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Iron-based layered double hydroxide packed with metal-organic frameworks for enhanced overall water-splitting electrocatalysis

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Tungsten 2024年第4期6卷 859-868页

作者： Long chen Yun Luo Zhi-Peng Yu Yi-Kun cheng Yang Zheng Li He Jia-Hao Xiong Wen-Wen Kong Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical Engineering Shihezi University Institute of Scientific Research Luzhou North Chemistry Industry Co.Ltd International Iberian Nanotechnology Laboratory (INL) CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and Devices Center of Materials Science and Optoelectronics Engineering Xinjiang Technical Institute of Physics and Chemistry of CAS

Designing hybrid materials with numerous catalytic active sites,high specific surface area,and interfacial interactions is an effective strategy to improve electrocatalytic *** this work,iron-based metal organic frameworks（Fe-MOFs）@（Co,Ni）Fe-layered double hydroxide（LDH） is successfully constructed using the similar "MOF growing on LDH" strategy for oxygen evolution reaction and hydrogen evolution reaction in the alkaline *** synthesized hybrid materials in this particular way show excellent electrochemical overall water-splitting performance with the cell voltage of 1.62 V at10 mA·cm-2in the alkaline environment due to the optimized adsorption/desorption properties of metal ions on oxygencontaining species and interfacial effects of hybrid ***-MOFs@（Co,Ni）Fe-LDH also exhibits excellent hydrogen and oxygen production efficiency of 370 and 175 μL·min-1,*** work draws on an effective approach to the fabrication of MOF@LDH structures and provides new insights into overall water-splitting in alkaline conditions.

关键词： Electrocatalysis Interfacial interactions Layered double hydroxide Metal–organic frameworks (MOFs) Water splitting

Unveiling the oral-gut connection:chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE^(−/−)Mice on a high-fat diet

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International Journal of Oral Science 2024年第3期16卷 515-527页

作者： Guowu Gan Shihan Lin Yufang Luo Yu Zeng Beibei Lu Ren Zhang Shuai chen Huaxiang Lei Zhiyu Cai Xiaojing Huang Fujian Key Laboratory of Oral Diseases&Fujian Provincial Engineering Research Center of Oral Biomaterial&Stomatology Key Laboratory of Fujian College and University School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Institute of Stomatology&Research Center of Dental and Craniofacial Implants School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Stomatology Fujian Medical University Union HospitalFuzhouChina

The aim of this study was to explore the impact of chronic apical periodontitis(CAP)on atherosclerosis in apoE^(−/−)mice fed high-fat diet(HFD).This investigation focused on the gut microbiota,metabolites,and intestinal barrier function to uncover potential links between oral health and cardiovascular disease(CVD).In this study,CAP was shown to exacerbate atherosclerosis in HFD-fed apoE^(−/−)mice,as evidenced by the increase in plaque size and volume in the aortic walls observed via Oil Red O staining.16S rRNA sequencing revealed significant alterations in the gut microbiota,with harmful bacterial species thriving while beneficial species *** profiling indicated disruptions in lipid metabolism and primary bile acid synthesis,leading to elevated levels of taurochenodeoxycholic acid(TCDCA),taurocholic acid(TCA),and tauroursodeoxycholic acid(TDCA).These metabolic shifts may contribute to atherosclerosis ***,impaired intestinal barrier function,characterized by reduced mucin expression and disrupted tight junction proteins,was *** increased intestinal permeability observed was positively correlated with the severity of atherosclerotic lesions,highlighting the importance of the intestinal barrier in cardiovascular *** conclusion,this research underscores the intricate interplay among oral health,gut microbiota composition,metabolite profiles,and CVD *** findings emphasize the importance of maintaining good oral hygiene as a potential preventive measure against cardiovascular issues,as well as the need for further investigations into the intricate mechanisms linking oral health,gut microbiota,and metabolic pathways in CVD development.

关键词： atherosclerosis metabolism impaired

MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination

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Neuroscience Bulletin 2024年第4期40卷 483-499页

作者： Xiaohong Dong Zhi Zhang Xin Shu Zi Zhuang Pinyi Liu Renyuan Liu Shengnan Xia Xinyu Bao Yun Xu Yan chen Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing210008China Department of Neurology Drum Tower Hospital of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China

Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter *** phagocytosing myelin debris in a timely manner can promote remyelination and contribute to the repair of white ***,milk fat globule-epidermal growth factor-factor 8(MFG-E8),a microglial phagocytosis-related protein,has not been well studied in hypoperfusion-related cognitive *** found that the expression of MFG-E8 was significantly decreased in the brain of mice after bilateral carotid artery stenosis(BCAS).MFG-E8 knockout mice demonstrated more severe BCAS-induced cognitive impairments in the behavioral *** addition,we discovered that the deletion of MFG-E8 aggravated white matter damage and the destruction of myelin microstructure through fluorescent staining and electron ***,MFG-E8 overexpression by AAV improved white matter injury and increased the number of mature oligodendrocytes after ***,in vitro and in vivo experiments showed that MFG-E8 could enhance the phagocytic function of microglia via theαVβ3/αVβ5/Rac1 pathway and IGF-1 production to promote the differentiation of oligodendrocyte progenitor cells into mature ***,we found that MFG-E8 was mainly derived from astrocytes,not *** findings suggest that MFG-E8 is a potential therapeutic target for cognitive impairments following cerebral hypoperfusion.

关键词： White matter injury Cognitive dysfunction MFG-E8 Remyelination Microglial phagocytosis

Unsupervised Color Segmentation with Reconstructed Spatial Weighted Gaussian Mixture Model and Random Color Histogram

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Computers, Materials & Continua 2024年第3期78卷 3323-3348页

作者： Umer Sadiq Khan Zhen Liu Fang Xu Muhib Ullah Khan Lerui chen Touseef Ahmed Khan Muhammad Kashif Khattak Yuquan Zhang School of Computer and Information Science Hubei Engineering UniversityXiaogan432000China Institute for AI Industrial Technology Research Hubei Engineering UniversityXiaogan432000China Key Lab of Mountain Hazards and Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu610041China University of Chinese Academy of Sciences Beijing100049China College of Aviation Zhongyuan University of TechnologyZhengzhou451191China Research Center of Digital Mountain and Remote Sensing Application Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu610041China School of Computer Science University of PoonchAzad Jammu Kashmir12350Pakistan School of Computer Science and Information Engineering Hubei UniversityWuhan430062China

Image classification and unsupervised image segmentation can be achieved using the Gaussian mixture *** the Gaussian mixture model enhances the flexibility of image segmentation,it does not reflect spatial information and is sensitive to the segmentation *** this study,we first present an efficient algorithm that incorporates spatial information into the Gaussian mixture model(GMM)without parameter *** proposed model highlights the residual region with considerable information and constructs color ***,we incorporate the content-based color saliency as spatial information in the Gaussian mixture *** segmentation is performed by clustering each pixel into an appropriate component according to the expectation maximization and maximum ***,the random color histogram assigns a unique color to each cluster and creates an attractive color by default for segmentation.A random color histogram serves as an effective tool for data visualization and is instrumental in the creation of generative art,facilitating both analytical and aesthetic *** experiments,we have used the Berkeley segmentation dataset BSDS-500 and Microsoft Research in Cambridge *** the study,the proposed model showcases notable advancements in unsupervised image segmentation,with probabilistic rand index(PRI)values reaching 0.80,BDE scores as low as 12.25 and 12.02,compactness variations at 0.59 and 0.7,and variation of information(VI)reduced to 2.0 and 1.49 for the BSDS-500 and MSRC datasets,respectively,outperforming current leading-edge methods and yielding more precise segmentations.

关键词： Unsupervised segmentation color saliency spatial weighted GMM random color histogram

Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis

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Genes & Diseases 2024年第5期11卷 442-455页

作者： Jianxiong Xu Jinxuan Wang Hongping Zhang Yidan chen Xiaojuan Zhang Ying Zhang Ming Xie Jun Xiao Juhui Qiu Guixue Wang Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering Modern Life Science Experiment Teaching Center of Bioengineering CollegeChongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China School of Basic Medical Sciences Chengdu Medical CollegeChengduSichuan 610500China Chongqing Emergency Medical Center(Chongqing University Central Hospital) Chongqing 400014China

The clearance of apoptotic cell debris,containing professional phagocytosis and non-professional phagocytosis,is essential for maintaining the homeostasis of healthy ***,we discovered that endothelial cells could engulf apoptotic cell debris in atherosclerotic ***-cell RNA sequencing(RNA-seq)has revealed a unique endothelial cell subpopulation in atherosclerosis,which was strongly associated with vascular injury-related ***,integrated analysis of three vascular injury-related RNA-seq datasets showed that the expression of scavenger receptor class B type 1(SR-B1)was up-regulated and specifically enriched in the phagocytosis pathway under vascular injury ***-cell RNA-seq and bulk RNA-seq indicate that SR-B1 was highly expressed in a unique endothelial cell subpopulation of mouse aorta and strongly associated with the reorganization of cellular adherent junctions and cytoskeleton which were necessary for ***,SR-B1 was strongly required for endothelial cells to engulf apoptotic cell debris in atherosclerotic plaque of both mouse and human ***,this study demonstrated that apoptotic cell debris could be engulfed by endothelial cells through SR-B1 and associated with the reorganization of cellular adherent junctions and cytoskeleton.

关键词： Apoptotic cell debris Atherosclerosis Endothelial engulfment Single-cell RNA sequencing Scavenger receptor class B type 1

Decoding the biochemical dialogue:metabolomic insights into soybean defense strategies against diverse pathogens

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Science China(Life Sciences) 2024年第10期67卷 2234-2250页

作者： Min Qiu Mengjun Tian Yaru Sun Huaibo Li Wenwen Huang Haibing Ouyang Shaoyan Lin chen Zhang Ming Wang Yuanchao Wang Sanya Institute of Nanjing Agricultural University Department of Plant PathologyNanjing Agricultural UniversityNanjing 210095China The Key Laboratory of Plant Immunity Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Soybean Disease and Pest Control(Ministry of Agriculture and Rural Affairs) Nanjing Agricultural UniversityNanjing 210095China China State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing 210095China

Soybean,a crucial global leguminous crop,confronts persistent threats from diverse pathogens,exerting a profound impact on global *** genetic dimensions of soybean-pathogen interactions have garnered attention,the intricate biochemical responses remain poorly *** this study,we applied targeted and untargeted liquid chromatography coupled to mass spectrometry(LC-MS)metabolite profiling to dissect the complex interplay between soybeans and five distinct *** analysis uncovered 627 idMS/MS spectra,leading to the identification of four main modules,encompassing flavonoids,isoflavonoids,triterpenoids,and amino acids and peptides,alongside other compounds such as *** shifts were observed in both primary and secondary metabolism in response to pathogenic *** notable were the bidirectional changes in total flavonoids across diverse pathogenic inoculations,while triterpenoids exhibited a general declining *** among the highly inducible total flavonoids were known representative antipathogen compounds(glyceollin I),backbone forms of isoflavonoids(daidzein,genistein,glycitein,formononetin),and newly purified compounds in this study(prunin).Subsequently,we delved into the biological roles of these five compounds,validating their diverse functions against pathogens:prunin significantly inhibited the vegetative growth and virulence of Phytophthora sojae;genistein exhibited a pronounced inhibitory effect on the vegetative growth and virulence of Phomopsis longicolla;daidzein and formononetin displayed significant repressive effects on the virulence of *** study underscores the potent utility of metabolomic tools,providing in-depth insights into plant-pathogen interactions from a biochemical *** findings not only contribute to plant pathology but also offer strategic pathways for bolstering plant resistance against diseases on a broader scale.

关键词： metabolome soybean soybean-pathogens interaction secondary metabolites triterpenoids flavonoids isoflavonoids antimicrobial compounds

Deep3DSketch-im:rapid high-fidelity AI 3D model generation by single freehand sketches

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 149-159页

作者： Tianrun chen Runlong CAO Zejian LI Ying ZANG Lingyun SUN College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China School of Software Technology Zhejiang UniversityHangzhou 310027China School of Information Engineering Huzhou UniversityHuzhou 313000China

The rise of artificial intelligence generated content(AIGC)has been remarkable in the language and image fields,but artificial intelligence(AI)generated three-dimensional(3D)models are still under-explored due to their complex nature and lack of training *** conventional approach of creating 3D content through computer-aided design(CAD)is labor-intensive and requires expertise,making it challenging for novice *** address this issue,we propose a sketch-based 3D modeling approach,Deep3DSketch-im,which uses a single freehand sketch for *** is a challenging task due to the sparsity and ***3DSketch-im uses a novel data representation called the signed distance field(SDF)to improve the sketch-to-3D model process by incorporating an implicit continuous field instead of voxel or points,and a specially designed neural network that can capture point and local *** experiments are conducted to demonstrate the effectiveness of the approach,achieving state-of-the-art(SOTA)performance on both synthetic and real ***,users show more satisfaction with results generated by Deep3DSketch-im,as reported in a user *** believe that Deep3DSketch-im has the potential to revolutionize the process of 3D modeling by providing an intuitive and easy-to-use solution for novice users.

关键词： Content creation Sketch Three-dimensional(3D)modeling 3D reconstruction Shape from X Artificial intelligence(AI)

Findings on three endocommensal scuticociliates(Protista,Ciliophora)from freshwater mollusks,including their morphology and molecular phylogeny with descriptions of two new species

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Marine Life Science & Technology 2024年第2期6卷 212-235页

作者： Tao Li Tengyue Zhang Mingjian Liu Zhe Zhang Jiachen Zhang Junhua Niu Xiangrui chen Saleh A.Al‑Farraj Weibo Song Institute of Evolution and Marine Biodiversity Ocean University of China and Key Laboratory of Evolution and Marine Biodiversity(Ministry of Education)Qingdao 266003China The Key Laboratory of Zoological Systematics and Application College of Life SciencesHebei UniversityBaoding 071002China College of Marine Life Sciences Ocean University of ChinaQingdao 266003China School of Marine Sciences Ningbo UniversityNingbo 315800China Zoology Department College of ScienceKing Saud University11451 RiyadhSaudi Arabia Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China

Species of the ciliate genera Myxophyllum and Conchophthirus are found as endocommensals of terrestrial and freshwater mollusks,*** far,there have been few studies of these genera and morphological data for most members are often *** the present work,two new species,Myxophyllum weishanense *** Conchophthirus paracurtus ***.,and a known species,Conchophthirus lamellidens,were isolated from hosts in Lake Weishan Wetland,*** studies indicate that *** *** be recognized mainly by the combination of about 60 somatic kineties on both ventral and dorsal sides and the presence of caudal *** paracurtus *** from congeners in its body shape and size,having a glabrous area on the posterior right side,and having fewer somatic *** addition,differences in their ITS2(Internally Transcribed Spacer 2)secondary structures support the discrimination of the two new species from their highly similar *** improved diagnosis for the poorly known species,***-lidens is also *** analyses reveal that members of the genus Myxophyllum belong to a fully supported clade that is sister to a large,poorly supported clade consisting of Hemispeiridae,Ancistridae,and several lineages of the nonmonophyletic *** Myxophyllum clade also includes Protophyra ovicola JQ956552,a possible *** of the two new Conchophthirus species cluster with other congeners in a fully supported clade that is unrelated to either the‘typical’thigmotrichs or to pleuronematids,thus conflicting with the traditional classification,and may represent an orphan scuticociliate lineage.

关键词： Ciliates Endocommensal ITS2 secondary structure Mollusks New taxa Wetland

Research progress on venous thrombosis development in patients with malignant tumors

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World Journal of Clinical Cases 2024年第11期12卷 1900-1908页

作者： Teng-Fei Wang Qian chen Jie Deng Shi-Liang Li Yuan Xu Si-Xing Ma Department of Vascular Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this *** recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related ***,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer *** conducted an extensive review encompassing pivotal historical and ongoing studies on *** review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.

关键词： Malignant tumor Venous thromboembolism Cancer-associated thrombosis Research progress