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Food Science and Human Wellness 2024年

作者： Shuqing Zhang Wenjing chen chen ma Yinghua Luo Li Dong Xiaosong Hu Fang chen Daotong Li College of Food Science and Nutritional Engineering National Engineering Research Centre for Fruit and Vegetable Processing Key Laboratory of Fruits and Vegetables Processing Ministry of Agriculture Engineering Research Centre for Fruits and Vegetables Processing Ministry of Education China Agricultural University

Neurodegenerative diseases (NDs)， mainly including Alzheimer’s disease， Parkinson’s disease， and Multiple sclerosis， represent a major public health challenge with the steady increase of aging population worldwide. Emerging evidence has revealed the key role of the microbiota-gut-brain axis in the pathogenesis of NDs. Diet is one of the most important environmental factors shaping the structure and function of gut microbiota. manipulating the gut microbiota through specific diet patterns may represent a promising approach for NDs prevention. In this review， we highlight gut microbiota variations in NDs， outline several crucial signaling pathways of the gut-brain communication， and discuss the interplay of nutrients-microbes and biological effect of diet-derived microbial metabolites on neural physiology. In particular， we summarized the current knowledge about the application of dietary patterns in NDs to prevent disease progression via the modulation of the gut microbiota. Our study provides novel insights on the diet-microbiota-gut-brain axis in neurodegenerative disorders and highlights the potential of developing microbiome-targeted personalized dietary intervention for NDs management.

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Highly selective growth of(6,5)single-walled carbon nanotubes from sigma phase alloy catalyst

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Nano Research 2024年第3期17卷 1999-2003页

作者： Liantao Xin chen ma Qianru Wu Shaokang Liu Linhai Li Xiuyun Zhang Liu Qian maoshuai He Dong Li Fangqian Han Shulan Hao Lihu Feng Yahan Li Huaping Liu Lili Zhang Chang Liu Jin Zhang College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042China Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Beijing National Laboratory for Condensed matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of Physics Science and Technology Yangzhou UniversityYangzhou 225002China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The chirality structure of a single-walled carbon nanotube(SWNT)strongly depends on the composition of catalyst used in the chemical vapor deposition process.In this study,we develop a porous magnesia supported manganese-rhenium(MnRe/MgO)catalyst for chirality-selective synthesis of SWNTs.Detailed characterizations reveal that(6,5)tubes with a selectivity higher than 70%are grown from the Re-rich MnRe/MgO catalyst.By comparing the SWNT growth results with those of monometallic Mn or Re,the formation of sigma phase,an intermetallic compound occurring in transition-metal alloy systems,is revealed to be crucial for the dominant synthesis of(6,5)SWNTs.This work not only extends the application of sigma phase alloy for catalytic synthesis of SWNTs,but also sheds lights on the growth of SWNTs with a high chirality selectivity.

关键词： single-walled carbon nanotubes sigma phase manganese-rhenium catalyst selective growth transition-metal alloy

An Empirical Model of Tropical Cyclone Intensity Forecast in the Western North Pacific

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Journal of Meteorological Research 2022年第5期36卷 691-702页

作者： chen ma Tim LI Jiangsu Meteorological Observatory Jiangsu Meteorological BureauNanjing 210019China Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)NanjingUniversityof Information Science&TechnologyNanjing210044China International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversityofHawaiiHI96822USA Key Laboratory of Transportation Meteorology China Meteorological AdministrationNanjing 210019China

The relative impact of environmental parameters on tropical cyclone(TC) intensification rate(IR) was investigated through a box difference index(BDI) method, using TC best track data from Joint Typhoon Warning Center and environmental fields from the NCEP final analysis data over the western North Pacific(WNP) during 2000–2018.There are total 6307 TC samples with a 6-h interval, of which about 14% belong to rapid intensification(RI) category. The analysis shows that RI occurs more frequently with higher environmental sea surface temperature, higher oceanic heat content, and lower upper-tropospheric temperature. A moderate easterly shear is more favorable for TC intensification. TC intensification happens mostly equatorward of 20°N while TC weakening happens mostly when TCs are located in the northwest of the basin. Mid-tropospheric relative humidity and vertical velocity are good indicators separating the intensification and non-intensification groups. A statistical model for TC intensity prediction was constructed based on six environmental predictors, with or without initial TC intensity. Both models are skillful based on Brier skill score(BSS) relative to climatology and in comparison with other statistical models, for both a training period(2000–2018) and an independent forecast period(2019–2020).

关键词： tropical cyclone rapid intensification prediction model

Characterization and application of a recombinant dopa decarboxylase from Harmonia axyridis for the efficient biosynthesis of dopamine

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Chinese Journal of Chemical Engineering 2022年第1期35卷 449-456页

作者： Siyuan Gao Yuanke Guo chen ma Ding ma Kequan chen Pingkai Ouyang Xin Wang State Key Laboratory of materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing 211816China

Here,a dopa decarboxylase(DDC)from Harmonia axyridis was heterogeneously expressed in Escherichia coli for the efficient biosynthesis of dopamine.For the production of recombinant DDC,the cultivation conditions including IPTG concentration,temperature and induction time were optimized and obtained an optimal specific enzyme activity of 51.72 U·mg^(-1) crude extracts.After the purification of DDC with a recovery yield of 68.79%,its activity was further characterized.The Vmax,Km,Kcat,and Kcat/Km of DDC for d ihyd roxy pheny la la nine(dopa)were 0.02 mmol·ml^(-1)·s^(-1),2.328 mmol·ml^(-1),10435.90 s^(-1) and4482.77 ml,mmol respectively.The highest DDC activity was observed at the condition of pH 7.5 and 45℃.With the purified DDC,the feasibility to produce dopamine from L-dopa was evaluated.The optimal yield was determined at the following bioconversion conditions:pH of 7,0,the reaction temperature of 40℃,0.4 mmol·L^(-1) of PLP and 4 g·L^(-1) of L-dopa,Subsequently,a fed-batch process for the production of dopamine was developed and the effect of oxygen was evaluated.The titer,yield and productivity of dopamine reached up to 21.99 g·L^(-1)80.88%and 14.66 g·L^(-1)·h^(-1) at 90 min under anaerobic condition.

关键词： Dopa decarboxylase Dopamine Enzyme catalysis Fed-batch bioconversion

Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals:current status and future perspectives

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Green Chemical Engineering 2023年第2期4卷 199-211页

作者： Jing Wang Ruirui Qin Yuanke Guo chen ma Xin Wang Kequan chen Pingkai Ouyang State Key Laboratory of materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing211816China

Methanol is becoming an attractive fermentation feedstock for large-scale bioproduction of chemicals,due to its natural abundance and mature production technology.Native methylotrophs,which can utilize methanol as the only source of carbon and energy,are ideal hosts for methanol bioconversion due to their high methanol utili-zation rate and have been extensively employed in the production of value-added chemicals from methanol.Here,we review the natural methanol utilization pathways in native methylotrophs,describing the available synthetic biology tools developed for engineering native methylotrophs,and discuss the strategies for improving their methanol utilization efficiency.Finally,the representative examples of engineering the native methylotrophs to produce value-added products from methanol are summarized.Furthermore,we also discuss the major challenges and possible solutions for the application of native methylotrophs in methanol-based biomanufacturing.

关键词： Native methylotrophs Methanol Biomanufacturing Value-added chemicals

Quasinormal modes and absorption of a massless scalar field for the magnetic Gauss-Bonnet black hole

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Communications in Theoretical Physics 2022年第6期74卷 113-121页

作者： chen ma Yu Zhang Qian Li Zhi-Wen Lin Faculty of Science Kunming University of Science and TechnologyKunmingYunnan 650500China

We study the massless scalar quasinormal frequencies of an asymptotically flat static and spherically symmetric black hole with a nonzero magnetic charge in four-dimensional extended scalar-tensor-Gauss-Bonnet theory. The results show that the real part of the quasinormal frequency becomes larger and the imaginary part becomes smaller with increasing the magnetic charge or the angular harmonic index. The existence of magnetic charges will reduce the damping of scalar perturbation, but increase the frequency. We also study the absorption crosssection of the scalar field in this black hole. We find that its curve will become lower as the magnetic charge increases, i.e. the magnetic charge will weaken the absorption capacity of the black hole. Meanwhile, the high-frequency limit of the total absorption cross-section is just the area of black hole shadow.

关键词： quasinormal modes scattering absorption cross-section massless scalar field magnetic Gauss-Bonnet black hole

Preparation and property of self-sealed plasma electrolytic oxide coating on magnesium alloy

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International Journal of Minerals,Metallurgy and materials 2023年第5期30卷 959-969页

作者： chen ma Dong Wang Jinyu Liu Ning Peng Wei Shang Yuqing Wen Guangxi Key Laboratory of Electrochemical and magnetochemical Function materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China

Plasma electrochemical oxidation (PEO) is a surface modification technology to form ceramic coatings on magnesium alloys However,its application is limited due to its defects.This work reports a novel preparation of in-situ sealing of PEO coatings by four-layer voltage and sol addition.The morphology and structure were characterized by scanning electron microscopy (SEM),energy dispersive X-ray spectroscopy (EDS),and X-ray diffractometer (XRD).Image-Pro Plus 6.0 was used to determine the porosity of the coating,which was decreased from 8.53%to 0.51%.Simultaneously,the coating thickness was increased by a factor of four.The anti-corrosion performance of each sample was evaluated using electrochemical tests,and the findings revealed that the corrosion current density of coatings (i_(corr)) of the samples were lowered from 9.152×10^(-2) to 6.152×10^(-4) ma·cm^(-2),and the total resistance (R_(T)) of the samples were enhanced from 2.19×10^(4) to 2.33×10^(5)Ω·cm^(2).The salt spray test used to simulate the actual environment showed that corrosion points appeared on the surface of the coating only at the 336 h.In addition,the mechanism of PEO self-sealing behavior was described in this article.

关键词： magnesium alloy in-situ sealing plasma electrolytic oxidation corrosion resistance

Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第5期23卷 407-422页

作者： Pengfei LI chen ma Jing LI Shanshan YOU Liuyi DANG Jingyu WU Zhifang HAO Jun LI Yuan ZHI Lin chen Shisheng SUN College of Life Science Northwest UniversityXi'an 710069China

macrophages are widely distributed immune cells that contribute to tissue homeostasis.Human THP-1 cells have been widely used in various macrophage-associated studies,especially those involving pro-inflammatory M1 and anti-inflammatory M2 phenotypes.However,the molecular characterization of four M2 subtypes(M2a,M2b,M2c,and M2d)derived from THP-1has not been fully investigated.In this study,we systematically analyzed the protein expression profiles of human THP-1-derived macrophages(M0,M1,M2a,M2b,M2c,and M2d)using quantitative proteomics approaches.The commonly and specially regulated proteins of the four M2 subtypes and their potential biological functions were further investigated.The results showed that M2a and M2b,and M2c and M2d have very similar protein expression profiles.These data could serve as an important resource for studies of macrophages using THP-1 cells,and provide a reference to distinguish different M2 subtypes in macrophage-associated diseases for subsequent clinical research.

关键词： macrophage THP-1 cells M2 subtype Proteomics Biological function

Preparation and cellular uptake behaviors of uniform fiber-like micelles with length controllability and high colloidal stability in aqueous media

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Fundamental Research 2023年第1期3卷 93-101页

作者： Junyu ma chen ma Xiaoyu Huang Pedro Henrique Hermes de Araujo Amit Kumal Goyal Guolin Lu Chun Feng Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai 200032China Department of Chemical Engineering and Food Engineering Federal University of Santa CatarinaFlorianópolis-SC88040-970SCBrazil Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanTehsil-Kishangarh-305801 Distt.-AjmerRajasthanIndia

Fragmentation/disassembly of fiber-like micelles generated by living crystalline-driven self-assembly(CDSA)is usually encountered in aqueous media,which hinders the applications of micelles.Herein,we report the generation of uniform fiber-like micelles consisting of a𝜋Л-conjugated oligo(p-phenylenevinylene)core and a crosslinking silica shell with grafted poly(ethylene glycol)(PEG)chains by the combination of living CDSA,silica chemistry and surface grafting-onto strategy.Owing to the presence of crosslinking silica shell and the outmost PEG chains,the resulting micelles exhibit excellent dispersity and colloidal stability in PBS buffer,BSA aqueous solution and upon heating at 80℃ for 2 h without micellar fragmentation/disassembly.The micelles also show negligible cytotoxicity toward both HeLa cervical cancer and HEK239T human embryonic kidney cell lines.Interestingly,micelles with Ln of 156 nm show the“stealth”property with no significant uptake by HeLa cells,whereas some certain amounts of micelles with Ln of 535 nm can penetrate into HeLa cells,showing length-dependent cellular uptake behaviors.These results provide a route to prepare uniform,colloidally stable fiber-like nanostructures with tunable length and functions derived for biomedical applications.

关键词： Fiber-like nanostructures Colloidal stability Living crystallization-driven self-assembly Silica shell Cellular uptake

Corrosion resistance and anti-soiling performance of micro-arc oxidation/graphene oxide/stearic acid superhydrophobic composite coating on magnesium alloys

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International Journal of Minerals,Metallurgy and materials 2023年第6期30卷 1128-1139页

作者： Dong Wang chen ma Jinyu Liu Weidong Li Wei Shang Ning Peng Yuqing Wen Guangxi Key Laboratory of Electrochemical and magnetochemical Function materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China

magnesium(Mg)alloys,the lightest metal construction material used in industry,play a vital role in future development.However,the poor corrosion resistance of Mg alloys in corrosion environments largely limits their potential wide applications.Therefore,a micro-arc oxidation/graphene oxide/stearic acid(maO/GO/SA)superhydrophobic composite coating with superior corrosion resistance was fabricated on a Mg alloy AZ91D through micro-arc oxidation(maO)technology,electrodeposition technique,and self-assembly technology.The composition and microstructure of the coating were characterized by scanning electron microscopy,X-ray diffraction,energy dispersive spectroscopy,and Raman spectroscopy.The effective protection of the maO/GO/SA composite coating applied to a substrate was evaluated using potentiodynamic polarization,electrochemical impedance spectroscopy tests,and salt spray tests.The results showed that the maO/GO/SA composite coating with a petal spherical structure had the best superhydrophobicity,and it attained a contact angle of 159.53°±2°.The maO/GO/SA composite coating exhibited high resistance to corrosion,according to electrochemical and salt spray tests.

关键词： magnesium alloy composite coating superhydrophobic corrosion resistance anti-soiling performance