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Refeeding syndrome in Southeastern Taiwan:Our experience with 11 cases

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World Journal of Gastroenterology 2014年第30期20卷 10525-10530页

作者： Li-Ju chen Huan-Lin chen Ming-Jong Bair Chia-hsien Wu I-Tsung Lin Yuan-Kai lee cheng-Hsin Chu Department of Nutrition Mackay Memorial Hospital Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Department of Nursing Meiho University Department of Pharmacy and Graduate Institute of Pharmaceutical Technology Tajen University Department of Nutrition and Gastroenterology Mackay Memorial Hospital Mackay Junior College of Medicine Nursingand Management College

AIM: To present our experience with refeeding syndrome in southeastern Taiwan.

关键词： Refeeding syndrome Nutrition status Cachexia Hypophosphatemia Risk assessment

Outcomes associated with the intention of loco-regional therapy prior to living donor liver transplantation for hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2020年第1期12卷 17-27页

作者： Tsung-Han Wu Yu-Chao Wang Chih-hsien cheng chen-Fang lee Ting-Jung Wu Hong-Shiue Chou Kun-Ming Chan Wei-chen lee Department of General Surgery and Chang Gung Transplantation Institute Chang Gung Memorial Hospital at LinkouChang Gung University College of MedicineTaoyuan 33305Taiwan Department of Organs Transplantation Institute Chang Gung University College of MedicineTaoyun 33305Taiwan

BACKGROUND Loco-regional therapy for hepatocellular carcinoma(HCC) during the period awaiting liver transplantation(LT) appears to be a logical approach to reduce the risk of tumor progression and dropout in the *** donor LT(LDLT)offers a flexible timing for transplantation providing timeframe for well preparation of *** To investigate outcomes in relation to the intention of pre-transplantation locoregional therapy in LDLT for HCC *** A total of 308 consecutive patients undergoing LDLTs for HCC between August2004 and December 2018 were retrospectively *** were grouped according to the intention of loco-regional therapy prior to LT,and outcomes of patients were analyzed and compared between *** Overall,38 patients(12.3%) were detected with HCC recurrence during the follow-up period after *** who were radiologically beyond the University of California at San Francisco criteria and received loco-regional therapy as down-staging therapy had significant inferior outcomes to other groups for both recurrence-free survival(RFS,P < 0.0005) and overall survival(P= 0.046).Moreover,patients with defined profound tumor necrosis(TN) by locoregional therapy had a superior RFS(5-year of 93.8%) as compared with others(P= 0.010).CONCLUSION LDLT features a flexible timely transplantation for patient with ***,the loco-regional therapy prior to LDLT does not seem to provide benefit unless a certain effect in terms of profound TN is noted.

关键词： Hepatocellular carcinoma Loco-regional therapy Living donor liver transplantation Outcomes Tumor necrosis Liver transplantation

Recent progress in the study of transition in the hypersonic boundary layer

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National Science Review 2019年第1期6卷 155-170页

作者： Cunbiao lee Shiyi chen State Key Laboratory for Turbulence and Complex Systems Advanced Aero Engine Collaborative Innovation Center Peking University

Turbulence is a universal form of fluid motion. It is the key issue in fluid mechanics. Very recently, it has become a bottleneck in some key engineering research of national importance, such as aeronautics,astronautics and navigation. Developed turbulence and the onset of turbulence, i.e. transition, are two interrelated parts of turbulence. The hypersonic boundary-layer transition is a strategic focus in the fluid mechanics community. This article reviews recent developments in the study of the hypersonic boundary-layer transition, research facilities and experimental techniques. The hypersonic quiet wind tunnel is introduced as a necessary device to obtain real flight data in near space. Near-wall measurement techniques, such as temperature-sensitive paint, near-wall particle image velocimetry and Rayleigh-scattering visualization, are shown. The most important issues in the recent development of the transition in the hypersonic boundary layer are addressed. The instability and nonlinear interaction of different instability modes are discussed. The recent contributions from China, especially at Peking University, are also introduced.

关键词： hypersonic boundary layer transition quiet wind tunnel

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑Young Kim Yang Li Guozhen Shen Jong‑Chul lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

KinasePhos 3.0:Redesign and Expansion of the Prediction on Kinase-specific Phosphorylation Sites

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 228-241页

作者： Renfei Ma Shangfu Li Wenshuo Li Lantian Yao hsien-Da Huang Tzong-Yi lee Warshel Institute for Computational Biology School of MedicineThe Chinese University of Hong KongShenzhen 518172China School of Life Sciences University of Science and Technology of ChinaHefei 230027China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China School of Life and Health Sciences School of MedicineThe Chinese University of Hong KongShenzhen 518172China

The purpose of this work is to enhance KinasePhos,a machine learning-based kinasespecific phosphorylation site prediction *** verified kinase-specific phosphorylation data were collected from PhosphoSitePlus,UniProtKB,the GPS 5.0,and *** total,41,421 experimentally verified kinase-specific phosphorylation sites were identified.A total of 1380 unique kinases were identified,including 753 with existing classification information from KinBase and the remaining 627 annotated by building a phylogenetic *** on this kinase classification,a total of 771 predictive models were built at the individual,family,and group levels,using at least 15 experimentally verified substrate sites in positive training *** improved models demonstrated their effectiveness compared with other prediction *** example,the prediction of sites phosphorylated by the protein kinase B,casein kinase 2,and protein kinase A families had accuracies of 94.5%,92.5%,and 90.0%,*** average prediction accuracy for all 771 models was 87.2%.For enhancing interpretability,the SHapley Additive exPlanations(SHAP)method was employed to assess feature *** web interface of KinasePhos 3.0 has been redesigned to provide comprehensive annotations of kinase-specific phosphorylation sites on multiple ***,considering the large scale of phosphoproteomic data,a downloadable prediction tool is available at https://***/KinasePhos/*** or https://***/tom-209/KinasePhos-3.0-executable-file.

关键词： Kinase-specific phosphorylation Phosphorylation site prediction Phosphorylation SHAP feature importance Kinase

Endoscopic salvage therapy after failed biliary cannulation using advanced techniques:A concise review

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World Journal of Gastroenterology 2022年第29期28卷 3803-3813页

作者： Yung-Kuan Tsou Kuang-Tse Pan Mu hsien lee cheng-Hui Lin Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalTaoyuan 333Taiwan

Therapeutic endoscopic retrograde cholangiopancreatography(ERCP)begins with successful biliary ***,it is not always be *** failure of the initial ERCP is attributed to two main aspects:the papilla/biliary orifice is endoscopically accessible,or it is *** the papilla/biliary orifice is accessible,bile duct cannulation failure can occur even with advanced cannulation techniques,including double guidewire techniques,transpancreatic sphincterotomy,needle-knife precut papillotomy,or *** is currently no consensus on the next steps of treatment in this ***,this review aims to propose and discuss potential endoscopic options for patients who have failed ERCP due to difficult bile duct *** options include interval ERCP,percutaneous-transhepatic-endoscopic rendezvous procedures(PTE-RV),and endoscopic ultrasound-assisted rendezvous procedures(EUS-RV).The overall success rate for interval ERCP was 76.3%(68%-79% between studies),and the overall adverse event rate was 7.5%(0-15.9% between studies).The overall success rate for PTE-RV was 88.7%(80.4%-100%between studies),and the overall adverse event rate was 13.2%(4.9%-19.2% between studies).For EUS-RV,the overall success rate was 82%-86.1%,and the overall adverse event rate was 13%-15.6%.Because interval ERCP has an acceptably high success rate and lower adverse event rate and does not require additional expertise,facilities,or other specialists,it can be considered the first choice for salvage ***-RV can also be considered if local experts are *** patients in urgent need of biliary drainage,PTE-RV should be considered.

关键词： Difficult biliary cannulation Endoscopic ultrasound Rendezvous Endoscopic retrograde cholangiopancreatography Percutaneous transhepatic biliary drainage Interval

Double balloon endoscopy increases the ERCP success rate in patients with a history of Billroth Ⅱ gastrectomy

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World Journal of Gastroenterology 2010年第36期16卷 4594-4598页

作者： Jui-Hsiang Tang Yung-Kuan Tsou Hao-Tsai cheng Mu-hsien lee Ching-Song lee Nai-Jen Liu Division of Digestive Therapeutic Endoscopy Department of Gastroenterology and HepatologyChang Gung Memorial Hospital College of Medicine Chang Gung University

AIM:To evaluate the effect of double balloon endoscope(DBE)on the endoscopic retrograde cholangio-pancreatography(ERCP)success rate in patients with a history of BillrothⅡ(BⅡ)***:From April 2006 to March 2007,32 patients with a BⅡgastrectomy underwent 34 ERCP *** all cases,the ERCP procedures were started using a *** intubation of the afferent loop or reaching the papilla failed,we changed to DBE for the ERCP procedure(DBE-ERCP).We assessed the success rate of afferent loop intubation,reaching the major papilla,selective cannulation,possibility of therapeutic approaches,procedure-related complications,and the overall success ***:Among the 32 patients with a history of BⅡgastrectomy,the duodenoscope was successfully passed up to the papilla in 22 patients(69%),and cannulation was successfully performed in 20 patients(63%).Six patients(2 with failure in afferent loop intubation and 4 with failure in reaching the papilla)underwent *** DBE reached the papilla in all the 6 patients(100%)and selective cannulation was successful in 5 patients(83%).Four patients(67%)who had common bile duct stones were successfully *** patient underwent diagnostic ERCP only and the other one,in whom selective cannulation failed,was diagnosed with papilla cancer proven by *** were no complications related to the *** overall ERCP success rate increased to 88%(28/32).CONCLUSION:The overall ERCP success rate increases with DBE in patients with a previous BⅡgastrectomy.

关键词： Double balloon endoscopy Endoscopic retrograde cholangiopancreatography BillrothⅡgastrectomy

Fundamental Understanding and Optimization Strategies for Dual‑Ion Batteries:A Review

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Nano-Micro Letters 2023年第8期15卷 205-224页

作者： Chong chen Chun‑Sing lee Yongbing Tang Advanced Energy Storage Technology Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Center of Super‑Diamond and Advanced Film(COSDAF) City University of Hong KongKowloon 999077Hong KongSARPeople’s Republic of China

There has been increasing demand for high-energy density and longcycle life rechargeable batteries to satisfy the ever-growing requirements for nextgeneration energy storage *** all available candidates,dual-ion batteries(DIBs)have drawn tremendous attention in the past few years from both academic and industrial battery communities because of their fascinating advantages of high working voltage,excellent safety,and environmental ***,the dynamic imbalance between the electrodes and the mismatch of traditional electrolyte systems remain *** fully employ the advantages of DIBs,the overall optimization of anode materials,cathode materials,and compatible electrolyte systems is urgently ***,we review the development history and the reaction mechanisms involved in ***,the optimization strategies toward DIB materials and electrolytes are *** addition,their energy-related applications are also ***,the research challenges and possible development directions of DIBs are outlined.

关键词： Dual-ion batteries Reaction mechanisms Optimization strategies Energy storage