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Ab Initio Calculations on Halogen Bond Between N—Br and Electron-donating Groups

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Chemical Research in Chinese Universities 2007年第3期23卷 355-359页

作者： WANG Yan-hua chen xue-song ZOU Jian-wei YU Qing-sen College of Biology and Environment Engineering Zhejiang Shuren University Hangzhou 310015P. R. China Key Laboratory for Molecular Design and Nutrition Engineering of Ningbo City Ningbo Institute of Technology Zhejiang University Ningbo 315100 P. R. China Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China

Ab initio calculations of complexes formed between N-bromosuccinimide and a series of electron-donating groups were performed at the level of MP2/Lanl2DZ^＊ to gain a deeper insight into the nature of the N--Br halogen bonding. For the small complexes, H3 C--Br… NH3 and H2 N--Br…NH3 , the primary calculation has demonstrated that the N--Br in H2 N--Br… NH3 can form a much stronger halogen-bonding complex than the C--Br. A comparison of neutral hydrogen bond complex series reveals that the electron-donating capacities of the atoms decrease in the order, N 〉 O 〉 S; 0 （ sp^3 ）〉 0 （ sp^2 ）, which is adequate for the C--Br halogen bonding. Interaction energies, in conjunction with the geometrical parameters show that the affinitive capacity of trihalide anions X^-3 with N-bromosuccinimide are markedly lower than that of the corresponding X^- with N-bromosuccinimide, even lower than those of neutral molecules with N-bromosueeinimide. AIM analyses further eorffirmed the above results.

关键词： Halogen bond N-bromosuccinimide Ab initio AIM theory Interaction energy

Recent advances in plant immunity with cell death:A review

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Journal of Integrative Agriculture 2022年第3期21卷 610-620页

作者： YIN Jun-jie XIONG Jun XU Li-ting chen xue-wei LI Wei-tao State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural University at WenjiangChengdu 611130P.R.China

Cell death is an important physiological phenomenon in *** can be programmed or *** cell death is usually induced by abiotic or biotic *** studies have shown that many proteins regulate both cell death and immunity in ***,we provide a review on the advances in plant immunity with cell death,especially the molecular regulation and underlying mechanisms of those proteins involved in both cell death and plant *** addition,we discuss potential approaches toward improving plant immunity without compromising plant growth.

关键词： cell death unprogrammed cell death programmed cell death hypersensitive response reactive oxygen species plant immunity resistance

An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage

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Neural Regeneration Research 2020年第10期15卷 1947-1954页

作者： Jun-Hui chen Ting Wu Wen-Yuan Xia Zhong-Hua Shi Chun-Lei Zhang Lei chen Qian-xue chen Yu-Hai Wang Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina Department of Cardiology Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina Department of Science and Education Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina

Atorvastatin has been shown to reduce early brain edema and neuronal death after subarachnoid hemorrhage,but its mechanism is not *** this study,rat models of subarachnoid hemorrhage were established by autologous blood injection in the cisterna *** models were intragastrically administered 20 mg/kg atorvastatin 24 hours before subarachnoid hemorrhage,12 and 36 hours after subarachnoid *** with the controls,atorvastatin treatment demonstrated that at 72 hours after subarachnoid hemorrhage,neurological function had clearly improved;brain edema was remarkably relieved;cell apoptosis was markedly reduced in the cerebral cortex of rats;the number of autophagy-related protein Beclin-1-positive cells and the expression levels of Beclin-1 and LC3 were increased compared with subarachnoid hemorrhage *** ultrastructural damage of neurons in the temporal lobe was also noticeably *** similarities between the effects of atorvastatin and rapamycin were seen in all the measured outcomes of subarachnoid ***,these were contrary to the results of 3-methyladenine injection,which inhibits the signaling pathway of *** findings indicate that atorvastatin plays an early neuroprotective role in subarachnoid hemorrhage by activating *** experimental protocol was approved by the Animal Ethics Committee of Anhui Medical University,China(904 Hospital of Joint Logistic Support Force of PLA;approval ***-2017-09)on February 22,2017.

关键词： 3-methyladenine apoptosis atorvastatin autophagy early brain injury LC3 neuroprotection rapamycin subarachnoid hemorrhage

Ultrasound-guided paravertebral nerve block anesthesia on the stress response and hemodynamics among lung cancer patients

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World Journal of Clinical Cases 2022年第7期10卷 2174-2183页

作者： Shu-Qing Zhen Ming Jin Yong-xue chen Jian-Hua Li Hua Wang Hui-Xia chen Department of Anesthesiology Handan Central HospitalHandan 056001Hebei ProvinceChina Department of Anesthesiology Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina

BACKGROUND Thoracic surgery for radical resection of lung tumor requires deep anesthesia which can lead to an adverse inflammatory response,loss of hemodynamic stability,and decreased immune ***,we evaluated the feasibility and benefits of ultrasound-guided paravertebral nerve block anesthesia,in combination with general anesthesia,for thoracic surgery for lung *** block was performed by diffusion of anesthetic drugs along the paravertebral space to achieve unilateral multi-segment intercostal nerve and dorsal branch nerve *** To evaluate the application of ultrasound-guided paravertebral nerve block anesthesia for lung cancer surgery to inform *** The analysis was based on 140 patients who underwent thoracic surgery for lung cancer at our hospital between January 2018 and May *** were randomly allocated to the peripheral+general anesthesia(observation)group(n=74)or to the general anesthesia(control)group(n=66).Patients in the observation group received ultrasound-guided paravertebral nerve block anesthesia combined with general anesthesia,with those in the control group receiving an epidural block combined with general *** outcomes included the operative and anesthesia times,as well as the mean arterial pressure(MAP),heart rate(HR),and blood oxygen saturation(SpO;)measured before surgery,15 min after anesthesia(T1),after intubation,5 min after skin incision,and before extubation(T4).RESULTS The dose of intra-operative use of remifentanil and propofol and the postoperative use of sufentanil was lower in the observation group(1.48±0.43 mg,760.50±92.28 mg,and 72.50±16.62 mg,respectively)than control group(P<0.05).At the four time points of measurement(T1 through T4),MAP and HR values were higher in the observation than control group(MAP,90.20±9.15 mmHg,85.50±7.22 mmHg,88.59±8.15 mmHg,and 90.02±10.02 mmHg,respectively;and HR,72.39±8.22 beats/min,69.03±9.03 beats/min,70.12±8.11 beats/min,and 71.24±9.01 beat

关键词： Ultrasound-guided paravertebral nerve block anesthesia Anesthesia Lung cancer Stress response Hemodynamics

Facial expression recognition based on improved completed local ternary patterns

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Optoelectronics Letters 2019年第3期15卷 224-230页

作者： LUO Yuan LIU Xing-yao ZHANG Yi chen xue-feng chen Zhuo Key Laboratory of Optoelectronic Information Sensing and Technology Chongqing University of Posts and TelecommunicationsChongqing400065China Engineering Research Center for Information Accessibility and Service Robots Chongqing University of Posts andTelecommunicationsChongqing400065China

The information of expression texture extracted by the completed local ternary patterns(CLTP) method is not accurate enough, which may cause low recognition rate. Therefore, an improved completed local ternary patterns(ICLTP) is proposed here. Firstly, the Scharr operator is used to calculate gradient magnitudes of images to enhance the detail of texture, which is beneficial to obtaining more accurate expression features. Secondly, two different neighborhoods of CLTP features are combined to obtain much information of facial expression. Finally, K nearest neighbor(KNN) and sparse representation classifier(SRC) are combined for classification and a 10-fold cross-validation method is tested in the JAFFE and CK+ databases. The results show that the ICLTP method can improve the recognition rate of facial expression and reduce the confusion between various expressions. Especially, the misrecognition rate of other six expressions recognized as neutral is reduced in the 7-class expression recognition.

关键词： LBP LTP Facial expression recognition based on improved completed local ternary patterns

D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study

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Neural Regeneration Research 2017年第12期12卷 2014-2020页

作者： Jun-hui Liu Xiang-kui Li Zhi-biao chen Qiang Cai Long Wang Ying-hu Ye Qian-xue chen Department of Neurosurgery Renmin Hospital of Wuhan University Department of Neurosurgery Affiliated Hospital of Shandong Medical College

Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysmal subarachnoid hemorrhage who were treated in Renmin Hospital of Wuhan University of China between 1 May 2014 and 30 March 2016. There were 57 males and 89 females included and average age of included patients was 57.03 years old. Serum samples were taken immediately on admission（within 48 hours after initial hemorrhage） and the levels of serum biomarkers were detected. Baseline information, complications, and outcomes at 6 months were recorded. Univariate and multivariate logistic regression analyses were used to explore the relationship between biomarkers and clinical outcomes. Receiver operating characteristic curves were obtained to investigate the possibility of the biomarkers predicting prognosis. Of the 146 patients, 102 patients achieved good outcomes and 44 patients had poor outcomes. Univariate and multivariate analyses showed that high World Federation of Neurosurgical Societies grade, high serum D-dimer levels, and high neurological complications were significantly associated with poor outcomes. Receiver operating characteristic curves verified that D-dimer levels were associated with poor outcomes. D-dimer levels strongly correlated with neurological complications. In conclusion, we suggest that D-dimer levels are a good independent prognostic factor for poor outcomes in patients with aneurysmal subarachnoid hemorrhage.

关键词： nerve regeneration aneurysmal subarachnoid hemorrhage D-dimer serum biomarkers complications prognosis logistic regressionanalysis neural regeneration

Parasitoid wasps as effective biological control agents

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Journal of Integrative Agriculture 2019年第4期18卷 705-715页

作者： WANG Zhi-zhi LIU Yin-quan SHI Min HUANG Jian-hua chen xue-xin Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects Zhejiang University State Key Lab of Rice Biology Zhejiang University Institute of Insect Sciences Zhejiang University

Biological control(biocontrol) is a safe, sustainable approach that takes advantage of natural enemies such as predators, parasitic insects or pathogens to manage pests in agroecosystems. Parasitoid wasps, a very large evolutionary group of hymenopteran insects, are well-known biological control agents for arthropod pests in agricultural and forest ecosystems. Here, we summarize the recent progress on the application of parasitoid wasps in biocontrol in China for the last five years. These include species diversity of parasitoid wasps, identification of dominant parasitoid wasps associated with insect pests and biocontrol practices(three types of biological control, i.e., classical, augmentative and conservation biological control) in several Chinese agroecosystems. We then treat different mass-rearing and release technologies and the commercialization of several parasitoid wasp species. We also summarize other work that may have a potential use in biocontrol, including the effect of plant volatiles on parasitoids and recent advance in the molecular mechanisms underlying the host regulation by parasitoid wasps. Future research area and applied perspectives are also discussed, noting that advances in biocontrol technologies in Chinese agriculture informs research at the global level.

关键词： parasitoid wasp predator biological control/biocontrol biological control/biocontrol agent cereal crop vegetable crop mass-rearing field release plant volatile parasitoid-host interaction

Low microRNA-139 expression associates with poor prognosis in patients with tumors: A meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 321-331页

作者： Jian-An chen Yan Yu chen xue Xiao-Long chen Guang-Ying Cui Juan Li Kong-Fei Li Zhi-Gang Ren Ran-Ran Sun Precision Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Clinical Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Hematology Yinzhou People’s Hospital Affiliated to Medical College of Ningbo UniversityNingbo 315040China

Background:microRNA-139(miR-139)is dysregulated in various types of tumors and plays a key role in ***-139 may be used as a diagnostic and prognostic biomarker of ***,the data from the literature are not *** present study aimed to verify the prognostic and diagnostic values of miR-139 in solid *** sources:PubMed,Web of Science and Embase databases were searched and publications from January 2011 to August 2017 were *** used Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)database to further validate this ***:Eight individual studies from seven articles were *** analyses showed that low miR-139 expression was related to worse overall survival(OS)[hazard ratio(HR)=2.27;95%confidence intervals(CI):1.74–2.95;P<0.001]in solid tumors,including hepatocellular carcinoma(HCC)and glioblastoma multiforme(GBM),consisting with the results of ***,our results of CRC showed that low miR-139 expression was associated with poor OS which was contradictory with the results in TCGA database and need larger samples to validate the phenomenon;whereas for CRC patients,high miR-139 expression predicted poor RFS,which was in good accordance with TCGA *** results of 27 microarrays from GEO database showed that miR-139 expression levels were lower in tumor tissues compared to adjacent non-tumor tissues or healthy *** miR-139 expression was also significantly correlated with poor differentiation grade(OR=3.57;95%CI:1.44–8.85;P=0.006).However,the combined data indicated that no associations between miR-139 expression and the following parameters such as age(pooled OR=1.50;95%CI:0.69–3.24;P=0.304),gender(pooled OR=0.92;95%CI:0.56–1.51;P=0.738),tumor size(pooled OR=1.51;95%CI:0.69–3.31;P=0.298),late tumor-node-metastasis stage(pooled OR=1.63;95%CI:0.99–2.68;P=0.057)and lymph-node-metastasis(pooled OR=0.66;95%CI:0.34–1.28;P=0.222).Conclusions:Low miR-139 expression was rel

关键词： microRNAs microRNA-139 TCGA dataset GEO database Prognosis

Numerical study of scattering Legendre moments and effect of anisotropic scattering on S_N shielding calculation

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Nuclear Science and Techniques 2019年第11期30卷 95-107页

作者： Cong Liu Xiao-Li Hu Bin Zhang You Gong Liang Zhang Yi-xue chen School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China China Nuclear Power Engineering Co.Ltd. Beijing 100840China China Institute of Atomic Energy Beijing 102413China

In neutron and photon transport problems,anisotropic scattering is of great importance for the particle flux,especially when the angular flux has a strong forward peak in shielding *** conventional Legendre expansion is widely used in discrete ordinates transport codes because of algebraic simplifications with spherical harmonics for the scattering ***,negative cross sections caused by the finitely truncated expansion may give rise to a negative source and flux.A simple method is adopted,based on integrating functions of scattering moments,to evaluate anisotropy and convergence of expanded functions.A series of problems were designed with angular fluxes of different anisotropy,and numerical simulations were performed using the ARES transport code to study different treatments and algorithms for *** show that the diagonal transport approximation is more stable and obtains a similar accuracy with the extended approximation.A conservative fixup for the negative source could ensure particle balance and improve computational accuracy significantly for photon *** effect of anisotropic scattering is problem-dependent,and no distinct differences among various methods are observed for volume source problems with a continuous energy *** beam source problems,flux results are sensitive to negative scattering functions,and strictly nonnegative cross sections need to be implemented.

关键词： Particle transport Shielding calculation Discrete ordinates method Anisotropic scattering Transport approximation Negative source fix-up