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Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis

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World Journal of Gastroenterology 2005年第41期11卷 6512-6517页

作者： Yan Gu chen-fang zhu Hitoshi Iwamoto Ji-Sheng chen Department of General Surgery The Ninth People's Hospital Shanghai Second Medical UniversityShanghai 200011 China Fifth Department of Surgery Tokyo Medical University Tokyo 193-8639 Japan Department of Hepatobiliary Surgery Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 China

AIM： To study the in vitro and in vivo inhibitory effects of genistein on invasive potential of Bel 7402 hepatocellular carcinoma （HCC） cells and to explore the underlying mechanism. METHODS： Bel 7402 HCC cells were exposed to genistein. The invasive activity of tumor cells was assayed in transwell cell culture chamber, p125^FAK expression and cell cycle were evaluated by a functional assay. Cell apoptosis analysis was performed with TUNEL method. In addition, bilateral subrenal capsule xenograft transplantation of HCC was performed in 10 nude mice. Genistein was injected and the invasion of HCC into the renal parenchyma was observed. Nicrovessels with immunohistochemical staining were detected. RESULTS： Genistein significantly inhibited the growth of Bel 7402 cells, the inhibitory rate of tumor cells was 26 -42%. The invasive potential of Bel 7402 cells in vitro was significantly inhibited, the inhibitory rate was 11- 28%. Genistein caused G2/M cell cycle arrest, S phase decreased significantly. The occurrence of apoptosis in genistein group increased significantly. The expression of p125^FAK in 5 μg/mL genistein group （15.26±0.16%） and 10 μg/mL genistein group （12.89±0.36%） was significantly lower than that in the control group （19.75± 1.12%, P〈0.05）. Tumor growth in genistein-treated nude mice was significantly retarded in comparison to control mice, the inhibitory rate of tumor growth was about 20%. Genistein also significantly inhibited the invasion of Bel 7402 cells into the renal parenchyma of nude mice with xenograft transplant. The positive unit value of microvessels in genistein-treated group （10.422 ±0.807） was significantly lower than that in control group （22.330 ± 5.696, P〈 0.01）. CONCLUSION： Genistein can effectively inhibit the invasive potential of Bel 7402 HCC cells by altering cell cycle, apoptosis and angiogenesis, inhibition of focal adhesion kinase may play a significant role in this process.

关键词： Genistein Human hepatocellular carcinoma Invasion Cell cycle Apoptosis Angiogenesis

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Sagliker syndrome: A case report of a rare manifestation of uncontrolled secondary hyperparathyroidism in chronic renal failure

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World Journal of Clinical Cases 2019年第22期7卷 3792-3799页

作者： Yu Yu chen-fang zhu Xiao Fu Hua Xu Department of General Surgery Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Discipline Construction Research Center of China Hospital Development Institute Shanghai Jiao Tong University

BACKGROUND Sagliker syndrome(SS)resulting from uncontrolled secondary hyperparathyroidism(SHPT)in chronic renal failure(CRF)is seldom *** SUMMARY A 24-year-old woman presented with asymmetric facial deformity and stature *** was diagnosed with SS,SHPT,CRF,and thyroid *** patient underwent a total parathyroidectomy and thyroidectomy with central lymph node *** patient’s condition was stable and was discharged from the *** Undergoing dialysis vintage,presenting high serum phosphate levels,and female gender may be risk factors for *** ossification in the craniomaxillofacial region is possibly activated in this special pathophysiological ***’s more,the choice of surgery mainly depends on the treatment goal and the experience of the individual surgeon.

关键词： Sagliker syndrome Secondary hyperparathyroidism Chronic renal failure Uremic leontiasis ossea Case report

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Papillary thyroid carcinoma occurring with undifferentiated pleomorphic sarcoma: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8336-8343页

作者： Yu-Li Lee Ya-Qiong cheng chen-fang zhu Hai-Zhong Huo Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineDiscipline Construction Research Center of China Hospital Development InstituteShanghai Jiao Tong UniversityShanghai 200011China

BACKGROUND Papillary thyroid cancer(PTC)is the most common malignant tumor of the ***,the coexistence of PTC and sarcoma in one patient is *** this article,we report the case of a patient who presented with both PTC and undifferentiated pleomorphic sarcoma(UPS),which has not been previously reported in the online Medline database(PubMed).CASE SUMMARY A 71-year-old man was admitted to our hospital for a mass on the right side of his neck for one month,which rapidly enlarged within 2 wk with distending *** patient was diagnosed with a thyroid malignancy by fine-needle aspiration and underwent total thyroidectomy and bilateral central lymph node *** and immunohistochemistry revealed features of both PTC and *** thyroid cancer 8 gene detection kit results showed BRAF and telomerase reverse transcriptase *** disease progressed rapidly,and the patient died four months after surgery from extensive lung *** Our report highlights the patient’s pathological characteristics and related genetic *** to the rapid development and poor prognosis of cooccurring PTC and sarcoma,it is important for clinical physicians and pathologists to raise awareness of this type of tumor.

关键词： Thyroid tumor Papillary thyroid carcinoma Undifferentiated pleomorphic sarcoma BRAF TERT Case report

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Multiple synchronous anorectal melanomas with different colors: A case report

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World Journal of Clinical Cases 2019年第11期7卷 1337-1343页

作者： Yan-Tao Cai Li-chen Cao chen-fang zhu Feng Zhao Bao-Xing Tian Shan-Yu Guo Department of General Surgery Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

BACKGROUND Anorectal melanoma (AM) is an extremely rare malignant tumor originating from anorectal melanocytes with a poor prognosis. AM has been reported to have a much lower incidence than cutaneous or choroid melanoma, accounting for 0.4%-1.6% of all melanomas. CASE SUMMARY We report a 76-year-old female patient diagnosed with anorectal malignant melanoma by colonoscopy and biopsy. Intraoperative examination revealed two distinct anorectal tumors, one melanotic and another amelanotic, as well as two pigmented mucosal zones at the dentate line level. Abdominal perineal resection was performed. A pathological report confirmed all four lesions to be melanomas. Postoperatively, we followed an immunotherapy protocol targeting PD-1 (nivolumab). The patient had 24 mo of disease-free follow-up upon completion of nivolumab treatment. CONCLUSION This is the first reported case presenting coexistence of pigmented and unpigmented AMs in the same patient.

关键词： Anorectal melanoma Melanotic Amelanotic Synchronous Case report

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Residual tumor and central lymph node metastasis after thermal ablation of papillary thyroid carcinoma: A case report and review of literature

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World Journal of Clinical Cases 2021年第1期9卷 252-261页

作者： Yu Hua Jia-Wen Yang Liu He Hua Xu Hai-Zhong Huo chen-fang zhu Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineDiscipline Construction Research Center of China Hospital Development InstituteShanghai Jiao Tong UniversityShanghai 200011China

BACKGROUND Debate exists regarding the use of thermal ablation(TA)to treat papillary thyroid carcinoma(PTC).Some studies have recommended TA as a new,efcient and safe technology for *** this article,we report one case of a residual tumor and central lymph node metastasis(CLNM)after TA for *** SUMMARY A 63-year-old female underwent bilateral ultrasound(US)-guided radiofrequency ablation for *** months later,she was diagnosed as thyroid cancer with suspected CLNM by US and contrast-enhanced computed *** subsequent fine-needle aspiration(FNA)biopsies were *** to her strong personal preference,she underwent total thyroidectomy and central lymph node *** tissue adhesion and a difficult dissection were noted during the *** pathology of the frozen sections during the operation was still *** final pathology results of paraffin-embedded sections revealed residual tumor cells at the edge of the PTC and *** TA may lead to a residual tumor in patients with ***-up using US and FNA biopsy may not be adequate to evaluate the residual *** should be carefully considered in PTC treatment.

关键词： Papillary thyroid carcinoma Thermal ablation Residual tumor Central lymph node metastasis Follow-up Case report

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Treatment of leiomyomatosis peritonealis disseminata with goserelin acetate: A case report and review of the literature

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World Journal of Clinical Cases 2021年第19期9卷 5217-5225页

作者： Jia-Wen Yang Yu Hua Hua Xu Liu He Hai-Zhong Huo chen-fang zhu Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineDiscipline Construction Research Center of China Hospital Development InstituteShanghai Jiao Tong UniversityShanghai 200011China

BACKGROUND Leiomyomatosis peritonealis disseminata(LPD)is a rare condition characterized by multiple pelvic and abdominal nodules,which are composed of smoothmuscle *** date,no more than 200 cases have been *** diagnosis of LPD is difficult and there are no guidelines on the treatment of ***,surgical excision is the ***,hormone blockade therapy can be an alternative *** SUMMARY A 33-year-old female patient with abdominal discomfort and palpable abdominal masses was admitted to our *** had undergone four surgeries related to uterine leiomyoma in the past 8 *** tomography revealed multiple nodules scattered within the abdominal wall and peritoneal *** symptoms and the result of the core-needle biopsy were consistent with *** patient refused surgery and was then treated with tamoxifen,ulipristal acetate(a selective progesterone receptor modulator),and goserelin acetate(a gonadotropin-releasing hormone agonist).Both tamoxifen and ulipristal acetate were not effective in controlling the disease ***,the patient achieved an excellent response when goserelin acetate was attempted with relieved syndromes and obvious shrinkage of *** largest nodule showed a 25%decrease in the sum of the longest diameters from pretreatment to *** to now,2 years have elapsed and the patient remains asymptomatic and there is no development of further *** Goserelin acetate is effective for the management of *** long-term use of goserelin acetate is thought to be safe and *** blockade therapy can replace repeated surgical excision in recurrent patients.

关键词： Goserelin acetate Leiomyomatosis peritonealis disseminata Hormone blockade therapy Conservative treatment Disseminated peritoneal leiomyomatosis Case report

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Nitrogen addition promotes soil carbon accumulation globally

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Science China Life Sciences 2025年第1期68卷 284-293页

作者： Xuemei Yang Suhui Ma Erhan Huang Danhua Zhang Guoping chen Jiangling zhu chengjun Ji Biao zhu Lingli Liu Jingyun fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

关键词： meta-analysis nitrogen enrichment soil organic carbon carbon accumulation carbon stability

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun fang chengyihan Gu Yinghan chen Wencheng Yan Yong Liang Weipeng Li chengjian zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang Wang Yasu chen Jie Li chen zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

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Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

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Science China(Information Sciences) 2025年第1期68卷 219-237页

作者： Xia JIANG Yanyan fang Xianlin ZENG Jian SUN Jie chen National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

关键词： proximal operator random reshuffling inexact computation compressed sensing nonsmooth optimization

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