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CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy

International Journal of Ophthalmology(English edition) 2017年第6期10卷 862-869页

作者： lin-Hui yuan Xiao-Long chen yu Di Mei-lin Liu Department of Ophthalmology Shengjing Affiliated Hospital of China Medical University Shenyang 110000 Liaoning Province China

AIM： To investigate the role of CCR7/p-ERKI/2/VEGF signaling in the mouse model of oxygen-induced retinopathy （OIR）. METHODS： Neonatal C57BL/6J mice were evenly randomized into four groups： normoxia, OIR, OIR control （treated with scramble siRNA）, and OIR treated （treated with CCR7 siRNA）. Normoxia group was not specially handled. Postnatal day 7 （P7） mice in the OIR group were exposed to 75%±5% oxygen for 5d （P7-P12） and then maintained under normoxic conditions for 5d （P12-P17）. Mice in the OIR control and OIR treated groups were given injections of scramble or CCR7 siRNA plasmid on P12 before returning to normoxic conditions for 5d （P12-P17）. Retina samples were collected from all mice on P17, stained with adenosine diphosphatase （ADPase）, and retinal neovascularization （RNV） was assessed. Retinas were also stained with hematoxylin and eosin （H＆E） for RNV quantitation. The distribution and expression of CCR7, p-ERKI/2 and vas- cular endothelial growth factor （VEGF） were assessed via immunohistochemistry, Western blot, and quantitative real-time polymerase chain reaction （qRT-PCR）. RESULTS： High oxygen promoted retinal neovascularization （P〈0.05） and increased the number of endothelial nuclei in new vessels extending from the retina to the vitreous body; CCR7 promoted this process （P〈0.05）. CCR7 and VEGF mRNA were expressed at higher levels in the OIR and OIR control groups than in the normoxia and OIR treated groups. CCR7, p-ERK1/2, and VEGF protein were expressed in the retinas of mice in the OIR and OIR control groups. Intravitreal injection of CCR7 siRNA significantly reduced CCR7, p-ERKI/2, and VEGF expression in the OIR mouse model （all P〈0.05）. CCR7 significantly enhancedthe neovascularization and non-perfusion areas in the OIR group （P〈0,05）, CCR7 siRNA significantly reduced levels of p-ERK1/2 and VEGF as compared to OIR controls （P〈0.05）. CONCLUSION： These results suggest that CCR7/p-ERK I/2NEGF signaling plays an important role in OIR, CCR7 may be a p

关键词： chemokine receptor type 7 vascularendothelial growth factor extracellular signal-regulated kinase retinal neovascularization retinopathy ofpremamrity

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Kinetic Behavior of Aggregation-Exchange Growth Process with Catalyzed-Birth

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Communications in Theoretical Physics 2007年第3期47卷 479-486页

作者： HAN An-Jia chen yu lin Zhen-Quan KE Jian-Hong Department of Physics Wenzhou University Wenzhou 325027 China

We propose an aggregation model of a two-species system to mimic the growth of cities＇ population and assets, in which irreversible coagulation reactions and exchange reactions occur between any two aggregates of the same species, and the monomer-birth reactions of one species occur by the catalysis Of the other species. In the case with population-catalyzed birth of assets, the rate kernel of an asset aggregate Bκ of size k grows to become an aggregate Bκ＋1 through a monomer-birth catalyzed by a population aggregate Aj of size j is J（κ,j） = Jkjλ. And in mutually catalyzed birth model, the birth rate kernels of population and assets are H（k,j）=Hkjη and J（k,j） = Jkjλ, respectively. The kinetics of the system is investigated based on the mean-field theory. In the model of population-catalyzed birth of aseets, the long-time asymptotic behavior of the assets aggregate size distribution obeys the conventional or modified scaling form. In mutually catalyzed birth system, the asymptotic behaviors of population and assets obey the conventional scaling form in the case of η=λ =0, and they obey the modified scaling form in the case of η=0, λ=1. In the case of η = λ= 1, the total mass of population aggregates and that of asset aggregates both grow much faster than those in population-catalyzed birth of assets model, and they approaches to infinite values in finite time.

关键词： kinetic behvavior aggregation-exchange growth catalyzed-birth scaling law rate equations

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Assessment of damage to buildings and farms during the 2011 M 9.0 earthquake and tsunami in Japan from remote sensing data

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Chinese Science Bulletin 2011年第20期56卷 2138-2144页

作者： GUO HuaDong chen yu FENG Qiang lin QiZhong WANG Fei Center for Earth Observation and Digital Earth Chinese Academy of SciencesBeijing 100094China

At 13:46 on March 11,2011(Beijing time),a great earthquake of magnitude of 9.0 occurred off the Pacific coast of northeastern Japan(Tohoku Region).After the earthquake,the Center for Earth Observation and Digital Earth(CEODE),Chinese Academy of Sciences,quickly launched a major disaster emergency response to assess the *** this paper,we have extracted buildings and farms in the heavily devastated area that includes Iwate,Miyagi,and Fukushima Prefectures,based on multi-spectral remote sensing *** have assessed building damage by overlaying seismic intensity and building *** addition,we have assessed the extent of building and farm damage caused by the tsunami through the establishment of a tsunami impact assessment model that is based on terrain and distance from the *** results were partially verified by high-resolution images obtained after the *** results show that about 76% of buildings in Miyagi Prefecture were affected by seismic intensity 6 and above,with 24% of the buildings and 12% of the farms destroyed by the *** huge losses were echoes at lesser amounts in Fukushima and *** results provide the support of basic data,which can be further developed by economic and social aspects of the disaster assessment.

关键词：影响评估模型遥感数据建筑物大地震海啸农场数据损坏日本

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Synthesis of Nitroanilines Catalyzed by Horseradish Peroxidase in the Presence of NaNO2 and H2O2

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Chemical Research in Chinese Universities 2013年第6期29卷 1164-1166页

作者： LIU Cong DAI Rong-ji lin Jie SUN Jian-hua chen Shi DENG yu-lin School of Life Science Beijing Institute of Technology Beijing 100081 P.R.China

The synthesis of nitroanilines catalyzed by horseradish peroxidase（HRP） in the presence of sodium nitrite and hydrogen peroxide was investigated, o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.

关键词： Nitroaniline Horseradish peroxidase Phenylamine Nitration Enzyme

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Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： chen yu lin Hung Ju chen Yi Kit Chan Wei Ping Hsia yu Len Huang Chia Jen Chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

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First total synthesis of 10α-hydroxy-4-muurolen-3-one and its C_(10)-isomer

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Chinese Chemical Letters 2008年第11期19卷 1265-1267页

作者： Fu Qiang Bi Li Jing Fang chen Xi Zhang yu lin Li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

An efficient synthetic route to muurolane type sesquiterpenes starting from （R）-carvone, employing allylic diazene rearrangement and the ring closing methesis （RCM） reaction as key steps, is described. The first asymmetric total synthesis of （-）-10α- hydroxy-4-muurolen-3-one 11 and （-）-10β-hydroxy-4-muurolen-3-one C was accomplished. Through the total synthesis, the absolute configurations of the natural products A, B and C were established.

关键词： 10α-Hydroxy-4-muurolen-3-one 10β-Hydroxy-4-muurolen-3-one Allylic diazene rearrangement RCM reaction Total synthesis

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The Impact of Technology-Integrated Instruction to Elementary Students＇ Language Learning Motivation and Performance

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Journal of Literature and Art Studies 2015年第8期5卷 679-685页

作者： chen yu-lin Tatung University Taipei China

This study aims to investigate technology-integrated language learning courses that benefit elementary language learners＇ desire to learn English （motivation） and how they are related to the student＇s performance. Theories guiding this investigation included Dornyei＇s L2 Motivational Self System and Gardner＇s Socio Psychological System to describe language learners＇ desire to learn （motivation）. Thirty-five 3rd grade elementary school students, who are learning English with technology at school, were included in this study. The result indicates that the features of technology students like to use while learning have positive and significant correlation with desire to learn English （motivation）; and their previous technology learning experience and motivation have significant influence on their final grade. This final analysis could provide a guideline for EFL teachers or students who are in teacher training programs to integrate technology into their future courses.

关键词： CALL motivation EFL performance

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Electrical Properties of ZnO/Si Heterostructure

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Chinese Physics Letters 2001年第8期18卷 1108-1110页

作者： LIU Ci-Hui chen yu-lin lin Bi-Xia ZHU Jun-Jie FU Zhu-Xi PENG Cong YANG Zhen Structure Research Laboratory Chinese Academy of Sciences Department of Physics University of Science and Technology of ChinaHefei 230026 Special Class for the Gifted Young University of Science and Technology of ChinaHefei 230026

The electrical Properties of a type of semiconductor heterostructure fabricated by depositing zinc oxide film on a silicon substrate are *** I-V,I-T curves,and deep level transient spectra are *** these results,we acq... 详细信息

关键词： transient heterostructure Properties

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Occurrence of pharmaceuticals and perfluorinated compounds and evaluation of the availability of reclaimed water in Kinmen

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Emerging Contaminants 2016年第3期2卷 135-144页

作者： Webber Wei-Po Lai Yen-Ching lin Hsin-Hsin Tung Shang-Lien Lo Angela yu-chen lin Graduate Institute of Environmental Engineering National Taiwan University71-Chou-shan RoadTaipei106Taiwan

Emerging contaminants have commonly been observed in environmental waters but have not been included in water quality assessments at many locations around the *** evaluate the availability of reclaimed water in Kinmen,Taiwan,this study provides the first survey of the distribution of thirty-three pharmaceuticals and five perfluorinated chemicals in lake waters and water from local wastewater treatment plants(WWTPs).The results showed that the target emerging contaminants in Kinmen lakes were at trace ng/L *** addition,most of the target compounds were present in the Jincheng and Taihu WWTP influents at ng/L concentrations levels,of which 5 compounds(erythromycin-H2O(1340 ng/L),ibuprofen(1763 ng/L),atenolol(1634 ng/L),acetaminophen(2143 ng/L),and caffeine(3113 ng/L))reached mg/L *** overall treatment efficiencies of the Jincheng and Taihu WWTPs with respect to these pharmaceuticals and perfluorinated chemicals were poor;half of the compounds were less than 50%*** compounds(sulfamethoxazole,erythromycin-H2O,clarithromycin,ciprofloxacin and ofloxacin)with risk quotient(RQ)values>1 in the effluent should be further investigated to understand their effects on the aquatic *** and advanced treatment units are found necessary to provide high-quality recycled water and sustainable water resources.

关键词： Emerging contaminant Perfluorinated compound Pharmaceutical Water scarcity Wastewater treatment plant

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Post-coital gross hematuria： an unusual presentation of benign prostatic hyperplasia

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Asian Journal of Andrology 2007年第6期9卷 856-858页

作者： Yi-Hong chen Pei-yu lin yu-Sheng cheng Johnny Shinn-Nan lin yung-Ming lin Department of Urology College of Medicine National Cheng Kung University Tainan Taiwan 704 China

Aim： To describe an unusual symptom of benign prostatic hyperplasia （BPH）. Methods： A patient presented to our urology clinic having experienced post-coital gross hematuria for 2 years. He had not experienced lower urinary tract symptoms （LUTS）. A series of examinations were performed to determine the source of bleeding. Results： The prostate was defined as the active bleeding source responsible for the patient＇s post-coital hematuria. Endoscopic fulguration did not alleviate the symptom. The use of dutasteride, a dual inhibitor of 5α-reductase, solved the problem. Conclusion： This study reports for the first time that post-coital gross hematuria is one of the clinical presentations of BPH, which can be successfully treated with 5α-reductase inhibitor.

关键词： prostate coitus hematuria

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