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Advances in Manufacturing 2019年第2期7卷 133-141页

作者： Yun-Song Lian chen-liang mu Ming Liu Hui-Feng chen Bin Yao Department of Mechanical and Electrical Engineering Xiamen University Xiamen 361102 Fujian People's Republic of China

A structural model of a soft/hard compositecoated textured (SHCCT) tool was proposed and substantiated by a three-dimensional numerical simulation. Its dry turning performance as applied to AISI-1045 steel was analyzed via three-factor five-level orthogonal experiments for different coating parameters, including coating thickness, coating material, and thickness ratio of the soft and hard coatings. In addition, the cutting performance of the proposed SHCCT tool was compared with those of uncoated non-textured, coated non?textured, and uncoated textured tools, and its superiority was proved by the significant reductions in the cutting force, and specifically, the cutting temperature. The optimal results were provided by the SHCCT tool with a WS2/ZrN soft/hard composite coating, a 0.9:0.1 thickness ratio of the above ingredients, and a total coating thickness of 0.5 μm.

关键词： Dry cutting performance Soft/hard composite-coated textured (SHCCT) tool Finite element analysis Coating parameters Cemented carbide

Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： Yun-Chuan Yang Zhi-Tao chen Da-Long Wan Hui Tang mu-Lin Liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

光固化纳米二氧化硅/环氧丙烯酸酯杂化涂料的制备与表征

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电镀与涂饰 2010年第7期29卷 54-58页

作者：李文军陈范才陈良木湖南大学化学生物传感与计量学国家重点实验室化学化工学院

通过在纳米SiO2粒子表面锚固热引发剂，然后在活性稀释单体中对纳米SiO2进行原位接枝聚合改性。将改性纳米SiO2和活性稀释单体的混合物直接与其他原料共混，制备了光固化纳米SiO2／环氧丙烯酸酯（EA）杂化涂料。采用傅立叶变换红外光谱... 详细信息

通过在纳米SiO2粒子表面锚固热引发剂，然后在活性稀释单体中对纳米SiO2进行原位接枝聚合改性。将改性纳米SiO2和活性稀释单体的混合物直接与其他原料共混，制备了光固化纳米SiO2／环氧丙烯酸酯（EA）杂化涂料。采用傅立叶变换红外光谱（FTIR）、扫描电镜（SEM）、热重分析（TG）和涂膜性能试验等对杂化涂料的结构与性能进行了研究。结果表明，聚合物链段通过化学键接枝到了纳米SiO2粒子表面；改性后的纳米SiO2在杂化膜中分散良好；在引入改性纳米SiO2后，涂膜的耐热性、抗冲击性、硬度、附着力等性能得到显著改善。

关键词：紫外光固化涂料纳米二氧化硅原位接枝聚合改性

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基于虚拟节点的传感器网络分布式数据存储

上海交通大学学报 2009年第11期43卷 1693-1697页

作者：陈涛牟亮郭得科陈洪辉罗雪山国防科技大学信息系统与管理学院长沙410073

针对无线传感器网络节点在恶劣环境中容易停止工作的问题,提出了一种基于虚拟节点的分布式数据存储方法.每个传感器节点管理一个真实节点和数个虚拟节点,并发起一个随机行走向其他传感器节点散布数据.真实节点和虚拟节点使用Fountain编... 详细信息

针对无线传感器网络节点在恶劣环境中容易停止工作的问题,提出了一种基于虚拟节点的分布式数据存储方法.每个传感器节点管理一个真实节点和数个虚拟节点,并发起一个随机行走向其他传感器节点散布数据.真实节点和虚拟节点使用Fountain编码对数据进行编码.获取部分编码后的数据,即可恢复全部原始数据.仿真结果表明:该方法具有非常高的解码效率,较低的能量消耗,并且算法对传感器节点的部分损坏具有较好的健壮性.

关键词：无线传感器网络虚拟节点 Fountain编码随机行走

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan Jie chen Jin-Zhong Yu Fei-Peng Xu Fei-Fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang Yong-Ping mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

电沉积镍-钼-钴泡沫合金析氢电极的工艺研究

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电镀与涂饰 2010年第8期29卷 1-3,17页

作者：陈良木陈范才李文军吴道明徐超王子天湖南大学化学化工学院湖南长沙410082

以聚氨酯海绵为基体,通过导电化处理、电沉积Ni–Mo–Co合金以及热分解处理工艺,制备了Ni–Mo–Co泡沫合金。研究了七水合硫酸钴和二水合钼酸钠用量、电流密度、温度等电沉积工艺参数对合金析氢性能的影响。结果表明,在七水合硫酸钴用量... 详细信息

以聚氨酯海绵为基体,通过导电化处理、电沉积Ni–Mo–Co合金以及热分解处理工艺,制备了Ni–Mo–Co泡沫合金。研究了七水合硫酸钴和二水合钼酸钠用量、电流密度、温度等电沉积工艺参数对合金析氢性能的影响。结果表明,在七水合硫酸钴用量为14g/L,二水合钼酸钠用量为10g/L,温度为35°C,电流密度为8A/dm2的条件下制备的泡沫合金有最高的析氢活性,具有很大的比表面积。扫描电镜观察显示,制备的Ni–Mo–Co合金为三维网状结构,合金骨架有大量的微裂纹,表面为均匀致密的球状颗粒。

关键词：镍-钼-钴泡沫合金电沉积析氢过电位比表面积电催化活性

The journey towards physiology and pathology: Tracing the path of neuregulin 4

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Genes & Diseases 2024年第2期11卷 687-700页

作者： Min chen Jieying Zhu Hongyang Luo Wangjing mu liang Guo School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Neuregulin 4 (Nrg4),an epidermal growth factor (EGF) family member,can bind to and activate the ErbB4 receptor tyrosine ***4 has five different isoforms by alternative splicing and performs a wide variety of ***4 is involved in a spectrum of physiological processes including neurobiogenesis,lipid metabolism,glucose metabolism,thermogenesis,and *** pathological processes,Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory *** addition,Nrg4 could ameliorate obesity,insulin resistance,and cardiovascular ***,Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy,improving lipid metabolism,and inhibiting cell death of ***,Nrg4 is closely related to the development of cancer,hyperthyroidism,and some other ***,elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

关键词： Angiogenesis Cardiovascular diseases Inflammation Insulin resistance Lipid and glucose metabolism NAFLD Neurobiogenesis Obesity

Review on non-dipole effects in ionization and harmonic generation of atoms and molecules

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Chinese Physics B 2020年第1期29卷 9-23页

作者： mu-Xue Wang Si-Ge chen Hao liang liang-You Peng State Key Laboratory for Artificial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Nano-optoelectronics Frontier Center of the Ministry of Education and Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Beijing Academy of Quantum Information Sciences Beijing 100193China

In this review,we will focus on recent progress on the investigations of nondipole effects in few-electron atoms and molecules interacting with light *** first briefly survey several popular theoretical methods and relevant concepts in strong field and attosecond physics beyond the dipole *** phenomena stemming from the breakdown of the dipole approximation are then discussed in various topics,including the radiation pressure and photon-momentum transfer,the atomic stabilization,the dynamic interference,and the high-order harmonic *** available,the corresponding experimental observations of these nondipole effects are also introduced respectively in each topics.

关键词： nondipole effects photon-momentum strong field approximation attosecond physics

Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes

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Genes & Diseases 2023年第3期10卷 877-890页

作者： Min chen Jie-Ying Zhu Wang-Jing mu liang Guo School of Kinesiology Shanghai University of SportShanghai 200438China Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Cysteine dioxygenase type 1 (CDO1), belonging to the mammalian non-heme Fe(II) dioxygenases family, is a key enzyme for cysteine catabolism. Its activity and expression is regulated through multiple mechanisms. CDO1 is involved in a spectrum of physiological processes including lipid metabolism, adipogenesis, osteoblastic differentiation, redox homeostasis, fertility, bile acid metabolism, sulfide metabolism, and organismal growth and development. Many of these processes are regulated directly or indirectly by CDO1-mediated metabolism of cysteine. In pathophysiological processes, the degree of CDO1 promoter methylation is closely related to the progression and malignancy of tumors, and overexpression of CDO1 will promote ferroptosis of cancer cells. Moreover, CDO1 may ameliorate metabolic disorders through the taurine-mediated improvement of lipid metabolism and insulin sensitivity and improve neurodegenerative diseases by regulating cysteine level. Therefore, elucidation of the mechanisms underlying the role of CDO1 would provide a clearer view of the therapeutic potential and possible risks of targeting this important enzyme.

关键词： Anti-tumor Antioxidation Cysteine Promoter methylation Taurine