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Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao chen Jiayi Ding Feng Zhang Shunyang chen Xin Hu Shiji Fang Lin Shen chenying Lu Zhongwei Zhao Jianfei Tu Gaofeng Shu Minjiang chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang Key Laboratory of Imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China Key Laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

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Source Camera Identification Algorithm Based on Multi-Scale Feature Fusion

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Computers, Materials & Continua 2024年第8期80卷 3047-3065页

作者： Jianfeng Lu Caijin Li Xiangye Huang chen Cui Mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Key Laboratory of Public Security Information Application Based on Big-Data Architecture Ministry of Public SecurityZhejiang Police CollegeHangzhou310000China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

The widespread availability of digital multimedia data has led to a new challenge in digital *** source camera identification algorithms usually rely on various traces in the capturing ***,these traces have become increasingly difficult to extract due to wide availability of various image processing *** Neural Networks(CNN)-based algorithms have demonstrated good discriminative capabilities for different brands and even different models of camera ***,their performances is not ideal in case of distinguishing between individual devices of the same model,because cameras of the same model typically use the same optical lens,image sensor,and image processing algorithms,that result in minimal overall *** this paper,we propose a camera forensics algorithm based on multi-scale feature fusion to address these *** proposed algorithm extracts different local features from feature maps of different scales and then fuses them to obtain a comprehensive feature *** representation is then fed into a subsequent camera fingerprint classification *** upon the Swin-T network,we utilize Transformer Blocks and Graph Convolutional Network(GCN)modules to fuse multi-scale features from different stages of the backbone ***,we conduct experiments on established datasets to demonstrate the feasibility and effectiveness of the proposed approach.

关键词： Source camera identification camera forensics convolutional neural network feature fusion transformer block graph convolutional network

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Pneumatically Actuated Soft Robotic Arm for Adaptable Grasping

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Acta Mechanica Solida Sinica 2018年第5期31卷 608-622页

作者： Zhe chen Xueya Liang Tonghao Wu Tenghao Yin Yuhai Xiang shaoxing Qu State Key Laboratory of Fluid Power and Mechatronic System 38 Zheda Road Hangzhou 310027 China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province 38 Zheda Road Hangzhou 310027 China Department of Engineering Mechanics Zhejiang University 38 Zheda Road Hangzhou 310027 China

Developing robotic manipulators capable of performing effective physical interac- tion tasks is a challenging topic. In this study, we design a soft robotic arm （SRA） with multiple degrees of freedom inspired by the flexible structures and the unique motion mechanism of the octopus arm. The SRA is fabricated with elastomeric materials, which consists of four series of integrated pneumatic chambers that play similar roles as the muscles in the octopus arm can achieve large bending in various directions with variable stiffness. This SRA displays specified movements via controlling pressure and selecting channels. Moreover, utilizing parallel control, the SRA demonstrates complicated three-dimensional motions. The force response and motion of the SRA are determined both experimentally and computationally. The applications of the present SRA include tightly coiling around the objects because of its large bending deformation （nearly 360°）, grasping multiple objects, and adjusting the grabbing mode in accordance with the shape of objects.

关键词： Soft robotic arm Elastomeric materials Soft manipulation Variable stiffness actuation

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改性足金材料的耐蚀性能研究

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黄金 2015年第3期36卷 6-9页

作者：李桂双陈燕兰袁军平陈绍兴卢焕洵广州番禺职业技术学院珠宝学院

传统足金/Au999在黄金首饰消费中占据了最大份额,它们具有高贵的黄色和优异的耐蚀性,但硬度过低的问题制约了饰品的艺术价值,也给制造和使用带来了问题。该文采用钴、锑、钪对足金进行了多元微合金化处理,并采用人工汗液浸泡法和电化学... 详细信息

传统足金/Au999在黄金首饰消费中占据了最大份额,它们具有高贵的黄色和优异的耐蚀性,但硬度过低的问题制约了饰品的艺术价值,也给制造和使用带来了问题。该文采用钴、锑、钪对足金进行了多元微合金化处理,并采用人工汗液浸泡法和电化学试验法检测了合金的腐蚀倾向和抗变色性能。试验结果表明:改性足金的初始颜色与Au999之间的色差仅处于肉眼可觉察的区间,它在人工汗液中的颜色变化率与其所处状态有关,呈现"形变时效态>固溶态>冷形变态"的顺序。改性足金在人工汗液中存在钝化行为,耐点蚀性能与Au999相当,表现出优良的抗变色性能。

关键词：足金强化颜色耐蚀性

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Design and analysis of an untethered micro flapping robot which can glide on the water

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Science China(Technological Sciences) 2022年第8期65卷 1749-1759页

作者： chen YanHong LIU YiDe LIU TaiShan LI Hua QU shaoxing YANG Wei State Key Laboratory of Fluid Power&Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvincesCenter for X-MechanicsDepartment of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Flapping-wing flying insects possess various advantages,such as high agility and *** design and manufacture of insect-scale flapping-wing micro aerial vehicle(FWMAV)have attracted increasing attention in recent *** to the limitations of size and weight,the FWMAV with an onboard battery which can fully mimic insect flight has not been *** this work,we design and fabricate a highly integrated flapping-wing microrobot named *** Robomoth consists of a carbon chassis,customized power and control devices,and two piezoelectric ceramic actuators symmetrically distributed in the thorax and controlled *** weighs 2.487 g,spans 5.9 cm in length,possesses 9 cm of wingspan,and carries a 0.355 g rechargeable lithium *** demonstrate the mobility of the Robomoth through untethered gliding and making turns on the water surface.A simplified dynamic model of the flapping system is proposed to explain the relationship between the driving frequency and the flapping *** Robomoth is one new untethered bioinspired flapping-wing robot that can perform stable water surface motion,which holds potential applications such as search and rescue on the *** robot can also provide insight for designing insect-scale flying vehicles.

关键词： micro/nanorobots biologically inspired robots flapping-wing flying piezoelectric ceramic actuator

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Full-parameter omnidirectional transformation optical devices

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National Science Review 2024年第3期11卷 92-99页

作者： Yuan Gao Yu Luo Jingjing Zhang Zhengjie Huang Bin Zheng Hongsheng chen Dexin Ye Interdisciplinary Center for Quantum Information State Key Laboratory of Extreme Photonics and InstrumentationZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang University School of Electrical and Electronic Engineering Nanyang Technological University CNRS-InternationalNTU-Thales Research Alliance Nanyang Technological University Institute of Electromagnetic Space Southeast University State Key Laboratory of Millimeter Waves Southeast University International Joint Innovation Center The Electromagnetics Academy at Zhejiang University Zhejiang University Key Laboratory of Advanced Micro/Nano Electronic Devices&Smart Systems of Zhejiang Jinhua Institute of Zhejiang UniversityZhejiang University shaoxing Institute of Zhejiang University Zhejiang University

Transformation optics(TO) provides an unprecedented technique to control electromagnetic(EM) waves by engineering the constitutive parameters of the surrounding medium through a proper spatial transformation. In general, ideal transformation optical devices require simultaneous electric and magnetic responses along all three dimensions. To ease the practical implementation, previous studies usually made use of reduced parameters or other simplified approaches, which inevitably introduce extra reflection or unwanted phase shift. Up to today, experimental realizations of full-parameter transformation optical devices in free space are still quite limited. Here, a general design strategy is proposed to solve this *** a specific example, a full-parameter spatial-compression TO medium with constitutive parameters taking the diagonal form diag(a, a, 1/a) for the TM wave incidence was designed and realized experimentally. Such spatial-compression TO media were then applied to the implementation of an ideal omnidirectional invisibility cloak capable of concealing a large-scale object over a wide range of illumination angles. Both the simulation and experiment confirm that the cloak allows for nearly unity transmission of EM waves in the forward direction without introducing extra scattering or phase shift. This work constitutes an important stepping stone for future practical implementation of arbitrary full-parameter omnidirectional transformation optical devices.

关键词： transformation optical devices omnidirectional impedance matching full-parameter invisibility cloak

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Application of the CatBoost Model for Stirred Reactor State Monitoring Based on Vibration Signals

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 647-663页

作者： Xukai Ren Huanwei Yu Xianfeng chen Yantong Tang Guobiao Wang Xiyong Du School of Mechanical Engineering Tianjin UniversityTianjin300354China Quality Department Shaoxing Key Laboratory of Special Equipment Intelligent Testing and EvaluationShaoxing312071China

Stirred reactors are key equipment in production,and unpredictable failures will result in significant economic losses and safety ***,it is necessary to monitor its health *** achieve this goal,in this study,five states of the stirred reactor were firstly preset:normal,shaft bending,blade eccentricity,bearing wear,and bolt *** signals along x,y and z axes were collected and analyzed in both the time domain and frequency ***,93 statistical features were extracted and evaluated by ReliefF,Maximal Information Coefficient(MIC)and *** above evaluation results were then fused by D-S evidence theory to extract the final 16 features that are most relevant to the state of the stirred ***,the CatBoost algorithm was introduced to establish the stirred reactor health monitoring *** validation results showed that the model achieves 100%accuracy in detecting the fault/normal state of the stirred reactor and 98%accuracy in diagnosing the type of fault.

关键词： Stirred reactor fault diagnosis vibration signal CatBoost

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Potential risks of organic contaminated soil after persulfate remediation:Harmful gaseous sulfur release

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Journal of Environmental Sciences 2024年第1期135卷 1-9页

作者： Yuyang Long Zixiao Wu Xiaodong Ding Jiansong chen Dongsheng Shen Jiali Shentu Cai Hui Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling Zhejiang Engineering Research Center of Non-ferrous Metal Waste RecyclingInstrumental Analysis CenterSchool of Environmental Science and EngineeringZhejiang Gongshang UniversityHangzhou 310012China Shangyu Yingtai Fine Chemical Co. Ltd.Shaoxing 312000China Hangzhou Ecological Environment Monitoring Center Hangzhou 310007China

Persulfate is considered a convenient and efficient remediation agent for organic contaminated ***,the potential risk of sulfur into the soil remediation by persulfate remains *** this study,glass bottles with different persulfate dosages and groundwater tables were set up to simulate persulfate remediation of organic pollutants(aniline).The results found sulfate to be the main end-product(83.0%–99.5%)of persulfate remediation after10 ***,H_(2)S accounted for 93.4%–99.4%of sulfur reduction end-products,suggesting that H_(2)S was the final fate of sulfur.H_(2)S was released rapidly after one to three days at a maximum concentration of 33.0 ppm,which is sufficient to make a person *** to the fitted curve results,H_(2)S concentration decreased to a safe concentration(0.15 ppm)after 20–85 ***,the maximum concentration of methanethiol reached 0.6 *** results indicated that secondary pollution from persulfate remediation could release harmful gases over a long ***,persulfate should be used more carefully as a remediation agent for soil contamination.

关键词： Gaseous sulfur release H_2S Long period potential risk Organic contaminated soil remediation Persulfate

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地方本科院校工学专业毕业生就业与专业相关性实证研究

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创新创业理论研究与实践 2024年第8期7卷 79-81页

作者：郭绍星曹庆楼陈芳芳黔南民族师范学院贵州都匀558000

毕业生就业与专业的相关性已经成为影响高质量就业的重要因素。该文利用某地方本科院校2023届毕业生就业调研数据,通过相关性检验及线性回归分析探索了该院校4个工学专业毕业生就业与专业相关性的影响因素及关联程度。通过数据分析,发... 详细信息

毕业生就业与专业的相关性已经成为影响高质量就业的重要因素。该文利用某地方本科院校2023届毕业生就业调研数据,通过相关性检验及线性回归分析探索了该院校4个工学专业毕业生就业与专业相关性的影响因素及关联程度。通过数据分析,发现该院校工学专业毕业生就业与专业的相关性从2021年的77.06%下降到了2023年的68.65%。研究发现:个人情况类、专业情况类和工作情况类3类变量对毕业生就业与专业相关性都有着不同程度的影响。

关键词：地方院校本科工学专业高校毕业生就业相关性

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Recovery of Li, Ni, Co and Mn from spent lithium-ion batteries assisted by organic acids: Process optimization and leaching mechanism

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 518-530页

作者： Liuyi Ren Bo Liu Shenxu Bao Wei Ding Yimin Zhang Xiaochuan Hou Chao Lin Bo chen School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China State Environmental Protection Key Laboratory of Mineral Metallurgical Resources Utilization and Pollution Control Wuhan University of Science and TechnologyWuhan 430081China Zhejiang New Era Zhongneng Recycling Technology Co. LtdShaoxing 312000China Shenzhen Water Planning&Design Institute Co. LtdShenzhen 518000China

The proper recycling of spent lithium-ion batteries(LIBs)can promote the recovery and utilization of valuable resources,while also negative environmental effects resulting from the presence of toxic and hazardous *** this study,a new environmentally friendly hydro-metallurgical process was proposed for leaching lithium(Li),nickel(Ni),cobalt(Co),and manganese(Mn)from spent LIBs using sulfuric acid with citric acid as a *** effects of the concentration of sulfuric acid,the leaching temperature,the leaching time,the solid-liquid ratio,and the reducing agent dosage on the leaching behavior of the above elements were *** parameters were optimized using response surface methodology(RSM)to maximize the recovery of metals from spent *** maxim-um recovery efficiencies of Li,Ni,Co,and Mn can reach 99.08%,98.76%,98.33%,and 97.63%.under the optimized conditions(the sulfuric acid concentration was 1.16 mol/L,the citric acid dosage was 15wt%,the solid-liquid ratio was 40 g/L,and the temperature was 83℃ for 120 min),*** was found that in the collaborative leaching process of sulfuric acid and citric acid,the citric acid initially provided strong reducing CO_(2)^(-),and the transition metal ions in the high state underwent a reduction reaction to produce transition metal ions in the low ***,citric acid can also act as a proton donor and chelate with lower-priced transition metal ions,thus speeding up the dissolution process.

关键词： spent lithium-ion batteries leaching response surface methodology sulfuric acid citric acid

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