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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi wang Junjie Yang Ganggang Zhang chen wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Fatal risk in hysteroscopic surgery that should not be overlooked:Uterine artery pseudoaneurysm

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World Journal of Clinical Cases 2025年第8期13卷 53-56页

作者： Mi-Si He Ke-Xiao Yu chen wang Department of Gynecologic Oncology Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing 400030China Department of Orthopedics Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China

This article provides a detailed account of the diagnosis and treatment of a case involving a uterine artery pseudoaneurysm(UAP),as well as an analysis of UAP *** finding emphasizes that UAP should be considered in patients presenting with abnormal genital bleeding after hysteroscopy and offers valuable insights and lessons for gynecologists in hysteroscopic *** patient underwent timely relevant examinations to confirm the diagnosis,allowing for crucial time required for her *** this study,the primary cause of UAP formation in the patient was attributed to a prior hysteroscopic surgical procedure conducted at another medical facility,suggesting that the selection and imple-mentation of dilatation catheters are some of the predisposing factors for *** conclusion,this case study offers a comprehensive analysis of the etiology of UAP and effectively provides timely diagnosis and treatment,offering valuable in-sights for the clinical diagnosis and management of UAP.

关键词： Editorial Uterine artery pseudoaneurysm Case report Hysteroscopic surgery Uterine arteriovenous malformations

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Occurring Mechanism and Restraining Method Research of Numerical Noise Signal in Penetration Simulation

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Chinese Journal of Mechanical Engineering 2016年第5期29卷 1037-1043页

作者： wang chen wang Yabin National Key Laboratory on Electromechanical Dynamic Control Beijing Institute of Technology Beijing 100081 China

In hard target penetration simulation, the existing researches of the convergence of results are mainly concentrating in the corresponding relationship between penetration depth and mesh scales. However, the influence of the mesh difference on the penetration resistance and acceleration signals are seldom refer to. This paper presents the occurring mechanism and restraining method of numerical noise signal in penetration simulation. First, the concept of the noise signal izs proposed. By taking a 3D penetration simulation as example, the influence of the noise signal on the penetration resistance in different mesh scales and impact velocity is studied. To ensure the convergence of the computational results, the grid scale of the target is encrypted to 1：1：8. In addition, modem spectrum analysis method is introduced to further analyze the penetration resistance signal. The research results presented is useful to improve the computational accuracy of high speed projectile penetration simulation, and provide important reference for carrying out structural design and optimization of fuze system.

关键词： hard target penetration numerical simulation signal of numerical noise spectral analysis

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Strict finite-time sliding mode control for a tethered space net robot

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Chinese Journal of Aeronautics 2023年第12期36卷 325-335页

作者： chen wang Fan ZHANG School of Construction Machinery Chang’an UniversityXi’an 710072China School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China

Tethered Space Net Robot(TSNR)is considered to be a promising approach for space debris removal,and accordingly it is also an interesting control problem due to its time-varying disturbances caused by an elastic and flexible net and a main connected *** this situation,the control scheme should be robust enough,low-frequency,and finite-time convergent in presence of external *** this paper,a robust controller with an advanced adaptive scheme is *** improve robustness,the disturbance is skillfully involved in the adaptive *** is strictly proven that the closed-loop system can converge to the desired trajectory in finite time in both reaching and sliding *** on the theoretical proof,adaptive gains and corresponding dynamic stability characteristics are further ***,the efficiency of the proposed control scheme is numerically proven via a *** proposed control scheme utilizes small and continuous control forces to compensate for the disturbance efficiently and track the desired trajectory quickly.

关键词： Modified adaptive supertwisting control Strict finite-time convergence Tethered space net robot(TSNR) Time-varying disturbance Underactuated system

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Transition characteristics for a small tail-sitter unmanned aerial vehicle

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Chinese Journal of Aeronautics 2021年第10期34卷 220-236页

作者： Jingyang ZHONG chen wang School of Construction Machinery Chang'an UniversityXi'an 710061China

Research on the transition phase of tail-sitter Unmanned Aerial Vehicles(UAVs)is crucial for trajectory planning and performance *** study focuses on the analysis of the transition characteristics and path of a small dual-rotor tail-sitter UAV,including static and dynamic *** system input time delay and actuator dynamics are specifically considered during the dynamic analysis,and these actual physical properties ensure that the computation results are reliable and *** UAV steady-state limit is obtained through static analysis,which is also adopted to verify the correctness of the dynamic *** regard to the dynamic analysis,several typical transition approaches are computed based on different initial states and optimization objective functions,and the different computations are applicable under specific task *** off-line dynamic results of the transition path and actuator output sequence could also be adopted as reference values for the transition process during real flight.A comparison of the static and dynamic results illustrates the necessity of combining these two methods for UAV transition characteristic ***,the UAV conceptual parameters related to the transition path are also studied,and the obtained quantitative characteristics provide feedback for the UAV conceptual design.

关键词： Actuator dynamics Tail-sitter Time delay Transition analysis UAV

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Parameter identification of nonlinear system via a dynamic frequency approach and its energy harvester application

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Acta Mechanica Sinica 2020年第3期36卷 606-617页

作者： Zhiwei Zhang Wei wang chen wang Tianjin Key Laboratory of Nonlinear Dynamics and Chaos Control Tianjin UniversityTianjin 300350China School of Computing and Engineering Hud

A dynamic frequency-based parameter identification approach is applied for the nonlinear system with periodic *** from the energy equation,the presented method uses a dynamic frequency to precisely obtain the analytical limit cycle expression of nonlinear system and utilizes it as the mathematic foundation for parameter *** from the time-domain approaches,the strategy of using limit cycle to describe the system response is unaffected by the influence of phase *** analytical expression is fitted with the value sets from phase coordinates measured in periodic oscillation of the nonlinear systems,and the unknown parameters are identified with the interior-reflective Newton *** the performance of this identification methodology is verified by an oscillator with nonlinear stiffness and ***,numerical simulations under noisy environment also verify the efficiency and robustness of the identification ***,we apply this parameter identification method to the modeling of a large-amplitude energy harvester,to improve the accuracy of mechanical *** surprisingly,good agreement is achieved between the experimental data and identified *** also verifies that the proposed approach is less time-consuming and more accuracy in identification procedure.

关键词： Parameter identification Dynamic frequency Nonlinear system Energy harvester

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久坐与社区老年人下肢肌力:跌倒恐惧与年龄的中介和调节作用

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中国组织工程研究 2025年第17期29卷 3566-3571页

作者：洪金涛王晶晶李岩松王晨弭守玲上海体育科学研究所(上海市反兴奋剂中心) 上海市200030 青岛大学体育学院山东省青岛市266071 复旦大学附属中山医院心内科上海市心血管病研究所上海市200032 国家放射与治疗临床医学研究中心上海市200032 心脏病全国重点实验室上海市200032 国家卫生健康委缺血性心脏病重点实验室上海市200032 中国医学科学院病毒性心脏病重点实验室上海市200032

背景:人体老龄化进程中,下肢肌肉力量会随着年龄的增长呈现显著的生理性下降,久坐、跌倒恐惧、年龄与下肢肌力之间可能存在一定关联,但它们之间的影响路径与效应关系尚不明确。目的:探究社区老年人久坐和下肢肌肉力量之间的关系,并探讨... 详细信息

背景:人体老龄化进程中,下肢肌肉力量会随着年龄的增长呈现显著的生理性下降,久坐、跌倒恐惧、年龄与下肢肌力之间可能存在一定关联,但它们之间的影响路径与效应关系尚不明确。目的:探究社区老年人久坐和下肢肌肉力量之间的关系,并探讨跌倒恐惧和年龄在上述两者关系中的作用。方法:共招募331名60岁及以上的上海市社区老年人。采用问卷调查法收集基本信息、人口学资料等;采用国际身体活动问卷-短卷评估久坐时间,采用30 s坐站测试测量下肢肌力,采用中文版国际跌倒效能量表测评跌倒恐惧。对数据进行描述统计、相关分析、基于回归的路径分析和中介效应检验。结果与结论:最终以318名老年人[78.9%为女性,平均年龄(67.8±5.5)岁]的有效数据纳入分析,其中久坐时间≥3 h的185名,<3 h的133名。①久坐和跌倒恐惧呈正相关关系(P<0.01),下肢肌力和久坐(P<0.01)、跌倒恐惧(P<0.001)均呈负相关关系。②久坐显著负向预测下肢肌力(β=-0.125,P<0.05),久坐显著正向预测跌倒恐惧(β=0.182,P<0.01);跌倒恐惧显著负向预测下肢肌力(β=-0.293,P<0.001)。③跌倒恐惧在久坐和下肢肌力之间起中介作用(β=-0.053,95%CI:-0.100至-0.018)。④久坐对跌倒恐惧的预测效应具有统计学意义(β=0.164,P<0.01),这说明年龄调节了久坐对跌倒恐惧的影响。

关键词：老年群体老龄化肌肉萎缩肌肉力量久坐跌倒恐惧中介效应调节作用

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On the role of sliding friction effect in nonlinear tri-hybrid vibration-based energy harvesting

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1295-1314页

作者： Jiamei wang Siukai LAI chen wang Yiting ZHANG Zhaolin chen Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057Guangdong ProvinceChina Hebei Key Laboratory of Mechanical Reliability for Heavy Equipments and Large Structures Yanshan UniversityQinghuangdao 066000Hebei ProvinceChina School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

This work aims to develop an experimental investigation into the effectiveness of the sliding-mode approach for hybrid vibration-based energy harvesting.A proposed sliding-mode triboelectric-electromagnetic-piezoelectric energy harvesting model involves a cantilever beam with a tip mass exposed to magnetic and frictional *** experimental findings indicate that the system can achieve its peak inter-well oscillation output within a low-frequency range of 4 Hz–6 *** has a lesser impact on the open-circuit voltage output at an excitation acceleration of 1.5g compared with *** distribution of tri-stability changes with the presence of *** model provides a deeper understanding of the influence of the dry friction coefficient(0.2–0.5) on the interactive behaviors of different generator units.

关键词： sliding mode tri-hybrid energy harvesting friction nonlinear behavior

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Highly selective phonon diffusive scattering in superionic layered AgCrSe_(2)

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npj Computational Materials 2020年第1期6卷 1433-1438页

作者： chen wang Yue chen Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong Kong SARChina HKU Zhejiang Institute of Research and Innovation 1623 Dayuan Road311305 Lin AnChina

Superionic materials that exhibit coexistence of rigid crystalline lattices and liquid-like fluctuating substructures have emerged as promising thermoelectric *** inadequate understanding of the phonon behavior in the superionic state,however,still prevents further revealing of the underlying correlation between the thermally induced liquid-like atomic dynamics and anomalous thermal transport ***,by adopting a hybrid scheme to directly characterize anharmonic phonon quasiparticles from ab-initio molecular dynamics,we manifest that low-energy transverse phonons dominated by Ag atoms totally collapse,whereas longitudinal optical phonons remain largely intact during the superionic transition.

关键词： properties transition ionic

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Promotional effect of ion-exchanged K on the low-temperature hydrothermal stability of Cu/SAPO-34 and its synergic application with Fe/Beta catalysts

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Frontiers of Environmental Science & Engineering 2021年第2期15卷 141-153页

作者： chen wang Jun wang Jianqiang wang Meiqing Shen School of Chemical Engineering&Technology Key Laboratory for Green Chemical Technology of State Education MinistryTianjin UniversityTianjin 300072China School of Environment and Safety Engineering North University of ChinaTaiyuan 030051China

K ions were introduced onto Cu/SAPO-34 catalysts via the ion-exchange process in order to improve their stability under low-temperature hydrothermal *** changes in structure and copper-species contents of these catalysts upon hydrothermal aging were probed in order to investigate their effects on selective catalytic reduction(SCR)*** the fresh Cu/SAPO-34 catalysts,K ions had little influence on the chabazite framework but effected their acidities by exchanging with acid *** hydrothermal aging,the structural integrity and amount of active sites decreased on pure Cu/*** the K-loaded catalysts showed improved chabazite structure,acidity,and active site conservation with increasing K ***,although the 0.7 wt%K catalyst maintained the same crystallinity,active site abundance,and low-temperature SCR activity as the fresh catalyst upon aging,an apparent decrease in SCR activity at high temperature was observed because of the inevitable decrease in the number of Brönsted acid *** compensate for the activity disadvantage of K-loaded Cu/SAPO-34 at high temperature,Fe/Beta catalysts were co-employed with K-loaded Cu/SAPO-34,and a wide active temperature window of SCR activity was ***,our study reveals that a combined system comprising Fe/Beta and K-loaded Cu/SAPO-34 catalysts shows promise for the elimination of NOx in real-world applications.

关键词： Selective catalytic reduction Cu/SAPO-34 catalyst Ion-exchanged K Low-temperature hydrothermal stability Fe/Beta catalyst

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