucleophiles towards aromatic rings Dinitro-2-chloro-5-trifluorotoluene and its bridged derivatives

Ultrasound assisted electrocatalytic oxidation of 3-chlorophenol in aqueous solution

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Journal of Environmental Science and Engineering 2008年第5期2卷 27-30,54页

作者： ZHU Run-ye chen Xia mei Yu wang Jia-de College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310032 China

Ultrasound assisted electrocatalytic process was used for enhancing decomposition efficiency of organic compounds. In this paper, the effect of ultrasonic frequency, ultrasonic intensity and pH value on 3-chlorophenol decomposition were studied. It was found that 3-chlorophenol in aqueous solution can be markedly decomposed by ultrasound assisted electrocatalytic process. The rate of decomposition increased with the increase of frequency, and low frequency is proper in the ultrasound assisted electrocatalytic system. The removal of 3-chlorophenol increased visibly with the increase of ultrasonic intensity until the intensity of 1.56 W/cm2. Alkaline condition is beneficial to 3-chlorophenol decomposition, the rate at pH 9.08 was higher than pH 2.48 and 6.85. The major intermediate formed during 3-chlorophenol decomposition was 2-chloro-pbenzoquinone, which was readily decomposed by ultrasound assisted electrocatalytic process.

关键词： 3-chlorophenol ultrasound assisted electrocatalysis ultrasonic frequency ultrasonic intensity

Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： Yang-Gang Luo mei Wu Hong-Guang chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy