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The pathogenic mechanism of syndactyly type V identified in aHoxd13Q50R knock-in mice

Bone Research 2024年第2期12卷 349-360页

作者： Han Wang xiumin chen Xiaolu Meng Yixuan Cao Shirui Han Keqiang Liu Ximeng Zhao Xiuli Zhao Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13Q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13Q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD13Q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

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Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China

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Journal of Traditional Chinese Medicine 2019年第2期39卷 275-280页

作者： Yuan Jun Xu Qianlei chen xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun Department of AIDS Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this ***: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression ***: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART.

关键词： Acquired immunodeficiency syndrome Chemical and drug induced liver injury Prevalence Antiretroviral therapy,highly active Medicine,Chinese traditional

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Survival rate:an indicator of the management of acquired immune deficiency syndrome using Traditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2015年第4期35卷 473-477页

作者： Liu Zhibin Meng Changhai Yang Jiping chen xiumin Jin Yantao Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Cellular Immunology Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province Department of Internal Chinese Medicine the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

Complementary and alternative medicine,including Traditional Chinese Medicine(TCM),has been used as therapy against acquired immune deficiency syndrome(AIDS) for almost 30 years. Based on evaluation indicators for AIDS treatment using TCM,we discuss why the survival rate(which has been used widely in Western Medicine) should be adopted as a new important indicator of TCM treatment for AIDS. We advise that further prospective or retrospective cohort studies should be carried out to confirm this hypothesis.

关键词： Acquired immunodeficiency syn-drome Survival rate Antiretroviral therapy highly active Medicine Chinese traditional

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Asymptomatic stage of human immunodeficiency virus infection is the optimal timing for its management with Traditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2015年第2期35卷 244-248页

作者： chen xiumin Yuan Qingting Liu Zhibin Yang Jiping Xu Liran Guo Huijun Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Academic Degrees & Graduate Education Henan University of Traditional Chinese Medicine Department of Cellular and Molecular Immunology Lab Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province

Acquired immune deficiency syndrome(AIDS) is a worldwide public health problem and an incurable *** roles of Traditional Chinese Medicine(TCM) on AIDS had been recognized and accepted by more and more *** a relatively long period,to initiate combination antiretroviral therapy(cART) for the asymptomatic human immunodeficiency virus(HIV) infection patient is not *** to TCM theory,not only the imbalance of Yin and Yang but also the disharmony of internal body function and external natural environment had occurred in the body of the patient,the imbalance and the disharmony should be adjusted by the means of the treatment based on the patters identified among the symptoms in terms of *** aimed to analyze the feature of patients with asymptomatic infection,and compare the advantages and disadvantages of the usage of cART for asymptomatic infection,explored the possible mechanism underlying TCM treatment of the asymptomatic infection,by reviewing the TCM treatment progress on asymptomatic HIV infection.

关键词： Acquired immunodeficiency syndrome Medicine Chinese traditional Antiretroviral therapy highly active Asymptomatic infections

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Effectiveness and safety of tripterygium glycosides tablet(雷公藤多苷片)for lupus nephritis:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2022年第5期42卷 671-680页

作者： ZHOU Yingyan LIANG Huasheng YAN Jingyao HE Xiaohong PAN Lili LI Xue chen Xianghong chen xiumin YANG Aicheng HUANG Qingchun Department of Rheumatology the Second Affiliated HospitalGuangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510006China Department of Nephrology Jiangmen Hospital of Chinese Medicine Affiliated to Jinan UniversityJiangmen 529000China

OBJECTIVE:To investigate the effectiveness and safety of tripterygium glycosides(TG)tablet(雷公藤多苷片)for the treatment of Lupus nephritis(LN).METHODS:Several databases were systematically searched including Pub Med,Embase,Cochrane,Wiley,China National Knowledge Infrastructure Database,Sino Med and Wanfang Library till June 20,***5.3 was utilized to analyze the data according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses ***:In total,8 randomized controlled trials involving 583 participants were ***-analyses showed that,compared with glucocorticoids(GC)alone,the combination with TG tablet provided a statistically significant improvement in total remission(TR)(RR=1.27,95%CI:1.08–1.50,P=0.004),complete remission(CR)(RR=1.61,95%CI:1.05–2.47,P=0.03)and C3 levels(WMD=0.27,95%CI:0.14–0.39,P<0.0001),C4 levels(WMD=0.12,95%CI:0.07–0.17,P<0.00001).No significant differences were seen in TR,CR,proteinuria,serum creatinine,C3 and C4(TR:RR=1.00,95%CI:0.87–1.16,P=0.95;CR:RR=1.10,95%CI:0.78–1.56,P=0.58;proteinuria levels:WMD=-0.06,95%CI:-0.13 to 0.01,P=0.10;serum creatinine levels:WMD=-0.01,95%CI:-7.36 to 7.35,P=1.00;C3 levels:WMD=0.01,95%CI:-0.06 to 0.07,P=0.84;C4 levels:WMD=-0.01,95%CI:-0.03 to 0.01,P=0.49)between azathioprine(AZA)/leflomit(LEF)+GC and TG tablet+*** events(hepatic dysfunction,nausea,vomitting)showed no statistical differences between the TG tablet+GC group and the GC *** were more new onset of irregular menstruation in the TG tablet+GC group than those in the AZA+GC(RR=3.57,95%CI:1.40–9.11,P=0.008)/LEF+GC(RR=6.69,95%CI:2.42-18.46,P=0.0002)group,but leucopenia lower than those in AZA+GC group(RR=0.38,95%CI:0.17-0.85,P=0.02)and alopecia(RR=0.14,95%CI:0.03-0.77,P=0.02)and rash(RR=0.09,95%CI:0.01-0.69,P=0.02)lower than those in LEF+GC ***:This review indicates that TG tablet maybe effective in LN ***,adverse events cannot be *** sample,multi-center,hig

关键词： tripterygium glycosides lupus nephritis treatment outcome safety systematic review Meta-analysis

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央视频《Young在春晚》:打造全民“闹新春”融媒体大联欢

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电视研究 2022年第6期 45-47页

作者：陈秀敏国家广播电视总局发展研究中心战略所

中央广播电视总台央视频深度探索媒体融合新模式,2022年除夕融媒体直播节目《Young在春晚》以年轻态、综艺感和强互动、沉浸式陪伴的方式解锁过年新姿势。本文认为,《Young在春晚》以更具“网感”的内容,实现了网络文化和综艺晚会的融... 详细信息

中央广播电视总台央视频深度探索媒体融合新模式,2022年除夕融媒体直播节目《Young在春晚》以年轻态、综艺感和强互动、沉浸式陪伴的方式解锁过年新姿势。本文认为,《Young在春晚》以更具“网感”的内容,实现了网络文化和综艺晚会的融合创新,打造了全民“闹新春”的融媒体大联欢,重塑了春节仪式感和网络共同体。通过深度探索媒体融合新模式,助力央视频成为国家级高品质的视频社交媒体。

关键词：融媒体央视频春节仪式感网络共同体

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Reliability and validity of dermatology life quality index: assessment of quality of life in human immunodeficiency virus/acquired immunodeficiency syndrome patients with pruritic papular eruption

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Journal of Traditional Chinese Medicine 2013年第5期33卷 580-583页

作者： Zhibin Liu Zheng Xie Li Zhang Yantao Jin Huijun Guo Ziqiang Jiang xiumin chen Jun Yuan Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliat-ed Hospital of Henan University ofTraditional Chinese Medi-cine Key Laboratory of Viral Dis-eases Prevention andTreatment ofTraditional Chinese Medi-cine of Henan Province Department of Acquired Im-mune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Tradition-al Chinese Medicine

OBJECTIVE: To test the reliability and validity of dermatology life quality index(DLQI) in simplified Chinese language by assessing the quality of life(QoL) in HIV(human immunodeficiency virus)/AIDS(Acquired immunodeficiency syndrome) patients with pruritic papular eruption(PPE). METHODS: A study of simplified-Chinese-versiond from10 questions with the principal component analysis and the contribution rate of the 3 common factors was 59.95%. CONCLUSION: The simplified-Chinese-version DIQL is an acceptable and valid scale for HIV/AIDS patients with PPE. It can be used to evaluate the QoL of HIV/AIDS patients with PPE in China.

关键词： Quality of life Dermatology HIV Acquired immunodeficiency syndrome Pruritic papular eruption

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Survival of people living with HIV after treatment with Traditional Chinese Medicine in Henan province of China: a retrospective cohortstudy

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Journal of Traditional Chinese Medicine 2014年第4期34卷 430-436页

作者： Yantao Jin Zhibin Liu xiumin chen Xin Wang Dan Wang Ziqiang Jiang Ying Liu Jian Wang Wen Zou Huijun Guo Liran Xu Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine National Center for AIDS/STD Control and Prevention Chinese Center for Disease ControlandPrevention Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province School of International Education Zhengzhou Railway Vocational and Technical College Traditional Chinese Medicine Center for Acquired Immune Deficiency Syndrome Prevention and Treatment China Academy of Traditional Chinese Medicine National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Traditional Chinese Medicine Center for Acquired Immune Deficiency Syndrome Prevention and Treatment China Academy of Traditional Chinese Medicine

OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating ***: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard ***:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+***: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results.

关键词： Retrospective studies HIV Acquired immunodeficiency syndrome Survival Medicine Chinese traditional

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轧机压下螺纹副承载特性测试研究

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中国机械工程 2006年第3期17卷 307-311页

作者：左大为陈秀敏申光宪燕山大学秦皇岛066004

依据相似准则,制作3500mm中厚板轧机电动压下传动螺纹副1/3的测试模型,采用电测法获取悬臂螺牙弯曲应变值,模拟实际轧制力和过平衡力作用下螺纹副螺牙各层载荷大小及分布。螺纹副测试结果和边界元、有限元法数值计算结果相比,螺牙层载... 详细信息

依据相似准则,制作3500mm中厚板轧机电动压下传动螺纹副1/3的测试模型,采用电测法获取悬臂螺牙弯曲应变值,模拟实际轧制力和过平衡力作用下螺纹副螺牙各层载荷大小及分布。螺纹副测试结果和边界元、有限元法数值计算结果相比,螺牙层载荷大小和分布规律基本吻合,证明电测法可行、直观且可靠。通过测定数据,证实了轻重两种载荷工况的不同承载特性,还发现螺母与丝杆轴线错移或倾斜的微尺度行为对载荷大小及分布影响极大的重要现象,为提高压下传动螺纹副寿命及可靠性提供了重要思路。

关键词：电测法中厚板轧机螺纹副压力分布

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深刻认识汽车产业发展规律

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中国工程科学 2019年第3期21卷 98-102页

作者：付于武陈秀敏中国汽车工程学会北京100055 中国工程院战略咨询中心北京100088

汽车产业经过 130 多年的沉淀,积累了不少全球业内普遍接受和认可的规律。当前,我国汽车产业正处于转型升级的战略机遇期,迫切需要提高对产业的认识,加强对产业发展规律的研究,避免浮躁、违背规律现象的出现。本文从技术、市场、人才等... 详细信息

汽车产业经过 130 多年的沉淀,积累了不少全球业内普遍接受和认可的规律。当前,我国汽车产业正处于转型升级的战略机遇期,迫切需要提高对产业的认识,加强对产业发展规律的研究,避免浮躁、违背规律现象的出现。本文从技术、市场、人才等多个角度,尝试归纳了汽车产业发展中转型与升级相辅相成的关系、资金技术劳动密集的产业特性、创新与协同的必然要求等九大规律,以指导和推动我国汽车产业健康、可持续发展。

关键词：汽车产业发展规律可持续发展

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