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Paricalcitol in hemodialysis patients with secondary hyperparathyroidism and its potential benefits

World Journal of Clinical Cases 2021年第33期9卷 10172-10179页

作者： Xiu chen Feng Zhao wei-Juan Pan Jia-Mei di wei-Nan Xie Ling Yuan Zhi Liu Department of Nephrology The First Affiliated Hospital of Anhui University of Science and Technology(The First People’s Hospital of Huainan)Huainan 232007Anhui ProvinceChina

BACKGROUND Secondary hyperparathyroidism(SHPT)is a common complication in patients with end-stage renal disease and it is also common in hemodialysis *** can increase bone fragility and calcification of blood vessels and soft tissues,which greatly increases the risk of *** To discuss the outcome,safety and other potential benefits of paricalcitol injection in hemodialysis patients with *** We recruited 40 patients who received hemodialysis at our hospital for chronic renal failure with SHPT between March and December *** received paricalcitol injection for 24 wk(starting dose,0.06–0.08μg/kg),three times per *** were followed up at the baseline(week 0),week 4,week 12 and week *** primary outcome indicator was the percentage of patients with a>30%decrease in intact parathyroid hormone(iPTH)levels at week 24 compared with the *** secondary outcome indicators included percentage decrease in iPTH levels at week 24,standard-reaching rate of iPTH(percentage of patients with iPTH down to 130–585 pg/mL),changes in serum levels of calcium(Ca),phosphate(P),Ca×P product,alkaline phosphatase(ALP),creatinine(Cre),hemoglobin(Hb),and C-reactive protein(CRP),and incidence of adverse events(AEs).RESULTS After 24 wk of treatment,iPTH levels decreased significantly(598.88±381.29 pg/mL vs 888.84±376.88 pg/mL,Pdifferences in the serum levels of calcium,Hb,Cre and CRP compared with the baseline(P>0.05).After 24 wk of treatment,serum P levels decreased compared with the baseline(1.91±0.40 mmol/L vs 2.16±0.66 mmol/L)(t=2.830,P<0.05).Ca×P product decreased significantly compared with the baseline(56.38±13.22 mg2/dL

关键词： Paricalcitol Hemodialysis Secondary hyperparathyroidism Drug efficacy Drug safety

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All-optical logic gates based on hierarchical photonic crystal modulated photoluminescence of perovskite nanocrystals

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Science China(Technological Sciences) 2023年第9期66卷 2735-2742页

作者： WANG Yun ZHA YanFang YANG YunYi LIU CiHui di YunSong CAO GuiYuan wei ShiBiao chen ZhiHui GAN ZhiXing Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationSchool of Artificial IntelligenceNanjing Normal UniversityNanjing 210023China Centre for Translational Atomaterials School of ScienceSwinburne University of TechnologyHawthorn VIC 3122Australia Nanophotonics Research Center Shenzhen Key Laboratory of Micro-Scale Optical Information TechnologyShenzhen UniversityShenzhen 518060China Key Laboratory of Advanced Transducers and Intelligent Control Systems Ministry of Education and Shanxi ProvinceCollege of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Halide perovskites exhibit high performance in all sorts of optoelectronic and photonic areas, suggesting their huge potential in integrated photonic devices. However, until now, all optical logic gates based on perovskites are still rarely explored, hindering the development of all-optical networks and computing. Herein, a new concept of all-optical logic gates is proposed based on the modulation of photoluminescence(PL) from perovskite nanocrystals(PNCs). A hierarchical photonic crystal(Hie PhC) is developed by self-assembling polystyrene(PS) and SiO2nanoparticles, which exhibit a higher PL enhancement than that of a monolayer PhC. Moreover, the light-controlled PL is realized by taking advantage of the high thermal response of the PL from PNCs/Hie PhC on polyethylene(PE) substrate, assisted by a graphene layer for light-heat conversion. Consequently, optical diode and triode are achieved based on the modulated PL, which exhibit contrast ratios(CR) of 24.7 and 74.0 dB, ***-optical logic gates, including “AND”, “OR” and “NOT”, are realized based on the optical diode and triode.

关键词： perovskite nanocrystals photonic crystals all-optical logic gates modulation of photoluminescence

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Fiber-based quantum secure direct communication without active polarization compensation

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Science China(Physics,Mechanics & Astronomy) 2022年第12期65卷 91-96页

作者： Xin Liu di Luo Guangshen Lin Zihao chen Chunfeng Huang Shizhuo Li chengxian Zhang Zhenrong Zhang Kejin wei Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning530004China Guangxi Key Laboratory of Multimedia Communications and Network Technology School of ComputerElectronicsand InformationGuangxi UniversityNanning530004China

Quantum secure direct communication(QSDC)that allows people to directly transmit confidential information through insecure channels is an important branch of quantum *** widespread adoption of the QSDC demands the development of simple and stable ***,most of the existent QSDC systems involve a complex self-alignment process at the initial stage and additional hardware to compensate environmental *** this study,we present a fiber-based QSDC system without active polarization *** system comprises a stable transmitter and a novel Sagnac-Mach-Zehnder interferometer for security *** robust system simplifies the self-alignment and is immune to environmental *** robustness of the system was theoretically and experimentally verified,and low bit error rates in a 12 min continuous operation with an active polarization scrambler were *** addition,we performed a proof-of-principle QSDC demonstration,and a secrecy capacity of 3.43 kbps over a 5 km fiber with a detection bit error rate of 0.85%±0.07%and a quantum bit error rate of 0.42%±0.05%were *** results confirm the viability of the proposed QSDC system for practical applications.

关键词： quantum secure direct communication Sagnac-Mach-Zehnder interferometer without active polarization compensation

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The effect of increased intra-abdominal pressure on orbital subarachnoid space width and intraocular pressure

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Neural Regeneration Research 2018年第2期13卷 353-359页

作者： Su-meng Liu Ning-li Wang Zhen-tao Zuo wei-wei chen di-ya Yang Zhen Li Yi-wen Cao Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Department of Neurology Xuanwu Hospital Capital Medical University

In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can re- lieve glaucomatous optic neuropathy. Increased intracranial pressure can also reduce optic nerve damage in glaucoma patients, and a safe, effective and noninvasive way to achieve this is by increasing the intra-abdominal pressure. The purpose of this study was to observe the changes in orbital subarachnoid space width and intraocular pressure at elevated intra-abdominal pressure. An inflatable abdominal belt was tied to each of 15 healthy volunteers, aged 22-30 years （12 females and 3 males）, at the navel level, without applying pressure to the abdomen, before they laid in the magnetic resonance imaging machine. The baseline orbital subarachnoid space width around the optic nerve was measured by magnetic resonance imaging at 1, 3, 9, and 15 mm behind the globe. The abdominal belt was inflated to increase the pressure to 40 mmHg （1 mmHg = 0.133 kPa）, then the orbital subarachnoid space width was measured every 10 minutes for 2 hours. After removal of the pressure, the measurement was repeated 10 and 20 minutes later. In a separate trial, the intraocular pressure was measured for all the subjects at the same time points, before, during and after elevated intra-abdominal pressure. Results showed that the baseline mean orbital subarachnoid space width was 0.88 ＋ 0.1 mm （range： 0.77-1.05 mm）, 0.77 ＋ 0.11 mm （range： 0.60-0.94 mm）, 0.70 ＋ 0.08 mm （range： 0.62-0.80 ram）, and 0.68 _＋ 0.08 mm （range： 0.57-0.77 mm） at 1, 3, 9, and 15 mm behind the globe, respectively. During the elevated intra-abdominal pressure, the orbital subarachnoid space width increased from the baseline and dilation of the optic nerve sheath was significant at 1, 3 and 9 mm behind the globe. After decompression of the abdominal pressure, the orbital subarachnoid space width normalized and returned to the baseline value. There was no significant difference in the intra

关键词： nerve regeneration intraocular pressure intra-abdominal pressure intracranial pressure trans-lamina cribrosa pressure difference orbital subarachnoid space width magnetic resonance imaging optic nerve sheath glaucoma cerebrospinal fluid pressure subarachnoid space neural regeneration

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Ultrafine particle emission characteristics of diesel engine by on-board and test bench measurement

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Journal of Environmental Sciences 2012年第11期24卷 1972-1978页

作者： cheng Huang diming Lou Zhiyuan Hu Piqiang Tai di Yao wei Hu Peng Li Jin Ren Changhong chen School of Automobile Studies Tongji UniversityShanghai 201804China Shanghai Academy of Environmental Sciences Shanghai 200233China

This study investigated the emission characteristics of *** particles based on test bench and on-board measurements. The bench test results showed the ultrafine particle number concentration of the diesel engine to be in the range of （0.56-8.35）×10^8 cm^-3. The on-board measurement results illustrated that the ultra_fine particles were strongly correlated with changes in real-world driving cycles. The particle number concentration was down to 2.0 ×10^6 cm^-3 and 2.7 ×10^7 cm^-3 under decelerating and idling operations and as high as 5.0×10^8 cm^-3 under accelerating operation. It was also indicated that the particle number measured by the two methods increased with the growth of engine load at each engine speed in both cases. The particle number presented a ＂U＂ shaped distribution with changing speed at high engine load conditions, which implies that the particle number will reach its lowest level at medium engine speeds. The particle sizes of both measurements showed single mode distributions. The peak of particle size was located at about 50-80 nm in the accumulation mode particle range. Nucleation mode particles will significantly increase at low engine load operations like idling and decelerating caused by the high concentration of unburned organic compounds.

关键词： ultrafine particle emission emission factor diesel engine on-board emission measurement TSI EEPS

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Unlocking the electrocatalytic activity of natural chalcopyrite using mechanochemistry

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Journal of Energy Chemistry 2022年第5期31卷 275-283页

作者： Zhijie chen Renji Zheng Wenfei wei wei wei Bing-Jie Ni Hong chen Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyNSW 2007Australia State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials(SKLISEM)School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055GuangdongChina

Manipulating the structure self-reconstruction of transition metal sulfide-based(pre)catalysts during the oxygen evolution reaction(OER) process is of great interest for developing cost-effective OER catalysts,which remains a central challenge. Here we realize a deep structure self-reconstruction of natural chalcopyrite to unlock its OER performance via mechanochemical activation. Compared with the manually milled counterpart(CuFeS_(2)-HM), the mechanically milled catalyst(CuFeS_(2)-BM) with a reduced crystallinity exhibits a 7.11 times higher OER activity at 1.53 V vs. RHE. In addition, the CuFeS_(2)-BM requires a low overpotential of 243 mV for generating 10 mA cm^(-2) and exhibits good stability over 24 h. Further investigations suggest that the excellent OER performance of CuFeS_(2)-BM mainly originates from the decreased crystallinity induced the in situ deep structure self-reconstruction of the originally sulfides into the electroactive and stable metal(oxy)hydroxide phase(e.g., a-Fe OOH) via S etching under OER conditions. This study demonstrates that regulating the crystallinity of catalysts is a promising design strategy for developing highly efficient OER catalysts via managing the structure self-reconstruction process, which can be further extended to the design of efficient catalysts for other advanced energy conversion devices. In addition, this study unveils the great potentials of engineering abundant natural minerals as cost-effective catalysts for diverse applications.

关键词： Mechanochemistry Crystallinity Oxygen evolution reaction Self-reconstruction Mineral electrocatalysts

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Dynamics of Bt cotton Cry1Ac protein content under an alternating high temperature regime and effects on nitrogen metabolism

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Journal of Integrative Agriculture 2018年第9期17卷 1991-1998页

作者： ZHANG Xiang RUI Qiu-zhi LIANG Pan-pan wei chen-hua DENG Guo-qiang chen Yuan DONG Zhao-di chen De-hua Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Yangzhou UniversityYangzhou 225009P.R.China Plant Genome Mapping Laboratory University of GeorgiaAthens 30605USA

This study was conducted to investigate the effects of alternating high temperature on CrylAc protein content on Bt cotton cultivars Sikang 1 （SK-1, a conventional cultivar） and Sikang 3 （SK-3, a hybrid cultivar）. In 2011 and 2012, cotton plants were subjected to high temperature treatments ranging from 32 to 40℃ in climate chambers to investigate the effects of high temperature on boll shell insecticidal protein expression. The experiments showed that significant decline of the boll shell insecticidal protein was detected at temperatures higher than 38℃ after 24 h. Based on the results, the cotton plants were treated with the threshold temperature of 38℃ from 6：00 a.m. to 6：00 p.m. followed by a normal temperature of 27℃ during the remaining night hours （DH/NN） in 2012 and 2013. These treatments were conducted at peak boll growth stage for both cultivars in study periods of 0, 4, 7, and 10 d. Temperature treatment of 32℃ from 6：00 a.m. to 6：00 p.m. and 27℃ in the remaining hours was set as control. The results showed that, compared with the control, after the DH/NN stress treatment applied for 7 d, the boll shell CrylAc protein content level was significantly decreased by 19.1 and 17.5% for SK-1 and by 15.3 and 13.7% for SK-3 in 2012 and 2013, respectively. Further analysis of nitrogen metabolic physiology under DH/NN showed that the soluble protein content and the glutamic pyruvic transaminase （GPT） activities decreased slightly after 4 d, and then decreased sharply after 7 d. The free amino acid content and the protease content increased sharply after 7 d. The changes in SK-1 were greater than those in SK-3. These results suggest that under DH/NN stress, boll shell CrylAc protein content decline was delayed. Reduced protein synthesis and increased protein degradation in the boll shell decreased protein content, including Bt protein, which may reduce resistance to the cotton bollworm.

关键词： Bt cotton alternating temperature CrylAc protein nitrogen metabolism

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Defective Ni_(3)S_(2)nanowires as highly active electrocatalysts for ethanol oxidative upgrading

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Nano Research 2022年第4期15卷 2987-2993页

作者： Yufeng Zhang wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue di Liu Rui Sui Qingqing Lv Xuerui Liu Yongsheng Wang wei chen Zhongbin Zhuang State Key Lab of Organic-Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Beijing Key Laboratory of Energy Environmental Catalysis Beijing University of Chemical TechnologyBeijing 100029China

Electrochemical upgrading of biomass ethanol to value-added chemicals is promising for sustainable ***,we synthesize defective Ni_(3)S_(2) nanowires(NWs),which show high activity towards electrochemical oxidation of ethanol to *** Ni_(3)S_(2) NWs are formed by the oriented attachment mechanism,and rich defects are introduced during the growth.A low onset potential of 1.31 V and high mass activity of 8,716 mA·mgNi^(-1) at 1.5 V are achieved using the synthesized Ni_(3)S_(2) NWs toward the ethanol electro-oxidation,which are better than the Ni(OH)2 NWs and the Ni_(3)S_(2) nanoparticles(NPs).And the selectivity for the acetate generation is ca.99%.The high activity of Ni_(3)S_(2) NWs is attributed to the easier oxidation of Ni(II)to the catalytically active Ni(III)species with the promotion from S component and rich *** results demonstrate that the defective NWs can be synthesized by the oriented attachment method and the defective Ni_(3)S_(2) NWs structure as the efficient nonnoble metal electrocatalysts for oxidative upgrading of ethanol.

关键词： nickel sulfide electrocatalyst ethanol oxidation defects oriented attachment

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Morinda citrifolia(Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor-κB Signaling Pathway

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Chinese Journal of Integrative Medicine 2021年第9期27卷 688-695页

作者： MA Ling-di LIN Gui-bin YANG Lu-bo CAO Jia-lin WANG Jian chen Qiong-di LI wei-qiang ZHONG Wang-jing Laboratory Center the Third People's Hospital of HuizhouAffiliated Hospital of Guangzhou Medical UniversityHuizhouGuangdong Province(516002)China Clinical Laboratory the Third People's Hospital of HuizhouAffiliated Hospital of Guangzhou Medical UniversityHuizhouGuangdong Province(516002)China

Objective:To study the mechanism of the anti-tumor effect of Morinda citrifolia(noni).Methods:The influences of noni juice on cell proliferation,apoptosis,invasion,migration and the activity of AKT/nuclear factor-κB(NF-κB)signaling pathway in A549 human lung cancer cells were detected by MTT,cell counting kit-8,colony formation,Annexin V/PI double labeling,transwel,scratch test and immunoblotting assay,respectively.A549 cells were inoculated into the right axilla of nude mice,followed by noni juice *** body weight of the nude mice was weighed,and the tumor volume and weight were *** proliferation and expression of apoptosis-related proteins were measured by immunohistochemistry,and the activity of NF-κB signaling pathway was measured by ***:The in vitro studies showed that noni juice inhibited the A549 cel s proliferation,migration and *** juice also promoted cel s apoptosis in A549 cel *** assay showed that the phosphorylation level of AKT,p50,and STAT3 proteins was inhibited to different extents after noni juice *** in vivo studies showed that noni juice effectively suppressed tumor formation of A549 cells in nude *** juice treatment inhibited the expression of Ki67,PCNA,and Bcl-2 protein in the tumor;while promoted the expression of caspase-3 ***,we also found that noni juice treatment could restrain the activity of AKT/NF-κB signaling pathway in the tumor ***:Noni juice inhibited the proliferation of A549 lung cancer cells,induced apoptosis,and inhibited cel invasion and migration via regulating AKT/NF-κB signaling pathway.

关键词： Morinda citrifolia noni juice Chinese medicine lung cancer cell AKT/NF-κB signaling pathway

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Research progress of catalysts for direct coal liquefaction

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Journal of Energy Chemistry 2025年第1期 481-497页

作者： wei Song Penggao Liu Xinyue chen Ting Wang Chunrong He Rui Hao Kaiyu Liu State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of Chemistry Xinjiang University College of Chemistry and Chemical Engineering Henan Polytechnic University Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical Engineering Central South University

Coal direct liquefaction technology is a crucial contemporary coal chemical technology for efficient and clean use of coal resources. The development of direct coal liquefaction technology and the promotion of alternative energy sources are important measures to guarantee energy security and economic security. However, several challenges need to be addressed, including low conversion rate, inadequate oil yield, significant coking, demanding reaction conditions, and high energy consumption. Extensive research has been conducted on these issues, but further exploration is required in certain aspects such as pyrolysis of macromolecules during the liquefaction process, hydrogen activation, catalysts' performance and stability, solvent hydrogenation, as well as interactions between free radicals to understand their mechanisms better. This paper presents a comprehensive analysis of the design strategy for efficient catalysts in coal liquefaction, encompassing the mechanism of coal liquefaction, catalyst construction,and enhancement of catalytic conversion efficiency. It serves as a comprehensive guide for further research endeavors. Firstly, it systematically summarizes the conversion mechanism of direct coal liquefaction, provides detailed descriptions of various catalyst design strategies, and especially outlines the catalytic mechanism. Furthermore, it addresses the challenges and prospects associated with constructing efficient catalysts for direct coal liquefaction based on an understanding of their action mechanisms.

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